[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dalin Tzu Chi General Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":156},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,76,105,127],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100644719","effect-of-simethicone-on-colon-preparation-during-water-exchange-colonoscopy-100644719",false,"NCT07674160","Effect of Simethicone on Colon Preparation During Water Exchange Colonoscopy","Effects of Simethicone on Colon Preparation in Water Exchange Colonoscopies: a Randomized Controlled Study","Inclusion Criteria:\n\n* Consecutive patients undergoing screening, surveillance, or diagnostic colonoscopy.\n* Procedures performed by participating endoscopists.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Colonoscopy performed using air insufflation or water immersion technique.\n* History of colorectal surgery (e.g., colectomy or colostomy).\n* Known or suspected colonic obstruction or severe stricture.\n* Requirement for inpatient bowel preparation.\n* Known allergy or hypersensitivity to simethicone.\n* Unable or unwilling to provide informed consent.",true,"ALL","20 Years","80 Years",{"count":21,"type":22},180,"ESTIMATED","INTERVENTIONAL",[25],"NA","Background: Colonoscopy reduces colorectal cancer mortality by enabling early detection and removal of adenomas. Its effectiveness, however, depends heavily on bowel preparation quality and mucosal visibility. Simethicone, an anti-foaming agent, decreases intraluminal bubbles and improves visualization; studies in conventional air-insufflation colonoscopy generally show benefits for cleanliness and patient comfort, but evidence in water-exchange (WE) colonoscopy remains limited.Objective: To evaluate whether adding oral simethicone to a split-dose polyethylene glycol (PEG) regimen further improves bowel cleanliness and procedural performance in WE colonoscopy.Methods: Adults undergoing outpatient colonoscopy will be randomly assigned (1:1) to a simethicone group or a control group, with a planned enrollment of 180 participants. All procedures will use the WE insertion technique, and endoscopists will be blinded to group allocation. The primary endpoint is the Boston Bowel Preparation Scale (BBPS); adequate preparation is defined as a total score ≥6 with all segment scores ≥2. Secondary endpoints include bubble score and CEBuS, adenoma detection rate (ADR), polyp detection rate (PDR), cecal intubation rate and time, withdrawal time, volume of water used and flushing\u002Firrigation metrics, and patient-reported tolerability and satisfaction.Expected Results: Compared with PEG alone, adding simethicone is expected to (1) increase the proportion of adequate BBPS preparations, (2) reduce bubble coverage, (3) maintain or potentially improve ADR\u002FPDR, and (4) enhance patient tolerability and satisfaction.Conclusion: If effective, this intervention would provide a simple, low-cost strategy to optimize the quality of WE colonoscopy.",[28],"Quality of Bowel Preparation",[30,31,32,33,34,35],"simethicone","Boston Bowel Preparation Scale (BBPS)","bubble score","Colon Endoscopic Bubble Scale（CEBuS)","adenoma detection rate (ADR)","water-exchange (WE) colonoscopy","NOT_YET_RECRUITING","2026-06-23",{"date":39,"type":40},"2026-06-29","ACTUAL",{"date":42,"type":22},"2026-08-01",{"date":44,"type":22},"2028-09-01",{"name":46,"class":47},"Dalin Tzu Chi General Hospital","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100541552","effect-of-jing-si-herbal-tea-liquid-packets-on-chronic-pharyngolaryngitis-100541552","NCT06331351","Effect of Jing Si Herbal Tea Liquid Packets on Chronic Pharyngolaryngitis","Effect of Jing Si Herbal Tea Liquid Packets on Chronic Pharyngolaryngitis: A Randomized, Double-blinded Clinical Trial","Inclusion Criteria:\n\n1. Adult men and women aged 20 to 70 years old.\n2. Patients with chronic pharyngitis\n\nExclusion Criteria:\n\n1. Patients who are bedridden or unable to take care of themselves.\n2. Dialysis patients.\n3. Patients who cannot understand the details of this study or cannot cooperate with the examination.\n4. History of alcohol or drug abuse.\n5. Pregnant and lactating women","70 Years",{"count":57,"type":22},120,[25],"Chronic pharyngolaryngitis is common and often make people suffer in many aspects. The etiology is numerous, for example, airway hypersensitivity, gastroesophageal acid regurgitation, sicca syndrome, anxiety, etc.\n\nThe investigators aimed to investigate the effect of Jing Si herbal tea liquid packets on chronic pharyngolaryngitis by a design of randomized, double-blind clinical trial in this study. The subjects who were bed-ridden, without self-care ability, receiving hemodialysis, no idea about the details of this study, poor compliance for this study, alcohol and\u002For drugs additives, pregnancy and breast-feeding women were excluded from this study.