[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Colorado State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":495},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,52,83,111,144,167,202,233,255,285,308,331,354,381,408,431,462],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100636769","digitally-enhanced-cognitive-behavioral-therapy-100636769",false,"NCT07569991","Digitally Enhanced Cognitive-Behavioral Therapy","Digitally Enhanced Cognitive-Behavioral Therapy for Adolescents With Depression and Obesity","CBT+","Inclusion Criteria:\n\n* Age 12-17 years\n* Body mass index (BMI) ≥85th percentile for age and sex\n* Elevated depression symptoms, Center for Epidemiologic Studies-Depression Scale (CES-D) ≥21\n\nExclusion Criteria:\n\n* Type 2 diabetes; Fasting glucose ≥126 mg\u002FdL or HbA1c ≥6.5\n* Major developmental (e.g., intellectual developmental disability) or medical or genetic condition (e.g. cancer, Bardet-Biedhl)\n* Pregnancy\u002Fbreastfeeding (females)\n* Bariatric surgery, weight loss medication, or weight loss \\>3% in the past 3 months\n* Active suicidality or self-harm","ALL","12 Years","17 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Adolescent depression is a major public health problem. Depression affects adolescents' emotional well-being now and in the future, and it also affects their physical health, especially the risk for heart disease and other cardiovascular and metabolic health problems. In adolescents with depression and obesity, evidence-based programs for depression, like cognitive-behavioral therapy (CBT), might improve physical health, in part by supporting healthy behaviors such as physical activity, nutritious eating, and getting enough sleep. Our preliminary studies provide support for this overarching hypothesis. If adolescents have access to a digital app to support practicing CBT skills in between program sessions, it might especially help them to learn skills that help to feel better and be healthier in their day-to-day lives. We are tailoring a digital app for this purpose and we will make changes to the app based on feedback from adolescents, their parents, and their doctors. Once the app is well-liked and helpful, and works well as a support for taking part in CBT, we will randomly assign 60 adolescents with depression and overweight\u002Fobesity to either \"CBT+\" - a CBT group program plus the app, or \"CBT-only\" - the CBT group program only. We will pilot test whether this research is feasible, likeable, and credible, learning information that will inform a larger study to test of CBT+ can support emotional well-being, health behavior, and cardiovascular and metabolic health in adolescents.",[28,29,30,31,32],"Depression in Adolescence","Obesity & Overweight","Cognitive-behavioral Therapy","Mobile Health Technology (mHealth)","Health Behavior",[34,35,36,37,38],"cognitive-behavioral therapy","depression","adolescents","cardiometabolic health","mHealth","NOT_YET_RECRUITING","2026-06-03",{"date":42,"type":43},"2026-06-05","ACTUAL",{"date":45,"type":22},"2027-01-01",{"date":47,"type":22},"2028-08-01",{"name":49,"class":50},"Colorado State University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":51},"100639378","influence-of-the-gut-microbiome-on-blueberry-polyphenol-metabolites-100639378","NCT07607158","Influence of the Gut Microbiome on Blueberry Polyphenol Metabolites","BlueBIOME","Inclusion Criteria:\n\n* Healthy adults ≥18 years of age\n* Able and willing to provide informed consent\n* Willing and able to adhere to all study procedures and visit requirements\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Pregnant or breastfeeding\n* Presence of chronic diseases, including but not limited to cardiovascular disease, diabetes, cancer, kidney, liver, gastrointestinal, or pancreatic disease\n* Use of medications for chronic diseases that may interfere with study outcomes\n* Any condition known to negatively impact nutrient absorption (e.g., inflammatory bowel disease, celiac disease, gastroparesis)\n* Anemia (hemoglobin \\\u003C13.5 g\u002FdL in men or \\\u003C12.0 g\u002FdL in women)\n* Body mass index (BMI) ≤18.5 kg\u002Fm²\n* Use of antibiotics within the past 2 months\n* Recent blood draw within 1 week prior to study participation\n* Currently participating in another research study involving a diet or exercise intervention\n* Known allergy or contraindication to blueberry products or study procedures\n* Unwilling or unable to comply with study requirements",true,"18 Years",{"count":62,"type":22},125,[25],"The objective of this study is to determine whether inter-individual differences in the gut microbiome influence exposure to blueberry polyphenol metabolites. We will use pharmacokinetics of blueberry polyphenols after an acute blueberry exposure to group individuals into \"metabotypes\", groups of individuals based on similarity in their metabolite profiles. We will then use multi-omic approaches to determine whether the gut microbiome predicts an individual's metabotype.",[66,67],"Microbiome Analysis","Metabolomics",[69,70,71,72,73],"Microbiome","Polyphenols","Metabotype","Pharmacokinetics","Metabolites","RECRUITING","2026-05-19",{"date":77,"type":43},"2026-05-26",{"date":79,"type":43},"2026-01-27",{"date":81,"type":22},"2028-01-01",{"name":49,"class":50},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":59,"sex":17,"minAge":60,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":51},"100615839","sex-differences-in-cold-induced-changes-in-maximal-fat-oxidation-100615839","NCT07297823","Sex Differences in Cold-Induced Changes in Maximal Fat Oxidation","Sex Differences in Cold-Induced Changes in Maximal Fat Oxidation: A Pilot Study","Inclusion Criteria:\n\n* Age 18-40 years (inclusive)\n* Weight stable (no change in body mass greater than 5 lbs. within the previous 6 months.