[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"College of Physicians and Surgeons Pakistan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":260},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,44,67,94,118,143,164,189,212,237],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100641597","assessment-of-post-operative-swelling-among-patients-following-extraction-of-impacted-third-molars-100641597",false,"NCT07655089","Assessment of Post Operative Swelling Among Patients Following Extraction of Impacted Third Molars","APOSTM","Inclusion Criteria:Patients aged 18-50 years. Male and female patients. Patients undergoing extraction of impacted mandibular third molars irrespective of angulation as evaluated radiographically.\n\nPatients with no periodontal pathology related to the involved tooth on clinical examination.\n\n\\-\n\nExclusion Criteria:\n\n* Patients with congenital or acquired bleeding disorders. Patients with any bony lesion adjacent to the impacted third molar. Medically immunocompromised patients.","ALL","18 Years","65 Years",{"count":20,"type":21},116,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial aims to compare Ward's incision and Comma incision regarding postoperative swelling following extraction of impacted mandibular third molars. Secondary outcomes include pain and bleeding assessed 48 hours after surgery. The findings will help identify the incision technique associated with better postoperative outcomes",[27],"Post Operative Swelling",[29,30,31],"Impacted Mandibular Third Molar","Swelling,","Oral Surgery","NOT_YET_RECRUITING","2026-06-12",{"date":35,"type":36},"2026-06-17","ACTUAL",{"date":38,"type":21},"2026-07-05",{"date":40,"type":21},"2026-08-05",{"name":42,"class":43},"College of Physicians and Surgeons Pakistan","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":64,"leadSponsor":66,"locationsCount":4},"100640249","effect-of-two-different-concentrations-of-sodium-hypochlorite-on-post-operative-pain-following-single-visit-root-canal-treatment-100640249","NCT07618182","Effect of Two Different Concentrations of Sodium Hypochlorite on Post-Operative Pain Following Single-Visit Root Canal Treatment","Effect of Two Different Concentrations of Sodium Hypochlorite on Post-Operative Pain Following Single-Visit Root Canal Treatment: A Randomized Controlled Trial","NaOCl-RCT","Inclusion Criteria:\n\n* Adult patients aged 18-60 years Systemically healthy individuals Permanent teeth with closed apices requiring primary root canal treatment Teeth diagnosed with symptomatic\u002Fasymptomatic irreversible pulpitis or pulpal necrosis Patients able to understand the Visual Analog Scale Patients willing to provide informed consent and complete follow-up\n\nExclusion Criteria:\n\n* Uncontrolled systemic diseases Pregnant or breastfeeding women Allergy to sodium hypochlorite or local anesthetics Previously endodontically treated teeth Teeth with root resorption, vertical root fracture, or open apex Severe periodontal disease or mobility Use of analgesics, antibiotics, or anti-inflammatory drugs within previous 7 days",{"count":20,"type":21},[24],"This randomized controlled trial aims to evaluate the effect of two different concentrations of sodium hypochlorite (2.5% and 5.25%) on post-operative pain following single-visit root canal treatment. A total of 116 participants requiring primary endodontic treatment will be randomly allocated into two groups according to irrigant concentration. Post-operative pain will be assessed using a 100-mm Visual Analog Scale at 6, 12, 24, and 48 hours after treatment. The study seeks to determine the concentration that provides optimal disinfection with minimal patient discomfort.",[56],"Post Operative Pain, Acute",[58,59],"Sodium Hypochlorite","Root Canal Treatment","2026-05-24",{"date":62,"type":36},"2026-06-01",{"date":38,"type":21},{"date":65,"type":21},"2026-12-30",{"name":42,"class":43},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":77,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":4},"100613816","postoperative-pain-after-single-vs-multiple-visit-root-canal-treatment-in-diabetic-patients-100613816","NCT07271511","Postoperative Pain After Single vs Multiple-Visit Root Canal Treatment in Diabetic Patients","Comparative Analysis of Postoperative Pain Following Single vs Multiple-Visit Root Canal Therapy in Single-Rooted Teeth of Diabetic Patients: A Randomized Controlled Trial","RCT-DM-Pain","Inclusion Criteria:Patients aged between 12 and 60 years.\n\nDiagnosed with Type 1 or Type 2 Diabetes Mellitus.\n\nIn need of root canal treatment on a single-rooted tooth.\n\nA clinical diagnosis of either irreversible pulpitis or necrotic pulp in the indicated tooth.\n\nWillingness and ability to understand and provide written informed consent (and assent with parental consent for minors).\n\n\\-\n\nExclusion Criteria:\n\n* Pregnancy.