[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Clinica Alemana de Santiago\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":131},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,79,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":35,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100610681","the-study-evaluates-the-effect-of-an-interactive-projector-as-a-distraction-for-children-during-anesthetic-induction-the-primary-objective-is-to-reduce-perioperative-anxiety-measured-with-the-modified-yale-preoperative-anxiety-scale-mypas-100610681",false,"NCT07230743","The Study Evaluates the Effect of an Interactive Projector as a Distraction for Children During Anesthetic Induction. The Primary Objective is to Reduce Perioperative Anxiety, Measured With the Modified Yale Preoperative Anxiety Scale (mYPAS).","Comparison of Anxiety During Mask Induction of Anesthesia in Pediatric Patients With an Immersive\u002FInteractive Technological Intervention Versus Traditional Care: A Latin American Experience","Inclusion Criteria:\n\n* Patients undergoing elective procedures under general anesthesia at Clinica Alemana\n* Parent or caregiver presence for mask induction\n* ASA I, II\n* Ages 2-6 years of age\n* Spanish speaking\n* Parental consent\u002Fpatient assent\n\nExclusion Criteria:\n\n* Patient or parental does not consent\n* ASA ≥ III\n* Emergency surgery\n* Intravenous induction of anesthesia\n* Patient with a significant neurological condition or major developmental disability\n* Severe visual or auditory defects\n* Patients admitted using a crib as the mode of transport",true,"ALL","2 Years","6 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is designed to evaluate the effect of technology as a distraction technique during anesthetic induction in children, starting from their arrival to the operating room. An interactive film will be displayed using a projector (BERT: Bedside Entertaining and Relaxation Tool) mounted on a whiteboard in front of the child's gurney. The primary outcome is perioperative anxiety, measured with the Modified Yale Preoperative Anxiety Scale (mYPAS).",[28,29,30,31,32,33,34],"Anxiety","Anxiety After Surgery","Induction of Anesthesia","Anxiety Preoperative","Anesthesia Care","Technology Use","Child Anxiety",[36,37],"Custom Projector-based Software Game","Pediatric Mask Induction Anxiety","RECRUITING","2025-11-13",{"date":41,"type":42},"2025-11-17","ACTUAL",{"date":44,"type":42},"2025-07-01",{"date":46,"type":22},"2026-07",{"name":48,"class":49},"Clinica Alemana de Santiago","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":16,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100591995","gastric-emptying-in-healthy-volunteers-and-glp-1-agonist-users-100591995","NCT06987669","Gastric Emptying in Healthy Volunteers and GLP-1 Agonist Users","Gastric Emptying Assessed by Gastric Ultrasound (US) in Healthy Volunteers and Semaglutide Users: Cohort Study","aGLP1-GUS","Inclusion Criteria:\n\n* 18 years old or older\n* Healthy volunteers or semaglutide users\n\nExclusion Criteria:\n\n* Bariatric surgery\n* Hiatal hernia\n* Impairment to give consent","18 Years",{"count":61,"type":22},155,"OBSERVATIONAL","This observational study aims to determine the gastric emptying kinetics assessed by ultrasound in healthy volunteers after a standard breakfast and the state of the stomach after a clear liquid diet for 18 \u002F24 hours in patients on GLP-1 agonist. The main questions it seeks to answer are:\n\n* Is the kinetic after a standard breakfast that includes ( avocado and eggs: high fat) as fast as a standard meal that does not involve this food?\n* Is a clear liquid diet of 18 to 24 hours enough to be an empty-stomach, assessed by Ultrasound in patients on GLP1 agonist?\n\nParticipants will be asked to do:\n\n-A baseline Gastric US will be performed for healthy volunteers, and then they will have a standardized breakfast. An hourly or bihourly assessment will be done by the US.",[65,66],"Diabetes Type 2","Obesity and Overweight",[68,69],"agonist GLP-1","perioperative fasting","NOT_YET_RECRUITING","2025-05-22",{"date":73,"type":42},"2025-05-23",{"date":75,"type":22},"2025-05-17",{"date":77,"type":22},"2027-12-31",{"name":48,"class":49},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100537097","acetazolamide-or-metolazone-in-acute-heart-failure-100537097","NCT06273397","Acetazolamide or Metolazone in Acute Heart Failure","ACME-AHF","Inclusion Criteria:\n\n* Acute heart failure: Hospitalization due to symptoms of heart failure, congestion signs documented with a congestion score greater than 1, NT-proBNP above 1000 pg\u002Fml.\n* Randomization within 24 hours of admission.\n\nExclusion Criteria:\n\n* Under 18 years of age.\n* Received more than one dose of intravenous furosemide before randomization.\n* Cause of heart failure: hypertrophic or restrictive cardiomyopathy, or constrictive pericarditis.\n* Acute coronary syndrome or severe acute valvulopathy as the cause of decompensation.\n* Systolic blood pressure \\\u003C 90mmHg before randomization.\n* Requirement for vasopressors, inotropes, or invasive mechanical ventilation. Use of intravenous vasodilators or non-invasive mechanical ventilation is allowed.