[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Corporacion Parc Tauli\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":389},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,54,87,111,144,169,194,225,257,279,299,322,350,368],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100641780","impact-of-sms-messaging-on-participation-in-colorectal-cancer-screening-100641780",false,"NCT07628998","Impact of SMS Messaging on Participation in Colorectal Cancer Screening","Impact of SMS Notifications on the Colorectal Cancer Screening Program","Inclusion Criteria:\n\n* Women and men aged 50 to 69 years.\n* Residents of the Vallès Occidental area.\n* Individuals invited to the Colorectal Cancer Screening Program (PDPCCR) who have not participated within 5 weeks of the initial invitation.\n\nExclusion Criteria:\n\n* Personal history of colorectal cancer.\n* Inflammatory bowel disease (IBD)\n* Colorectal polyps requiring specific clinical follow-up.\n* Hereditary polyposis syndromes.\n* High-risk family history of colorectal cancer: a first-degree relative diagnosed before age 50, or two or more first-degree relatives at any age.\n* Severe morbidity that precludes the performance of a colonoscopy in the event of a positive test result.",true,"ALL","50 Years","69 Years",{"count":21,"type":22},10084,"ESTIMATED","INTERVENTIONAL",[25],"NA","Colorectal cancer is a leading cause of mortality in Catalonia. Although early detection programs using the fecal immunochemical test (FIT) are effective in reducing both incidence and mortality, their success relies on high population participation. Currently, in the Vallès Occidental region, the participation rate stands at 42%, which is below the 65% minimum recommended by European health authorities. The objective of this randomized controlled trial is to evaluate whether sending a reminder text message (SMS) is an effective tool to increase participation in the screening program. The study will include 10,084 participants aged between 50 and 69 years. Half of the participants will receive a reminder SMS five weeks after their initial invitation, while the other half will follow the standard of care involving postal letters. Researchers anticipate that this strategy will not only increase the number of individuals undergoing screening but also shorten the response time and reduce the need for sending postal reminders",[28,29],"Colorectal Neoplasms","Early Detection of Cancer",[31,32,33,34,35,36,37,38,39,40],"Colorectal Cancer Screening","Text Messaging","Fecal Occult Blood Test","Public Health","Patient Participation","Reminder Systems","SMS Reminders","mHealth","Cancer Prevention","Patient Adherence","RECRUITING","2026-06-18",{"date":44,"type":45},"2026-06-22","ACTUAL",{"date":47,"type":45},"2026-05-05",{"date":49,"type":22},"2026-12",{"name":51,"class":52},"Corporacion Parc Tauli","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":4},"100641399","inflammatory-and-genetic-predictors-of-cognitive-and-emotional-recovery-after-critical-illness-100641399","NCT07659431","Inflammatory and Genetic Predictors of Cognitive and Emotional Recovery After Critical Illness","Unraveling the Role of Cognitive Reserve, Inflammatory Phenotype and Genetic Vulnerability on Cognitive and Emotional Recovery After Critical Illness","CORE-ICU","Inclusion Criteria:\n\n* Adult patients (≥18 years)\n* Admitted to a medical-surgical ICU or cardiac ICU for causes of critical illness (e.g., acute pulmonary oedema, myocardial infarction, aortic dissection)\n* With or without the need for invasive mechanical ventilation\n* With an expected ICU stay of ≥48 hours\n* Resident in Catalonia or the Principality of Asturias\n* Who speak Catalan and\u002For Spanish\n* Who are able to provide informed consent personally or through an authorised representative (e.g., a family member)\n\nExclusion Criteria:\n\n* Non-authorisation by the patient and\u002For relatives for inclusion in the study\n* Patients admitted to a neurocritical ICU\n* History of severe neurological disease (including dementia or focal brain injury with functional and cognitive impairment) prior to ICU admission\n* History of severe psychiatric disorders (schizophrenia, bipolar disorder, major depressive disorder)\n* Intellectual disability (IQ \\\u003C80) or other neurodevelopmental disorders, such as autism spectrum disorder\n* Patients who develop secondary complications (e.g., infections, stroke, traumatic brain injury, or other non-transient acquired brain injury) after ICU discharge that may compromise the results of emotional and neuropsychological evaluations during the recovery phase\n* Moderate to severe cognitive impairment (Short-IQCODE \\>57) preventing independent participation in telemedicine or face-to-face follow-up\n* Readmission to the ICU within 12 months after ICU discharge\n* Language barrier (non-Spanish- and\u002For non-Catalan-speaking patients)\n* Patients with a life expectancy \\\u003C1 year or not eligible for active treatment measures","18 Years",{"count":64,"type":22},114,"OBSERVATIONAL","Survivors of critical illness frequently develop persistent cognitive and emotional impairments, known as post-intensive care syndrome (PICS), which substantially impact quality of life and long-term recovery. While prior research has mainly focused on identifying risk factors, the mechanisms underlying resilience to these sequelae remain poorly understood. Emerging evidence suggests that biological factors, including inflammatory responses and genetic vulnerability, together with cognitive reserve, may play a key role in shaping recovery trajectories.