\n\nKnown history of allergy to local anesthetics.\n\nPresence of large periapical radiolucent lesions (typically defined as \\>5mm in diameter).\n\nCurrent use of long-term analgesic or anti-inflammatory medication (which could alter pain perception).\n\nTeeth with complex root canal anatomy (e.g., calcified canals, C-shaped canals) that would complicate standard treatment.",{"count":76,"type":21},200,[24],"A short description of the clinical study, including a brief statement of the clinical study's hypothesis, written in language intended for the lay public.",[80,81],"Diabetes Mellitus","Postoperative Pain After Endodontic Treatment",[83,84,85],"Single-Visit Endodontics","Multiple-Visit Endodontic","Root canal therapy","2026-03-16",{"date":88,"type":36},"2026-03-18",{"date":90,"type":21},"2026-05-15",{"date":92,"type":21},"2026-06-15",{"name":42,"class":43},{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":104,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":117,"locationsCount":4},"100627786","comparing-two-root-canal-cleaning-solutions-chlorhexidine-vs-sodium-hypochlorite-for-pain-after-treatment-100627786","NCT07453160","Comparing Two Root Canal Cleaning Solutions (Chlorhexidine vs. Sodium Hypochlorite) for Pain After Treatment","Comparison of Postoperative Pain Using 2% Chlorhexidine Versus 5.25% Sodium Hypochlorite as Root Canal Irrigants in Non-surgical Root Canal Treatment: A Randomized Controlled Trial","CHXvsNaOCl-Pai","Inclusion Criteria:\n\nAdults aged 18-65 years\n\n* Any gender\n* Requiring non-surgical root canal treatment\n* Willing to provide written informed consent\n* Able to report postoperative pain using a validated pain assessment scale -\n\nExclusion Criteria:Known hypersensitivity or allergy to chlorhexidine or sodium hypochlorite\n\n* Systemic conditions affecting pain perception (e.g., diabetes with neuropathy, fibromyalgia)\n* Medications affecting pain perception (e.g., chronic analgesics, corticosteroids, antidepressants)\n* Preoperative dental pain in the tooth scheduled for treatment\n* Pregnancy or lactation\n* Teeth with resorbed roots\n* Mobile teeth (pathological mobility)\n* Open apices",{"count":103,"type":21},90,[24],"Brief Summary (A short description for the lay public)\n\nThis study aims to find out if the type of cleaning solution used during a root canal affects the pain a patient feels the next day. A root canal procedure involves cleaning the inside of the tooth. Two common cleaning solutions are chlorhexidine (CHX) and sodium hypochlorite (NaOCl, also known as bleach). While both are effective, it is not clear if one causes more discomfort than the other.\n\nIn this research, half of the participants will have their root canal cleaned with CHX, and the other half with NaOCl. We will then ask all participants to rate their pain 24 hours after the procedure using a simple pain scale. Our goal is to see if there is a difference in pain levels between the two groups. The results will help dentists choose the best solution to make their patients more comfortable after treatment",[107],"Postoperative Pain",[109,110],"Postoperative pain","Root canal treatment","2026-03-03",{"date":113,"type":36},"2026-03-05",{"date":115,"type":21},"2026-02-15",{"date":92,"type":21},{"name":42,"class":43},{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":124,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":128,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":141,"locationsCount":142},"100611980","early-phase-1-comparison-of-permethrin-based-treatment-strategies-against-scabies-in-infants-and-young-children-100611980","NCT07247630","Comparison of Permethrin-Based Treatment Strategies Against Scabies in Infants and Young Children","Inclusion Criteria:\n\n* 1 month to 4 years age.\n* Both gender\n* Scabies as defined in operational definition\n\nExclusion Criteria:\n\n* • Drug sensitivity test results for hypersensitivity to permethrin\n\n  * Having renal or hepatic impairment.\n  * Individuals with additional long-term skin and systemic disorders (such as diabetes, hypertension, asthma, epilepsy, acne, psoriasis)","1 Month","4 Years",{"count":127,"type":21},68,[129],"EARLY_PHASE1","To compare the efficacy of different permethrin-based therapies for scabies infestations in infants and young children.",[132],"Scabies",[134],"Permethrin based treatment strategies","2026-02-01",{"date":137,"type":36},"2026-02-03",{"date":139,"type":21},"2026-01-15",{"date":92,"type":21},{"name":42,"class":43},1,{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":22,"phases":151,"briefSummary":152,"conditions":153,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":4},"100618054","finerenone-for-cardiorenal-protection-in-diabetic-ckd-impact-on-renal-function-decline-and-heart-failure-100618054","NCT07326631","Finerenone for Cardiorenal Protection in Diabetic CKD: Impact on Renal Function Decline and Heart Failure","Inclusion Criteria:\n\n* Adults aged ≥18 years.