[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dan Bing\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":86},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100632576","manual-acupuncture-for-acute-primary-tinnitus-100632576",false,"NCT07515482","Manual Acupuncture for Acute Primary Tinnitus","Manual Acupuncture Versus Sham Acupuncture and Usual Care for Acute Primary Tinnitus: Multicentre, Randomized Clinical Trial","Inclusion Criteria:\n\n1. Aged 18-65 years, male or female;\n2. Primary complaint is persistent tinnitus (unilateral or bilateral);\n3. Meet the diagnostic criteria for primary tinnitus according to the 2014 Clinical Practice Guideline developed by the American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF);\n4. Had continuous tinnitus ≥2 weeks and \\\u003C6 months;\n5. Tinnitus should be bothersome, with a screening THI score 28-76;\n6. Acupuncture naive;\n7. Able to provide written informed consent.\n\nExclusion Criteria:\n\n1. Objective tinnitus;\n2. Pulsatile tinnitus;\n3. Diagnosed as secondary tinnitus as evaluated by audiologists and clinicians(Menière's disease, temporomandibular joint disorder or other diseases);\n4. Had evidence of conductive hearing loss (confirmed by abnormal otoscopy or tympanogram);\n5. Had contraindications for acupuncture, including curent pregnant, severe anemia, coagulation disorders, etc;\n6. Having difficulties in expressing their symptoms clearly( severe mental disorders or cognitive impairment);\n7. Currently suffering from other serious acute or chronic organic diseases, such as cerebrovascular, cardiovascular, liver, kidney, hematological diseases, infectious diseases, or malignant tumors;\n8. Has received intratympanic injection, postauricular injection, corticosteroids, or other medications for tinnitus treatment (includingTraditional Chinese Medicine or proprietary Chinese medicines) within the past 2 weeks or at baseline;\n9. Participated in other clinical trials, particularly those closely related to tinnitus treatment, such as sound therapy;\n10. have a strong desire for medication treatment.","ALL","18 Years","65 Years",{"count":20,"type":21},180,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical trial aims to assess the efficacy of manual acupuncture for patients with acute primary tinnitus.",[27],"Tinnitus",[27,29],"acupuncture","NOT_YET_RECRUITING","2026-06-10",{"date":33,"type":34},"2026-06-11","ACTUAL",{"date":36,"type":21},"2026-06-15",{"date":38,"type":21},"2027-12-12",{"name":40,"class":41},"Dan Bing","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":4},"100544197","genetic-feature-of-congenital-hearing-loss-in-chinese-population-100544197","NCT06365749","Genetic Feature of Congenital Hearing Loss in Chinese Population","Exome Sequencing Explored the Genetic Characteristics Congenital Hearing Loss in Chinese Population","Inclusion Criteria:\n\n* Age up to 6 months\n* Fail in the neonatal hearing screening programs, including oto-acoustic emissions and automated auditory brain stem response\n* Promise to complete the tests required at baseline and follow-ups by the legal representative\n* Informed consent by the legal representative\n\nExclusion Criteria:\n\n* Congenital infections related to acquired or congenital hearing loss, including rubella virus, cytomegalovirus, herpes simplex virus, rubella virus, toxoplasma gondii and treponema pallidum infections\n* Other explicit otologic conditions which could induce hearing loss, including cerumen, otitis media, congenital middle ear abnormalities, microtia and external ear abnormalities\n* A drug with ototoxicity usage during pregnancy\n* Other severe congenital anomalies","6 Months",{"count":52,"type":21},50,"OBSERVATIONAL","Congenital hearing loss, as well as hearing loss present at birth, is one of the most common chronic conditions in children, with a prevalence of permanent bilateral hearing loss of 2.83 per 1000 children of primary school age, which is mainly caused by genetic factors. The goal of this observational study is to learn about novel causative genes in infants with hearing loss in the Chinese population. The main problem it aims to deal with are:\n\n* to present the genetic characteristics of the infant with hearing loss in the Chinese population\n* to build up a prognostic model base on diverse data.\n\nParticipants will be asked to receive audiological tests and collection of the peripheral blood sample.",[56,57],"Congenital Hearing Loss","Congenital Deafness","2024-04-09",{"date":60,"type":34},"2024-04-15",{"date":62,"type":21},"2024-04-23",{"date":64,"type":21},"2026-11-23",{"name":40,"class":41},{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":16,"minAge":74,"maxAge":18,"enrollmentInfo":75,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":82,"startDateStruct":83,"completionDateStruct":84,"leadSponsor":85,"locationsCount":4},"100544199","multi-omics-characteristics-and-prognosis-of-idiopathic-sudden-sensorineural-hearing-loss-100544199","NCT06365775","Multi-omics Characteristics and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss","Multi-omics Characteristics and Prognosis in Patients With Idiopathic Sudden Sensorineural Hearing Loss","Inclusion Criteria:\n\n* Age ≥ 4\n* Participants with SSNHL: unilateral or bilateral sensorineural hearing loss of \\> 30 dB HL (decibel) involving at least 3 continuous test frequencies developing within 72 hours\n* Healthy controls: people with PTA thresholds of all test frequencies ≤ 20 dB HL and without otologic disease in the last 3 months\n* Completed informed consent and promised to finish follow-ups\n\nExclusion Criteria:\n\n* Hearing loss with explicit causes, including noise-induced, Ménière's disease, ototoxicity exposure, mumps infection or history of syphilis infection and so on.\n* A history of head trauma or otologic surgery.\n* Malformation of temporal bone discovered by computed tomography (CT)\n* Retro-cochlear lesion discovered by magnetic resonance imaging (MRI)\n* Pregnant women",true,"4 Years",{"count":76,"type":21},400,"The goal of this observational study is to describe the multi-omics characteristics and to learn about the prognostic factors in patients with idiopathic sudden sensorineural hearing loss (SSNHL). The main problems it aims to deal with are:\n\n* if there is a difference in data of exome and targeted sequencing among patients with SSNHL affecting bilateral and unilateral sides, and healthy controls\n* if there is a difference in the parameter of MRI among patients with SSNHL affecting bilateral and unilateral sides, and healthy controls\n* to find out which factor from multi-omics data relates to outcomes of SSNHL\n* to develop the best prognostics model based on the multi-omics data.\n\nParticipants will be received audiological tests, blood specimen collection and radiological examination. Researchers will explore the relationship between the multi-omics data and the prognosis and develop the predictive model.",[79,80,81],"Sudden Sensorineural Hearing Loss","Hearing Loss, Sensorineural","Hearing Loss, Sudden",{"date":60,"type":34},{"date":62,"type":21},{"date":64,"type":21},{"name":40,"class":41},""]