[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Damascus University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":287},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,47,70,97,125,158,186,215,240,263],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100641279","tissue-adhesive-versus-sutures-in-oral-biopsy-closure-100641279",false,"NCT07654166","Tissue Adhesive Versus Sutures in Oral Biopsy Closure","Comparison of Tissue Adhesive and Surgical Sutures for Wound Closure After Oral Excisional Biopsies: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n-Patients clinically diagnosed with oral fibroma located on the\n\nlabial mucosa (lip) or buccal mucosa (cheek).\n\n* Lesion requires excisional biopsy.\n* Lesion size greater than 3 mm and less than 3 cm in\n\ngreatest diameter.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women.\n* Patients taking anticoagulant medications (blood thinners).\n* Patients with infectious diseases such as hepatitis, HIV, etc.\n* Patients taking immunosuppressants.\n* Patients with uncontrolled diabetes mellitus.\n* Patients taking medications that affect bleeding and wound healing.","ALL","18 Years","80 Years",{"count":20,"type":21},28,"ESTIMATED","INTERVENTIONAL",[24],"NA","Excisional biopsies are commonly performed in the oral mucosa, and proper wound closure and hemostasis are critical for the success of the surgical procedure. Suturing remains the gold standard for closing surgical incisions; however, it has several drawbacks, including being time-consuming and requiring technical skill for proper placement. In addition, access to posterior areas of the oral cavity can be challenging. Suturing may also cause patient discomfort during needle penetration of tissues and can serve as a potential pathway for microbial contamination. Therefore, this randomized controlled clinical trial aims to evaluate one of the latest tissue adhesives from the cyanoacrylate group (PeriAcryl 90 HV) compared to conventional surgical sutures (Nylon 4-0) for wound closure following oral excisional biopsies. A total of 28 patients with oral fibroma will be randomly assigned to either the tissue adhesive group or the suture group (14 patients per group).",[27],"Mouth Neoplasms",[29,30,31,32,33],"PeriAcryl 90 HV","Oral fibroma","surgical sutures","excisional biopsy","tissue adhesive","RECRUITING","2026-06-16",{"date":37,"type":38},"2026-06-18","ACTUAL",{"date":40,"type":38},"2025-08-12",{"date":42,"type":21},"2027-12",{"name":44,"class":45},"Damascus University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":46},"100642259","comparison-of-the-efficacy-of-clobetasol-propionate-005-mouthwash-photobiomodulation-and-their-combination-in-managing-of-oral-lesions-in-patient-with-pemphigus-vulgaris-100642259","NCT07641725","Comparison of the Efficacy of Clobetasol Propionate 0.05% Mouthwash, Photobiomodulation, and Their Combination in Managing of Oral Lesions in Patient With Pemphigus Vulgaris.","Evaluation of the Effectiveness of Clobetasol Propionate 0.05% and Photobiomodulation in the Management of Oral Lesions in Patients With Pemphigus Vulgaris. (Three-arm Randomized Controlled Clinical Study)","Inclusion Criteria:\n\n1. Confirmed diagnosis of Pemphigus Vulgaris based on clinical presentation, histopathology, and immunopathological findings (positive direct and indirect immunofluorescence), according to World Health Organization (WHO) standards.\n2. Presence of active erosive or ulcerative oral lesions with a maximum diameter exceeding 1 cm.\n3. Patients currently maintained on a stable systemic corticosteroid regimen not exceeding 1 mg\u002Fkg\u002Fday.\n\nExclusion Criteria:\n\n1. Co-existing chronic systemic conditions, including significant gastrointestinal disorders or uncontrolled diabetes mellitus.\n2. History or current evidence of malignancy.\n3. Concurrent use of systemic antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), or hormonal therapies that may interfere with the study outcomes.