[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Coordinación de Investigación en Salud, Mexico\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":176},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,85,115,147],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100639549","cohort-study-of-metabolic-disease-and-hypertension-100639549",false,"NCT07577063","Cohort Study of Metabolic Disease and Hypertension","Metabolic Disease and Hypertension in Adults: A Prospective Cohort Study (Phase One)","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* No prior diagnosis of type 2 diabetes mellitus or hypertension\n* Receiving care at primary health care units of the Mexican Social Security Institute (IMSS) or IMSS-Bienestar\n* Willing and able to provide informed consent\n* Willing to participate in baseline and annual follow-up assessments\n\nExclusion Criteria:\n\n* Prior diagnosis of type 2 diabetes mellitus or hypertension\n* Pregnancy at the time of enrollment\n* Any condition that limits the ability to perform study procedures, including the six-minute walk test\n* Any condition that, in the opinion of the investigators, may interfere with participation or follow-up",true,"ALL","18 Years","65 Years",{"count":21,"type":22},2500,"ESTIMATED","5 Years","OBSERVATIONAL","The goal of this observational study is to learn how type 2 diabetes and high blood pressure develop over time in adults in Mexico. The study will include men and women between 18 and 65 years of age who do not have a previous diagnosis of these conditions.\n\nThe main questions this study aims to answer are:\n\nWhat factors increase the risk of developing type 2 diabetes? What factors increase the risk of developing high blood pressure?\n\nParticipants will not receive any experimental treatment. Researchers will observe their health as part of their regular medical care.\n\nParticipants will:\n\nAttend an initial visit that includes physical measurements, blood tests, and questionnaires about their health, lifestyle, and environment Perform a simple walking test to measure physical fitness Return once a year for follow-up visits over a period of five years\n\nDuring the study, researchers will monitor participants to identify new cases of type 2 diabetes and high blood pressure.\n\nThe results of this study may help improve prevention strategies and support public health programs aimed at reducing chronic diseases in Mexico.",[27,28],"Type 2 Diabetes Mellitus (T2DM)","Hypertension (HTN)",[30,31,32,33,34,35],"Type 2 Diabetes Mellitus","Hypertension","Cardiometabolic risk","Obesity","Prediabetes","Prehypertension","NOT_YET_RECRUITING","2026-05-05",{"date":39,"type":40},"2026-05-11","ACTUAL",{"date":42,"type":22},"2026-06",{"date":44,"type":22},"2031-12",{"name":46,"class":47},"Coordinación de Investigación en Salud, Mexico","OTHER_GOV",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":48},"100612071","telerehabilitation-program-to-improve-function-in-people-with-chronic-low-back-pain-compared-with-conventional-care-100612071","NCT07248813","Telerehabilitation Program to Improve Function in People With Chronic Low Back Pain Compared With Conventional Care","Effectiveness of an Additional Telerehabilitation Program Combined With Conventional Care on Functional Improvement in Patients With Chronic Low Back Pain at the Primary Care Level in the Mexican Institute of Social Security (IMSS): A Pragmatic Randomized Controlled Trial","TELEREHAB-LC","Inclusion Criteria:\n\n* Adults between 18 and 60 years of age.\n* Clinical diagnosis of chronic non-specific low back pain (duration ≥ 12 weeks).\n* Pain intensity ≥ 3 on the Visual Analogue Scale (VAS) at baseline.\n* Enrolled as beneficiaries of the Mexican Institute of Social Security (IMSS) and receiving care at a primary care clinic.\n* Access to a smartphone or computer with internet connection.\n* Ability to read and understand written instructions in Spanish.\n* Willingness to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Specific causes of low back pain (e.g., fractures, tumors, infections, inflammatory or rheumatic diseases).\n* Neurological deficits suggestive of radiculopathy or myelopathy.\n* Pregnancy.\n* Severe psychiatric or cognitive disorders that limit participation.\n* Recent spinal surgery (within the last 6 months).\n* Participation in another rehabilitation or exercise program for low back pain within the previous 3 months.\n* Any medical condition that contraindicates physical exercise, as determined by the treating physician.\n\nThe upper age limit of 60 years was established to minimize confounding factors related to advanced degenerative joint disease. Individuals older than 60 frequently present radiographic or clinical signs of grade III or higher lumbar osteoarthritis, which may produce chronic pain and functional limitation independent of the intervention. Including these participants could obscure the true effect of the telerehabilitation program on functional improvement and pain reduction in patients with non-specific chronic low back pain.","60 Years",{"count":59,"type":22},200,"INTERVENTIONAL",[62],"NA","The goal of this clinical trial is to evaluate whether an additional telerehabilitation program, combined with conventional care, can improve functional recovery in adults with chronic low back pain treated in primary care clinics of the Mexican Institute of Social Security (IMSS).