[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Cleveland Dental Institute\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":155},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,65,87,111,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100559504","phase-1-risk-of-nerve-damage-after-administration-of-local-anesthesia-100559504",false,"NCT06564987","Risk of Nerve Damage After Administration of Local Anesthesia","Risk of Nerve Damage After Administration of an Inferior Alveolar Nerve Block Using 4% Articaine Versus 2% Lidocaine","Inclusion Criteria:\n\n* Patients with age between 18-55 years old\n* Patients need IANB\n* healthy patient\n\nExclusion Criteria:\n\n* medical conditions\n* allergies\n* medications\n* pregnancy and breastfeeding\n* inability to provide informed consent\n* specific dental or medical history.",true,"ALL","18 Years","55 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"PHASE1","This research aims to evaluate of the risk of nerve damage following the administration of articaine 4% and lidocaine 2% for Inferior Alveolar nerve Block (IANB). A Randomized Controlled Clinical Trial will be conducted where the patient will be randomly assigned to one the two groups; articaine 4% and Lidocaine 2%. The type of LA will be concealed to the operator, investigators and assessors. The patients will be monitored for any aigns of nerve parathesia for 3 months after the procedure.",[28],"Inferior Alveolar Nerve Injuries","RECRUITING","2024-08-23",{"date":32,"type":33},"2024-08-26","ACTUAL",{"date":35,"type":33},"2024-01-01",{"date":37,"type":22},"2025-03-31",{"name":39,"class":40},"Cleveland Dental Institute","OTHER",2,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":62,"leadSponsor":63,"locationsCount":64},"100558606","auto-transplantation-of-wisdom-teeth-100558606","NCT06553300","Auto Transplantation of Wisdom Teeth","Auto Transplantation of Wisdom Teeth With or Without Platelet Rich Fibrin for Replacement of Non-Restorable Posterior Teeth.","Inclusion Criteria:\n\n* male and female\n* aged between 20 and 50 years\n* devoid of systemic ailments\n* complying with the study procedures\n* holding an Anesthesiologists classification of 1 or 2\n* possessing mandibular or maxillary immature wisdom teeth\n\nExclusion Criteria:\n\n* systemic diseases that might impede the healing process\n* Patients with pacemakers\n* Individuals harboring allergies to medications or antibiotics\n* active smokers\n* patients afflicted with periodontal diseases","50 Years",{"count":51,"type":22},20,[53],"NA","Autotransplantation emerges as a viable alternative to tooth extraction and prosthetic restoration when conventional endodontic treatments are unfeasible or contraindicated. The success of autotransplantation is influenced by diverse factors, including root development stage, tooth morphology, surgical technique, extraoral duration, recipient socket shape, recipient bed vascularity, and periodontal ligament cell vitality. Preserving periodontal ligament quality and achieving tissue adaptation are pivotal for successful tooth transplantation. Successful donor tooth replacement is influenced by variables like fitting attempts, alveolus-root distance, extra-alveolar time, surgical skill, and extraction trauma intensity.",[56,57],"Autotransplantation of Wisdom Teeth","Patelet Rich Fibrin","2024-08-09",{"date":60,"type":33},"2024-08-14",{"date":35,"type":33},{"date":37,"type":22},{"name":39,"class":40},1,{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":23,"phases":75,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":84,"leadSponsor":86,"locationsCount":64},"100557447","phase-2-pain-after-buffered-vs-non-buffered-articaine-100557447","NCT06538233","Pain After Buffered Vs Non Buffered Articaine","A Comparison of Pain Response During Administration of Buffered Articaine Versus Non-buffered Articaine Local Anesthetics for Dental Treatment in Adult","Inclusion Criteria:\n\n* Males and females, age- 18 to 60 yrs.\n* Medically free.\n* Need a dental treatment in the upper anterior region.\n\nExclusion Criteria:\n\n* Periodontally affected teeth.\n* Radiographic bone loss.\n* Upnormal length of the teeth.","60 Years",{"count":74,"type":22},108,[76],"PHASE2","Pain after buffered versus non buffered articaine.",[79],"Pain","2024-07-31",{"date":82,"type":33},"2024-08-05",{"date":35,"type":33},{"date":85,"type":22},"2025-01-31",{"name":39,"class":40},{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":49,"enrollmentInfo":94,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":110,"locationsCount":64},"100556551","pain-measured-by-nrs-and-eeg-in-acute-pulpitis-100556551","NCT06526572","Pain Measured by NRS and EEG in Acute Pulpitis","Measuring Pain Perception in Patients With Symptomatic Acute Pulpitis and Resistant to Inferior Alveolar Nerve Block Using NRS and Brain Waves","Inclusion Criteria:\n\nAdults aged \\[18-50 years\\]. Clinically diagnosed with symptomatic acute pulpitis based on dental examination and radiographic findings.