\n* Willing to abstain from caffeine and alcohol for 24-hours prior to two different study visits\n* Competency in English as informally assessed by comprehension of the Informed Consent. This study involves maximal exercise testing; for safety reasons, the ability for clear and rapid communication will be necessary between the research participants and the investigators.\n* Regular exercise (i.e., at least 150 minutes of moderate-vigorous exercise per week)\n\nExclusion Criteria:\n\n* Use of hormonal contraceptives\n* History of autonomic, cardio-pulmonary, and\u002For metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and\u002For diabetes)\n* Pregnancy or breast feeding\n* Habitual use of tobacco\u002Fnicotine products or recreational drugs (2 or more uses within the previous month)","40 Years",{"count":92,"type":22},20,[25],"The purpose of this research study is to determine if the cold-induced change in fat burning during exercise is different between females and males.",[96],"Exercise",[98,99,100,101,102],"exercise","fat","temperature","cold","metabolism","2026-05-13",{"date":105,"type":43},"2026-05-15",{"date":107,"type":43},"2026-04-15",{"date":109,"type":22},"2027-06-30",{"name":49,"class":50},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":59,"sex":118,"minAge":18,"maxAge":19,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":121,"briefSummary":122,"conditions":123,"keywords":132,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":143},"100480983","cognitive-behavioral-therapy-and-exercise-training-in-adolescents-at-risk-for-type-2-diabetes-100480983","NCT05543083","Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes","CBTeX","Inclusion Criteria:\n\n* Female\n* Age 12-17 years\n* Body Mass Index (BMI)\\>= 85 for age and sex\n* Type 2 Diabetes (T2D) first-or second-degree relative\n* Center for Epidemiologic Studies Depression Scale (CES-D) total score \\>=21\n\nExclusion Criteria:\n\n* T2D\u002F Type 1 Diabetes (T1D) or any major medical condition (e.g. cardiovascular, renal) that would prohibit the ability to participate in exercise training\n* Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) conduct disorder, substance abuse\u002F dependence, obsessive compulsive disorder, panic attacks, post-traumatic stress disorder, anorexia\u002Fbulimia, \\& schizophrenia\n* Insulin sensitizers, weight loss medications \\& chronic steroids\n* Structured weight loss treatment or bariatric surgery\n* Pregnancy, nursing","FEMALE",{"count":120,"type":22},300,[25],"The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or a combination of cognitive-behavioral therapy and exercise training groups, decreases stress, improves mood, increases physical activity and physical fitness, and decreases insulin resistance among teenagers at risk for diabetes.",[124,125,126,127,128,129,130,131],"Insulin Resistance","Depression","Depressive Disorder","Mood Disorders","Mental Disorder in Adolescence","Hyperinsulinism","Glucose Metabolism Disorders","Metabolic Disease",[133,134],"Adolescent Type 2 Diabetes Prevention","Exercise Training","2026-04-17",{"date":137,"type":43},"2026-04-22",{"date":139,"type":43},"2023-06-02",{"date":141,"type":22},"2029-03-31",{"name":49,"class":50},2,{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":59,"sex":17,"minAge":60,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":23,"phases":153,"briefSummary":154,"conditions":155,"keywords":157,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":166,"locationsCount":51},"100482025","brain-stimulation-effects-on-cognitive-task-performance-100482025","NCT05556655","Brain Stimulation Effects on Cognitive Task Performance","Inclusion Criteria:\n\n* Right-handed\n* Fluent in English\n\nExclusion Criteria:\n\n* History of seizures or epilepsy\n* Family history of epilepsy\n* Significant medical or neurological diagnoses\n* History of common headache or migraine\n* History of common or recent syncope\n* History of moderate\u002Fsevere, multiple mild, or past 12 months head injury\n* History of psychiatric, psychological, or neurodevelopmental disorder\n* History of alcohol or recreational drug abuse or dependence\n* Current visual or hearing difficulties that interfere with cognitive testing\n* History of cochlear implants\n* Current pregnancy\n* History of metal in the head or neck (except braces and fillings)\n* Current non-removable piercings in the neck or head\n* History of implanted neurostimulator\n* History of cardiac pacemaker or intracardiac lines\n* History of medication infusion device\n* Current use of medications that increase the excitability of the brain\n* History of problems with TMS or MRI procedures\n* History of EEG for suspected epilepsy\n* Alcohol or recreational drug use in the 48 hours prior to TMS\n* Inadequate sleep in the 48 hours prior to TMS\n* Headache or feeling faint in the 24 hours prior to TMS.","65 Years",{"count":152,"type":22},100,[25],"The purpose of this study is to determine optimal task design parameters for the measurement of transcranial magnetic stimulation (TMS) effects on cognition.",[156],"Cognitive Function",[158,159],"Transcranial Magnetic