\n* Diagnosed cases of type 2 diabetes mellitus.\n* Chronic kidney disease with eGFR 25-90 mL\u002Fmin\u002F1.73m² and\u002For UACR ≥30 mg\u002Fg.\n* On stable ACE inhibitor or ARB therapy for at least 4 weeks.\n* Serum potassium ≤4.8 mmol\u002FL.\n* Provided written informed consent.\n\nExclusion Criteria:\n\n* Symptomatic heart failure (NYHA class II-IV).\n* eGFR \\\u003C25 mL\u002Fmin\u002F1.73m² or on maintenance dialysis.\n* Known non-diabetic kidney disease.\n* Recent major cardiovascular event (within 30 days).\n* Serum potassium \\>4.8 mmol\u002FL or history of severe hyperkalaemia.\n* Contraindication or hypersensitivity to finerenone.\n* Pregnancy or lactation.\n* Any condition limiting compliance or follow-up.",{"count":150,"type":21},120,[24],"To assess the effect of Finerinone on slowing renal function decline and improving cardiovascular outcomes, particularly heart failure risk, in patients with diabetic CKD.",[154,155],"Diabetic Kidney Disease (DKD)","Heart Failure","2025-12-24",{"date":158,"type":36},"2026-01-08",{"date":160,"type":21},"2026-01-01",{"date":162,"type":21},"2026-07-01",{"name":42,"class":43},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":173,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":4},"100614271","comparing-two-surgical-methods-to-prevent-pterygium-regrowth-100614271","NCT07277426","Comparing Two Surgical Methods to Prevent Pterygium Regrowth","Evaluation of Conjunctival Rotational Flap Compared to Conjunctival Autograft After Surgical Removal of Primary Pterygium: A Randomized Controlled Trial","Inclusion Criteria:\n\n* • Age 18-60\n\n  * Either gender\n  * Primary pterygium\n\nExclusion Criteria:\n\n* • Collagen vascular disease\n\n  * Autoimmune disorders\n  * Pregnancy\n  * Ocular surface infection\n  * Previous limbal surgery\n  * Recurrent or pseudo-pterygium\n  * Ocular trauma\n  * Corneal opacity\u002Fdegeneration'",{"count":172,"type":21},342,[24],"This study compares two surgical techniques for preventing the regrowth of a pterygium, a non-cancerous growth on the eye. After surgically removing the pterygium, surgeons will cover the area with either a flap of nearby tissue that is rotated into place (Rotational Flap) or with a free graft of tissue taken from under the upper eyelid (Autograft). The main goal is to see which method is better at preventing the pterygium from growing back over a 6-month period. A total of 342 patients with a primary pterygium will be randomly assigned to one of the two surgical groups.",[176],"Pterygium",[178,179,180],"Conjunctival Autograft","Conjunctival Rotational Flap","Pterygium Recurrence","2025-11-30",{"date":183,"type":36},"2025-12-11",{"date":185,"type":21},"2026-02-02",{"date":187,"type":21},"2026-07-02",{"name":42,"class":43},{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":195,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":197,"targetDuration":4,"studyType":22,"phases":199,"briefSummary":200,"conditions":201,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":4},"100611374","influence-of-maintaining-apical-patency-on-post-endodontic-pain-in-molars-100611374","NCT07239752","Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars","Influence of Maintaining Apical Patency in Post-Endodontic Pain in Molars With Necrotic Pulp and Apical Periodontitis: A Randomized Controlled Trial","IMAP-Pain","Inclusion Criteria:Adult patients aged 18-65 years.\n\nMedically healthy, classified as American Society of Anesthesiologists (ASA) Physical Status I or II.\n\nPresence of a single permanent molar tooth diagnosed with necrotic pulp and symptomatic apical periodontitis, and indicated for primary root canal treatment.\n\nPatients who provide informed written consent to participate in the study. -\n\nExclusion Criteria:\n\nTeeth with prior endodontic treatment or complex anatomy (e.g., calcified canals, severe curvature).\n\nPatients with significant systemic illness (e.g., uncontrolled diabetes, immunocompromised status) or pregnancy.\n\nHistory of analgesic intake within 72 hours prior to the root canal procedure.\n\nNon-restorable teeth, teeth with severe periodontal disease (pocket depth \\>5mm), or teeth with root fractures.