\n\nThe aim of this multicenter, prospective observational study is to investigate how cognitive reserve, inflammatory phenotype, and genetic profiles interact to influence cognitive and emotional recovery after critical illness. Adult patients will be recruited at Intensive Care Unit (ICU) admission across two centers in Spain. Clinical and sociodemographic data will be collected during the ICU stay, and biological samples obtained early after admission will undergo transcriptomic and genetic analyses. Cognitive and emotional outcomes will be assessed at hospital discharge and at 3 and 12 months post-discharge using standardised neuropsychological and telemedicine-based evaluations.\n\nBy integrating clinical, biological, and cognitive data, this study seeks to identify recovery phenotypes and resilience mechanisms in PICS. The results may contribute to improved risk stratification, inform personalized interventions, and support the development of future strategies aimed at reducing the long-term burden of critical illness.",[68,69],"Post-Intensive Care Syndrome (PICS)","Critical Illness",[71,72,73,74,75,76,77,78],"Cognitive reserve","cognitive impairment","Inflammation biomarkers","APOE","ICU survivors","Emotional Outcomes","Post-intensive care syndrome (PICS)","Critical illness","NOT_YET_RECRUITING","2026-06-16",{"date":44,"type":45},{"date":83,"type":22},"2026-07",{"date":85,"type":22},"2028-06",{"name":51,"class":52},{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":53},"100615908","assessing-fluid-responsiveness-using-non-invasive-hybrid-diffuse-optics-on-peripheral-muscle-100615908","NCT07298720","Assessing Fluid-responsiveness Using Non-invasive Hybrid Diffuse Optics on Peripheral Muscle","hDOS-CO","Inclusion Criteria:\n\n* Invasive blood pressure monitoring through an arterial line\n\nExclusion Criteria:\n\n* Patients with suspected pregnancy\n* Intra-abdominal hypertension\n* Elevated intracranial pressure",{"count":95,"type":22},200,"Proof-of-concept observational study including ICU patients undergoing a PLR maneuver. Local microvasculature will be assessed with the hDOS platform on the brachioradialis muscle, deriving the microvascular blood flow index (BFI) and tissue oxygen saturation (StO2). CO will be assessed via an invasive hemodynamic monitor based on pulse waveform analysis through the patient's arterial line. The correlation over time between CO and microvascular parameters, and the ability of microvascular variables for predicting a positive CO response (increase \\> 10%) will be assessed.",[69],[99,100,101,102],"Fluid-responsiveness","Hemodynamic monitoring","Preload-responsiveness","Cardiac output","2026-03-16",{"date":105,"type":45},"2026-03-18",{"date":107,"type":45},"2025-01-07",{"date":109,"type":22},"2027-01-01",{"name":51,"class":52},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":23,"phases":122,"briefSummary":123,"conditions":124,"keywords":127,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":4},"100618452","conservative-management-in-primary-spontaneous-pneumothorax-a-multicenter-randomized-non-inferiority-study-100618452","NCT07331805","Conservative Management in Primary Spontaneous Pneumothorax: a Multicenter Randomized Non-inferiority Study","Randomized, Multicenter, Non-inferiority Clinical Trial to Design a Conservative Strategy for the Treatment of Primary Spontaneous Pneumothorax (PSP)","CONNEP","Inclusion Criteria:\n\n* Age: \\>18 and ≤60 years at the time of enrollment.\n* Diagnosis: Primary spontaneous pneumothorax of large size (lung collapse ≥30% by the Collins method on chest X-ray).\n* Episode type: Any episode of primary spontaneous pneumothorax.\n* Clinical stability suitable for observation without immediate intervention: Systolic BP \\>90 mmHg, heart rate \\\u003C140 bpm, oxygen saturation \\>90% (with supplemental oxygen if needed), respiratory rate 15-30 breaths\u002Fmin.\n* Consent: Has read and understood the participant information sheet and signed informed consent.\n\nExclusion Criteria:\n\n* Pre-existing lung disease that may predispose to pneumothorax (e.g., COPD, cystic fibrosis, interstitial lung disease, tuberculosis, pulmonary neoplasm).\n* Indication for urgent thoracic surgery (e.g., imaging highly suggestive of giant bullae\u002Fblebs requiring immediate surgical intervention).