[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Damanhour Teaching Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":137},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,72,96,115],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100500192","phase-4-dexmedetomidine-versus-dexamethasone-as-adjuvants-to-bupivacaine-for-intermediate-cervical-plexus-block-100500192",false,"NCT05793060","Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Intermediate Cervical Plexus Block","Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Ultrasound-guided Intermediate Cervical Plexus Block in Patients Undergoing Thyroidectomy","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status ≤ II\n* Age from 21 to 60 years\n* Body Mass Index (BMI) ≤ 35 kg\u002Fm2\n\nExclusion Criteria:\n\n* ASA physical status \\> II\n* Age \\\u003C 21 years or \\> 50 years\n* BMI \\> 35 kg\u002Fm2\n* Bronchial asthma\n* Chronic obstructive pulmonary disease\n* Restrictive lung diseases\n* Sick sinus syndrome\n* Sinus bradycardia\n* Hypertension\n* Chronic hypotension\n* Ischemic heart disease\n* Coagulopathies\n* Hepatic insufficiency\n* Renal insufficiency\n* Diabetes mellitus\n* Peripheral neuropathy\n* Thyroid malignancy\n* Hyperthyroidism\n* Substernal goiter\n* Patients on beta-blockers\n* Patients using pacemakers\n* Alcohol or drug abuse\n* Allergy to the study drugs","ALL","21 Years","60 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Background: Many thyroidectomy patients suffer from postoperative pain that could delay early hospital discharge and place a significant burden on both the patient and the healthcare team. Bilateral intermediate cervical plexus block (ICPB) provides good analgesia for neck surgery, including thyroidectomy. However, the duration of a single-shot nerve block is usually short. Therefore, adjuvants are used in peripheral nerve blocks.\n\nObjectives: To compare the safety and efficacy of dexmedetomidine versus dexamethasone as adjuvants to bupivacaine in ultrasound-guided intermediate cervical plexus block in patients undergoing total thyroidectomy under general anesthesia.\n\nPatients and Methods: This is a randomized, double-blind, phase four, prospective clinical trial; carried out on 60 patients, who were candidates for total thyroidectomy under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received bilateral ICPB with isobaric bupivacaine plus dexmedetomidine, and group B, received bilateral ICPB with isobaric bupivacaine plus dexamethasone.",[27],"Analgesia",[29,30,31,32],"Cervical plexus block","Dexamethasone","Dexmedetomidine","Thyroidectomy","RECRUITING","2026-01-09",{"date":36,"type":37},"2026-01-12","ACTUAL",{"date":39,"type":37},"2025-08-01",{"date":41,"type":21},"2026-12-15",{"name":43,"class":44},"Damanhour Teaching Hospital","OTHER_GOV",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":66,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":45},"100452241","nylon-versus-polyurethane-epidural-catheters-in-patients-undergoing-major-orthopedic-surgery-100452241","NCT05168943","Nylon Versus Polyurethane Epidural Catheters In Patients Undergoing Major Orthopedic Surgery","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status ≤ II\n* Age from 21 to 60 years\n* Body Mass Index (BMI) \\\u003C 35\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status \\> II\n* Age \\\u003C 21 years or \\> 60 years\n* Body Mass Index (BMI) ≥ 35\n* Contraindications to regional anesthesia (including coagulopathy and infection at the injection site)\n* Uncooperative patients\n* Patients with known allergy to local anesthetics or opioids",{"count":20,"type":21},[54],"NA","Objectives: To compare the safety and efficacy of nylon (polyamide) epidural catheter versus polyurethane epidural catheter in patients undergoing major orthopedic surgery under continuous epidural anesthesia.\n\nBackground: Continuous epidural anesthesia is the most common anesthetic technique used in orthopedic surgery. However, the use of epidural catheters is associated with complications. The insertion of the catheter may be associated with intravascular or intrathecal placement, nerve root irritation, paresthesia, kinking, hematoma, or breakage during catheter removal.