\n\nDemonstrates resistance to inferior alveolar nerve block (IANB). Willing and able to provide informed consent to participate in the study. Able to communicate effectively in the language used for study procedures.\n\nExclusion Criteria:\n\nIndividuals with known neurological or psychiatric disorders affecting pain perception.\n\nPregnant individuals or those breastfeeding at the time of the study. History of severe allergies or adverse reactions to local anesthetics or EEG gel.\n\nPresence of significant medical conditions that may contraindicate dental procedures or EEG recordings.\n\nIndividuals taking medications that could significantly affect pain perception (e.g., strong analgesics, sedatives).\n\nAny contraindications for dental procedures or EEG recordings as determined by the study's dental and medical professionals.\n\nInability to understand and follow study instructions.",{"count":95,"type":22},50,"OBSERVATIONAL","The aim of the proposed study is to investigate and comprehensively understand pain perception in patients diagnosed with symptomatic acute pulpitis who are resistant to inferior alveolar nerve block (IANB).\n\nThe study aims to achieve this by utilizing a dual approach that combines subjective self-reporting of pain intensity using the Numeric Rating Scale (NRS) with objective neurophysiological assessment through brain wave analysis using electroencephalography (EEG).\n\nBy integrating these two methods, the study seeks to explore potential correlations between self-reported pain scores and neural responses recorded through EEG, providing insights into the pain experience of this specific patient population.\n\nUltimately, the goal of the study is to enhance the understanding of pain perception mechanisms in individuals with symptomatic acute pulpitis resistant to IANB and potentially guide the development of more effective and personalized pain management strategies for these patients.",[99],"Acute Pulpitis",[101,102,103,104],"Acute pulpits","Electroencephalography","Numerical rate scale","Inferior Alveolar Nerve Block","2024-07-29",{"date":80,"type":33},{"date":108,"type":33},"2023-07-01",{"date":85,"type":22},{"name":39,"class":40},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":49,"enrollmentInfo":118,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":64},"100556704","postoperative-pain-after-activation-of-irrigant-100556704","NCT06528574","Postoperative Pain After Activation of Irrigant","Incidence of Postoperative Pain After Activation of Irrigant With Apical Negative Pressure and Ultrasonics in Mandibular Molar Teeth With Irreversible Pulpitis: A Randomized Controlled Trial","Inclusion Criteria:\n\nMales and females Age :20-50 Mandibular mature first molars with symptomatic acute pulpitis Medically free patients\n\nExclusion Criteria:\n\nPulp necrosis or apical periodontitis Periodontal disease Vertical root fracture Radiographic apical radiolucency\n\n\\-",{"count":119,"type":22},84,[53],"The purpose of this research is to analyze the levels of pain after cleaning and shaping in individuals who are receiving root canal therapy using the IVAC irrigation approach, and those who are treated with ultrasonic irrigation techniques, negative pressure irrigation technique and traditional irrigation techniques.\n\nPICOTS Question:\n\nDoes the new Dent's iVac irrigation protocol has an effect on reduction of postoperative pain\n\nBy enlisting at least 84 suitable individuals who are undergoing the identical endodontic procedure.\n\npain will be measures by assessing pain levels through a standardized numerical rate scale (NRS) at certain time intervals after root canal treatment, 6 hours, 12 hours, 24 hours, 48 hours, and 72 hours.",[79],"2024-07-26",{"date":125,"type":33},"2024-07-30",{"date":127,"type":33},"2023-08-01",{"date":129,"type":22},"2025-04-30",{"name":39,"class":40},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":138,"maxAge":72,"enrollmentInfo":139,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":152,"leadSponsor":154,"locationsCount":64},"100555296","pain-perception-measurement-by-eeg-and-nrs-100555296","NCT06510244","Pain Perception Measurement by EEG and NRS","Measuring Pain Perception to the Same Stimulus in Different Patients Using Electroencephalography and Numerical Rate Scale","Inclusion Criteria:\n\n* Males and females\n* Age: 20-60 years.\n* Tooth #8 vital and mature. No history of dentoalveolar trauma.\n* Adequate coronal tooth structure.\n\nExclusion Criteria:\n\n* Chronic periodontitis.\n* Vertical root fracture.\n* Immature teeth.\n* Necrotic teeth.\n* Systemic diseases that affect the healing process.\n* Non restorable teeth.","20 Years",{"count":140,"type":22},100,"Observational study at CDI Cleveland Dental Institute. Investigators will assess the pain perception in one group of patients using two non-invasive methods. First, a numerical rate scale (NRS) and second, a brain wave EEG.",[79,102,143],"Toothache",[145,146,147],"pain perception","Numeric Pain Rating Scale","electroencephalography","2024-07-19",{"date":150,"type":33},"2024-07-22",{"date":35,"type":33},{"date":153,"type":22},"2025-04",{"name":39,"class":40},""]