[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Creighton University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":127},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,74,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100581666","the-influence-of-movement-velocity-biofeedback-on-muscle-activation-and-self-perception-in-older-adults-with-sarcopenia-100581666",false,"NCT06853275","The Influence of Movement Velocity Biofeedback on Muscle Activation and Self Perception in Older Adults With Sarcopenia","Inclusion Criteria:\n\n* Community-dwelling older adults 60-95 years of age\n* Physically independent\n* Free of severe mental impairment\n* Score 4 or greater on the SARC-F sarcopenia questionnaire\n\nExclusion Criteria:\n\n* Participated in a structured resistance training program in the last 12 months\n* Had a lower extremity injury or surgical intervention within the past 6 months\n* Have neuromuscular (i.e., Parkinson's Disease, Multiple Sclerosis), circulatory, or edema pathology","ALL","60 Years","95 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","The overall objective for this clinical trial is to provide evidence for internal and external cueing for physical therapists and other rehabilitation clinicians to optimize resistance training within rehabilitation for older adults. The main questions it aims to answer are:\n\n* What is the impact of external focus (providing velocity of movement for each repetition) compared to internal focus (i.e., no cues, control group) on physical percent velocity loss and neuromuscular activation in older adults with sarcopenia?\n* Does internal and external focus influence motivation and perceptual workload following resistance training in older adults with sarcopenia?\n\nResearchers will compare external focus to internal focus to see if external focus impacts percent velocity loss, motivation, and perceived workload.\n\nParticipants will:\n\n* Visit the lab once per week for 3 weeks\n* Perform exercise testing using a leg press\n* Answer questionnaires regarding perceived workload and motivation before and after exercise",[26,27,28],"Sarcopenia","Sarcopenia in Elderly","Age-associated Muscle Loss",[30,31,32,26,33],"Geriatrics","Neuromuscular","Rehabilitation","Velocity-based training","RECRUITING","2026-03-16",{"date":37,"type":38},"2026-03-18","ACTUAL",{"date":40,"type":38},"2025-08-01",{"date":42,"type":20},"2027-12-31",{"name":44,"class":45},"Creighton University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":15,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":46},"100572374","subthreshold-vestibular-stimulation-as-a-strategy-for-rehabilitation-100572374","NCT06732440","Subthreshold Vestibular Stimulation as a Strategy for Rehabilitation","Inclusion Criteria for Bilateral Vestibular Hypofunction:\n\n1\\. Bilateral lateral canal VOR gain of \\\u003C 0.8 on video head impulse testing OR bilateral positive bedside head impulse test\n\nInclusion Criteria for Unilateral Vestibular Hypofunction:\n\n1\\. Unilateral yaw aVOR gain of \\\u003C 0.8 on video head impulse testing OR unilateral positive bedside head impulse test\n\nInclusion Criteria for all Participants:\n\n1. Must be able to stand for 5 minutes unassisted\n2. No leg or foot amputations\n3. No lower limb braces\n4. Not currently pregnant by self-report\n5. Weight \\\u003C= 300 pounds (due to limitations of testing equipment)\n\nExclusion Criteria for all participants:\n\n1. Severe head trauma or traumatic brain injury\n2. History of seizures\n3. Alternative neurologic illness or condition known to impact vestibular or balance function (e.g., stroke, neurodegenerative disorders, demyelinating illness)\n4. Major psychiatric (e.g., panic disorder, psychosis, etc.) disorder\n5. Any of the following eye diseases or conditions: amblyopia (or \"lazy eye\") or history of amblyopia, diagnosis of age- related macular degeneration, retina dystrophy, glaucoma, cataracts,\n6. Recent (\\\u003C6 months) orthopedic injury that may affect test performance\n7. Recent surgery (\\\u003C 6 months) that may impact test performance.\n8. Other severe health problems (heart disease, pulmonary disease, cancer, etc.) that may affect test performance\n9. Due to potentially nauseogenic nature of some motions and to protect fetus and mother, pregnant women will also be excluded from this study\n\n   * Since the investigators cannot address every possible potential individual recruit in advance, additional exclusion criteria may be required.",true,"19 Years","89 Years",{"count":57,"type":20},48,[23],"The nervous system responds to changes in external or internal conditions by altering the behavior of neurons through multiple forms of neural plasticity. A specific form of plasticity, \"homeostatic plasticity\", stabilizes neural activity by driving the excitability of neurons toward a \"set-point\" level of activity. Over the last six years, new data have come to light showing that the vestibular system also possess a robust capacity to modulate sensitivity to self-motion cues in response to prolonged periods of motion. Collectively, these studies have demonstrated a capacity to use motion perturbations (i.e., low, or high levels of vestibular stimulation) to dynamically adjust the sensitivity of the vestibular system on both the single neuron and behavioral levels. The ability to use subthreshold motion stimuli to drive plasticity in the vestibular system motivates this study. The investigators aim to determine the impact of subthreshold motion on (a) balance performance and (b) balance training in individuals with peripheral vestibular hypofunction.",[61,62,63,64],"Vestibular Hypofunction","Bilateral Vestibular Hypofunction","Presbyvestibulopathy","Healthy Controls",[62,66],"Vestibular Rehabilitation",{"date":68,"type":38},"2026-03-17",{"date":70,"type":38},"2026-02-09",{"date":72,"type":20},"2026-12-31",{"name":44,"class":45},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":53,"sex":15,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},"100606108","improving-exercise-adherence-with-app-technology-for-at-risk-adults-living-in-rural-kansas-and-nebraska-100606108","NCT07171255","Improving