Stimulation","TMS","2026-04-02",{"date":162,"type":43},"2026-04-08",{"date":164,"type":43},"2023-04-20",{"date":81,"type":22},{"name":49,"class":50},{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":23,"phases":176,"briefSummary":177,"conditions":178,"keywords":186,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":51},"100615261","survivors-uniting-for-remote-guided-exercise-100615261","NCT07290309","Survivors Uniting for Remote Guided Exercise","Efficacy of a Group-based Videoconference Intervention to Increase Physical Activity in Cancer Survivors","SURGE","Inclusion Criteria:\n\n* Able to speak\u002Fread English,\n* Diagnosed with any type of cancer within the last 5 years\n* Completed primary or adjuvant treatment (i.e., chemotherapy, radiation therapy, surgery) with no planned treatment within the next nine months. This does not include long-term or chronic therapies such as anti-hormone or targeted therapies (e.g., aromatase inhibitor, androgen deprivation therapy, immunotherapies)\n\nExclusion Criteria:\n\n* Existing participation in ≥150 minutes per week of at least moderate intensity aerobic exercise\n* Known contraindications for non-medically supervised moderate or greater intensity exercise (e.g., uncontrolled hypertension, inability to walk without an assistive device)\n* Current or planned participation in another structured program or intervention intended to encourage participation in exercise or physical activity.",{"count":120,"type":22},[25],"The goal of this research study is to look at how live, online group exercise compares to recorded videos for helping increase physical activity levels, improve physical fitness and quality of life, and reduce loneliness among those living with and beyond cancer. The following aims have been established for this study:\n\n* Aim 1: Examine the effect of a group-based videoconference physical activity (PA) intervention on moderate to vigorous physical activity \\[MVPA\\] (i.e., aerobic and resistance exercise).\n* Aim 2: Examine the effect of the intervention on additional health-related outcomes including physical fitness (i.e., aerobic endurance, muscular strength), and quality of life at both timepoints.\n* Aim 3: Explore potential mediators and moderators of intervention effects. We will examine mediators (e.g., self-efficacy, outcome expectations, group cohesion) and moderators (e.g., age, cancer stage, neighborhood walkability) of the intervention on MVPA.\n* Exploratory Aim: Determine whether a group-based videoconference PA intervention reduces loneliness among cancer survivors.\n\nResearchers will randomize participants into one of two guided exercise groups that are 12-weeks long in duration. Participants will be asked to complete online fitness assessments and surveys as well as wear a physical activity monitor device and watch a few times throughout the study. The whole study is 9-months long in duration with a 6-month free-living period where no study activities will take place.",[179,180,181,182,183,184,185],"Cancer","Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma)","Physical Activity","Physical Activity Behavior","Cancer (With or Without Metastasis)","Cancer - Chronic Lymphocytic Leukemia","Cancer - Ovarian",[187,188,189,190,191,98,192,193],"Exercise oncology","Physical activity for cancer survivors","Group based exercise","Virtual exercise","physical activity","remote study","Cancer survivors","2026-03-27",{"date":196,"type":43},"2026-03-31",{"date":198,"type":43},"2026-02-06",{"date":200,"type":22},"2030-03-01",{"name":49,"class":50},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":23,"phases":212,"briefSummary":213,"conditions":214,"keywords":217,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":232},"100543695","sustaining-physical-activity-after-cancer-exercise-sessions-100543695","NCT06359210","Sustaining Physical Activity After Cancer Exercise Sessions","An Adaptive Physical Activity Maintenance Intervention","SPAACES","Inclusion Criteria:\n\n* ≥18 years old,\n* Able to speak\u002Fread English,\n* Diagnosed with any type of cancer,\n* Completed primary or adjuvant treatment (i.e., chemotherapy, radiation therapy, surgery) within the previous five years, with no planned treatment within the next nine months. This does not include long-term or chronic therapies such as anti-hormone or targeted therapies (e.g., aromatase inhibitor, androgen deprivation therapy),\n* Participant is registered\u002Fenrolled to participate in one of three community-based exercise programs.\n\nExclusion Criteria:\n\n* Existing participation in ≥90 minutes per week of at least moderate intensity aerobic exercise AND two or more days per week of resistance exercise or known contraindications for exercise.\n* Known contraindications for non-medically supervised moderate or greater intensity exercise (e.g., uncontrolled hypertension, inability to walk without an assistive device)\n* Current or planned participation in another exercise oncology program (not one of the three community partner exercise programs), or previous participation in another or one of the three community partner exercise programs in the past 12-months.",{"count":211,"type":22},105,[25],"The goal of this clinical trial is to develop and test an adaptive physical activity (PA) maintenance intervention for cancer survivors, after participating in a community-based exercise oncology program. The main questions it aims to answer are:\n\n* Aim 1: Examine the feasibility and acceptability of the intervention among cancer survivors and community partners. The researchers will utilize quantitative surveys, focus groups, and semi-structured interviews to collect information about feasibility, implementation, adaptation, and sustainability.