[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Clinact\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":65},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100354078","respiratory-support-in-chronic-obstructive-pulmonary-disease-copd-patients-100354078",false,"NCT03890224","Respiratory Support in Chronic Obstructive Pulmonary Disease (COPD) Patients","Respiratory Support in Chronic Obstructive Pulmonary Disease (COPD) Patients After Acute Exacerbation With Monitoring the Quality of Support","Inclusion Criteria:\n\n* 1\\) Patients with COPD, GOLD C or D and Forced expiratory volume in one second (FEV1)\\\u003C65%;\n* 2\\) AHRF (pH\\\u003C7,35 and PaCO2≥45mm Hg (≥6kPa) treated more than 24h with Ventilation (non-invasive or invasive);\n* 3\\) 48h to 2 weeks with pH\\>7.35, and PaCO2\\>45 (\\>6kPa) after NIV withdrawal, during daytime at rest without oxygen or ventilatory support (or with O2 if patients are not able to avoid O2 with immediate desaturation below 80%).\n\nExclusion Criteria:\n\n1. Patient treated with chronic NIV or continuous positive airway pressure (CPAP) device, with ongoing treatment;\n2. Primary diagnosis of restrictive lung disease causing hypercapnia i.e. obesity hypoventilation and chest wall disease, however these patients will be included if the \"FEV1\u002FForced vital capacity (FVC)\" ratio is \\\u003C60% and the FEV1 \\\u003C50% if the predominant defect is considered to be obstructive by the center clinician;\n3. BMI \\> 35 kg\u002Fm2;\n4. Sedative medication causing hypercapnia (\\> 3 drugs or more than 20mg of morphine\u002Fday);\n5. Polygraphic diagnosis of Obstructive Sleep Apnoea Syndrome (AHI\\>30\u002Fh (French criteria);\n6. Cognitive impairment that would prevent informed consent into the trial\n7. Pregnancy;\n8. Tobacco use \\\u003C 10 pack-year;\n9. Psychiatric disease necessitating anti-psychotic medication, ongoing treatment for drug or alcohol addiction, persons of no fixed abode post-discharge;\n10. Unstable coronary artery syndrome;\n11. Age \\\u003C18 years;\n12. Inability to comply with the protocol;\n13. Expected survival\\\u003C12 months due to any situation other than COPD disease;\n14. Duration of ICU stay\\>10 days;\n15. No affiliated to national health insurance;\n16. Measure of legal protection (guardianship, wardship or judicial protection) for patients over the age of majority.","ALL","18 Years",{"count":19,"type":20},400,"ESTIMATED","INTERVENTIONAL",[23],"NA","The hypothesis of this study is that any of 3 modalities of home non- invasive ventilation (NIV) compared to 'no NIV' (=hospital NIV) will reduce re-admission to hospital or death in COPD patients who remain persistently hypercapnic following an exacerbation requiring NIV.",[26,27],"Chronic Obstructive Pulmonary Disease","COPD Exacerbation",[29],"Respiratory Support","RECRUITING","2024-06-17",{"date":33,"type":34},"2024-06-20","ACTUAL",{"date":36,"type":34},"2019-07-04",{"date":38,"type":20},"2027-02-28",{"name":40,"class":41},"Clinact","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":42},"100551894","research-into-diagnostic-and-prognostic-molecular-and-imaging-biomarkers-of-ocular-disorders-associated-with-neurovascular-deregulation-biocor-cohort-100551894","NCT06466018","Research Into Diagnostic and Prognostic Molecular and Imaging Biomarkers of Ocular Disorders Associated With Neurovascular Deregulation: Biocor Cohort","Recherche de Biomarqueurs moléculaires et d'Imagerie Diagnostiques et Pronostiques Des Atteintes Oculaires associées à Des dérégulations Neurovasculaires : Cohorte Biocor","BIOCOR","Inclusion Criteria:\n\n* Male or female \\> 18 years of age, of European origin, with signed ± genetic consent\n* Clear ocular media for OCT and autofluorescence imaging\n* Signed consent form\n* Be affiliated to a health insurance scheme\n* Control patients are patients scheduled for cataract surgery or visual assessment.\n\nExclusion Criteria:\n\n* High myopia \\> 6D\n* Diabetic retinopathy, hereditary retinal dystrophy, untreated retinal detachment, choroidal ocular tumor, choroidal hemangioma\n* Epithelial or stromal keratopathy other than ocular rosacea\n* Corneal surgery less than 3 months old, keratoplasty\n* Deprived of liberty or under guardianship or curatorship",true,{"count":19,"type":20},[23],"BIOCOR is an interventional clinical trial whose main objectives are Objectif are identify molecular biomarker(s) of ocular rosacea and pachychoroid. Endpoints are : Correlation between pachychoroidosis (defined by choroidal phenotype parameters in OCT and autofluorescence) or the stage of ocular rosacea (ROSCO(29) definition) and biological markers selected on the basis of preclinical work (animal model) and by unbiased methods (proteomics, metabolomics, meibum lipidomics). The study of circulating, ocular and functional biomarkers would enable us to confirm our hypothesis and identify patients who could benefit from treatments that regulate the ANS and\u002For mineralocorticoid pathways.",[56,57],"Ocular Rosacea","Pachychoroid Disease","2024-06-13",{"date":33,"type":34},{"date":61,"type":34},"2024-03-19",{"date":63,"type":20},"2026-10-01",{"name":40,"class":41},""]