[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Coventry University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":112},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,87],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100545086","decision-support-system-for-diagnosis-and-progression-of-heart-failure-100545086",false,"NCT06377319","Decision Support System for Diagnosis and Progression of Heart Failure","Clinical Validation of an Artificial Intelligence Based Decision Support System for Predicting Risk, Diagnosis, and Progression of Heart Failure","STRATIFYHF","1. Inclusion criteria for patients at risk of heart failure:\n\n   1. Individuals at risk of developing HF ≥45 years of age sub-divided into two categories based on current definitions i.e.,\n\n      (i) patients with current or prior symptoms or signs of HF, but without structural, biomarker, or genetic markers of heart disease but have evidence of one of the following: hypertension, cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, known exposure to cardiotoxins and family history of cardiomyopathy and\n\n      (ii) Patients with current or prior symptoms or signs of HF and have evidence of one of the following - structural heart disease (e.g. Left ventricular (LV) hypertrophy, chamber enlargement, wall motion abnormality, valvular disease), abnormal cardiac function (e.g., reduced LV or right ventricular systolic function, evidence of increased filling pressures or abnormal diastolic function), elevated natriuretic peptide or elevated cardiac troponin on exposure to a cardiotoxin.\n   2. All patients willing to visit the clinical research facility and able to provide written informed consent.\n2. Inclusion criteria for patients with confirmed diagnosis of heart failure:\n\n   1. Patients with confirmed diagnosis of HF (heart failure reduced ejection fraction; heart failure mildly reduced ejection fraction; heart failure improved ejection fraction; and heart failure preserved ejection fraction) over the previous 24 months or\n   2. hospitalisation due to HF ≥45 years of age\n   3. willing to visit the clinical research facility and able to provide written informed consent.\n3. Exclusion criteria for at-risk individuals and diagnosed heart failure patients:\n\n   1. inability to provide verbal informed consent\n   2. presenting with severe symptoms\n   3. major co-morbidity or other alternative diagnoses (e.g., malignancy, severe respiratory disease, mental health problem); recent acute coronary syndrome (within 60 days)\n   4. severe physical disability preventing independence\n   5. scheduled or implanted pacemaker or cardio-defibrillator in the last 3 months\n   6. severe renal insufficiency\n   7. present or planned pregnancy\n   8. life expectancy less than 12 months.","ALL","45 Years",{"count":20,"type":21},1600,"ESTIMATED","OBSERVATIONAL","Heart failure (HF) is a complex clinical syndrome associated with impaired heart function, poor quality of life for patients and high healthcare costs. Accurate risk stratification and early diagnosis in HF are challenging as signs and symptoms are non-specific. Here the investigators propose to address this global challenge by developing novel analytic methods for HF (STRATIFYHF). A prospective clinical study will collect patient-specific data related to medical history, a physical examination for signs and symptoms, blood tests including natriuretic peptides, an electrocardiogram (ECG), an echocardiogram (ultrasound of the heart), cardiovascular magnetic resonance imaging (MRI), demographic, socio-economic and lifestyle data along with novel technologies (cardiac output response to stress (CORS) test and voice recognition biomarkers) from individuals at-risk of developing HF and those with a confirmed diagnosis of HF. STRATIFYHF will use these data to develop, validate and implement the first artificial intelligence (AI)-based, Decision Support System (DSS) for assessing and predicting the risk of HF development, its early diagnosis and progression. STRATIFYHF will integrate 1) patient-specific data i.e. demographic, clinical, genetic, lifestyle and socio-economic, 2) an AI-based digital patient library and AI-driven algorithms for risk stratification, early diagnosis, and disease progression in HF, and 3) a highly innovative multifunctional AI-based DSS and mobile application for informing a patient-centred, personalised, prevention and treatment strategies for HF.",[25],"Heart Failure",[27,28,29,30,31],"heart failure","risk prediction","diagnosis","progression","decision support