\n* Aim 2: Examine the effects of the intervention among cancer survivors. The researchers will compare the proportion of participants achieving the exercise guidelines for cancer survivors six-months following completion of the initial exercise program.\n\nParticipants will participate in a community-based exercise oncology program and then return to three months of free living. Based on the PA measured at the three-month follow-up, participants will be categorized as a \"Responder\" or \"Incomplete Responder\", and then randomized to the PA maintenance intervention. Researchers will compare those that are classified as Responders (meeting exercise guidelines for cancer survivors) and Incomplete Responders (not meeting guidelines for cancer survivors) to see what level of intervention is needed to influence sustainable behavior change in this population.",[215,182,216],"Exercise Oncology","Behavior Change Interventions",[218,191,219,220,221,222,223],"exercise oncology","behavior change","adaptive intervention","cancer survivors","physical activity maintenance","community partnerships","2026-03-17",{"date":226,"type":43},"2026-03-19",{"date":228,"type":43},"2024-03-04",{"date":230,"type":22},"2026-12-31",{"name":49,"class":50},3,{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":118,"minAge":240,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":23,"phases":243,"briefSummary":244,"conditions":245,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":51},"100624177","oral-antioxidant-therapy-targeted-to-the-mitochondria-for-improving-brain-artery-health-in-postmenopausal-women-100624177","NCT07406243","Oral Antioxidant Therapy Targeted to the Mitochondria for Improving Brain Artery Health in Postmenopausal Women","Mitochondrial-Targeted Antioxidant Supplementation for Improving Cerebrovascular Function in Postmenopausal Women","Inclusion Criteria:\n\n* Age 60 years or older;\n* Postmenopausal women defined as at least 1 year without menses as self-reported;\n* Estrogen-deficient; no hormone therapies (e.g., estrogen, progesterone, testosterone, DHEA, oral contraceptives, etc.) within the previous 6 months;\n* Ability to provide informed consent;\n* Willing to accept random assignment to condition;\n* Body mass index (BMI) ≤35 kg\u002Fm2;\n* Mini-mental state examination score ≥21;\n* Weight stable in the prior 3 months;\n* Abstinence from antioxidant or CoQ10 therapy for 3 months; and\n* Absence of clinical disease as determined by the physician of record following a medical history and blood chemistries\n\nExclusion Criteria:\n\n* History of uncontrolled hypertension;\n* Currently meeting aerobic exercise guidelines of ≥75 mins\u002Fweek of vigorous or ≥150 mins\u002Fweek of moderate intensity exercise as assessed by Modified Activity Questionnaire;\n* Current smoker;\n* Alcohol dependence or abuse;\n* Other chronic medical conditions; and\n* Subject report of blood donation within 8 weeks prior to enrolling.","60 Years",{"count":242,"type":22},86,[25],"The goal of this clinical trial is to learn if 3 months of taking the dietary supplement MitoQ \\[a mitochondria-targeted antioxidant that targets to reduce mitochondrial reactive oxygen species (mitoROS)\\] works to treat age- and menopause-related reductions in brain artery (cerebrovascular) function in postmenopausal women 60 years of age or older free of clinical disease. The main questions it aims to answer are:\n\nDoes MitoQ improve cerebrovascular function in postmenopausal women?\n\nIf so, does MitoQ improve cerebrovascular function by lowering mitoROS in these arteries?\n\nResearchers will compare MitoQ to a placebo (a look-alike substance that contains no drug) to see if MitoQ can improve cerebrovascular function by lowering mitoROS in arteries involved in brain health and function.\n\nParticipants will:\n\nTake MitoQ (20 mg\u002Fday) or a placebo every day for 3 months\n\nVisit the research laboratory at baseline and then after 3 months for cerebrovascular testing; there is also a check-in visit at 6 weeks, which is the halfway point\n\nKeep track of symptoms and events during their treatment period to report to the study team",[246,247],"Aging","Postmenopause",{"date":249,"type":43},"2026-02-12",{"date":251,"type":22},"2026-04",{"date":253,"type":22},"2030-07",{"name":49,"class":50},{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":59,"sex":17,"minAge":60,"maxAge":150,"enrollmentInfo":262,"targetDuration":4,"studyType":23,"phases":264,"briefSummary":265,"conditions":266,"keywords":270,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":51},"100558361","impact-of-circulating-and-tissue-specific-lipids-on-vascular-function-and-insulin-sensitivity-in-chronic-night-shift-workers-100558361","NCT06550115","Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers","SHINE","Inclusion Criteria:\n\n* 18-65 years old\n* worked the night shift for the last 1 year or more,\n* habitually sleep 5-9 hours per 24h period (night shift workers typically experience chronic insufficient sleep),\n* body mass index (BMI) of 20.0 - 35.0 kg\u002Fm2 and weight stable (plus or minus 5% of current body weight in the last 6 months); sedentary to mild physical activity level (less than 2 days of planned exercise per week);\n\nExclusion Criteria:\n\n* existing diagnosed sleep or eating disorder (e.g. obstructive sleep apnea \\[OSA\\], periodic limb movements of sleep \\[PLMS\\], narcolepsy, travel more than 1 time zone in 3 weeks before the study; anorexia nervosa, more than one