\n* Pregnancy or breastfeeding.","60 Years",{"count":121,"type":22},436,[25],"The goal of this randomized clinical trial is to find out whether a conservative management strategy (active observation without an initial invasive procedure) can treat as effectively as the standard treatment with chest tube drainage in adults with a large primary spontaneous pneumothorax who are clinically stable. Participants include men and women 18 to 60 years old with a lung collapse ≥30% (by Collins method).\n\nThe main questions are:\n\n* Is conservative management not inferior to chest tube drainage for achieving complete lung re-expansion at 8 weeks (on chest X-ray)?\n* What are the differences between the two strategies in complications, recurrence at 2 years, quality of life, length of hospital stay, number of additional procedures, and healthcare costs?\n\nComparison groups:\n\n* Conservative management: in-hospital observation with a control chest X-ray no earlier than 4 hours; if the person remains stable, discharge home with scheduled outpatient follow-up and serial X-rays until resolution.\n* Standard treatment (chest tube): chest tube placement and hospital admission; discharge based on clinical progress with routine outpatient follow-up.\n\nResearchers will compare both groups to see whether conservative management works just as well to resolve the pneumothorax at 8 weeks and whether it leads to fewer complications, shorter hospital stays, better quality of life, and lower costs.\n\nWhat will participants be asked to do? Review the participant information sheet and sign informed consent.\n\nBe randomized by computer (REDCap) to either conservative management or chest tube drainage.\n\nDepending on the assigned group:\n\n* Conservative group: remain under observation initially, have a chest X-ray at ≥4 hours; if still stable, go home with clinic visits (about 1 week after discharge and then every \\~2 weeks) until the pneumothorax has resolved.\n* Chest tube group: undergo chest tube insertion, stay in the hospital, and attend routine outpatient follow-up after discharge.\n\nUndergo chest X-rays interpreted by the clinical team (with centralized review procedures).\n\nComplete brief symptom assessments, quality-of-life questionnaires (e.g., EQ-5D-5L), and attend follow-up visits or phone calls for up to 2 years to check for recurrences.\n\nThis is a multicenter study conducted in several hospitals in Spain. The planned sample size is 436 participants (218 per group), with a non-inferiority margin of 5% and the primary assessment at 8 weeks.",[125,126],"Primary Spontaneous Pneumothorax (PSP)","Conservative Management (Active Observation)",[125,128,129,130,131,132,133,134,135],"Conservative management","Active observation \u002F No initial intervention","Chest tube drainage (standard care)","Complete lung re-expansion at 8 weeks","Chest X-ray; Collins method (size estimation)","Clinical stability (stable PSP)","Recurrence (up to 2 years)","Quality of life and cost-effectiveness","2026-01-05",{"date":138,"type":45},"2026-01-12",{"date":140,"type":22},"2026-01-01",{"date":142,"type":22},"2028-11-01",{"name":51,"class":52},{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":154,"conditions":155,"keywords":157,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":53},"100554520","metabolic-cluster-analysis-in-septic-shock-patients-100554520","NCT06500156","Metabolic Cluster Analysis in Septic Shock Patients","Metabolic Cluster Analysis in Septic Shock Patients Undergoing Hemodynamic Resuscitation. A Multicenter Observational Study","ACMEcat","Inclusion Criteria:\n\n\\- Septic shock patients within the first 24 hours of ICU admission, and selected by the attending physician for performing a fluid challenge (FC) due to suspected tissue hypoperfusion (elevated lactate and\u002For ScvO2 \\\u003C 70%).\n\nExclusion Criteria:\n\n* Age under 18 years old\n* Uncontrolled hemodynamic instability, defined as the need for significant changes in vasopressor support (\\> 10% from baseline dose) within the 15-minute period prior to, and\u002For during the administration of fluids.\n* Patients receiving continuous renal replacement therapies, since the CO values obtained from the thermodilution techniques might be potentially affected.",{"count":153,"type":22},120,"Observational study including septic shock patients within 24 hours of ICU admission, monitored with a cardiac output estimation system, with ongoing resuscitation. Hemodynamic and metabolic parameters before and after a fluid challenge (FC) will be measured.",[156],"Septic Shock",[158,159,160],"septic shock","hemodynamic resuscitation","cardiovascular monitoring","2025-11-28",{"date":163,"type":45},"2025-12-05",{"date":165,"type":45},"2024-05-01",{"date":167,"type":22},"2026-10-31",{"name":51,"class":52},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":17,"minAge":177,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":181,"conditions":182,"keywords":184,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":193,"locationsCount":53},"100613477","mathematical-analysis-of-signals-and-clinical-parameters-provided-by-non-invasive-home-ventilation-devices-100613477","NCT07267104","Mathematical Analysis of Signals and Clinical Parameters Provided by Non-invasive Home Ventilation Devices","SAGE-NIV: Surveillance and Artificial Intelligence Guidance for Exacerbations in COPD Patients With Home Non-Invasive Ventilation","SAGE-NIV","Inclusion Criteria:\n\n* Age between 40 and 80 years.