\n\nA questionnaire for health and habits was performed at the start of the study, and a questionnaire for Reflux Symptom Index (RSI) was performed at the start and the end of the study. Finally, Student's t-test was used to test the difference between the Jing Si herbal tea group and the control group. And, multivariate linear regression was used to test the violation of clinical factors on the treatment outcome of Jing Si herbal tea liquid packets on chronic pharyngolaryngitis.",[61],"Chronic Pharyngitis",[63,64,65],"Chronic pharyngitis","Jing Si herbal tea liquid packets","clinical trial","RECRUITING","2026-02-05",{"date":69,"type":40},"2026-02-09",{"date":71,"type":40},"2024-02-22",{"date":73,"type":22},"2026-12-31",{"name":46,"class":47},1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100606817","effectiveness-of-whole-body-vibration-on-health-outcomes-in-older-adults-with-dynapenic-abdominal-obesity-100606817","NCT07180485","Effectiveness of Whole Body Vibration on Health Outcomes in Older Adults With Dynapenic Abdominal Obesity","The Effectiveness of Whole Body Vibration Training in Improving Brain Activity, Bone Mineral Density, Quality of Life, and Biomarkers for the Older People With Dynapenic Abdominal Obesity","Inclusion Criteria:\n\nOutpatients aged 65 years or older\n\nDiagnosed with dynapenic abdominal obesity\n\nAble to understand and follow simple instructions\n\nAble to communicate clearly and express their own will\n\nWilling to sign the informed consent form\n\nExclusion Criteria:\n\nInability to communicate in Mandarin or Taiwanese, resulting in inability to participate in research activities\n\nSevere visual or hearing impairment that hinders study participation\n\nPresence of cognitive impairment, musculoskeletal or severe osteoporosis-related conditions\n\nRefusal to sign the informed consent form","65 Years","100 Years",{"count":57,"type":22},[25],"This study focuses on whole body vibration training (WBVT), a form of neuromuscular training that uses mechanical vibrations. WBVT has been shown to improve muscle function, bone mineral density, and quality of life. While some benefits have been observed in the elderly population, there remains a research gap concerning its effectiveness in older adults with dynapenic abdominal obesity. Therefore, the findings of this study will provide new evidence for health interventions targeting this specific group.\n\nThis research targets outpatients aged 65 and above who meet the criteria for dynapenic abdominal obesity. It aims to evaluate the effects of WBVT on brain activity, osteoporosis, quality of life, and biological markers. The study period is from February 1, 2025, to January 31, 2027, with a planned sample size of 120 participants, equally divided into an experimental group and a control group (60 participants each).",[89,90],"Dynapenia","Abdominal Obesity",[92,93,94,95,96],"whole-body vibration training","brain activity","bone mineral density","quality of life","biomarkers","2025-09-16",{"date":99,"type":40},"2025-09-18",{"date":101,"type":22},"2025-10-01",{"date":103,"type":22},"2027-10-01",{"name":46,"class":47},{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":75},"100590108","the-effects-of-prune-juice-on-bowel-movement-patterns-constipation-symptoms-and-quality-of-life-100590108","NCT06963125","The Effects of Prune Juice on Bowel Movement Patterns, Constipation Symptoms, and Quality of Life","The Effects of Different Doses of Prune Juice on Bowel Movement Patterns, Constipation Symptoms, and Quality of Life Among Older Adults in Long-Term Care Facilities","Inclusion Criteria:\n\n* Older adults aged 65 to 100 years\n* Cognitively aware and able to express their opinions\n* Diagnosed with functional constipation\n\nExclusion Criteria:\n\n* Diagnosis of diabetes mellitus\n* Cognitive impairment, including moderate to severe dementia or psychiatric disorders\n* Aphasia\n* Severe hearing impairment\n* Presence of gastrointestinal diseases, including:\n* Gastrointestinal bleeding\n* Intestinal obstruction\n* Abdominal tumors\n* Irritable bowel syndrome\n* Acute diverticulitis\n* Diarrhea\n* Crohn's disease\n* Ulcerative colitis\n* History of abdominal surgery\n* Regular use of probiotics\n* Regular use of traditional Chinese medicine or folk remedies for constipation relief\n* Difficulty swallowing or risk of aspiration\n* Major illnesses, such as current cancer treatment or severe cardiovascular diseases\n* Currently hospitalized",{"count":113,"type":22},90,[25],"This