\n4. Pregnancy or active lactation. Note: These criteria are strictly enforced to ensure that the study population remains homogeneous regarding the systemic treatment protocol.",{"count":55,"type":21},30,[24],"Pemphigus vulgaris (PV) is a chronic, potentially life-threatening autoimmune mucocutaneous disorder that significantly impairs patients' quality of life. While systemic corticosteroids and immunosuppressants remain the standard of care, many patients suffer from persistent, painful oral lesions that exhibit delayed healing or poor response to conventional systemic protocols. This clinical trial investigates the efficacy and safety of supportive topical interventions: clobetasol propionate 0.05% mouthwash and photobiomodulation therapy (PBMT)-a non-invasive approach designed to accelerate tissue repair, and their combination. The primary objective is to identify effective adjunctive topical therapies that can facilitate the healing of oral erosions, mitigate pain, and potentially allow for a reduction in systemic medication dosages, thereby minimizing long-term treatment-related complications and improving overall patient outcomes.",[59],"Oral Lesions in Patients With Pemphigus Vulgaris",[61],"Pemphigus vulgaris - Photobiomodulation - Clobetasol propionate - Autoimmune Blistering Diseases.","2026-06-08",{"date":64,"type":38},"2026-06-11",{"date":66,"type":38},"2025-11-01",{"date":68,"type":21},"2026-12-01",{"name":44,"class":45},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":46},"100638909","using-chin-bone-rings-for-sinus-lifting-and-dental-implants-in-one-surgery-100638909","NCT07619846","Using Chin Bone Rings for Sinus Lifting and Dental Implants in One Surgery","Evaluation of Effectiveness of Bone Ring Technique in One Stage Surgery of External Maxillary Sinus Lifting With Implantation: A Prospective Case Series","BRT-SINUS","Inclusion Criteria:\n\n* Need for dental implant in posterior maxilla (premolar\u002Fmolar).\n* Residual alveolar bone height ≤4 mm on preoperative CBCT.\n* Age ≥18 years.\n* Controlled systemic health.\n* Able to comply with procedures and follow up.\n* Good oral hygiene.\n* Signed written informed consent.\n\nExclusion Criteria:\n\n* Uncontrolled systemic disease.\n* Head\u002Fneck radiotherapy.\n* Bisphosphonate therapy \\>3 years.\n* Autoimmune disease affecting healing.\n* Pregnancy\u002Flactation.\n* Active maxillary sinus pathology (sinusitis, cysts, polyps, tumours).\n* Heavy smoking (\\>10 cigarettes\u002Fday).\n* Severe bruxism.","70 Years",{"count":5,"type":21},[24],"This study evaluates the Bone Ring Technique, a single stage procedure that combines external sinus floor elevation and dental implant placement using an autogenous bone ring harvested from the chin. Ten patients with residual alveolar bone height ≤4 mm in the posterior maxilla will be enrolled. Implant stability (ISQ), vertical bone gain, peri implant bone density, and implant survival will be assessed over 6 months. The aim is to reduce treatment time and surgical interventions compared to traditional two stage approaches.",[83],"Severe Alveolar Bone Atrophy of the Posterior Maxilla With Residual Bone Height ≤4 mm",[85,86,87],"Bone Ring Technique","Maxillary Sinus Floor Elevation","Dental Implant","NOT_YET_RECRUITING","2026-06-03",{"date":91,"type":38},"2026-06-04",{"date":93,"type":21},"2026-05-31",{"date":95,"type":21},"2027-03-21",{"name":44,"class":45},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":16,"minAge":105,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":110,"conditions":111,"keywords":114,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":46},"100643391","video-enhanced-tell-show-do-for-managing-dental-anxiety-in-children-100643391","NCT07632547","Video-Enhanced Tell-Show-Do for Managing Dental Anxiety in Children","Reinforcing the Tell-Show-Do Technique With a Simulated Real-mouth Video to Manage Dental Anxiety in Children During Dental Treatment (A Randomized Controlled Trial)","Inclusion Criteria:\n\n1. Children aged 4-6 years, with or without previous dental experience.\n2. Children with a positive behavior rating according to the Frankl scale.\n3. Children with primary molars requiring conservative dental treatment.\n\nExclusion Criteria:\n\n1. Children with systemic or mental disorders.\n2. Children who received sedative or analgesic medications within the 3 hours prior to the dental visit.",true,"4 Years","6 Years",{"count":108,"type":21},80,[24],"This study is the first of its kind to examine the effect of integrating the real oral environment with a video that supports the expressions used during the Tell-Show-Do technique (such as \"we will see the cavity,\" \"the cavity will drink juice to fall asleep,\" and \"we will clean the tooth from the cavity\"). This approach aims to enhance the Tell-Show-Do technique, build trust with the child, and reduce anxiety at the different stages of dental treatment in the clinical setting.",[112,113],"Distraction","Behavior Management",[115,116,117],"Dental anxiety","Video modeling \u002F Simulation","Tell-Show-Do technique","2026-06-02",{"date":62,"type":38},{"date":121,"type":38},"2026-04-01",{"date":123,"type":21},"2026-08-01",{"name":44,"class":45},{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":139,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":46},"100633859","comparison-between-liquid-fibrin-and-soft-laser-effects-on-healing-and-relapse-after-lip-repositioning-surgery-100633859","NCT07532161","Comparison Between Liquid Fibrin and Soft Laser Effects on Healing and Relapse After Lip Repositioning Surgery","Comparison Between The Effect of Liquid Platelet-Rich Fibrin and Low-Level Laser Therapy on Enhancing Healing and Reducing Relapse After Lip Repositioning Surgery","Inclusion Criteria:\n\n1. Patients of both genders.