food allergy to maintain flexibility in diet planning);\n* following any TRE (time-restricted eating) or intermittent fasting plan in the last year;\n* following any special diet plan, like paleo, keto, gluten-free or vegan, that can affect the primary lipid outcome measures in the last 6 months; any clinically significant surgical condition within the last year;\n* diagnosed diabetes or cardiovascular disease\n\n  * The prevalence of insomnia in shift workers is fairly high, ranging from 12.8% to 76.4%, which is higher than estimated for the general population. Insomnia itself is associated with elevated neural cardiovascular responsiveness to stress compared to people without insomnia. Thus, since excessive sleepiness and symptoms of insomnia may be present in night shift workers they will not be exclusionary.",{"count":263,"type":22},50,[25],"People who experience repeated bouts of circadian misalignment, such as shift workers, are at higher risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D) compared to daytime workers. However, the mechanism(s) by which shift work and associated circadian misalignment increase CVD and T2D risk are unknown. This project will examine whether elevated plasma lipids are a mechanism by which circadian misalignment impairs vascular function, insulin sensitivity, glucose homeostasis and muscle lipid accumulation, which could be targeted to prevent and treat cardiometabolic disease in people who chronically experience circadian misalignment, which includes more than 20% of the US workforce.",[267,131,268,269],"Circadian Rhythm Sleep Disorder of Shift Work Type","Insulin Sensitivity","Blood Pressure",[271,272,273,274,275,276],"Shift work","Sleep","Blood sugar","Metabolism","Lipids","Blood pressure","2025-12-15",{"date":279,"type":43},"2025-12-17",{"date":281,"type":43},"2024-03-01",{"date":283,"type":22},"2029-06",{"name":49,"class":50},{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":289,"acronym":4,"eligibilityCriteria":290,"healthyVolunteers":59,"sex":17,"minAge":60,"maxAge":90,"enrollmentInfo":291,"targetDuration":4,"studyType":23,"phases":293,"briefSummary":294,"conditions":295,"keywords":297,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":51},"100605371","use-of-neuromuscular-electrical-stimulation-to-prevent-exercise-resistance-100605371","NCT07161648","Use of Neuromuscular Electrical Stimulation to Prevent Exercise Resistance","Inclusion Criteria:\n\n* Regularly active (more than 30 minutes of exercise per day, 3 days per week, over the previous 12 months)\n* Ability to complete at least one hour of treadmill exercise (i.e. jogging\u002Frunning),\n* Willing to abstain from caffeine and alcohol for 24-hours prior to three different study visits\n* Competency in English\n\nExclusion Criteria:\n\n* Current or previous injuries that may hinder a participant's ability to exercise on a treadmill\n* A history of cardiopulmonary disorder that may be contra-indicative to treadmill exercise\n* Current use of cardio-pulmonary medication to treat a cardio-pulmonary condition\n* Currently breastfeeding\n* Pregnancy",{"count":292,"type":22},30,[25],"The study will find out if 100 minutes of electrical stimulation of muscle prevents the unfavorable consequence of insufficient exercise.",[296],"Fat Metabolism",[98,298,299],"exercise resistance","electrical stimulation","2025-11-13",{"date":302,"type":43},"2025-11-14",{"date":304,"type":43},"2024-10-17",{"date":306,"type":22},"2026-09-30",{"name":49,"class":50},{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":4,"eligibilityCriteria":314,"healthyVolunteers":59,"sex":17,"minAge":315,"maxAge":316,"enrollmentInfo":317,"targetDuration":4,"studyType":23,"phases":319,"briefSummary":320,"conditions":321,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":51},"100536060","distinguishing-alcohol-intoxication-cannabis-intoxication-and-co-intoxication-using-electroencephalography-eeg-100536060","NCT06259916","Distinguishing Alcohol Intoxication, Cannabis Intoxication and Co-intoxication Using Electroencephalography (EEG)","Developing Predictive Models to Distinguish Alcohol Use, Cannabis Use and Co-use: An Exploration of Electroencephalography (EEG) Metrics and Traditional Intoxication Measures","Inclusion Criteria:\n\n* 21-50 years old\n* Heavy drinkers (consuming more than 4 drinks\u002Fday or more than 14 drinks\u002Fweek for men, or more than 3 drinks\u002Fday or more than 7 drinks\u002Fweek for women)\n* Regular users of legal-market flower cannabis (at least 2x\u002Fweek in past 3 months)\n* report simultaneously using alcohol and legal-market flower cannabis at least once per month in the past 3 months\n* English speakers.\n\nExclusion Criteria:\n\n* Daily tobacco users\n* Diagnosed with or seeking treatment for alcohol use disorder (AUD) or other substance use disorder (SUD)\n* Females cannot be pregnant, breastfeeding or trying to become pregnant\n* Meet criteria for psychotic, bipolar or major depressive disorder with suicidal ideation, or history of these disorders, 5) Current use of psychotropic (except anti-depressants)\n* Report illicit drug use in past 60-days or fail drug screen on the day of the study appointment\n* Major medical condition contraindicating alcohol and\u002For cannabis consumption.","21 Years","50 Years",{"count":318,"type":22},99,[25],"This is a randomized, parallel-group study designed to explore the differences between cannabis intoxication, alcohol intoxication and co-intoxication involving both alcohol and cannabis, utilizing electroencephalography (EEG) as well