[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Clinical Nutrition Research Center, Illinois Institute of Technology\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":122},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,79,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100642973","food-and-metabolism-study-100642973",false,"NCT07624500","Food and Metabolism Study","Effects of Avocado on Triglyceride Metabolism in Individuals With Insulin Resistance","FAM","Inclusion Criteria:\n\n* Men or women, 40-70 years of age.\n* Fasting triglycerides (TG) \\>115 mg\u002FdL.\n* Insulin resistance as measured by Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) \\>2.5.\n* Able to provide informed consent.\n* Able to comply with and perform the procedures requested by the protocol, specifically eat all the meals and snacks provided by the study which will be almost all your food (\\~ 80% of calories per day).\n* Able to come to the clinic up to 6 times during the study.\n* Able to maintain usual physical activity pattern.\n* Able to avoid\u002Fabstain from alcohol and vigorous physical activity for 24 hours prior to and during study visit.\n\nExclusion Criteria:\n\n* Men and women with known or suspected intolerance, allergies or hypersensitivity to study foods or interventions.\n* Fasting blood sugar ≥125 mg\u002FdL. Men and women with blood pressure \\>160 mmHg (systolic) \u002F 100 mmHg (diastolic) at the screening visit.\n* Men and women with history of diabetes cardiovascular events, respiratory, renal, gastrointestinal, hepatic or eye disease or surgery- within a year.\n* Men and women who have or had cancer other than non-melanoma skin cancer in the past 5 years.\n* Men and women taking over the counter or prescription medications or dietary supplements that may interfere with study procedures or endpoints.\n* Men and women who are on a specialized diet (vegan, vegetarian, keto, etc.). - - Men and women who consume nuts or peanuts daily or most days of the week.\n* Men and women who are not weight stable (+\u002F-10lbs in previous 2 months). Men and women who have excessive use of drugs or alcohol (ie., addictions) within the past 2 years.\n* Men and women with documented physical or mental disease\u002Fcondition, which might limit participation in or completion of the study or, that, in the opinion of the investigator, could interfere with the interpretation of the study results.\n* Women who are known to be pregnant or who are intending to become pregnant over the course of the study.\n* Women who are lactating.\n* Major trauma or a surgical event within 2 months (or longer depending on trauma or event) and after consultation with PI. Has used antibiotics within the previous 2 months.\n* History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional.\n* Excessive coffee and tea consumers (\\> 4 cups\u002Fd).\n* Donated blood within the last 3 months.\n* Women who are taking an unstable dose and brand of hormonal contraceptives and\u002For a stable dose and brand for less than 6 months.\n* Unusual working hours (working overnight).",true,"ALL","40 Years","70 Years",{"count":22,"type":23},82,"ESTIMATED","INTERVENTIONAL",[26],"NA","In this study, Investigators are interested in looking at the influence of eating avocados regularly, which are rich in healthy fats, fibers, and unique carbohydrates, on triglyceride and glucose metabolism in people with prediabetes and insulin resistance.",[29,30,31,32],"Prediabetes","Insulin Resistance","Triglycerides","Lipids Metabolism",[31,34,35,36],"Insulin resistance","Glucose metabolism","Lipids metabolism","RECRUITING","2026-06-29",{"date":40,"type":41},"2026-07-01","ACTUAL",{"date":43,"type":41},"2026-06-03",{"date":45,"type":23},"2027-12-31",{"name":47,"class":48},"Clinical Nutrition Research Center, Illinois Institute of Technology","INDUSTRY",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":18,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":49},"100642748","mathematical-modeling-of-blood-sugar-and-hormone-responses-in-insulin-dependent-type-2-diabetes-100642748","NCT07650682","Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes","Mathematical Modeling of Type 2 Diabetes Mellitus","MT2D","Inclusion Criteria:\n\n* Men or women, 18-65 years of age\n* Diagnosed with insulin-dependent type 2 diabetes mellitus HbA1c ≥ 6.5% at screening\n* Current insulin therapy for ≥ 6 months