\n2. Patients presenting with a gummy smile in the maxillary anterior region (more than 3 mm) due to upper lip hypermobility.\n3. Age 18-50 years.\n4. Systemically healthy individuals, classified as ASA physical status I or II according to the American Society of Anesthesiologists (ASA) classification; that is, patients without systemic disease or with mild, well-controlled systemic conditions.\n5. Patients with good oral hygiene, defined as an O'Leary Plaque Index ≤ 40%.\n6. No previous lip repositioning surgery.\n\nExclusion Criteria:\n\n1. Pregnancy and lactation.\n2. Individuals with a previous history of receiving facial Botox or filler injections.\n3. Systemic diseases or conditions that contraindicate the use of local anesthesia.\n4. Any physical condition that impairs the ability to perform proper oral hygiene measures.\n5. Patients who are smokers or alcohol consumers.\n6. Inability or unwillingness to cooperate.\n7. In adequate width of attached gingiva.\n8. Vertical maxillary excess (moderate to severe) requiring orthognathic intervention.\n9. Short upper lip\n10. Gingival display primarily caused by altered passive eruption requiring crown lengthening.","50 Years",{"count":134,"type":21},22,[24],"A gummy smile can negatively affect a patient's self-confidence and satisfaction with their appearance, leading many individuals to seek effective esthetic solutions. The etiology of this condition varies and may include vertical maxillary excess, short upper lip, hyperactive upper lip, gingival enlargement, or altered passive eruption.\n\nLip Repositioning Surgery is one of the minimally invasive esthetic surgical procedures used to reduce the amount of gingival display during smiling. Despite its effectiveness, this surgery may be associated with challenges such as pain, swelling, delayed wound healing, and the possibility of postoperative relapse over time, which could compromise both esthetic and functional outcomes.\n\nTo overcome these challenges and enhance surgical outcomes, adjunctive techniques have been introduced to promote healing and determine whether enhancing the biological healing process can reduce the rate of relapse after LRS. Among the most prominent of these are Injectable Platelet-Rich Fibrin (i-PRF) and Low-Level Laser Therapy (LLLT).",[138],"Gummy Smile",[140,141,142,143,144,145,146,147,148,149],"Excessive gingival display","Gummy smile","Lip Repositioning Surgery","Injectable Platelet-Rich Fibrin (i-PRF)","Liquid Platelet-Rich Fibrin","Low-Level Laser Therapy (LLLT)","Wound healing","Postoperative relapse","Gingival display reduction","Esthetic dentistry","2026-04-24",{"date":152,"type":38},"2026-04-29",{"date":154,"type":38},"2026-04-20",{"date":156,"type":21},"2027-01-31",{"name":44,"class":45},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":22,"phases":167,"briefSummary":168,"conditions":169,"keywords":172,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":46},"100589199","efficacy-of-carbohydrate-loading-in-diabetic-type-2-patients-undergoing-cabg-surgery-on-cpb-100589199","NCT06951308","Efficacy of Carbohydrate Loading in Diabetic Type 2 Patients Undergoing CABG Surgery on CPB","CLDM-CABG","Inclusion Criteria:\n\nAll diabetic type 2 patients undergoing isolated on-pump coronary artery bypass surgery.\n\nExclusion Criteria:\n\n* Missing data.\n* Patients outside the study period.\n* Patients undergoing other cardiac surgeries.