Exercise Adherence With App Technology for At-Risk Adults Living in Rural Kansas and Nebraska","RemoteEx+","Inclusion Criteria:\n\n* Age 40-85 years\n* Characterized as underactive by the Telephone Assessment of Physical Activity (TAPA)50\n* Self-reported proficiency in English\n* Own a smartphone and willing to download an application\n* Primary care provider clearance to participate for those who do not pass the PAR-Q+51\n* Live in a rural area (Rural-Urban Commuting Area \\[RUCA\\] Codes) 52\n\nExclusion Criteria:\n\n* Contraindications to high-intensity exercise\n* Cognitive impairment (\\\u003C19 on the Telephone Montreal Cognitive Assessment \\[MoCA\\])\n* Neurodegenerative or acute neurological diagnoses (e.g., Parkinson's disease, stroke, traumatic brain injury)\n* Orthopedic surgery or injuries in the last 6 months","40 Years","85 Years",{"count":84,"type":20},54,[23],"Alzheimer's disease and related dementias are a public health crisis impacting individuals across the world. In the United States, adults living in rural areas face an elevated risk for cognitive impairment mainly due to disparities in care, higher sedentary behavior, and reduced education. This project proposes to assess the impact of a remotely delivered exercise program (i.e., RemoteEx+) through a smartphone application. The app is programmed by our team and provides video demonstrations of exercises, workout regimes, motivational messaging, and weekly ADRD risk reduction education. The project aims to assess with a pre\u002Fpost design the following aims:\n\n* Aim 1. Assess the RemoteEx+ intervention exercise adherence, efficacy, enjoyment, and quality of life. We hypothesize that rural adults will report high exercise adherence (80% of session adherence), efficacy (\\>50% on Self Efficacy for Exercise), and enjoyment (\\>5.0 on Intrinsic Motivation Inventory - Interest \u002F Enjoyment Subscale) and that these variables will be positively correlated with quality of life scores (36-Item Short Form Health Survey \\[SF-36\\])\n* Aim 2. Determine the impact of a technology-driven exercise program on blood pressure and functional mobility associated with dementia risk. We hypothesize that the exercise program will result in improvements in blood pressure and functional mobility (2-minute step test and 30-second chair rise test) and that participants with high exercise adherence will see the greatest improvements in biomarkers associated with reduced dementia risk.\n* Aim 3. Reduce health disparities among rural-dwelling Nebraska and Kansas residents. We hypothesize that RemoteEx+ will reduce barriers to exercise (Barriers to Being Active Quiz and improve knowledge surrounding dementia and modifiable risk factors (Dementia Knowledge Assessment Tool - Version 2 \\[DKAT2\\]) that will result in fewer lifestyle-related health disparities for the communities involved in this study.\n\nThe results from this project will inform whether RemoteEx+ has an impact on the stated outcomes above for adults living in rural areas.",[88],"Sedentary Middle Age and Older Aged Adults","2025-09-10",{"date":91,"type":38},"2025-09-12",{"date":93,"type":38},"2025-08-22",{"date":95,"type":20},"2026-06-30",{"name":44,"class":45},2,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":53,"sex":104,"minAge":105,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":108,"phases":4,"briefSummary":109,"conditions":110,"keywords":115,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":46},"100493138","skeletal-effects-of-type-1-diabetes-on-low-trauma-fracture-risk-100493138","NCT05701254","Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk","Inclusion Criteria:\n\nCriteria for enrollment of female diabetics\n\n1. No chronic disease diagnoses that may affect bone, as confirmed by the PI.\n2. Normal clinical history, physical, and clinical laboratory exam (except for usual complications of a 10+-year diabetic, i.e., \\~minimal neuropathy or retinopathy, known, but asymptomatic mild vascular disease, etc.)\n3. Glomelular Filtration Rate (GFR) \\>45 ml\u002Fmin (Renal Association lower limit for \"mild\" kidney failure).\n4. Willingness to sign a consent form.\n5. Willingness to undergo a transilial bone biopsy incision that yields 2 bone specimens.\n6. No abnormalities in clinical blood chemistry measurements (small, age-related decreases in GFR, will be permitted).\n7. Caucasian\n\nCriteria for each non-diabetic subject, compared to their matched diabetic:\n\n1. Dual-energy x-ray absorptiometry (DXA) measures (BMD, gm\u002Fcm) must be within +\u002F- 15% in total hip.\n2. Body mass index (BMI) must be within +\u002F-10%.\n3. Age must be within +\u002F- 5 years.\n4. Caucasian\n\nExclusion Criteria:\n\n1. Women who have had Type 1 diabetes for less than 10 years.\n2. Non-insulin dependent Type 1 diabetic.\n3. Less than 50 years old.\n4. Less than 5 years post menopausal.","FEMALE","50 Years",{"count":107,"type":20},80,"OBSERVATIONAL","Patients with Type 1 Diabetes Mellitus (T1DM) have a higher risk of low-trauma (osteoporotic) fracture that is 7-12 times higher than non-diabetics. The bone density of people with Type 1 Diabetes is higher at the time of fracture than in non-diabetics. This suggests the presence of underlying bone tissue mechanical defects. The potential benefits to participants would be knowledge gained about their bone density and the results of laboratory tests. On a wider scale, there may be general benefits to society because the knowledge gained from this study may help better understand the effects of diabetes on bone health",[111,112,113,114],"Type 1 Diabetes","Osteopenia","Bone Loss","Fractures, Bone",[116,117,118],"Bone","Cortical Bone","Mechanical Strength","2024-09-23",{"date":121,"type":38},"2024-09-25",{"date":123,"type":38},"2019-06-18",{"date":125,"type":20},"2025-01",{"name":44,"class":45},""]