prior to screening\n* Nonsmokers (past smokers can be allowed if they have abstained for a minimum of 12 months)\n* Judged to be in good health based on medical history (i.e., no clinical evidence of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or hepatic disease)\n* Able to provide informed consent\n* Able to comply with and perform the procedures requested by the protocol (including dietary restrictions, consumption of study foods, records of food diary, sample collection procedures, and study visit schedule)\n\nExclusion Criteria:\n\n* Men and women with known or suspected intolerance, allergies, or hypersensitivity to study foods\n* Men and women with low hemoglobin (Hgb) levels below 9.5 g\u002FdL at the screening visit, indicating anemia\n* Men and women with blood pressure \\>160 mmHg (systolic) \u002F 100 mmHg (diastolic) at the screening visit\n* Women who are pregnant or planning to become pregnant during the study\n* Major trauma or a surgical event within 2 months (or longer depending on trauma or event) and after consultation with PI.\n* Vegan or other extreme dietary regimens (e.g., Atkins diet, etc.) as judged by the investigator\n* History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional\n* Donated blood within the last 3 months\n* Unstable weight: gained or lost weight +\u002F- 5 kg (11 lbs) in previous 2 months\n* Unusual working hours i.e., working overnight (e.g. 3rd shift)","18 Years","65 Years",{"count":61,"type":23},25,"OBSERVATIONAL","This observational study aims to collect detailed metabolic and physiologic data from adults with insulin-dependent type 2 diabetes mellitus following consumption of a mixed meal tolerance test. Participants will undergo frequent blood sampling over a 4-hour period after consuming a standardized liquid mixed meal to measure glucose, insulin, glucagon, C-peptide, and triglyceride responses. Participants will also use continuous glucose monitoring and wearable physical activity tracking devices during free-living conditions.\n\nThe purpose of this study is to develop mathematical models and digital representations (\"digital twins\") of people with type 2 diabetes mellitus. These models may help researchers better understand metabolic responses to meals, physical activity, and diabetes treatments, and may support future development of personalized diabetes technologies and therapies.",[65,66],"Type 2 Diabetes","Insulin Dependent Diabetes",[68,69,70],"Liquid Meal Test","Digital Twin","Continuous Glucose Monitoring","2026-06-12",{"date":73,"type":41},"2026-06-16",{"date":75,"type":41},"2026-05-20",{"date":77,"type":23},"2027-03-20",{"name":47,"class":48},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":17,"sex":18,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":24,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":49},"100591879","optimizing-mangos-glycemic-impact-investigating-mango-consumption-timing-in-prediabetic-individuals-100591879","NCT06986161","Optimizing Mango's Glycemic Impact: Investigating Mango Consumption Timing in Prediabetic Individuals","Optimizing Mango's Glycemic Impact: Investigating Mango Consumption Timing in Relation to Meal in Prediabetic Individuals","MG3","Inclusion Criteria:\n\n* Be between 20-60 years old.\n* Have a BMI of 25-35 kilograms per square meter.\n* Have fasting blood glucose between 100-125 milligrams per deciliter or Glycated hemoglobin (HbA1c) between 5.7-6.4%.\n* Be non-smokers for at least 12 months.\n* Be generally healthy, with no major organ-related diseases.\n* Not take medications or supplements that could interfere with the study.\n* Be able to follow study procedures, including dietary restrictions and scheduled visits.\n\nExclusion Criteria:\n\n* Smoke, vape, or use marijuana.\n* Have allergies or intolerance to mangoes or study foods.\n* Have blood pressure above 160\u002F100 millimeters of Mercury.\n* Have fasting blood glucose above 125 milligrams per deciliter.\n* Have a history of major heart disease, stroke, or cancer in the past five years.\n* Be pregnant, planning to become pregnant, or breastfeeding.\n* Take anti-inflammatory drugs or certain dietary supplements.\n* Have had major surgery or trauma in the past two months.\n* Follow extreme diets (e.g., vegan, Atkins).\n* Have used antibiotics in the last six weeks.\n* Have a history of eating disorders or substance abuse in the past two years.