study investigates the effects of different prune juice dosages on bowel movement patterns, constipation symptoms, and quality of life in older adults. Using a factorial experimental design, 90 participants aged 65 to 100 with functional constipation will be randomly assigned to receive 100 mL, 150 mL, or 200 mL of prune juice daily for four weeks. The study aims to determine a safe and effective dosage for constipation management, offering a non-pharmacological approach to improving bowel health in older adults.",[117,118],"Constipation in Older Adults","Functional Constipation in Elderly","2025-09-08",{"date":121,"type":40},"2025-09-12",{"date":123,"type":40},"2025-05-26",{"date":125,"type":22},"2026-11-30",{"name":46,"class":47},{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":134,"minAge":18,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":23,"phases":136,"briefSummary":139,"conditions":140,"keywords":144,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":75},"100542538","phase-2-dinalbuphine-ester-naldebain-for-pain-management-after-cesarean-section-100542538","NCT06344169","Dinalbuphine Ester (Naldebain) for Pain Management After Cesarean Section","Efficacy of Parenteral Injection of an Extended Release Kappa-receptor Opioid Sebacoyl Dinalbuphine Ester for Pain Management After Cesarean Section: a Randomized, Open-label, Non-inferiority Trial","Inclusion Criteria:\n\n* term primipara or multipara who are scheduled for elective cesarean section\n\nExclusion Criteria:\n\n1. Severe pregnancy-induced complication (such as preeclampsia, eclampsia, poorly control pregnancy-induced hypertension and\u002For diabetes)\n2. High risk for postpartum hemorrhage\n3. Contraindicated for neuraxial block\n4. Preterm (gestational age\\\u003C 36 week) delivery\n5. Emergency cesarean section\n6. After-office hour schedule\n7. History of substance abuse\n8. Known allergy to nalbuphine, benzyl benzoate or sesame oil\n9. Eligible parturient who are not willing to follow the assignment of treatment after randomization","FEMALE",{"count":57,"type":22},[137,138],"PHASE2","PHASE3","Inadequate postoperative pain management can lead to physical and psychological distress in patients as well as impact surgical wound healing and increase the risk of developing postoperative delirium and cardiopulmonary and thromboembolic events. Severe postoperative pain may also result in the development of chronic post-surgical pain (CPSP), which in turn can lead to prolonged use of opioids and increased health-care costs. A descriptive survey study in 60 postpartum women who received cesarean section suggested that the presence of postoperative pain significantly reduced the willingness of breastfeeding and infant care. The incidence of CPSP after cesarean delivery has been reported to vary from 1% to 18% up to 1 year after operation. Intrathecal morphine (ITM) injection is considered as the standard pain management strategy for post-cesarean pain. However, the overall analgesic effect of ITM is about 8-12h and it is associated with pruritus, nausea\u002Fvomiting, urinary retention, constipation, mental status change, and respiratory depression. Therefore, the development of a safe, conveniently operated, and long-lasting analgesic strategy, which serves as background pain control modality up to several days after cesarean section should provide clinically beneficial advantages in the management of acute postoperative pain and prevention of CPSP in postpartum women. Naldebain® is prodrug of nalbuphine, which was approved by the Taiwan FDA in 2017. Naldebain® is rapidly hydrolyzed by tissue of plasma esterase to release nalbuphine. The bioavailability of nalbuphine following intramuscular injection Naldebain® was 85.4%, and it took approximately 6 days for the complete release of Naldebain® into the blood circulation. Therefore, a single parenteral injection of Naldebain® could provide long lasting analgesic effect in several phase II trials. However, Naldebain® has not been tested in the pain control after cesarean section. Therefore, this PI-initiated prospective, randomized, open-label, non-inferiority trial aims to investigate the clinical efficacy of Naldebain® in management of acute postoperative pain in term parturient who receive elective cesarean section to provide analgesic effect that is not inferior to the standard ITM and prevent the development of CPSP.",[141,142,143],"Postsurgical Pain","Cesarean Section","Chronic Post-surgical Pain",[145,146,147],"kappa agonist","mu agonist","Intrathecal morphine","2025-05-06",{"date":150,"type":40},"2025-05-09",{"date":152,"type":40},"2024-05-06",{"date":154,"type":22},"2026-06-14",{"name":46,"class":47},""]