[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Comprehensive Cancer Centre The Netherlands\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":78},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100510821","high-risk-prostate-cancer-radiation-versus-surgery-100510821",false,"NCT05931419","High-Risk prostatE Cancer radiatiOn Versus surgERy","High-Risk prostatE Cancer radiatiOn Versus surgERy (RECOVER)","RECOVER","Inclusion Criteria:\n\n* Histologically confirmed de novo non-metastatic high-risk prostate cancer.\n* cT3a-bN0M0, according to the 8th edition of the Tumour, Node, Metastasis (TNM) classification, with the exception that clinical T-stage will be based on digital rectal examination and magnetic resonance imaging (the highest stage will be used) and\u002For\n* International Society of Urological Pathology (ISUP) grade ≥4 and\u002For\n* Prostate-Specific Antigen (PSA) value at diagnosis greater than 20 ng\u002FmL\n* Fit for treatment with either RARP or EBRT +\u002F- ADT (WHO performance status 0-1)\n* Living in the Netherlands\n* Able to read and understand the Dutch language\n\nExclusion Criteria:\n\n* Histological types other than adenocarcinoma\n* Diagnosis and\u002For treatment in a hospital abroad\n* Treatment with Androgen Receptor Targeted Agents (ARTA) as part of the initial treatment plan","MALE","50 Years","75 Years",{"count":21,"type":22},837,"ESTIMATED","5 Years","OBSERVATIONAL","Prospective cohort study comparing robot-assisted radical prostatectomy and external beam radiotherapy +\u002F- androgen deprivation therapy for high-risk non-metastatic prostate cancer in terms of health-related quality of life, functional outcomes, cost-effectiveness, progression-free survival and distant metastasis-free survival.",[27,28],"Prostate Cancer","Prostate Adenocarcinoma",[30,31,32,33,34,35,36],"Radical prostatectomy","Radiotherapy","Health-related quality of life","Functional outcomes","Progression-free survival","Distant metastases-free survival","Cost-effectiveness","RECRUITING","2026-05-21",{"date":40,"type":41},"2026-05-22","ACTUAL",{"date":43,"type":41},"2023-02-16",{"date":45,"type":22},"2030-06-30",{"name":47,"class":48},"Comprehensive Cancer Centre The Netherlands","OTHER",28,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":58,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},"100398991","distress-in-cervical-cancer-patients-and-partners-100398991","NCT04475354","Distress In CErvical Cancer Patients and Partners","Mechanisms Explaining Psychological Distress In CErvical Cancer Patients and Partners (DICE): a Population-based Prospective Study","DICE","Patients\n\nInclusion Criteria:\n\n* Newly diagnosed with cervical cancer stage I, II or III\n* \\>18 years or older\n\nExclusion Criteria:\n\n* Participants with cognitive impairment will not be included because of expected difficulties in completing the questionnaires without assistance.\n* Participants who are not able to read or write Dutch will be excluded, as they are not able to complete a Dutch questionnaire.\n\nPartners\n\nInclusion Criteria:\n\n* Partner of patient participating in the study\n* \\>18 years\n\nExclusion Criteria:\n\n* Participants with cognitive impairment will not be included because of expected difficulties in completing the questionnaires without assistance.\n* Participants who are not able to read or write Dutch will be excluded, as they are not able to complete a Dutch questionnaire.","ALL","18 Years",{"count":61,"type":22},832,"Rationale: A growing number of cervical cancer patients live years beyond their cancer diagnosis and ultimately survive their disease. Cervical cancer patients report higher levels of psychological distress compared to other (gynecological) cancer types, resulting in physical and psychosocial limitations. The mechanisms explaining why some patients do, and others do not experience persistent psychological distress after cervical cancer remain unclear.\n\nObjective: Gain insight into the mechanisms explaining psychological distress (i.e. anxiety, depression, cancer worry, perceived stress) in a prospective population-based sample of cervical cancer patients. Factors to be studied include characteristics of the individual (demographical and clinical, including comorbidities), characteristics of the environment ((sexual) relationships), biological function (cortisol, melatonin and sex hormone production assessed in scalp hair, inflammation and telomere length assessed in blood, overall quality of life (EORTC QLQ-C30), symptoms (EORTC QLQ-CX24), functional status (physical activity and sleep measured using the Actigraph activity tracker, and food intake measured using the online 'Eetmeter'), and general health perceptions (B-IPQ). The second aim is to assess the impact of cervical cancer on partners' distress (cancer worry, illness perceptions, relationship quality, dyadic coping).",[64,65,66,67,68],"Cervical Cancer","Psychologic Stress","Psychological Distress","Survivorship","Quality of Life","2023-12-05",{"date":71,"type":41},"2023-12-06",{"date":73,"type":41},"2020-11-01",{"date":75,"type":22},"2030-01",{"name":47,"class":48},6,""]