\n\nThe main questions it aims to answer are:\n\n* Does the telerehabilitation program lead to greater functional improvement, measured by the Oswestry Disability Index (ODI), compared with conventional care alone?\n* Does the program reduce pain intensity and improve adherence and satisfaction among participants?\n\nResearchers will compare patients receiving conventional care plus telerehabilitation with those receiving conventional care only to determine whether the digital intervention provides additional clinical benefits.\n\nParticipants will:\n\n* Continue their usual medical care for chronic low back pain at IMSS clinics.\n* Follow a 6-week telerehabilitation program delivered through an online platform, including educational videos, stretching and strengthening exercises, and weekly virtual check-ins.\n* Complete baseline and post-intervention assessments of pain, disability, and satisfaction.",[65],"Chronic Low Back Pain (Non-specific, Uncomplicated)",[67,68,69,70,71,72,73,74,75],"TELEMEDICINE","Physical Therapy","Primary Care","Oswestry Disability Index","Rehabilitation Program","Telerehabilitation","Pragmatic Clinical Trial","Pain Management","Adherence","RECRUITING","2025-11-18",{"date":79,"type":40},"2025-11-25",{"date":81,"type":40},"2025-10-03",{"date":83,"type":22},"2026-12-20",{"name":46,"class":47},{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":60,"phases":95,"briefSummary":96,"conditions":97,"keywords":102,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":48},"100365342","efficacy-of-fistulotomy-for-biliary-cannulation-100365342","NCT04037007","Efficacy of Fistulotomy for Biliary Cannulation","Efficacy and Safety of Precut Fistulotomy vs Conventional Cannulation Technique as a Primary Approach to Biliary Access According to the Endoscopist Experience Degree in ERCP","Inclusion Criteria:\n\n* All patients undergoing ERCP with suspected or confirmed of choledocholithiasis, malignant and benign biliary stenosis.\n\nExclusion Criteria:\n\n* patients with previous ERCP, altered gastro-duodenal anatomy by previous surgery, suspicion or diagnosis of ampullary neoplasm, duodenal cancer, periampullary diverticula types 1 and 2, pregnant women, coagulopathy with INR greater than 1.5.\n\nElimination Criteria:\n\n\\- Incomplete procedure due to anesthesia adverse events.","90 Years",{"count":94,"type":22},320,[62],"Access to the main bile duct is the first step in order to perform a therapeutic maneuver for biliary diseases. Early precut has been shown to ameliorate cannulation success rate, specially in difficult cannulation cases, when compared to guidewire cannulation (which is considered, for most, the standard technique). We aim to perform a randomized clinical trial comparing fistulotomy (F) precut vs guidewire cannulation (CC), as a primary cannulation technique, and compare outcomes between high experienced endoscopists (\\> 200 ERCPs\\[Endoscopic Retrograde cholangiopancreatography\\]) and low experienced endoscopists (\\\u003C 200 ERCPs).",[98,99,100,101],"Cholangiocarcinoma","Choledocholithiasis; Cholangitis","Pancreatic Cancer","Pancreatitis",[103,104,105,106],"Precut sphincterotomy","Fistulotomy","Biliary cannulation","Efficacy","2025-04-28",{"date":109,"type":40},"2025-05-01",{"date":111,"type":40},"2019-07-03",{"date":113,"type":22},"2026-12-01",{"name":46,"class":47},{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":17,"minAge":123,"maxAge":18,"enrollmentInfo":124,"targetDuration":4,"studyType":60,"phases":126,"briefSummary":127,"conditions":128,"keywords":132,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":48},"100581212","efficacy-and-safety-of-vitamin-d-supplementation-in-pediatric-patients-with-obesity-100581212","NCT06847373","Efficacy and Safety of Vitamin D Supplementation in Pediatric Patients with Obesity","Efecto De La Suplementación De Vitamina D En La Resistencia a La Insulina En Escolares Y Adolescentes Con Obesidad","VD","Inclusion Criteria:\n\n* Male and female participants.\n* Participants aged between 10 and 18 years.\n* Obesity as defined by a Body Mass Index (BMI) in the \\>95th percentile according to the World Health Organization's age and sex-specific tables.\n* Willingness to participate in the study.\n* Residency in Mexico City.\n\nExclusion Criteria:\n\n* Patients with comorbidities not attributable to obesity, such as chronic kidney disease, heart failure, liver cirrhosis, etc.\n* Patients with Prader-Willi syndrome, Albright's hereditary osteodystrophy, Borjesson-Forssman-Lehmann syndrome.\n* Patients currently taking vitamin supplements.\n* Patients undergoing pharmacological treatment for obesity.