\n* Patients diagnosed with type 1 diabetes mellitus.",{"count":166,"type":21},50,[24],"Enhanced recovery after surgery protocols aim to optimize perioperative care and improve surgical outcomes. Preoperative carbohydrate loading has demonstrated benefits in reducing insulin resistance and improving patient outcomes. While non-diabetic patients benefit from this approach, its efficacy in diabetic type 2 patients undergoing CABG remains less understood. This study aims to address this gab by evaluating the physiological and clinical outcomes for carbohydrate loading in this specific population.",[170,171],"Heart Surgery","Ischemic Heart Disease",[173,174,175,176,177],"Enhanced recovery program","carbohydrate loading","coronary artery bypass grafting","heart surgery","postoperative recovery","2026-03-17",{"date":180,"type":38},"2026-03-19",{"date":182,"type":38},"2025-04-01",{"date":184,"type":21},"2026-12-31",{"name":44,"class":45},{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":16,"minAge":194,"maxAge":195,"enrollmentInfo":196,"targetDuration":4,"studyType":22,"phases":197,"briefSummary":198,"conditions":199,"keywords":202,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":46},"100620484","impact-of-different-cardioplegia-solutions-on-indicators-of-myocardial-injury-during-coronary-surgery-100620484","NCT07358221","Impact of Different Cardioplegia Solutions on Indicators of Myocardial Injury During Coronary Surgery","Impact of Different Cardioplegia Solutions on Extracellular Vesicles-derived miRNAs, Complement System, and Neutrophil Extracellular Traps (NETs) as Indicators of Myocardial Injury During Coronary Artery Bypass Surgery","Cardioplegia2","Inclusion Criteria:\n\n* All consecutive patients undergoing elective primary coronary artery bypass grafting will be enrolled in this study.\n\nExclusion Criteria:\n\n* Patients will be excluded from this study if they had suffered from previous myocardial infarction, had reduced ejection fraction or were undergoing combined or repeated surgery","40 Years","75 Years",{"count":55,"type":21},[24],"The aim of the present study is to investigate intra-operative changes in markers of myocardial injury during ischemia and reperfusion, comparing three methods of myocardial protection; St. Thomas' cold crystalloid cardioplegia, Calafiore warm blood cardioplegia, or modified del Nido cold blood cardioplegia in routine coronary artery bypass grafting procedures.",[200,201],"Coronary Artery Bypass Grafting (CABG) Surgery","Myocardial Protection",[203,204,205,206],"coronary surgery","cardioplegia","complement activation","myocardial injury","2026-01-14",{"date":209,"type":38},"2026-01-22",{"date":211,"type":21},"2026-02",{"date":213,"type":21},"2027-02",{"name":44,"class":45},{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":222,"targetDuration":223,"studyType":224,"phases":4,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":46},"100613915","cardiac-self-efficacy-in-patients-with-chronic-thromboembolic-pulmonary-hypertension-100613915","NCT07272798","Cardiac Self-Efficacy in Patients With Chronic Thromboembolic Pulmonary Hypertension","CTEPH3","Inclusion Criteria:\n\n* all patients undergoing pulmonary thromboendarterectomy for CTEPH\n* Able to read and understand the informed consent form and study questionnaires\n\nExclusion Criteria:\n\n* Patients undergoing Balloon Pulmonary Angioplasty (BPA) or receiving only medical therapy (as the focus is on the surgical cohort).\n* Emergency or salvage PEA procedures (to ensure stable baseline assessment).\n* Inability to complete the questionnaires due to severe cognitive impairment, psychiatric illness, or language barrier.",{"count":5,"type":21},"6 Months","OBSERVATIONAL","This study aims to analyze the effect of Pulmonary Endarterectomy (PEA) on patients' self-confidence in managing their chronic illness.\n\nPatients' confidence (or self-efficacy) will be measured using the following questionnaires: 10-item Perceived Efficacy in Patient-Physician Interaction Scale (PEPPI), Self-Efficacy for Managing Chronic Diseases 6-item Scale (SEMCD-6), Sullivan's cardiac self-efficacy scale 13-items (SCSES). The association between improved confidence and better physical results will be analyzed, such as being able to walk longer (6 mint walk test (6-Minute Walk Test)).\n\nUltimately, this study will help understanding the psychological side of recovery and might lead to better support programs to help patients feel more capable and live better lives after their operation.",[227],"Chronic Thromboembolic Pulmonary Hypertension",[229,230,231],"Chronic thromboembolic pulmonary hypertension","self efficacy","functional capacity","2025-12-09",{"date":234,"type":38},"2025-12-17",{"date":236,"type":38},"2025-11-20",{"date":238,"type":21},"2026-11-20",{"name":44,"class":45},{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":16,"minAge":247,"maxAge":18,"enrollmentInfo":248,"targetDuration":4,"studyType":22,"phases":250,"briefSummary":251,"conditions":252,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":46},"100554264","clinical-outcomes-of-biologically-oriented-preparation-technique-100554264","NCT06496828","Clinical Outcomes of Biologically Oriented Preparation Technique","Clinical Performance of All-Ceramic Crowns on Teeth Prepared With Biologically Oriented Preparation Technique Compared to Horizontal Preparation","Inclusion Criteria:\n\n* Patients older than 18.