\n* COPD diagnosed by pulmonary function tests.\n* Home NIV therapy with good adherence (minimum daily compliance \\> 5 hours) for at least 6 months.\n* Users of the ResMed LUMIS 150 ventilator. This is due to the presence of the decoding tool and a larger storage capacity (more than 100 nights) in the removable device of the ventilator.\n* Acute exacerbation requiring hospital admission or home care.\n\nExclusion Criteria:\n\n* Lack of informed consent.\n* Previous clinical instability defined by the need for antibiotics and\u002For systemic corticosteroids in the two months prior to the inclusion exacerbation, excluding the 48 hours prior to admission, as this was considered part of the inclusion clinical picture.","40 Years","80 Years",{"count":180,"type":22},75,"This study will look at people with COPD who use a home breathing machine called non-invasive ventilation (NIV). NIV machines collect information about your breathing, such as air flow, pressure, and mask leaks.\n\nResearchers want to use a computer program, called artificial intelligence (AI), to study this information. The goal is to find early signs that your breathing may be getting worse.\n\nPeople with COPD who already use NIV at home may join this study. The study does not change your treatment. It only uses the breathing data already recorded by your NIV machine.\n\nThe computer program will look for patterns in the data. These patterns may help doctors:\n\nNotice early warning signs of a COPD flare-up Find problems with how you and the machine work together Improve the way NIV is monitored at home The main goal is to create a tool that helps patients and doctors manage home NIV more easily and more safely.",[183],"COPD (Chronic Obstructive Pulmonary Disease)",[185,186,187],"COPD","Artificial Intelligent","exacerbations","2025-11-24",{"date":163,"type":45},{"date":191,"type":45},"2025-03-25",{"date":49,"type":22},{"name":51,"class":52},{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":23,"phases":205,"briefSummary":206,"conditions":207,"keywords":210,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":53},"100596101","eeg-based-neurofeedback-to-improve-emotion-regulation-in-major-depressive-disorder-a-randomized-clinical-trial-100596101","NCT07041073","EEG-based Neurofeedback to Improve Emotion Regulation in Major Depressive Disorder: A Randomized Clinical Trial","Restoring Emotional Stability Through Neurofeedback and AI for Transformative Empowerment","RESoNATE","Inclusion Criteria:\n\n* A primary diagnosis of Major Depressive Disorder (MDD), established by qualified psychiatrists according to DSM-5 criteria.\n* Patients with comorbid anxiety or anxiety symptoms will be included, provided that MDD is the primary diagnosis.\n* Participants must score at least 20 on the Montgomery-Åsberg Depression Rating Scale (MADRS), indicating a moderate level of depression.\n* All participants must be on a stable psychopharmacological treatment for at least 6 weeks before beginning of the study.\n\nExclusion Criteria:\n\n* Patients with a concurrent diagnosis of MDD and other severe psychiatric disorders.\n* Patients with serious physical illnesses that could interfere with study participation or the interpretation of results.\n* Participants currently undergoing structured psychotherapy or other interventions unrelated to standard psychopharmacological treatment.\n* Patients presenting with active suicidal ideation, as measured by the Columbia-Suicide Severity Rating Scale (C-SSRS), at the time of screening will not be eligible due to associated risks.\n* Active substance abuse or dependence (except nicotine).\n* Intellectual disability or conditions that interfere with the ability to provide informed consent and complete the intervention (e.g., severe visual or hearing impairments).\n* Pregnancy.","65 Years",{"count":204,"type":22},72,[25],"The goal of this clinical trial is to evaluate whether EEG-based neurofeedback targeting the emotion regulation network through swLORETA can improve emotional regulation and reduce symptoms in adults with Major Depressive Disorder (MDD) who have not responded sufficiently to first-line treatments. The main questions it aims to answer are:\n\n* Does EEG-neurofeedback improve emotional self-regulation and reduce clinical symptoms in patients with MDD with or without anxiety symptoms?\n* Are changes in EEG resting-state activity and stress biomarkers (e.g., cortisol) associated with clinical improvement?\n\nResearchers will compare an active neurofeedback group, a sham (placebo) neurofeedback group, and a treatment-as-usual control group to see if real-time EEG-neurofeedback leads to greater improvement in mood, emotional regulation, and neurophysiological indicators than placebo or no additional intervention.