as more traditional intoxication measures such as breath alcohol concentration and balance metrics. If eligible for the study, participants will be randomized to complete one study session in our mobile laboratory, during which they will use either alcohol, cannabis (which will be self-administered, ad libitum) or both alcohol and cannabis.",[322,323],"Cannabis Use","Alcohol Use, Unspecified","2025-11-12",{"date":300,"type":43},{"date":327,"type":43},"2024-01-05",{"date":329,"type":22},"2026-05-30",{"name":49,"class":50},{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":4,"eligibilityCriteria":337,"healthyVolunteers":59,"sex":17,"minAge":338,"maxAge":339,"enrollmentInfo":340,"targetDuration":4,"studyType":23,"phases":342,"briefSummary":343,"conditions":344,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":348,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":143},"100520159","health-without-barrierssalud-sin-barreras-100520159","NCT06052943","Health Without Barriers\u002FSalud Sin Barreras","Family-Inclusive Lifestyle Intervention for Teenagers in Rural Colorado","Inclusion Criteria:\n\nFamilies must have at least 1 teen that is between the ages of 11-19 years old and reside in La Plata, Montezuma, or Archuleta Counties.\n\nExclusion Criteria:\n\n* Participants will not take part in the program and\u002For research activities if they have a medical and\u002For psychological\u002Fbehavioral condition that, in the opinion of the Colorado State University\u002FExtension program team, could interfere with safety for themselves or others or interfere with the capability of the participant or other participants to potentially benefit from the program (e.g., severe emotional-behavioral disturbance, inability to follow facilitator directions) .\n* Parents\u002Fguardians will not take part in the program and\u002For research activities if they have a medical and\u002For psychological\u002Fbehavioral condition that, in the opinion of the Colorado State University\u002FExtension program team, could interfere with safety for themselves or others or interfere with the capability of their family or other participating families to potentially benefit from the program (e.g., using drugs or alcohol or under the use of drugs\u002Falcohol during program sessions, aggressive or inappropriate behavior toward other participants).","11 Years","19 Years",{"count":341,"type":22},175,[25],"The goal of this study is to address a key health inequity - lack of community access to evidence-based programs to prevent chronic health conditions (e.g., Type 2 Diabetes) - by tailoring and delivering a family-based lifestyle and stress management intervention, Health Without Barriers\u002FSalud Sin Barreras, for adolescents and their families living in rural Southwest Colorado. The intervention is a lifestyle program that addresses healthy lifestyle habits within the family context to support adolescent mental health (mindfulness intervention) and healthy weight (physical activity, nutrition, and parent education).",[345,346,347],"Mental Health Wellness","Family Research","Lifestyle Risk Reduction",{"date":300,"type":43},{"date":350,"type":43},"2022-09-21",{"date":352,"type":22},"2027-06",{"name":49,"class":50},{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":360,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":118,"minAge":60,"maxAge":4,"enrollmentInfo":362,"targetDuration":4,"studyType":23,"phases":363,"briefSummary":364,"conditions":365,"keywords":368,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":380,"locationsCount":51},"100610112","latinas-integrating-fitness-and-therapy-100610112","NCT07223346","Latinas Integrating Fitness and Therapy","Latinas Integrating Fitness and Therapy (LIFT)","LIFT","Inclusion Criteria: 1) currently undergoing or within 6-months of completing primary cancer(s) (2) self-identify as Latina and female, (3) over the age of 18 years, (4) reside in Colorado, (4) have access to internet, and be (5) English or Spanish speaking.\n\nExclusion Criteria: (1) metastatic disease, (2) known contraindications for exercise (e.g. existing CVD or metabolic disease, use of an assistive-walking device, severe ataxia, etc.), (3) part of a vulnerable population (pregnant, homeless, in prison, have auditory impairment), and (4) currently participating in mental health counseling with a licensed professional and\u002For a structured exercise program.",{"count":92,"type":22},[25],"Investigators are studying how combining a stepped-care mental health counseling program with an evidence-based exercise program can help Latina cancer survivors feel better mentally and physically. The goal is to improve stress, emotions, and physical activity during and after cancer treatment. In addition, investigators will examine the feasibility and acceptability of the intervention among Latina cancer survivors.",[366,96,181,367],"Stepped Care Cognitive Behavioral Therapy","Anxiety Depression",[369,370,371,96,372],"Latina cancer survivors","Mental health counseling","Stepped-care","Physical activity","2025-10-29",{"date":375,"type":43},"2025-10-31",{"date":377,"type":43},"2025-10-01",{"date":379,"type":22},"2027-05",{"name":49,"class":50},{"id":382,"slug":383,"hasResults":11,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":387,"eligibilityCriteria":388,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":150,"enrollmentInfo":389,"targetDuration":4,"studyType":23,"phases":391,"briefSummary":392,"conditions":393,"keywords":395,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":51},"100601190","diet-and-microbiome-interactions-application-in-posttraumatic-stress-disorder-in-adults-consuming-vegetable-drinks-100601190","NCT07107269","Diet and Microbiome Interactions: Application in Posttraumatic Stress Disorder in Adults Consuming Vegetable Drinks","Diet and Microbiome Interactions: Application in Posttraumatic Stress Disorder","DMAPS","Inclusion Criteria:\n\n* Healthy adults (age 18-65) with a diagnosis of PTSD and a BMI \\\u003C35. Participants should be willing to follow the study protocols and attend all clinic visits.