[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Clinique Trenel\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":80},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100597171","low-level-light-therapy-versus-intense-pulsed-light-to-prevent-iatrogenic-dry-eye-disease-after-cataract-surgery-100597171",false,"NCT07055022","Low-level Light Therapy Versus Intense Pulsed Light to Prevent Iatrogenic Dry Eye Disease After Cataract Surgery","Low-level Light Therapy Versus Intense Pulsed Light to Prevent Iatrogenic Dry Eye Disease After Cataract Surgery: a Randomised Controlled Trial","EDACS","Inclusion Criteria:\n\n* aged ≥50 years\n* scheduled for bilateral cataract surgery by phacoemulsification\n* without current DED treatment, including eye drops, for at least two months before the inclusion\n* with preoperative OSDI ≤22 points, indicating absence of DED or mild DED\n* who signed the informed consent and are willing to comply with the protocol requirements based on the investigator's judgment\n* affiliated with a social security scheme\n* with an ability to answer questionnaires and to communicate freely in French.\n\nExclusion Criteria:\n\n* set to undergo implantation of a multifocal intraocular lens\n* using contact lenses\n* with any of the following in the included eye: (i) age-related macular degeneration (AMD), (ii) previous ocular surgery, (iii) abnormal clinical exam of the ocular surface or (iv) undergoing any ocular treatment\n* with systemic contraindications, including autoimmune diseases (e.g., Sjögren syndrome)\n* with general contraindications for LLLT or IPL treatment: dark pigmented skin (Fitzpatrick grade ≥5), skin photosensitivity (regardless if innate, pathological or medically-induced), or neurological light sensitivity (e.g. epilepsy, light-induced migraines)\n* with contraindications for LLLT or IPL treatment limited to the treatment area: history of skin cancer, skin pigmented lesions, as well as fixed\u002Fpermanent skin piercings, face tattoos, semi-permanent make-up (including microblading) or skin defects\n* with any concomitant disease or disorder which, in the opinion of the investigator, may put the patient at risk or may influence the result of the study\n* with protected status under articles L1121-6, LL121-8 and L1122-2 of the French Public Health Code\n* who cannot comply with the protocol requirements based on the investigator's judgment.","ALL","50 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Dry eye disease (DED) is a frequent ocular surface disease (OSD) of multifactorial origin, characterised by disruption of tear film homeostasis and associated with ocular discomfort and\u002For visual disturbance. Cataract surgery, which is one of the most often performed interventions worldwide, can induce or worsen the symptoms of DED. Despite lack of guidelines on DED prophylaxis before cataract surgery in the general population, there is a growing interest in this topic due to the high prevalence of postoperative DED. A recent randomised controlled trial (RCT) with one month follow-up showed that prophylactic low-level light therapy (LLLT) before and after cataract surgery in patients without pre-existing DED significantly improved postoperative tear film stability, as well as reduced ocular discomfort, compared to no prophylaxis. Apart from LLLT, another light-based treatment for DED is intense pulsed light (IPL); the treatments have shown favourable outcomes in the management of DED, both as stand-alone choices or in combination.",[27,28],"Cataract Surgery","Eye Dryness",[30,31,32,33,34,35,36,37,38,39,40],"IPL","LLLT","Intense Pulse Light","Low Level Light Therapy","cataract surgery","phacoemulsification","prophylaxis","prevention","eye dryness","dry eye disease","DED","NOT_YET_RECRUITING","2025-07-07",{"date":44,"type":45},"2025-07-08","ACTUAL",{"date":47,"type":21},"2025-09-30",{"date":49,"type":21},"2026-06-30",{"name":51,"class":52},"Clinique Trenel","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100595253","comparing-articular-noise-and-its-perception-between-two-different-types-of-individualized-total-knee-arthroplasty-100595253","NCT07030049","Comparing Articular Noise and Its Perception Between Two Different Types of Individualized Total Knee Arthroplasty","Monocentric, Randomized Study, Comparing Articular Noise and Its Perception Between Two Different Types of Individualized Total Knee Arthroplasty","ANIKA","Inclusion Criteria:\n\nAdult patients:\n\n* receiving elective primary TKA as a treatment for osteoarthritis\n* with an intact and functional posterior cruciate ligament\n* with no previous knee surgery, on the ipsi- or contra-lateral knee\n* who signed the informed consent and are willing to comply with the protocol requirements based on the investigator's judgment.\n* affiliated with a social security scheme\n* with an ability to answer questionnaires and to communicate freely in French.\n\nExclusion Criteria:\n\nPatients:\n\n* that underwent previous knee surgery, except arthroscopic surgery, on their ipsilateral knee\n* with coronal deformities \\>20°\n* that are pregnant\n* any contraindication mentioned in the instructions for use of the medical devices under investigation\n* with protected status under articles L1121-6, LL121-8 and L1122-2 of the French Public Health Code\n* with other significant disease or disorder which, in the opinion of the investigating surgeon, may put the participant at risk because of participation in the study, or may influence the result of the study\n* who cannot comply with the protocol requirements based on the investigator's judgment.","18 Years",{"count":64,"type":21},210,[24],"Knee osteoarthritis is a degenerative joint disorder leading to pain and limited movement. Total knee arthroplasty (TKA) has transformed the treatment of knee osteoarthritis, resulting in long-term outcomes that enhance the quality of life for patients. Some individuals report experiencing noise after undergoing TKA. However, there are few randomized controlled trials that assess postoperative noise following the procedure. Additionally, no research has been conducted on individualized TKA, which involves custom-made prostheses tailored to a patient's knee shape. This study aimed to compare the incidence of noise reported by patients who undergo a primary individualized TKA using either cruciate-retaining or posterior-stabilized designs.",[68,69],"Osteoarthritis","TKA",[71,69,72],"osteoarthritis","articular noise","2025-06-23",{"date":75,"type":45},"2025-06-26",{"date":47,"type":21},{"date":78,"type":21},"2028-09-30",{"name":51,"class":52},""]