\n\nParticipants will:\n\n* Receive 10 sessions of either real or sham EEG-neurofeedback (or no sessions in the control group) over 5 weeks.\n* Complete clinical, psychological, and neurophysiological assessments before (week 0) and after the intervention (week 6).\n* Provide repeated saliva samples to assess stress-related biomarkers at week 0 and week 6.\n* Continue their standard pharmacological treatment throughout the study.",[208,209],"Major Depression With Comorbid Anxiety Symptoms","Major Depressive Disorder (MDD)",[211,212,213,214,215,216],"neurofeedback","eeg","MDD","anxiety","depression","emotion regulation","2025-06-18",{"date":219,"type":45},"2025-06-27",{"date":221,"type":45},"2025-05-19",{"date":223,"type":22},"2026-09",{"name":51,"class":52},{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":178,"enrollmentInfo":232,"targetDuration":4,"studyType":23,"phases":234,"briefSummary":235,"conditions":236,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":53},"100562489","clinical-evaluation-and-cost-effectiveness-analysis-of-3d-digital-surgery-in-traumatology-100562489","NCT06603831","Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology","Randomized, Prospective and Multicenter Clinical Study for the Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology and Orthopedic Surgery","Inclusion Criteria:\n\n\\- Patients that requires one of the following surgical procedures \u002F interventions: Radius osteotomy due to non-articular metaphyseal malunion Complex acetabular arthroplasty Thoracic-lumbar spine arthrodesis.\n\n-Patients that can understand the clinical study and that are able to read, understand and sign the consent form\n\nExclusion Criteria:\n\n* Patients that are not able to read, understand or sign the consent form.\n* Patients that can't or have no support to complete the clinical trial.\n* Patients with complex deformities or complications that would require mandatory personalized digital surgery treatment",{"count":233,"type":22},180,[25],"Digital surgery, in combination with patient specific instrumentation (PSI) is being used more and more in traumatology due to its proven benefits and applications. Nowadays, medical case planning and an optimal preparation before surgery are still a challenge for surgeons. This lack of preparation is translated into longer surgical procedures, potential complications, unnecessary sterilization of materials and a high number of fluoroscopies. 2D techniques such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and X-rays remain essential for medical planning, however, in many cases, a 3D visualization is needed to achieve better results, especially in complex cases.The use of personalized medical instruments such as surgical guides has proven to increase clinical accuracy, assuring a better correction of bone deformities, and allowing a more precise location of implants and screw positioning. Furthermore, the use of 3D-printed patient-specific prosthesis can lead to better clinical outcomes as they reduce the number of complications as well as they present a longer lifespan compared to conventional generic implants.Despite the potential of 3D technology in the medical field, there is still a lack of robust studies that compares clinical benefits between digital surgery and conventional 2D surgery, and its economic impact is still unknown. Thus, the investigators propose this randomized, prospective and multi-center clinical study to evaluate the use of 3D technology in traumatology. The aim of this project is to prove that digital surgery is a cost-effective methodology and therefore it should be adopted by the public health system as a gold standard procedure.",[237,238,239,240,241,242,243,244,245,246,247,248],"Radius; Deformity","Hip Osteoarthritis","Hip Arthritis","Hip Arthropathy","Spine Injury","Radius; Anomaly","Vertebra; Degeneration","Vertebral Fracture","Hip Prosthesis Infection","Spinal Fusion","Spine Osteoarthritis","Spinal Deformity","2024-11-08",{"date":251,"type":45},"2024-11-12",{"date":253,"type":45},"2024-10-21",{"date":255,"type":22},"2027-12-31",{"name":51,"class":52},{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":23,"phases":267,"briefSummary":268,"conditions":269,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":53},"100536613","a-clinical-study-to-compare-functional-outcomes-after-surgery-using-a-transverse-or-longitudinal-surgical-incision-in-the-skin-100536613","NCT06267105","A Clinical Study to Compare Functional Outcomes After Surgery Using a Transverse or Longitudinal Surgical Incision in the Skin.","Clinical Study to Compare Functional Results in Patients Affected by Trigger Finger When Surgery is Performed Through a Transverse or Longitudinal Surgical Incision in the Skin.","Inclusion Criteria:\n\n* Patients over 18 years of age.\n* Clinical diagnosis of trigger finger grade II to IV.\n\nGrade I (pre-trigger) Pain, history of entrapment, but not demonstrable on physical examination, tenderness over the A1 pulley.