[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Compremium AG\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":66},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100610072","non-invasive-intracranial-pressure-estimation-by-measurement-of-the-occlusion-pressure-of-the-isolated-periorbital-vein-100610072",false,"NCT07222826","Non-invasive Intracranial Pressure Estimation by Measurement of the Occlusion Pressure of the Isolated Periorbital Vein","Non-invasive Intracranial Pressure Estimation by Measurement of the Occlusion Pressure of the Isolated Periorbital Vein (NICE-ICP)","Inclusion Criteria:\n\n* Male or female\n* Age \\> 18\n* Equipped with an invasive ICP monitor as part of standard of care\n\nExclusion Criteria:\n\n* Presence of facial and\u002For skull trauma that could hinder placement of the pneumatic mask or contraindicate ultrasound on the forehead\n* History of recent cranial surgery or hemicraniectomy\n* Active bleeding (proven or suspected)\n* History or known pathological condition or injury linked to the orbital socket influencingvenous outflow (e.g. Grave disease, tumor, inflammation, trauma, glaucoma, etc.)\n* History, or known vein stenosis in ophthalmic veins\u002Fcavernous sinus\n* Any other condition that would interfere with measurement technique and routine clinical care according to the judgment of the investigator.","ALL","18 Years",{"count":19,"type":20},15,"ESTIMATED","INTERVENTIONAL",[23],"NA","Elevated intracranial pressure is a common complication of brain injury which means that the pressure within the skull rises above normal levels. The negative impact of increased intracranial pressure (ICP) on the prognosis of patients has been strongly shown in numerous studies and ICP-based treatment is associated with an important reduction of risk of death. Invasive ICP measurement methods are nowadays a standard of care in severe brain injury. The two available ways of measuring ICP require neurosurgical procedure to implant a catheter and probes within the brain and present risks and complications for the patient, such as infections and intracranial bleeding. In addition, invasive recording of ICP requires neurosurgical expertise and intensive care unit (ICU) facilities, limiting the application of ICP measurements to patients of the acute neuro-ICU (neuro-Intensive Care Unit) with acute brain damage requiring close surveillance to prevent further deterioration of neural tissue and disability. Non-invasive ICP monitoring benefits include no risk of complications seen in invasive monitoring, helping in deciding which patient needs invasive ICP monitoring, and providing ongoing long-term measurements of ICP without having to insert a new device every time. Although many non-invasive ICP measurement methods have been explored, to date, none of them have shown clinical success or usefulness. One under-explored window to ICP is the orbital vein, a small blood vessel located near your eye, which we think could provide a direct link to the intracranial pressure. The study device, called the CPMX3 system, is a non-invasive method to measure pressure in a superficial periorbital vein.",[26,27],"Intracranial Pressure","Intracranial Pressure Changes","RECRUITING","2025-10-28",{"date":31,"type":32},"2025-10-30","ACTUAL",{"date":34,"type":32},"2025-09-30",{"date":36,"type":20},"2026-09-30",{"name":38,"class":39},"Compremium AG","INDUSTRY",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":40},"100584110","non-invasive-central-venous-pressure-estimation-in-pediatric-patients-100584110","NCT06885073","Non-invasive Central Venous Pressure Estimation in Pediatric Patients","CPMX-CVP-Ped","Inclusion Criteria\n\n* Provision of signed and dated informed consent form\n* Male or female\n* Age: birth to 21 years of age\n* Equipped with a central venous catheter (CVC) for central venous pressure (CVP) monitoring indication as part of standard of care, or undergoing cardiac catheterization.\n\nExclusion Criteria:\n\n* Weight less than 2.5kg at the time of enrollment.\n* Bilateral external jugular veins not accessible due to vascular access or dressing.\n* Bilateral skin lesion contraindicating neck Ultrasound\n* Active bleeding\n* Clinically unstable, per clinical assessment by attending physician and\u002For surgeon","21 Years",{"count":50,"type":20},100,[23],"Central Venous Pressure (CVP) is a standard parameter for hemodynamic monitoring and is currently measured through the insertion of a catheter. The pediatric population is especially vulnerable to risks associated to this invasive procedure, including infection, thrombosis, and pneumothorax. The proposed pilot study will evaluate safety and preliminary efficacy of a new non-invasive ultrasound-based venous occlusion pressure (VOP) monitoring device (CPMX2) in children equipped with an invasive catheter for CVP monitoring as part of standard of care.",[54],"Central Venous Pressure",[56,57],"central venous pressure","venous hypertension","2025-09-12",{"date":60,"type":32},"2025-09-18",{"date":62,"type":32},"2025-03-10",{"date":64,"type":20},"2026-03-31",{"name":38,"class":39},""]