[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Clinical Centre of Serbia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":108},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100638263","opioid-free-anesthesia-and-pain-study-in-cardiac-surgery-patients-100638263",false,"NCT07618130","Opioid-Free Anesthesia and Pain Study in Cardiac Surgery Patients","Assessment od the Effects of Opioid-Free Anesthesia on Acute and Chronich Postsurgical Pain in Cardiac Surgery Patinets: A Prospective Randomized Controlled Trial","OFPAINS-CS","Inclusion Criteria:\n\n* elective cardiac surgery patients\n\nExclusion Criteria:\n\n* Emergecy cardiac surgery patients","ALL","18 Years","99 Years",{"count":21,"type":22},400,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to compare the effect of opioid-free anesthesia on the intensity of acute and chronic postoperative pain in patients undergoing cardiac surgery. The study will also evaluate the safety of opioid-free anesthesia in this patient population.\n\nThe main questions it aims to answer are:\n\n* Is opioid-free anesthesia effective in reducing the intensity of acute and chronic postoperative pain in cardiac surgery patients?\n* Is this anesthetic technique safe in this patient population? Patients will be randomized before surgery into two groups. In the first group, anesthesia will be performed with opioids, while in the second group, anesthesia will be performed without opioids. Researchers will measure acute postoperative pain during the first 48 hours using the Numeric Rating Pain Scale (NRPS). Chronic postoperative pain will be assessed after 3 months via a telephone interview.\n\nAdditionally, the incidence of adverse events-including postoperative delirium (POD), hemodynamic instability, respiratory complications, constipation, and postoperative nausea and vomiting (PONV)-as well as overall treatment outcomes, will be evaluated.",[28,29,30,31],"Posoperativ Pain","Chronich Pain","Postoperativ Delirum","Opoid-free Managment",[33],"OPIOPID-FREE, ANESTHESIA, CARDIAC SURGERY, ACUT PAIN, CHRONICH PAIN, POD","NOT_YET_RECRUITING","2026-05-24",{"date":37,"type":38},"2026-06-01","ACTUAL",{"date":40,"type":22},"2026-07-01",{"date":42,"type":22},"2027-11-20",{"name":44,"class":45},"Clinical Centre of Serbia","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":46},"100559949","iops-technology-during-cannnulation-of-contralateral-limb-in-evar-100559949","NCT06570785","IOPS Technology During Cannnulation of Contralateral Limb in EVAR","Contralateral Limb Cannulation Using Intra-Operative Positioning SystemTechnology in Endovascular Aneurysm Repair","IOPS","Inclusion Criteria:\n\n\\- All patients (over 18 years of age) with infrarenal AAA treated between 1st September 2024 and 1st May 2025 undergoing standard EVAR according to the IFU\n\nExclusion Criteria:\n\n* Patients who are pregnant\n* Patients who are under 40 years of age\n* Patients who have symptomatic or ruptured AAA\n* Patients with more advanced AAA: juxtarenal, pararenal, suprarenal, thoracic, thoracoabdominal AAA\n* Non-atherosclerotic origin of disease: dissection, connective tissue disorders, mycotic AAA, posttraumatic AAA\n* Patients who were treated in a conservative manner\n* Patients undergoing open surgery\n* Patients undergoing more advanced treatment options: fenestrated\u002Fbranched EVAR, endostaplers, chimney EVAR, iliac branch devices, etc.","40 Years","100 Years",{"count":58,"type":22},80,"OBSERVATIONAL","Short-term results are favorable for EndoVascular Aneurysm Repair (EVAR) compared to open surgery. One of the major drawbacks to this shift is the need for fluoroscopy and contrast dyes to visualise endovascular devices. The use of fluoroscopy exposes both patients and caregivers to harmful ionizing radiation. Because of the harmful effects of radiation, recent radiation protection guidelines strongly recommend as low as reasonably achievable (ALARA) principle. The need for additional radiation-reducing navigation techniques is high, with the ultimate goal of performing endovascular procedures without radiation at all.