[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Compugen Ltd\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":75},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100584406","phase-1-a-clinical-trial-to-evaluate-the-safety-and-efficacy-of-com701-in-relapsed-platinum-sensitive-ovarian-cancer-100584406",false,"NCT06888921","A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer","An Adaptive Clinical Platform Trial to Evaluate the Safety and Efficacy of COM701 as Monotherapy or Combination Therapy as Maintenance Therapy in Participants With Relapsed Platinum Sensitive Ovarian Cancer (PSOC)","MAIA-ovarian","Inclusion Criteria:\n\n* Has relapsed platinum sensitive epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer\n* Has completed at least 2 previous courses (i.e. lines) of platinum-containing therapy\n* For the last chemotherapy course prior to being randomized into the study, must have had a minimum of 4 cycles of a platinum containing regimen and achieved a partial or complete tumor response.\n* Has received prior maintenance therapy with bevacizumab or a PARP inhibitor if eligible and is not a candidate for, or has declined in writing, bevacizumab or PARP inhibitor therapy.\n* Have recovered from toxicities of prior chemotherapy or other therapy (to grade 1 or less, except for alopecia and neuropathy recovered to a ≤grade 2).\n\nExclusion Criteria:\n\n* Has had 4 or more lines of cytotoxic chemotherapy in total\n* Is being treated with immunosuppressive doses of systemic medications, such as steroids within 2 weeks before study drug administration\n* Has had prior treatment with PD-1, PD-L1, anti-PVRIG, TIGIT or any other check point inhibitors\n* Presence of radiographic or biopsy proven liver metastases at the beginning or completion of current line of platinum-based chemotherapy.\n* Drainage of ascites during last 2 cycles of last chemotherapy or any time after completion of the last chemotherapy regimen.\n* Bowel obstruction in the 6 weeks prior to randomization.\n* Have known active central nervous system metastases and\u002For carcinomatous meningitis \u002F leptomeningeal carcinomatosis.\n* Has active hepatitis B virus (HBV) or hepatitis C virus (HCV), or subjects with human immunodeficiency virus (HIV).\n* Has active and clinically relevant bacterial, fungal, or viral infection that is not controlled or requires systemic antibiotics, antifungals, or antivirals, respectively.\n* Has received a live viral vaccine within 30 days of planned start of study treatment or requiring a live vaccine during the study.\n* Has a history of severe allergic, anaphylactic, or other hypersensitivity reactions to a human or humanized monoclonal antibody (mAb) or allergy to any excipients in the investigational products.\n* Has any serious or unstable concomitant systemic disorder\n* Has any other condition that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the opinion of the investigator, would make the subject inappropriate for entry into the study.\n* Is currently participating in or have participated in a clinical study and received an investigational agent or used an investigational device within 4 weeks prior to the first dose of study treatment.\n* Is pregnant or breastfeeding or planning to become pregnant during the period of the study.","FEMALE","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","The goal of this clinical trial is to learn if the experimental antibody COM701 delays the progression of ovarian cancer in participants with Relapsed Platinum Sensitive Ovarian Cancer. It will also learn about the safety of COM701.\n\nThe main questions the trial aims to answer are:\n\n* Does COM701, when used as a maintenance treatment, stop or slow the progression of ovarian cancer?\n* Does COM701 delay the time to needing a new anti-cancer treatment?\n* What side effects do participants have when taking COM701?\n\nParticipants will:\n\n* Visit the clinic once every 3 weeks during which the study treatment will be administered intravenously\n* Undergo various tests and procedures to monitor general health throughout the trial including physical examinations, vital sign measurements (heart rate, blood pressure, breathing, and body temperature), weight measurements, electrocardiography (ECG), blood and urine tests and pregnancy tests if relevant.\n* Undergo various tests and procedures to assess disease response throughout the trial including tumor imaging by CT scans or MRI to assess the tumor, its location, and size, and the testing of a sample of tumor tissue (from a prior biopsy or a fresh biopsy if feasible, to evaluate tumor response to treatment and to measure levels of tumor markers,",[28,29],"Ovarian Cancer","Ovarian Cancer Recurrent",[31,32],"maintenance therapy","relapsed platinum sensitive ovarian cancer","RECRUITING","2026-03-31",{"date":36,"type":37},"2026-04-01","ACTUAL",{"date":39,"type":37},"2025-07-21",{"date":41,"type":21},"2027-03",{"name":43,"class":44},"Compugen Ltd","INDUSTRY",28,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100574466","phase-1-a-clinical-trial-to-assess-com503-in-participants-with-advanced-solid-malignancies-100574466","NCT06759649","A Clinical Trial to Assess COM503 in Participants With Advanced Solid Malignancies","A First-in-Human, Phase 1 Dose Escalation and Dose Expansion Trial to Assess the Safety and Tolerability of COM503 as Monotherapy and in Combination Therapy in Participants With Advanced Solid Malignancies","Inclusion Criteria:\n\n* Participants with histologically\u002Fcytologically confirmed advanced recurrent or metastatic solid tumor malignancy\n* Part 1 (dose escalation): Participants must have had disease progression on or following all available standard of care (SOC) therapies known to confer clinical benefit.\n* Part 2 (dose expansion): Participants may be enrolled following disease progression that has progressed after at least 1 available standard therapy; or for whom standard therapy has proven to be ineffective or intolerable or is considered inappropriate; or for whom a clinical trial of an investigational agent is a recognized SOC.\n* Participants must have a solid tumor measurable by computed tomography (CT) or magnetic resonance imaging (MRI) as per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) criteria by investigator assessment\n\nExclusion Criteria:\n\n* History of another malignancy within 2 years prior to the first trial intervention administration (unless the malignancy was treated with curative intent with low risk of recurrence \\[e.g., nonmelanoma skin cancer, histologically confirmed complete excision of carcinoma in situ, or similar\\] which are allowed to enroll).\n* Therapy with Immunosuppressive doses of systemic medications, such as steroids (doses \\>10 mg\u002Fday prednisone or equivalent daily) within 2 weeks before trial intervention administration\n* Have known active central nervous system (CNS) metastases and\u002For leptomeningeal disease (LMD).\n* Active and clinically relevant bacterial, fungal, or viral infection that is not controlled or requires systemic antibiotics, antifungals, or antivirals, respectively.\n* Ascites or pleural effusion that is symptomatic and\u002For requiring drainage within 2 weeks prior to the first trial intervention administration.\n* Have active hepatitis B virus (HBV) or hepatitis C virus (HCV), or participants with human immunodeficiency virus (HIV).\n* Any medical condition that, in the investigator's or sponsor's opinion, poses an undue risk to the participant's participation in the trial.","ALL",{"count":55,"type":21},200,[24],"The overall goal of this first-in-human (FIH) clinical trial is to learn about the safety and dosing of COM503 when given alone or in combination with zimberelimab in participants with advanced solid tumors.\n\nThe primary objectives of this study are:\n\n* To assess the safety and tolerability of COM503 as monotherapy and COM503 in combination with zimberelimab in participants with advanced solid tumors.\n* To identify the maximum tolerated dose (MTD) \u002F maximum administered dose (MAD) and\u002For the recommended phase 2 dose (RP2D) of COM503 as monotherapy and in combination with zimberelimab in participants with advanced solid tumors.",[59,60],"Neoplasm","Cancer, Malignant Tumors",[62,63,64,65],"first-in-human","oncology","monoclonal antibody","immunotherapy","2026-02-26",{"date":68,"type":37},"2026-02-27",{"date":70,"type":37},"2025-01-07",{"date":72,"type":21},"2027-11-22",{"name":43,"class":44},11,""]