\n\nPatients and Methods: This was a prospective, randomized, double-blind clinical trial; carried out on 60 patients undergoing major orthopedic surgery under continuous epidural anesthesia. Patients were randomly allocated into two equal groups; group N, using Nylon catheter, and group P, using Polyurethane catheter.",[57,58,59,60,61],"Epidural; Anesthesia","Catheter Complications","Catheter Blockage","Catheter Dysfunction","Catheter Breakage",[63,64,65],"Epidural Anesthesia","Nylon (Polyamide) Epidural Catheter","Polyurethane Epidural Catheter",{"date":36,"type":37},{"date":68,"type":37},"2025-07-01",{"date":70,"type":21},"2026-12-30",{"name":43,"class":44},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":79,"maxAge":18,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":93,"leadSponsor":95,"locationsCount":45},"100566332","rhomboid-intercostal-block-versus-retrolaminar-block-for-postoperative-analgesia-after-thoracoscopic-sympathectomy-100566332","NCT06653803","Rhomboid Intercostal Block Versus Retrolaminar Block for Postoperative Analgesia After Thoracoscopic Sympathectomy","Ultrasound-guided Rhomboid Intercostal Block Versus Retrolaminar Block for Postoperative Analgesia After Thoracoscopic Sympathectomy: A Randomized Clinical Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status ≤ II\n* Age from 18 to 60 years\n* Body Mass Index (BMI) \\\u003C 35 kg\u002Fm²\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status \\> II\n* Age \\\u003C 18 years or \\> 60 years\n* Body Mass Index (BMI) ≥ 35\n* Local infection at the puncture site\n* Altered mental status\n* Pregnant women\n* Allergy to study drugs\n* Chronic pain\n* Coagulation abnormalities or on anticoagulants\n* Severe hepatic or kidney disease","18 Years",{"count":20,"type":21},[54],"Background: Although thoracoscopic sympathectomy is made via small incisions, it is associated with severe postoperative pain. Both Rhomboid intercostal block (RIB) and Retrolaminar block (RLB) are recent techniques used for pain control after such procedures\n\nObjectives: To compare the effectiveness of RIB and RLB in providing postoperative analgesia after thoracoscopic sympathectomy in adult patients and their impact on the patient's outcomes.\n\nPatients and Methods: This prospective, randomized (1:1), double-blind clinical trial; will be carried out on 60 patients scheduled for elective thoracoscopic sympathectomy under general anesthesia at our hospital. Patients will be randomly allocated into two equal groups (30 patients each) and will receive: in group A; general anesthesia with intraoperative ipsilateral ultrasound-guided RIB, whereas in group B; general anesthesia with intraoperative ipsilateral ultrasound-guided RLB.",[84],"Post Operative Pain",[86,87,88],"Rhomboid Intercostal Block","Retrolaminar Block","Regional Analgesia","2025-08-20",{"date":91,"type":37},"2025-08-21",{"date":39,"type":37},{"date":94,"type":21},"2026-01-30",{"name":43,"class":44},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":104,"briefSummary":105,"conditions":106,"keywords":107,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":110,"startDateStruct":111,"completionDateStruct":112,"leadSponsor":114,"locationsCount":45},"100453085","erector-spinae-plane-block-versus-rectus-sheath-block-for-postoperative-analgesia-after-supraumbilical-surgery-100453085","NCT05179928","Erector Spinae Plane Block Versus Rectus Sheath Block for Postoperative Analgesia After Supraumbilical Surgery","Is Erector Spinae Plane Block More Effective Than Rectus Sheath Block for Postoperative Analgesia After Supraumbilical Surgery in Adult Patients","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status ≤ II\n* Age from 21 to 60 years\n* Body Mass Index (BMI) \\\u003C 35 kg\u002Fm²\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status \\> II\n* Age \\\u003C 21 years or \\> 60 years\n* Body Mass Index (BMI) ≥ 35\n* Local infection at the puncture site\n* Altered mental status\n* Pregnant women\n* Allergy to study drugs\n* Chronic pain\n* Coagulation abnormalities or on anticoagulants\n* Severe hepatic or kidney disease",{"count":20,"type":21},[54],"Objectives: To compare the effectiveness of erector spinae plane block (ESPB) and rectus sheath block (RSB) in providing postoperative analgesia after supraumbilical surgery in adult patients and their impact on the patient's outcomes.