\n* Drink more than three cups of coffee or tea per day.\n* Have donated blood in the last three months.\n* Be professional athletes or do excessive exercise.\n* Have had weight changes of more than 11 pounds in the past two months.\n* Work overnight shifts.","20 Years","60 Years",{"count":90,"type":23},30,[26],"The purpose of this study is to investigate the effect of mango intake on metabolic and inflammatory responses relative to meals in individuals at risk of developing diabetes, as well as to understand how the beneficial compounds found in mangoes are absorbed and processed in the body.",[94],"Pre Diabetes","2025-07-10",{"date":97,"type":41},"2025-07-11",{"date":99,"type":41},"2025-04-14",{"date":101,"type":23},"2026-12-31",{"name":47,"class":48},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":88,"enrollmentInfo":110,"targetDuration":4,"studyType":24,"phases":112,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":121,"locationsCount":49},"100558809","meganatural-bp-gse-on-blood-pressure-and-cardiometabolic-risk-factors-100558809","NCT06555952","MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors","GSEBP","Inclusion Criteria:\n\n* 40-60 years of age\n* BMI \\\u003C 30kg\u002Fm2\n* elevated blood pressure 120-140 mmHg (systolic) \u002F \\\u003C90 mmHg (diastolic) at screening visit\n* Has fasting blood glucose concentration between 100-125 mg\u002FdL or HbA1c 5.7-6.4%.\n* Not taking any medications that would interfere with outcomes of the study, i.e. blood pressure lowering medications or anti-diabetes medications.\n* Able to provide informed consent\n* Able to comply and perform the procedures requested by the protocol (including dietary restrictions, consumption of study foods, records of food diary and GI tolerance questionnaire, sample collection procedures and study visit schedule)\n* Able to maintain usual physical activity pattern\n* Able to avoid \u002F abstain from alcohol and vigorous physical activity for 24 hours prior to and during study visit\n\nExclusion Criteria:\n\n* Men and women with known or suspected intolerance, allergies or hypersensitivity to study foods or interventions\n* Men and women with diabetes or have documented liver, kidney, cardiac, gastrointestinal, metabolic or respiratory diseases.\n* Men and women with documented physical or mental disease\u002Fcondition or major surgery as revealed by history or physical examination, which might limit participation in or completion of the study or, that, in the opinion of the investigator, could interfere with the interpretation of the study results.\n* Women who are known to be pregnant or who are intending to become pregnant over the course of the study\n* Women who are lactating\n* Taking medication or dietary supplements that may interfere with the outcomes of the study; This may include anti-inflammatory medication (ibuprofen, Aleve\u002Fnaproxen, aspirin, etc.)\n* Major trauma or a surgical event within 2 months (or longer depending on trauma or event) and after consultation with PI.\n* Has used antibiotics within the previous 2 months\n* Had colonoscopy within 3 months\n* History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional\n* Substance (alcohol or drug) abuse within the last 2 years\n* Excessive coffee and tea consumers (\\> 4 cups\u002Fd)\n* Donated blood within last 3 months\n* Men and women who do excessive exercise regularly or are an athlete\n* Unstable weight: gained or lost weight +\u002F- 5 kg (11 lbs) in previous 2 months\n* Women who are taking unstable dose and brand of hormonal contraceptives and\u002For stable dose and brand less than 6 months\n* Unusual working hours i.e., working overnight (e.g. 3rd shift)\n* Follows a vegan diet or any extreme dietary patterns",{"count":111,"type":23},80,[26],"Inflammation and stressors can interfere with the function of the lining of blood vessels and insulin activity, therefore, investigators are aiming to see how the Grape seed Extract (GSE) called MegaNatural BP can help with limiting the effects of these factors. This research will study the effects of taking 150mg of MegaNatural BP GSE per day on blood pressure levels along with influences on heart health through assessing the function of the blood vessel lining and levels of inflammation.",[115,94],"Hypertension",{"date":117,"type":41},"2025-07-15",{"date":119,"type":41},"2024-08-08",{"date":101,"type":23},{"name":47,"class":48},""]