\n* Glomerular filtration rate \\\u003C 20ml\u002Fmin\u002F1.73m2.\n* Potassium \\\u003C 2.5 mEQ\u002FL or Sodium \\\u003C 125 mEQ\u002FL before randomization.\n* pH \\\u003C 7.2 or Bicarbonate \\\u003C 15mEQ\u002FL before randomization.\n* Use of another diuretic in addition to furosemide before randomization. Dapagliflozin or Empagliflozin can be maintained upon admission or initiated early during hospitalization if desired by the treating physician (variable to be recorded).\n* Patients who cannot achieve adequate recording of variables (e.g., inability to quantify diuresis or weight).\n* Pregnant or lactating individuals. If of childbearing age and there is inconsistency with contraceptive use or reasonable doubts about current pregnancy, a pregnancy test must be conducted before study entry.",{"count":87,"type":22},1050,[25],"Impact of Acute Heart Failure:\n\nAccording to the World Health Organization (WHO), approximately 26 million people suffer from Heart Failure (HF), with a mortality rate of up to 50% within five years of diagnosis. Acute Heart Failure (AHF) exacerbations, leading to hospitalization, are common and represent the primary cause of hospital admissions in those over 65. Effective decongestion during hospitalization is crucial, as failure to achieve it doubles the risk of rehospitalization and mortality, incurring significant healthcare costs.\n\nUse of Diuretics in Acute Heart Failure:\n\nDiuretics, particularly loop diuretics like furosemide, are a cornerstone in managing AHF by inducing natriuresis and achieving decongestion. Clinical experience supports their use, though limited clinical trials exist. Pharmacological concepts guide their administration, emphasizing intravenous delivery in high doses and adjusting subsequent doses based on decongestive efficacy. Additionally, sequential tubular blockade with other diuretics like metolazone and acetazolamide is explored to enhance decongestion.\n\nUse of Metolazone and Acetazolamide:\n\nSequential tubular blockade, using metolazone and acetazolamide in conjunction with furosemide, aims to achieve rapid and effective decongestion. While metolazone targets the distal tubule, inhibiting sodium-chloride channels, acetazolamide affects proximal tubular function. Studies like ADVOR (acetazolamide) and CLOROTIC (thiazide-like diuretic) demonstrate the potential benefits of combining these diuretics for quicker decongestion but with potential risks (in the case of Hydrochlorothiazide).\n\nOutcomes Measured by Major Studies:\n\nRecent studies assessing decongestion in AHF reveal a lack of uniformity in outcome selection. The primary focus should be on reducing rehospitalizations and post-discharge mortality by achieving effective decongestion. The ADVOR study, using a simple congestion score based on clinical and imaging criteria, underscores the importance of reaching a congestion score of 0 or 1 promptly.\n\nCongestion Monitoring:\n\nMonitoring diuretic treatment solely based on clinical aspects may not capture subclinical congestion, necessitating biochemical and imaging parameters. The ACME-AHF trial proposes a diagnostic score integrating clinical and imaging aspects to evaluate congestion status. Secondary outcomes include cumulative diuresis, weight loss, diuretic efficiency, and natriuresis, with a focus on natriuresis as a reliable physiological parameter for decongestion.\n\nAim of the study:\n\nThe ACME-AHF trial is designed to compare the efficacy and safety of two diuretic combination strategies: acetazolamide with furosemide and metolazone with furosemide. The primary objective is to relieve congestion, assessed using a congestion score, within the first three days of treatment during an hospitalization for acute heart failure.",[91,92],"Heart Failure Acute","Decompensated Heart Failure",[94,95,91],"Acetazolamide","Metolazone","2024-03-14",{"date":98,"type":42},"2024-03-18",{"date":100,"type":22},"2024-05-01",{"date":102,"type":22},"2027-05-01",{"name":48,"class":49},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":112,"targetDuration":114,"studyType":62,"phases":4,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":50},"100506068","registry-of-anesthesia-and-perioperative-medicine-100506068","NCT05869578","Registry of Anesthesia and Perioperative Medicine","Registry of Patients Subjected to the Perioperative Care of the Anesthesia Service of Clinica Alemana of Santiago Chile","RAMP","Inclusion Criteria:\n\n* All individuals\n* Individuals agreeing to participate in the study by signing a consent\n\nExclusion Criteria:\n\n* The subjects who had insufficient data in their files",{"count":113,"type":22},10000,"1 Year","To assess mortality and morbidity associated to anesthesia interventions",[117,118,119,120,121,122],"Perioperative Complication","Perioperative\u002FPostoperative Complications","Anesthesia Morbidity","Anesthesia; Adverse Effect","Anesthesia Complication","Anesthesia; Reaction","2023-05-19",{"date":125,"type":42},"2023-05-22",{"date":127,"type":22},"2023-06-01",{"date":129,"type":22},"2045-01-01",{"name":48,"class":49},""]