\n\nGrade II (active) Demonstrable entrapment, but the patient can actively extend the finger.\n\nGrade III (passive) Demonstrable entrapment, patient requires passive extension IIIA or inability to actively flex IIIB.\n\nGrade IV (contracture) Demonstrable entrapment with fixed flexion contracture of the PIP.\n\nExclusion Criteria:\n\n* Thumb\n* Polydigital\n* Allergy to local anesthetics and\u002For vasoconstrictor agents.\n* Previous surgery\n* Patients who, in the researcher's opinion, are not good candidates for the study (e.g. inability to comply with the follow-up program, comorbidity, poor physical or mental health in general, drug or alcohol abuse problems...).","100 Years",{"count":266,"type":22},36,[25],"Trigger finger is a common pathology in the hand. Patients suffer from pain and depending on which tasks, patients have difficulty to perform them. Its treatment in initial and less serious phases includes conservative measures, but failure of these may require releasing the trigger finger with surgery. The surgical technique performed for trigger finger is the opening of the A1 pulley, the skin incisions used for this surgery are various (transverse, longitudinal, oblique). Trigger finger surgery presents good results in terms of resolution, but complications may also occur. The reason for this study is to assess whether there are functional differences using the Dash scale when we perform a transverse or longitudinal incision in trigger finger surgery.",[270],"Functional Disturbance as Result","2024-08-13",{"date":273,"type":45},"2024-08-15",{"date":275,"type":45},"2024-05-15",{"date":277,"type":22},"2025-03",{"name":51,"class":52},{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":264,"enrollmentInfo":286,"targetDuration":4,"studyType":23,"phases":288,"briefSummary":289,"conditions":290,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":53},"100514122","music-during-the-reduction-of-distal-radius-fractures-as-an-adjunctive-therapy-for-pain-and-anxiety-management-100514122","NCT05974384","Music During the Reduction of Distal Radius Fractures as an Adjunctive Therapy for Pain and Anxiety Management.","Music During the Reduction of Distal Radius Fractures as an Adjunctive Therapy for Pain and Anxiety Management: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients older than 18 years.\n* Clinical and radiological diagnosis of a fracture of the distal end of a closed radius that has an indication for closed reduction.\n\nExclusion Criteria:\n\n* Diagnosis of other concomitant fractures.\n* Allergy to local anesthetics.\n* Significant hearing impairment and\u002For use of hearing aids.\n* Patients whose comorbidities prevent correct participation in the procedure (such as cognitive impairment, diagnosis of psychiatric diseases, patients under the influence of drugs...).",{"count":287,"type":22},100,[25],"Fractures of the distal end of the radius are one of the most frequent fractures diagnosed in the emergency room. The initial management, and in many cases definitive, is carried out through manipulation, closed reduction and immobilization in the emergency room. Different methods of anesthesia have been described to reduce pain during the manipulation and reduction procedure, such as: hematoma block, periosteal block, general anesthesia, intravenous regional anesthesia, nitrous oxide, intramuscular sedation, and conscious sedation. Despite the use of different methods of anesthesia, none is fully effective and each of these methods is not free of complications. Adjuvant measures could play an important role in improving the patient's experience during the procedure, however, there is little evidence in this regard.\n\nMusic is increasingly being studied and developed as an adjunctive therapy in the management of pain and anxiety in different medical procedures, demonstrating a statistically significant reduction in pain and anxiety. However, in the literature there is no evidence of studies that evaluate the effect of music during the reduction of fractures in traumatology as an adjuvant therapy for the management of pain and anxiety.\n\nIn our experience, despite the anesthesia used, reductions of distal radius fractures are usually a painful procedure that involves a certain degree of discomfort for the patient. For this reason, the investigators believe this study is necessary, as it could demonstrate a new adjuvant therapy that reduces pain and anxiety and improves the overall experience of the patient, in addition to being music, a low-cost tool with no risks for patient safety.",[291],"Distal Radius Fracture Reduction",{"date":293,"type":45},"2024-08-14",{"date":295,"type":45},"2023-03-01",{"date":297,"type":22},"2025-03-01",{"name":51,"class":52},{"id":300,"slug":301,"hasResults":11,"nctId":302,"briefTitle":303,"officialTitle":304,"acronym":305,"eligibilityCriteria":306,"healthyVolunteers":16,"sex":17,"minAge":62,"maxAge":202,"enrollmentInfo":307,"targetDuration":4,"studyType":23,"phases":309,"briefSummary":310,"conditions":311,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":53},"100557219","postoperative-pain-in-the-surgical-treatment-of-hemorrhoids-conventional-hemorrhoidectomy-with-a-monopolar-electric-scaler-vs-bipolar-energy-with-caiman-aesculap-100557219","NCT06535269","Postoperative