[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":70},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100633774","early-phase-1-comparison-of-effectiveness-of-intralesional-injectioms-of-5-flourouracil-alone-verses-its-cpmbination-with-cryotherapy-in-the-treatment-of-keloids-100633774",false,"NCT07531056","Comparison Of Effectiveness Of Intralesional Injectioms Of 5 Flourouracil Alone Verses Its Cpmbination With Cryotherapy In The Treatment Of Keloids","A Randomized Controlled Trial Comparing The Effectiveness And Safety Of iIntralesional 5 Flourouracil Monotherapy Verses 5 Flourouracil Combined With Cryotherapy; In The Treatment Of Keloid Scars","Inclusion Criteria:\n\n* Patients willing to participate in the study\n* Patients of age group of 18 -50 years.\n* Patients having symptomatic keloids i.e., having pain, pruritus, restriction of movement, scar tension or disfigurement.\n\nExclusion Criteria\n\n:• Pregnant women or lactating women\n\n* Patients with history of hepatic, renal, cardiac diseases or chronic diarrhea.\n* Patients on immunosuppressant medications due to other diseases\n* Patients having myelosuppression checked by CBC.\n* Patient taking warfarin.\n* Patients with history of hypersensitivity to 5FU.","ALL","18 Years","50 Years",{"count":20,"type":21},88,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","The goal of this clinical trial is to learn how well intralesional 5 fluorouracil with cryotherapy works to treat keloids as compared to intralesional 5 fluorouracil alone on keloids. It will also learn about the safety of both these treatments. The main questions it aims to answer are:\n\n* What well does cryotherapy followed by intralesional 5 fluorouracil (5FU) work to treat keloids as compared to 5 fluorouracil (5FU) alone?\n* What is participant's satisfaction when treated with cryotherapy followed by intralesional 5 fluorouracil (5FU) as compared to 5 fluorouracil (5FU) alone?\n* What skin problems do participants have when treated with cryotherapy followed by intralesional 5 fluorouracil (5FU) and 5 fluorouracil (5FU) alone? Researchers will compare cryotherapy followed by intralesional 5 fluorouracil (5FU) with 5 fluorouracil (5FU) alone to see how well both work.\n\nParticipants will be divided into two groups:\n\nFor Group A: Cryotherapy will be done at lesion site followed by intralesional 5FU every 3 weekly.\n\nFor Group B: Intralesional 5FU will be given at lesion site every 3 weekly. Keloids will be assessed at the start of trial and then after 12 weeks of treatment.",[27],"Keloids",[27,29,30],"Intralesional injectioms","5-FU","RECRUITING","2026-04-21",{"date":34,"type":35},"2026-04-24","ACTUAL",{"date":37,"type":35},"2025-12-22",{"date":39,"type":21},"2026-09-20",{"name":41,"class":42},"Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100623605","early-phase-1-effectiveness-of-micro-needling-with-5-fluorouracil-versus-potent-topical-steroids-in-the-treatment-of-limited-vitiligo-100623605","NCT07398807","Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo","Effectiveness of Combining Micro Needling With 5 Fluorouracil Versus Potent Topical Steroids; in Treating Limited Vitiligo- Randomised Controlled Study","Inclusion Criteria:\n\n* Patients willing to participate in the study\n* Patients of age group of 05 -70 years.\n* Vitiligo involving less than or equal to 10% body surface area.\n\nExclusion Criteria:\n\n* Patients using or have used other treatments for vitiligo\n* Pregnant women or lactating women\n* Patients with unstable vitiligo\n* Patients on immunosuppressant medications due to other diseases\n* Patients having anemia, immunosuppression, bleeding disorder, taking anticoagulants or anti-platelet drugs or having epilepsy\n* Patient having history of keloids or hypertrophic scars\n* Patients with history of hypersensitivity to either of the drugs","4 Years","70 Years",{"count":54,"type":21},40,[24],"The goal of this clinical trial is to learn how well 5 fluorouracil (5FU) with micro-needling works to treat limited vitiligo as compared to strong steroid applied on skin. It will also learn about the safety of both these treatments. The main questions it aims to answer are:\n\n* How well does 5FU with microneedling work to treat vitiligo by returning pigmentation in vitiligo patches as compared to steroid?\n* What is participant's satisfaction when treated with 5FU with microneedling as compared to steroid?\n* What skin problems do participants have when treated with FU with microneedling and steroid?\n\nResearchers will compare 5FU with microneedling to steroid application to see how well both work to return pigment in vitiligo patches.\n\nParticipants will be divided into two groups. For Group A, 5 FU will be rubbed and absorbed on the vitiligo patch after micro-needling every 2 weeks.\n\nFor group B, topical 0.05% clobetasol propionate ointment will be applied twice a day on the vitiligo patches for 12 weeks.\n\nVitiligo patches will be assessed at the start of trial and then after 12 weeks of treatment.",[58],"Vitiligo",[58,60,61,30],"Limited","Microneedling","2026-02-12",{"date":64,"type":35},"2026-02-17",{"date":66,"type":35},"2025-08-08",{"date":68,"type":21},"2026-02",{"name":41,"class":42},""]