\n* Patients who already present insulin resistance and, although they have not previously received medication, are currently indicated for pharmacological treatment with metformin.","10 Years",{"count":125,"type":22},40,[62],"Introduction: Vitamin D deficiency is commonly observed in patients with obesity, primarily due to sequestration by adipose tissue. Recent research highlights the importance of this deficiency, showing a correlation between low vitamin D levels and mechanisms contributing to insulin resistance.\n\nObjectives: This study aims to compare the effects of supplementing with 4,000 IU of vitamin D versus 1,000 IU over six months on insulin resistance and the leptin\u002Fadiponectin ratio in school-aged children and adolescents with obesity.\n\nMaterials and Methods: A controlled clinical trial will be conducted involving 40 children with obesity aged 10 to 18 years (BMI \\>95th percentile). Participating children and their parents will undergo measurements such as weight, height, BMI, body fat, and Tanner stage. All participants will receive dietary and physical activity recommendations based on WHO guidelines. After initial assessments, participants will be randomly assigned to receive either 4,000 IU or 1,000 IU of vitamin D. They will be monitored monthly for capsule intake and adverse effects, with follow-up measurements of anthropometry, leptin, adiponectin, insulin \\& lipid profile.\n\nStatistical Analysis: Baseline characteristics will be compared using t-Student or U-Mann Whitney tests, depending on variable distribution. The intervention's impact will be assessed by calculating deltas for body fat and biochemical measurements, with significance tested using paired t-tests or Wilcoxon tests. Covariance analysis (ANCOVA) will be used to adjust for confounding variables.",[129,130,131],"Vitamin D","Insulin Resistance","Obesity, Childhood",[133,134,135,136,137,138],"vitamin D","insulin resistence","obesity","leptin","adiponectin","pediatric","2025-03-21",{"date":141,"type":40},"2025-03-24",{"date":143,"type":40},"2025-03-01",{"date":145,"type":22},"2025-10-30",{"name":46,"class":47},{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":17,"minAge":154,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":60,"phases":158,"briefSummary":159,"conditions":160,"keywords":162,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":175,"locationsCount":48},"100506494","virtual-reality-versus-constraint-induced-movement-on-hemiparesis-in-cerebrovascular-event-100506494","NCT05875116","Virtual Reality Versus Constraint-induced Movement on Hemiparesis in Cerebrovascular Event","Effect of Different Therapeutic Modalities With Virtual Reality or Modified Constraint-induced Movement Therapy Compared With Usual Physical and Occupational Therapy on Motor Recovery of Paretic Limbs in Patients With Cerebrovascular Event","Inclusion Criteria:\n\n* Adult patients between 35 and 70 years of age and with a clinically and tomographically proven diagnosis of a cerebral vascular event in the territory of the middle cerebral artery.\n* Patients with hemiparesis secondary to the cerebrovascular event\n* Patients with a maximum Ashworth of 2 and Brunnstrom of minimum 4\n* Patients with or without aphasia\n* Patients with evolution between 1 to 3 months from hospital discharge of the cerebrovascular event\n* Patients with cerebrovascular event of any sex\n* Patients with vascular event without cognitive deficit\n* Patients who agree to participate by signing an informed consent, by them or their family member or person in charge.\n\nExclusion Criteria:\n\n* Patients who develop dementia or neurological-psychomotor complications during the study.\n* Patients who present a new cerebrovascular event during the investigation\n* Patients who do not complete at least 90% of the program\n* Patients in whom a lack of family support or secondary gain is detected.","35 Years","70 Years",{"count":157,"type":22},119,[62],"The objective of this clinical trial is to measure the effect of Rehabilitation with Virtual Reality or Modified Constraint-Induced Movement Therapy on hemiparesis in patients with Cerebral Vascular Event.\n\nThe question to be answered is: What is the effect of different therapeutic modalities supported by Virtual Reality or Modified Constraint-Induced Movement Therapy compared with usual Physical and Occupational Therapy on motor recovery of paretic limbs in patients with Cerebrovascular Event?\n\nThe patients will carry out activities of:\n\n* Virtual reality or\n* Movement Restriction-Induction Therapy.\n\nThe investigators will compare the changes in the functionality of the paretic hemibody with a group undergoing regular physical and occupational therapy, as well as language and treatment-related satisfaction.",[161],"Stroke Sequelae",[163,164,165,166,167,168],"Constraint-induced movement therapy","Hemiparesis","Neurorehabilitation","Satisfaction","Stroke","Virtual Reality","2024-08-21",{"date":171,"type":40},"2024-08-23",{"date":173,"type":40},"2018-08-17",{"date":169,"type":22},{"name":46,"class":47},""]