Pain in the Surgical Treatment of Hemorrhoids: Conventional Hemorrhoidectomy With a Monopolar Electric Scaler VS Bipolar Energy With Caiman® (Aesculap®)","Prospective Randomized Study on Postoperative Pain in the Surgical Treatment of Hemorrhoids Through Conventional Hemorrhoidectomy With a Monopolar Electric Scalpel or Bipolar Energy With Caiman® (Aesculap®)","TAUHEMOR","Inclusion Criteria:\n\n* All patients with 2 or 3 bundles of grade III-IV hemorrhoids (Goligher classification) clinically symptomatic and subject to outpatient hemorrhoidectomy\n* Voluntary participation.\n* ASA I-II-III.\n\nExclusion Criteria:\n\n* Failure to meet the inclusion criteria.\n* ASA IV.\n* Allergic to Paracetamol, derivatives of morphine.\n* Allergic to NSAIDs.\n* Synchronous colorectal neoplasia.\n* Coagulation disorders.\n* Thrombosed hemorrhoid.\n* Inflammatory bowel disease.\n* Liver cirrhosis and\u002For portal hypertension.\n* Pregnant women.\n* Difficulty following up by phone and\u002For in person.",{"count":308,"type":22},27,[25],"To demonstrate that postoperative pain secondary to Milligan and Morgan hemorrhoidectomy with Caiman® (AESCULAP®) and subsequent oral conventional analgesia is at least not greater than that generated after hemorrhoidectomy with monopolar diathermy and intravenous analgesia with care home at discharge.",[312,313],"Hemorrhoid Pain","Hemorrhoidectomy","2024-08-01",{"date":316,"type":45},"2024-08-02",{"date":318,"type":45},"2022-11-02",{"date":320,"type":22},"2025-07",{"name":51,"class":52},{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":328,"eligibilityCriteria":329,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":330,"targetDuration":4,"studyType":23,"phases":332,"briefSummary":334,"conditions":335,"keywords":337,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":4},"100550707","phase-3-preoperative-chemoradiotherapy-and-transanal-endoscopic-microsurgery-versus-ttransanal-endoscopic-microsurgery-in-t1-n0-m0-rectal-cancer-tautem-t1-study-100550707","NCT06450574","Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study)","Prospective, Controlled and Randomized Phase III Multicentric Study of the Treatment of T1,N0,M0 Rectal Cancer. Neoadjuvant Therapy and Transanal Endoscopic Surgery vs. Transanal Endoscopic Surgery (TAUTEM-T1 Study)","TAUTEM-T1","Inclusion Criteria:\n\n* Indication by multidisciplinary committee of indication for local excision, according to ESMO and NCCN criteria.\n* Rectal adenocarcinomas in the biopsy, located at a distance from the anal margin less than or equal to 10 cm measured by rigid rectoscopy at the time of ER.\n* Preoperative staging by ER and pelvic MRI of T1,N0. In case of disparity, higher staging will be considered the definitive diagnosis. If it is greater than T1, it will be excluded.\n* Tumors equal to or less than 4 cm in maximum diameter measured by MRI.\n* ASA index equal to or less than III.\n* Absence of distant metastases by abdominal CT and chest X-ray (if inconclusive, Thoracic CT)\n\nExclusion Criteria:\n\n* Preoperative staging by EER or pelvic MRI higher than T1 or N0.\n* Presence of distant metastases. Synchrony with other colorectal adenocarcinomas.\n* Undifferentiated rectal adenocarcinomas or with the presence of poor prognostic factors in the preoperative biopsy (undifferentiated, venous, lymphatic or perineural infiltration, budding) .\n* Patients with intolerance to preoperative chemotherapy or radiotherapy.\n* Do not sign informed consent.",{"count":331,"type":22},106,[333],"PHASE3","Introduction: The standard treatment for rectal adenocarcinoma is total mesorectal excision (TME), a technique involving resection of the rectum, with or without a temporary or permanent stoma. TME is associated with high morbidity and genitourinary alterations. On the other hand, transanal endoscopic surgery (TEM) allows access to tumors up to 20 cm from the anal margin, with much lower postoperative morbidity and without the need for ostomy. For T1, N0, M0 rectal adenocarcinomas without poor prognostic factors, TEM is the technique of choice. However, recent studies have described local recurrences of up to 20%. Our group, TAUTEM, has just completed a phase III clinical trial in T2-T3ab, N0, M0 rectal cancer, comparing preoperative chemoradiotherapy (CRT) and TEM versus TME, with very positive results in terms of postoperative morbidity, quality of life, and a local recurrence rate of 7.4%, not inferior to TME.\n\nThese results encourage our TAUTEM group to launch a similar project at the T1, N0, M0 stage, comparing standard TEM treatment versus QRT and TEM, aiming to improve rectal preservation outcomes and enhance results regarding local recurrence, distant recurrence, and oncologic survival.