\n\nExclusion Criteria:\n\n* Exclusion criteria include antibiotic use within the previous three months, BMI\\>35, vegan or vegetarian diet, allergies to any of the foods included in the intervention beverages, an unstable medication regimen, and diagnosis of diseases such as gastrointestinal diseases, cancer, CVD, diabetes or autoimmune disease and pregnancy or breastfeeding. Specific medication use (other than antibiotics) would not disqualify an individual if they have had a stable medication regimen for at least two months prior to beginning the study and remain on their medication for the study duration. However, medication changes or antibiotic use during the study would be a reason for dismissal Additionally, inclusion or exclusion in the study will be determined case-by-case based on self-reported supplement use or if the individual feels they are unable to adhere to the study requirements, which includes consuming beverages daily, providing stool or blood samples, tracking bowel movements and symptoms, and attending scheduled clinic visits.",{"count":390,"type":22},40,[25],"The gut microbiome has been shown to impact various facets of human health, including mental health. Studies have shown that populations with more agrarian lifestyles tend to have fewer chronic diseases and mental health issues than industrialized populations. A possible factor in these differences is the loss of co-evolved gut microbial taxa that has occurred with Westernization. This hypothesis, termed \"Old Friends Hypothesis\" suggests that the loss of certain gut microbes leads to immune dysregulation and increased chronic inflammation that contributes to development of cancers, cardiometabolic diseases and even neuroinflammation that can lead to negative behavioral and mental health outcomes. Other studies have shown that increasing the intake of plant foods may help increase diversity of the microbes in the gut and that this increased diversity could lead to better health outcomes in humans.\n\nThe investigators propose to evaluate daily consumption of a drink consisting of a high diversity of plants (30 plant species) for four weeks on the diversity of the gut microbiome, biological signatures of inflammation, quality of life, sleep quality, and PTSD symptoms among persons with a diagnosis of PTSD.\n\nThe investigators hypothesize that four weeks of daily consumption of this high plant diversity beverage (30 plant species) will increase gut microbiome ɑ-diversity, reduce markers of systemic inflammation, and improve PTSD symptom severity relative to daily consumption of a beverage containing only three plant species.",[394],"PTSD - Post Traumatic Stress Disorder",[396,397,398,399],"PTSD","Post Traumatic Stress Disorder","Highly Diverse Fruit and Vegetable Drink","PTSD and microbiome","2025-07-30",{"date":402,"type":43},"2025-08-06",{"date":404,"type":43},"2025-06-25",{"date":406,"type":22},"2026-07",{"name":49,"class":50},{"id":409,"slug":410,"hasResults":11,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":414,"eligibilityCriteria":415,"healthyVolunteers":59,"sex":17,"minAge":60,"maxAge":416,"enrollmentInfo":417,"targetDuration":4,"studyType":23,"phases":419,"briefSummary":420,"conditions":421,"keywords":422,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":426,"completionDateStruct":428,"leadSponsor":430,"locationsCount":51},"100436675","countermeasures-to-circadian-misalignment-100436675","NCT04966351","Countermeasures to Circadian Misalignment","Time-restricted Feeding to Mitigate Metabolic Impairments During Circadian Misalignment","C2CM","Inclusion Criteria:\n\n1. 18-35 old; men and women; equal numbers of women and men will be included.\n2. Body Mass Index (BMI) between 20.0 and 24.9 (\"normal\" weight).\n3. Physical activity history: inactive to habitual moderate physical activity level\n4. Sleep\u002Fwake history: habitual sleep duration between 7-9.25 hours.\n5. Altitude history: Potential subjects must have lived at Denver altitude or higher for at least 3 months prior to inpatient stay.\n\nExclusion Criteria:\n\n1. Any clinically significant medical, psychiatric, or sleep disorder\n2. Use of prescribed medications\u002Fsupplements\u002Fillicit drugs within one month prior to study\n3. History of shift work in year prior to study, or travel more than one time zone in three weeks prior to study. \\[NOTE: Subjects can be studied at a later date.\\]\n4. Women with history of prior gynecological pathology, \\\u003C1 year post-partum, breast-feeding and\u002For pregnant.\n5. Non-English speakers will be excluded, as we do not have access to a translator who could rely accurate information to the participant for the consent or throughout the study.","35 Years",{"count":418,"type":22},32,[25],"Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable.\n\nThis project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.",[267,131,268],[271,272,273,274],"2025-07-21",{"date":425,"type":43},"2025-07-24",{"date":427,"type":43},"2021-07-07",{"date":429,"type":22},"2026-06-30",{"name":49,"class":50},{"id":432,"slug":433,"hasResults":11,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":437,"eligibilityCriteria":438,"healthyVolunteers":11,"sex":17,"minAge":439,"maxAge":439,"enrollmentInfo":440,"targetDuration":4,"studyType":23,"phases":442,"briefSummary":443,"conditions":444,"keywords":448,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":51},"100599223","walnuts-as-an-infant-solid-food-for-health-100599223","NCT07081698","Walnuts as an Infant Solid Food for Health","Walnut as a First Food During Complementary Feeding on Gut Microbiota and Immunity Development in Breastfed Infants","WISH","Inclusion Criteria:\n\n* Full term: gestational age ≥ 37 weeks\n* Generally healthy without conditions that would affect normal growth\n* No significant consumption of complementary food (e.g., no more than 1 oz of solid foods per week)\n* Exclusively breastfed (\\\u003C 2 weeks of cumulative formula exposure)\n\nExclusion Criteria:\n\n* Adults unable to consent\n* Pregnant women\n* Prisoners","5 Months",{"count":441,"type":22},90,[25],"The objective is to investigate the effect of walnuts on gut microbiota, inflammatory markers, atopic dermatitis status, and indices of allergy outcomes in breastfed infants during early complementary feeding.\n\nThe three primary aims include:\n\nAim 1: Evaluate the effect of walnut consumption on gut microbiota structure and function, inflammation, atopic dermatitis, and allergy outcomes.\n\nAim 2: Evaluate the impact of walnut consumption on infant growth trajectories and risk of overweight.\n\nAim 3 (exploratory): Identify walnut-specific food signatures that are associated with gut microbiota and immunity biomarkers using a novel nutri-metabolomics technique.",[445,446,447],"Gut -Microbiota","Inflammatory Markers","Infant Development",[449,69,450,451,452,453],"Walnut","Infant","Pediatric","Nutrition","Health","2025-07-16",{"date":456,"type":43},"2025-07-23",{"date":458,"type":43},"2025-05-18",{"date":460,"type":22},"2027-12-31",{"name":49,"class":50},{"id":463,"slug":4,"hasResults":11,"nctId":464,"briefTitle":465,"officialTitle":466,"acronym":467,"eligibilityCriteria":468,"healthyVolunteers":59,"sex":17,"minAge":338,"maxAge":4,"enrollmentInfo":469,"targetDuration":4,"studyType":23,"phases":471,"briefSummary":472,"conditions":473,"keywords":481,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":494,"locationsCount":51},"100579291","NCT06822387","Health Without Barriers\u002FSalud Sin Barreras- Northern Colorado","Growing an Extension Network for Multisite Dissemination and Implementation of Intensive Health Behavior and Lifestyle Treatment","HWB\u002FSSB","Inclusion Criteria:\n\nAdolescent subjects\n\n* Between the ages 11-19 years old\n* Reside in Larimer County, Weld County, or the surrounding areas.\n\nParent\u002Fguardian subjects:\n\n* 18 years old or older\n* Are parents\u002Fguardians of an adolescent between the ages of 11-19\n* Reside in Larimer County, Weld County, or the surrounding areas\n\nFacilitators subjects\n\n* 18 years old or older\n* Reside in Larimer County, Weld County, or the surrounding areas\n* Are planning to or have facilitated HWB\n\nExclusion Criteria\n\nAdolescents subjects will not take part in the research activities if they have a medical and\u002For psychological\u002Fbehavioral condition that, in the opinion of the Colorado State University\u002FExtension program team, could interfere with safety for themselves or others or interfere with the capability of the participant or other participants to potentially benefit from the program (e.g., severe emotional-behavioral disturbance, inability to follow facilitator directions).\n\nParents\u002Fguardians will not take part in the research activities if they have a medical and\u002For psychological\u002Fbehavioral condition that, in the opinion of the Colorado State University\u002FExtension program team, could interfere with safety for themselves or others or interfere with the capability of their family or other participating families to potentially benefit from the program (e.g., using drugs or alcohol or under the use of drugs\u002Falcohol during program sessions, aggressive or inappropriate behavior toward other participants).\n\nThere is no exclusion for facilitator subjects.",{"count":470,"type":22},140,[25],"The overarching goal of this work is to address the limited access to evidence-based health behavior and lifestyle interventions for youth and families most impacted by preventable chronic diseases, including obesity and type 2 diabetes. In the current project, we implement a small single-arm pilot and feasibility trial of Health Without Barriers\u002FSalud Sin Barreras (HWB\u002FSSB), a culturally-adapted, whole-family intensive health behavior and lifestyle intervention to 11-19-year-old adolescents and their families living in Northern Colorado. Objectives are refining the HWB\u002FSSB community facilitator training, evaluating the feasibility and acceptability of HWB\u002FSSB implementation, and characterizing changes in health outcomes among adolescent participants.",[347,474,475,476,477,478,479,480],"Adolescent Health","Family Health","Cardio-metabolic Health","Mental Health","Wellness Program","Type 2 Diabetes","Obesity, Adolescent",[482,483,484,452,181,485,486,487],"Whole-family","Mindfulness","Wellness education","Stress reduction","Health Without Barriers","Salud Sin Barreras","2025-04-29",{"date":490,"type":43},"2025-05-02",{"date":492,"type":43},"2025-04-07",{"date":429,"type":22},{"name":49,"class":50},""]