\n\nExclusion Criteria:\n\n\\-",{"count":198,"type":21},48,[24],"This randomized controlled trial will investigate if maintaining apical patency-a technique where a small file is gently moved past the root's end during cleaning-affects pain after a root canal. The study will include 48 adult patients needing root canal treatment on a back molar tooth with a dead nerve and infection at the root tip. Participants will be randomly assigned to one of two groups: one where the apical patency technique is used, and one where it is not. All other treatment steps will be identical. Patients will record their pain levels on a standard scale (0-100 mm Visual Analog Scale) at 6, 12, 24, 48, and 72 hours after the procedure. The goal is to determine if this specific technique influences the intensity and duration of post-treatment pain",[202,203],"Periapical Periodontitis","Dental Pulp Necrosis","2025-11-16",{"date":206,"type":36},"2025-11-20",{"date":208,"type":21},"2026-02-10",{"date":210,"type":21},"2026-10-10",{"name":42,"class":43},{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":16,"minAge":218,"maxAge":219,"enrollmentInfo":220,"targetDuration":4,"studyType":22,"phases":222,"briefSummary":223,"conditions":224,"keywords":228,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":234,"leadSponsor":236,"locationsCount":4},"100590823","comparison-of-endodontic-flare-up-in-single-visit-root-canal-treatment-versus-multiple-visit-root-canal-treatment-in-patients-visiting-scd-swat-100590823","NCT06972433","Comparison of Endodontic Flare up in Single Visit Root Canal Treatment Versus Multiple Visit Root Canal Treatment in Patients Visiting Scd, Swat.","Inclusion Criteria:\n\n* Children in the age group \\>10 years with deep caries approximating pulp on radiograph and indicated for a root canal treatment.\n* Proper bone support.\n* No evidence of severe mobility\u002Fdischarge of frank pus\n* Radiographically tooth indicated for root canal treatment.\n* Permanent first molars with periapical radiolucency not exceeding 3 mm × 3 mm in size.\n* Complete root formation.\n* Teeth in which the initial master file (K-File)binds at the apex were of ISO size 45 or less.\n\nExclusion Criteria:\n\n* Tooth\u002Fteeth with extensive periodontal pathology\u002F periapical radiolucency.\n* Teeth with evidence of internal or external root resorption involving more than one third of the root length.\n* Children with facial cellulitis or significant extraoral swelling.\n* Patients with any systemic diseases.\n* Patients who had been taking Antibiotics ,nonsteroidal anti-inflammatory drugs, corticosteroids at time of treatment.\n* Pregnant patients","10 Years","60 Years",{"count":221,"type":21},344,[24],"This randomized controlled trial aims to compare the incidence of endodontic flare-ups in patients undergoing single-visit versus multiple-visit root canal treatment (RCT) at Saidu College of Dentistry, Swat. The study will recruit 344 patients aged above 10 and below 60 years, with permanent first molars indicated for RCT and meeting specific clinical and radiographic criteria. Participants will be randomly allocated into two groups: one receiving single-visit RCT and the other receiving multiple-visit RCT. Pain and flare-up incidence will be evaluated using the Visual Analog Scale (VAS) and swelling grading criteria at 6, 24, and 48 hours post-treatment. The primary outcome is the frequency of endodontic flare-ups requiring additional intervention. The study also examines the role of occlusal reduction in managing postoperative discomfort. Data will be analyzed using SPSS v23 with chi-square and Fisher's exact tests to compare outcomes. The findings aim to inform evidence-based protocols for endodontic treatment in the local population.",[225,226,227],"Postoperative Complication","Root Canal Therapy","Pulpitis - Irreversible",[229],"enddoontic flare-ups, root canal therapy, single visit root canal treatment, multiple visit root canal treatment","2025-05-13",{"date":232,"type":36},"2025-05-15",{"date":160,"type":21},{"date":235,"type":21},"2026-06-30",{"name":42,"class":43},{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":243,"sex":16,"minAge":244,"maxAge":245,"enrollmentInfo":246,"targetDuration":4,"studyType":22,"phases":247,"briefSummary":248,"conditions":249,"keywords":4,"overallStatus":251,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":142},"100560145","effects-of-timing-of-cord-clamping-on-serum-calcium-levels-in-neonates-100560145","NCT06573333","Effects of Timing of Cord Clamping on Serum Calcium Levels in Neonates","Inclusion Criteria:\n\n* Neonates born at gestational age 37 weeks to 41 weeks with no maternal complication. Parents who give consent for inclusion in the study\n\nExclusion Criteria:\n\n* Mothers with evidence of clinical disease (diabetes, preeclampsia, hypertension). Babies with congenital malformations and intrauterine growth restriction.",true,"1 Minute","6 Hours",{"count":76,"type":21},[24],"Title: Effect of timing of cord clamping of serum calcium levels in neonates Background: Hypocalcemia is a common metabolic problem in neonatal period. Most cases of hypocalcemia are asymptomatic however, the symptomatic cases require prompt management.\n\nObjective: The objective is to determine the effects of early and delayed cord on serum calcium level in neonates Study Design: Randomized Controlled Trial",[250],"Serum Calcium Concentration","RECRUITING","2024-08-24",{"date":254,"type":36},"2024-08-27",{"date":256,"type":36},"2024-01-01",{"date":258,"type":21},"2024-09-30",{"name":42,"class":43},""]