\n* Two teeth at least needed to be restored with full crowns (each patient needs at least two single crowns).\n* Stable occlusion.\n* Good oral hygiene.\n* Periodontally healthy teeth.\n* Nonsmoking or smoking less than ten cigarettes\u002Fday.\n* Probing depth between 1 and 3 mm.\n\nExclusion Criteria:\n\n* Patients younger than 18.\n* Parafunctional habits.\n* Active periodontal disease.\n* Poor oral hygiene.\n* Systemic disease that may affect the periodontal health.\n* Pregnancy.\n* Radiation or chemotherapy.\n* Treatment by Bisphosphonates medication.\n* Patients who are unable or unwilling to attend follow-up visits","19 Years",{"count":249,"type":21},60,[24],"This study aims to evaluate the periodontal response of teeth prepared with a biologically oriented preparation technique (BOPT) compared to conventional preparation for all-ceramic crowns.",[253,254],"Crowns","Tooth Preparation","2025-08-19",{"date":257,"type":38},"2025-08-21",{"date":259,"type":38},"2024-04-30",{"date":261,"type":21},"2027-12-30",{"name":44,"class":45},{"id":264,"slug":265,"hasResults":11,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":104,"sex":16,"minAge":17,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":22,"phases":272,"briefSummary":273,"conditions":274,"keywords":276,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":286,"locationsCount":46},"100580468","enhancing-soft-tissues-around-inserted-implants-by-two-different-methods-100580468","NCT06837688","Enhancing Soft Tissues Around Inserted Implants by Two Different Methods","Evaluation of Xenogeneic Collagen Matrix Versus Connective Tissue Graft to Enhance Soft Tissue Profile Around Single Dental Implants in the Aesthetic Zone","Inclusion Criteria:\n\n* Aged 18 years or older.\n* Good oral hygiene, defined as full-mouth plaque score ≤25%.\n* Having a single missing tooth in the aesthetic zone of the maxilla.\n* Tooth extraction occurred at least 3 months prior to enrolment.\n* Having adequate bone volume for implant placement (bucco-palatal bone dimension of at least 6 mm).\n* Having at least 5 mm of keratinized tissue width at the implant site.\n\nExclusion Criteria:\n\n* Systemic diseases.\n* Smoking.\n* Periodontal disease.\n* Untreated caries lesions.\n* Need for horizontal bone augmentation at the time of implant placement.","60 Years",{"count":55,"type":21},[24],"This randomized controlled clinical trial investigates the efficacy of xenogeneic collagen matrix (XCM) versus autogenous subepithelial connective tissue graft (SCTG) in enhancing the peri-implant soft tissue profile around single dental implants in the aesthetic zone of the anterior maxilla. Thirty adult patients with a single missing tooth, adequate bone volume, and sufficient keratinized tissue will be recruited at Damascus University. Each patient will undergo a fully digital workflow for implant planning-including CBCT imaging, intraoral scanning, and CAD\u002FCAM fabrication of a surgical guide and provisional restoration-to ensure precision in implant placement. Immediately following implant insertion, patients will be randomly allocated (1:1) to either receive a CTG harvested from the palatal mucosa using a single incision technique or an XCM (Mucoderm®, Botiss Biomaterials) that is adapted and secured to the buccal mucosa. The primary outcome is the increase in buccal soft tissue profile, measured via superimposed digital surface models at baseline, immediately postoperatively, and at 3 months. Secondary outcomes include patient-reported measures (pain, edema, aesthetic satisfaction), clinical parameters (keratinized tissue width, soft tissue height), peri-implant health assessments, and radiographic assessment. By comparing these two methods, the study aims to determine whether the less invasive XCM can offer outcomes comparable to the CTG standard while reducing donor site morbidity and overall surgical time.",[275],"Missing Teeth",[277,278,279],"Peri-implant soft tissue augmentation","Xenogeneic collagen matrix","Connective tissue graft","2025-03-03",{"date":282,"type":38},"2025-03-05",{"date":284,"type":38},"2025-03-01",{"date":184,"type":21},{"name":44,"class":45},""]