\n\nBackground: Supraumbilical surgery for hernia repair is the second-most-popular after surgical inguinal hernia repair and is accompanied by moderate to severe postoperative pain, so patients always require large doses of opioids within the first postoperative day. Because opioids have several adverse effects such as drowsiness, pruritus, nausea, and vomiting, regional analgesic techniques are an essential component of postoperative opioid-sparing analgesia. Previous studies have shown that regional analgesic techniques after abdominal wall surgeries can be an essential element of a postoperative pain management strategy with minimal adverse effects and hemodynamic responses.\n\nESPB provides both somatic and visceral analgesia to the abdominal wall, through the blockade of the anterior rami of spinal nerves and the rami communicants involving sympathetic nerve fibers. RSB provides analgesia to the anterior abdominal wall from the xiphoid process to the symphysis pubis, through the blockade of the anterior rami of the 7th to 12th intercostal nerves. The dermatomal distribution of ESPB and RSB makes them ideal regional analgesic techniques after abdominal surgery, and to our knowledge, there were no previous trials that studied the difference between them.\n\nPatients and Methods: This was a prospective, randomized (1:1), double-blind clinical trial on 60 patients scheduled for elective supraumbilical surgery under general anesthesia at our hospital. Patients will be randomly allocated into two equal groups (30 patients each) and will receive: in group E; general anesthesia with postoperative bilateral ultrasound-guided ESPB, whereas in group R; general anesthesia with postoperative bilateral ultrasound-guided RSB.",[84],[108,109,88],"Erector Spinae Plane Block","Rectus Sheath Block",{"date":91,"type":37},{"date":39,"type":37},{"date":113,"type":21},"2026-03-01",{"name":43,"class":44},{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":125,"conditions":126,"keywords":128,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":133,"startDateStruct":134,"completionDateStruct":135,"leadSponsor":136,"locationsCount":45},"100432678","phase-4-premedication-with-atenolol-versus-metoprolol-for-controlled-hypotensive-anesthesia-during-nasal-surgeries-100432678","NCT04914234","Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries","Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries. A Randomized Clinical Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status ≤ II\n* Age from 21 to 50 years\n\nExclusion Criteria:\n\n* ASA physical status \\> II\n* Age \\\u003C 21 years or \\> 50 years\n* Pregnant women\n* Breastfeeding\n* Bronchial asthma\n* Chronic obstructive pulmonary disease\n* Diabetes Mellitus\n* Hypertension\n* Ischemic heart disease\n* Rheumatic heart disease\n* Heart failure\n* Heart block\n* Sick sinus syndrome\n* Sinus bradycardia\n* Chronic hypotension\n* Anemia (Hb \\\u003C 10 g\u002Fdl)\n* Renal or hepatic dysfunction\n* Central nervous system disease\n* Allergic fungal sinusitis\n* Patients on beta-blockers\n* Alcohol or drug abuse\n* Anticoagulation therapy,\n* Bleeding diathesis\n* Agents influencing autonomic nervous system\n* Allergy to the study drugs\n* Any contraindication of oral intake","50 Years",{"count":20,"type":21},[24],"Objectives: To compare the safety and efficacy of oral atenolol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during nasal surgeries.\n\nBackground: Mucosal bleeding is the most frequent complication with nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, increases operation time, and consequently increases blood loss. There are several pharmacological and non-pharmacological techniques for the appropriate control of intraoperative bleeding.\n\nPatients and Methods: This was a prospective, randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received oral atenolol, and group M, received oral metoprolol.",[127],"Hypotension Drug-Induced",[129,130,131,132],"atenolol","controlled hypotension","metoprolol","nasal surgery",{"date":91,"type":37},{"date":39,"type":37},{"date":94,"type":21},{"name":43,"class":44},""]