\n\nIn response to these challenges, Centerline Biomedical (Cleveland, Ohio, USA) has developed a proprietary electromagnetic tracking and positioning system called the Intra-Operative Positioning System (IOPS). This medical device provides surgeons with 3D visualization for increased surgical precision while reducing the radiation exposure for patients and healthcare professionals. IOPS provides 3D electromagnetic navigation of interventional devices as an adjunct to fluoroscopy. During the intervention, the IOPS devices can be visualized with on-screen image guidance. The IOPS guidewires and catheters can be used together or combined with off-the-shelf 0.035-inch catheters and guidewires, as needed.\n\nThis study aims to describe the influence of IOPS technology on radiation exposure during cannulation of the contralateral limb (CL) during standard EVAR.",[62,63,64],"Abdominal Aortic Aneurysm","Abdominal Aortic Aneurysm Without Rupture","Radiation Exposure",[62,66,67],"EndoVascular Aneurysm Repair","Radiation Protection","2024-11-17",{"date":70,"type":38},"2024-11-20",{"date":72,"type":22},"2025-01-20",{"date":74,"type":22},"2025-11-03",{"name":44,"class":45},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":83,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":85,"conditions":86,"keywords":91,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":46},"100535552","treatment-of-tasc-c-and-d-aortoiliac-lesions-100535552","NCT06253312","Treatment of TASC C and D Aortoiliac Lesions","Comparison of Open Surgery, Hybrid and Endovascular Repair for Complex TASC C\u002FD Aortoiliac Lesions","Inclusion Criteria:\n\n* All patients (over 18 years of age) with a history of atherosclerotic peripheral arterial disease treated between 1st January 2015 and 1st January 2022\n* All management strategies will be included (endovascular, hybrid, and open)\n\nExclusion Criteria:\n\n* Patients who are pregnant\n* Patients who are under 18 years of age\n* Patients who have acute limb ischemia or acute on chronic ischemia\n* Non-atherosclerotic origin of disease: cyclist disease, trauma, dissection\n* Patients who were treated in conservative manner\n* Patients who underwent primary major amputation\n* Patients with limited life expectancy (less than 2 years)",{"count":84,"type":22},900,"Background:\n\nThe treatment of patients with complex aortoiliac disease (AID), classified as Trans-Atlantic Inter-Society consensus II (TASC) class C and D, presents a dilemma for vascular surgeons. Current guidelines recommend either open surgical reconstruction (OR), hybrid repair (HR) combining iliac stenting with femoral endarterectomy, or total endovascular repair (ER). While traditional OR with aortobifemoral bypass (ABF) is associated with excellent long term patency results, it is associated with significant perioperative morbidity with some studies citing mortality rates of up to 4-8%. The advancement of endovascular techniques has led to many trials suggesting that endovascular management of TASC II C and D lesions is a potential alternative treatment to open strategies mainly in the subset of patients with high surgical risk, given the substantially less perioperative morbidity and mortality compared to OR.\n\nAim:\n\nThe aim of this trial is to evaluate the short, mid-, and long-term results of open repair, hybrid and endovascular repair in the treatment patients with complex, TASC C and D, aortoiliac lesions.\n\nMethodology:\n\nThis is a retrospective cohort study planning to include vascular surgery centers from the following countries: Italy, Portugal, Spain, and Serbia. Data will be collected on demographics, baseline comorbidities, anatomy and morphology of the aortoiliac and femoral bifurcation disease, intraoperative, postoperative, and follow-up data. Propensity score analysis will be performed by matching open repair patients in all three groups (open, hybrid, and endovascular repair) controlling for demographics, baseline comorbidities, anatomical and morphological data.\n\nEndpoints:\n\nPrimary endpoints are all-cause mortality and the major adverse limb events (major amputation - below and above the knee, new onset acute limb ischaemia, reintervention of the treated arterial segment). The secondary endpoints are the 30-day complications and primary patency.",[87,88,89,90],"Peripheral Arterial Disease","Aortoiliac Occlusive Disease","Leriche Syndrome","Peripheral Vascular Disease",[92,93,94,95,96,97,98],"peripheral arterial disease","aortoiliac disease","TASC C,D","open surgery","hybrid repair","endovascular repair","atherosclerosis","RECRUITING","2024-08-21",{"date":102,"type":38},"2024-08-23",{"date":104,"type":38},"2024-05-01",{"date":106,"type":22},"2025-09-01",{"name":44,"class":45},""]