system","NOT_YET_RECRUITING","2024-10-14",{"date":35,"type":36},"2024-10-16","ACTUAL",{"date":38,"type":21},"2024-11-01",{"date":40,"type":21},"2027-07-31",{"name":42,"class":43},"Coventry University","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":70,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},"100526587","from-the-heart-comparing-the-effects-of-spiritual-and-secular-meditation-on-psychophysiology-cognition-mental-health-and-social-functioning-in-healthy-adults-100526587","NCT06136676","From the Heart: Comparing the Effects of Spiritual and Secular Meditation on Psychophysiology, Cognition, Mental Health, and Social Functioning in Healthy Adults","From the Heart Multi-Centre Study: Comparing the Effects of Spiritual and Secular Meditation on Psychophysiology, Cognition, Mental Health, and Social Functioning in Healthy Adults","Inclusion Criteria:\n\n* 18 to 60 years old\n* able to read, speak and understand English\n* willing to be randomly assigned to all the conditions, with religious affiliation restricting allocation to either the Christian or Islamic type of spiritual meditation conditions\n* consider oneself to be a Christian or Muslim and pray at least weekly\n\nExclusion Criteria:\n\n* currently suffer from any mental health conditions or use medication to manage mental health conditions\n* long-term serious physical medical problems, such as liver, brain, kidney, or other life-threatening chronic diseases\n* a history of a heart condition, high blood pressure, Raynaud syndrome, diabetes, or musculoskeletal condition\n* the current use of anxiolytics\u002Fmood stabilizers.",true,"18 Years","60 Years",{"count":55,"type":21},288,"INTERVENTIONAL",[58],"NA","The purpose of this study is to investigate and compare the effects of Christian and Islamic heart-centred spiritual meditation to mindfulness meditation and waitlist control conditions, respectively, in healthy adults. The potential effects will be studied at multiple levels, with a focus on psychophysiology, cognition, mental health, and social functioning.",[61,62,63,64,65,66,67,68,69],"Prosocial Behavior","Forgiveness","Empathy","Pain","Attention","Depression","Stress","Anxiety","Mental Well-being",[71,72,73,74,62,63,64,65,66,67,68,75,76],"Christian spiritual meditation","Islamic spiritual meditation","Mindfulness","Prosociality","Well-being","Heart-centred spirituality","RECRUITING","2024-08-20",{"date":80,"type":36},"2024-08-22",{"date":82,"type":36},"2024-06-06",{"date":84,"type":21},"2025-12",{"name":42,"class":43},2,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":56,"phases":98,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100501294","home-based-exercise-for-adults-living-with-overweight-and-obesity-100501294","NCT05807386","Home-Based Exercise for Adults Living With Overweight and Obesity","WE Are Active and In This toGetHer (WEIGH): a Randomised Controlled Trial to Ascertain the Feasibility of a Home-based Exercise Programme for People Living With Overweight and Obesity","WEIGH","Inclusion Criteria:\n\n* BMI ≥25kg\u002Fm² or BMI ≥30kg\u002Fm²\n* English speaking\n* Able to follow visual and verbal instructions\n* Access to the internet and accompanying technology (e.g. laptop or tablet)\n* Physically able to undertake aerobic, resistance and flexibility exercise\n\nExclusion Criteria:\n\n* Unable to provide informed consent\n* Receiving invasive medical treatment or planned surgery preceding to, or during, the programme\n* Severe mental or physical limitations precluding participation safely in the home environment\n* No access to the internet and\u002For facilitative technology such as a laptop or tablet\n* Pregnancy\n* Current smoker or vaping.\n* Currently or very recently stopped taking weight loss medication (within the last two weeks)\n* Recently experienced substantial weight change (defined as 5% within 6-12 months)\n* Presence of contraindications to exercise\n* Pacemaker and\u002For other implanted metal device\n* At high risk of cardiovascular event","64 Years",{"count":97,"type":21},30,[58],"The study aims to implement a 12-week home-based exercise programme utilising an online intervention delivery platform. The focus will be on increasing exercise behaviour within the participant's home setting using aerobic, resistance and flexibility exercises as well as behaviour change techniques. Following the programme, semi-structured interviews will be conducted, to explore participant experiences.\n\nIt is hypothesised that the exercise programme will be feasible, accessible and acceptable.",[101],"Overweight and Obesity",[103],"home-based exercise","2024-02-08",{"date":106,"type":36},"2024-02-12",{"date":108,"type":21},"2025-01",{"date":110,"type":21},"2027-06",{"name":42,"class":43},""]