\n\nMethod: Prospective, controlled, randomized phase III multicenter clinical trial. Patients with rectal adenocarcinoma within 10 cm of the anal margin and up to 4 cm in size, staged as T1, N0, M0, will be included. These patients will be randomized into two groups: TEM after CRT and TEM alone. Postoperative morbidity and mortality, CRT side effects, and quality of life will be recorded. The minimum follow-up will evaluate rectal preservation and local recurrence and survival at two and three years. The sample size calculation for the study will be 106 patients.\n\nConclusions: The aim of the study is to improve oncological outcomes in stage T1, N0, M0 rectal cancer through preoperative chemoradiotherapy associated with local surgery (TEM).",[336],"Rectal Cancer Stage I",[338,339,340,341],"Preoperative chemoradiotherapy","Transanal endoscopic microsurgery","Rectal Cancer","T1-N0-M0 Rectal cancer","2024-06-07",{"date":344,"type":45},"2024-06-10",{"date":346,"type":22},"2024-10",{"date":348,"type":22},"2027-10",{"name":51,"class":52},{"id":351,"slug":352,"hasResults":11,"nctId":353,"briefTitle":354,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":11,"sex":17,"minAge":177,"maxAge":4,"enrollmentInfo":356,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":357,"conditions":358,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":53},"100508271","prospective-descriptive-study-of-injuries-associated-to-anterior-shoulder-dislocations-in-patients-over-40-years-100508271","NCT05898243","Prospective Descriptive Study of Injuries Associated to Anterior Shoulder Dislocations in Patients Over 40 Years","Inclusion Criteria:\n\n* More than 40 years old\n* First episode of traumatic anterior gelnohumeral dislocation seen in Rx\n* Acceptance to be checked over 2 years\n* Acceptance to be submitted to TAC, NMR, EMG and Bilateral Ultrasound\n\nExclusion Criteria:\n\n* Previous fractures in this extremity\n* Previous neurovascular lesions in this extremity\n* Other associated lesions\n* Cognitive alterations or dementia which prevent completing the protocols. Patients with \\\u003C14 points in Mini-mental test.",{"count":153,"type":22},"The glenohumeral joint has the highest rate of dislocation of the whole body, due to its high mobility and the special characteristics of its anatomy. It is estimated that every year between 1-2% of the population will suffer from glenohumeral dislocation. The vast majority of studies are based on young patients under the age of 40, given that at this age they have the higher incidence and at the same time, they have higher redislocation index. However, the investigators are in front of a more active population with a longer life expectancy. That is why the cases of anterior glenohumeral dislocations are increasing in people older than 40 years. Given that most studies focus on younger patients, the investigators lack knowledge about which injuries are associated with dislocation at this age and whether these influence its clinical evolution.",[359],"Anterior Glenohumeral Dislocations","2024-02-06",{"date":362,"type":45},"2024-02-07",{"date":364,"type":45},"2023-06-01",{"date":366,"type":22},"2028-05-31",{"name":51,"class":52},{"id":369,"slug":370,"hasResults":11,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":375,"targetDuration":4,"studyType":23,"phases":377,"briefSummary":378,"conditions":379,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":4},"100496688","omentectomy-vs-omental-preservation-in-resectable-cancer-100496688","NCT05747482","Omentectomy vs Omental Preservation in Resectable Cancer","Non-inferiority Randomized Clinical Trial Comparing Omenectomy and Omental Preservation in Resectable Gastric Cancer","Inclusion Criteria:\n\n* Older than 18 years old\n* Resectable gastric cancer\n* Gastric cancer T3-4 N+\u002F- M0\n\nExclusion Criteria:\n\n* M1\n* Non surgical patients for medical status\n* Non resectable gastric cancer during surgery\n* Endoscopic resectable gastric cancer",{"count":376,"type":22},569,[25],"European clinical guidelines do not establish a clear recommendation neither for nor against omentectomy of this segment, the American clinical guidelines recommend omentectomy in view of its potential long-term oncological benefit, and Japanese clinical guidelines only recommend 2nd segment omentectomy in locally advanced gastric cancers (stage T3-T4) recommending omental preservation in early gastric cancers (stage T1-T2).\n\nFaced with this lack of consensus, we propose a randomized, prospective and multicentric study in patients with resectable gastric cancer in stage T3-4 N+\u002F- M0. Patients will be randomized into two groups, one where omentectomy of the 2nd omental portion will be performed and another where omental preservation will be performed.\n\nThe aim of our study is to analyze the disease-free interval and survival between both groups, also comparing postoperative complications and mortality.",[380],"Cancer of Stomach","2023-02-16",{"date":383,"type":45},"2023-02-28",{"date":385,"type":22},"2024-01-01",{"date":387,"type":22},"2031-07-01",{"name":51,"class":52},""]