[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Danderyd Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":305},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,49,95,131,154,184,207,235,256,280],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100639665","virtual-reality-based-interventions-after-brain-injury-100639665",false,"NCT07586566","Virtual Reality Based Interventions After Brain Injury","The Effectiveness of Virtual Reality Based Interventions on Cognitive Function After Brain Injury","Inclusion Criteria:\n\nParticipants will be recruited from both the inpatient and outpatient units at the Department of Rehabilitation Medicine, Danderyd Hospital.\n\nInclusion criteria:\n\n1. Patients with acquired brain injury in need of multiprofessional rehabilitation admitted to the clinic are eligible if they\n2. are between 18 and 65 years;\n3. present with attention deficits and\n4. are deemed suitable for direct attention training by the rehabilitation team.\n\nExclusion Criteria:\n\n1. Epilepsy or suspected epilepsy;\n2. non-fluent in Swedish\n3. severe fatigue or\u002Fand cognitive dysfunction that makes participation difficult.","ALL","18 Years","65 Years",{"count":20,"type":21},15,"ESTIMATED","INTERVENTIONAL",[24],"NA","After a brain injury, cognitive impairments are common, affecting an individual's independence and quality of life. Although various training programs are used in rehabilitation, it remains unclear how effective they are in real-life settings. The project now being planned at CogTech, a technology-driven rehabilitation unit at Danderyd Hospital, aims to evaluate new methods that can enhance both training effectiveness and motivation.\n\nIn the project, the effect of game-based training in virtual reality (VR) on cognition will be evaluated. VR offers a more realistic and engaging environment, which may improve the transfer of training outcomes to everyday situations. In this feasibility study, ten patients at the clinic will receive VR-training at 15 occasions in addition to rehabilitation as usual.\n\nThe results may contribute to the development of more individualized rehabilitation, reduced treatment times, and improved quality of life for people with brain injury.",[27],"Acquired Brain Injury (Including Stroke)",[29,30,31,32,33,34,35],"cognition","rehabilitation","vr","virtual reality","ar","augmented reality","acquired brain injury","NOT_YET_RECRUITING","2026-05-08",{"date":39,"type":40},"2026-05-14","ACTUAL",{"date":42,"type":21},"2026-06-01",{"date":44,"type":21},"2028-07-31",{"name":46,"class":47},"Danderyd Hospital","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":77,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":48},"100629594","expanded-studies-on-the-scapis-stockholm-reexamination-cohort-100629594","NCT07476703","Expanded Studies on the SCAPIS Stockholm Reexamination Cohort","Expanded Studies of Risk Factors for Pulmonary-, Liver-, and Cardiovascular Disease in the SCAPIS 2 Stockholm Reexamination","SCAPIS-ReEx","Inclusion Criteria: Subjects already included in the main \u002F general SCAPIS reexamination study in Stockholm.\n\nExclusion Criteria: Inability to provide consent.",true,"56 Years","74 Years",{"count":61,"type":21},1400,"OBSERVATIONAL","The Swedish CArdioPulmonary bioImage Study (SCAPIS) is a unique, large-scale national research initiative involving 30,000 randomly selected individuals aged 50-64, recruited between 2014 and 2018. The study is a collaborative effort among six university hospitals across Sweden. A follow-up study, SCAPIS 2, is conducted for half of the original participants. In Stockholm, 2,500 individuals will be re-examined at Danderyd University Hospital and Karolinska Institutet.\n\nSCAPIS 2 includes a core set of examinations involving blood sampling, questionnaires, and imaging. In addition to these, complementary local investigations are conducted to enable more detailed research questions. This protocol describes the additional studies conducted in the Stockholm cohort. All complementary assessments aim to identify risk factors for current and future lung, liver, and cardiovascular diseases.:\n\nEXTENDED SAMPLING: Saliva and Blood Samples with Blood Cell Isolation. EXTENDED QUESTIONNAIRES: Dyspnea, Sleep, Respiratory Infections, and Dental Health.\n\nEXTENDED IMAGING AND PHYSIOLOGICAL MEASUREMENTS Cardiac Ultrasound and Abdominal Aortic Measurements. Liver Elastography. Vascular Stiffness by cuff-based pulse wave analysis and Photoplethysmography (PPG). Valvular and Vascular Calcification by CT imaging.",[65,66,67,68,69,70,71,72,73,74,75,76],"Coronary Artery Disease","Arterial Stiffness, Blood Pressure","AORTIC VALVE DISEASES","Mitral Valve Stenosis and\u002For Insufficiency","Heart Failure","Pulmonary Disease, Chronic Obstructive (COPD)","Steatohepatitis","Inflammation Biomarkers","Lipid Profile","Oral Microbiota","MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease","Metabolic Associated-dysfunction Steatohepatitis (MASH)",[78,79,80,81,82,83,84,85],"coronary artery disease","arterial stiffness","MASLD","COPD","inflammation","dyslipidemia","aortic aneurysm","oral microbiota","RECRUITING","2026-03-12",{"date":89,"type":40},"2026-03-17",{"date":91,"type":40},"2024-04-08",{"date":93,"type":21},"2026-08-30",{"name":46,"class":47},{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":105,"briefSummary":106,"conditions":107,"keywords":113,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":48},"100598573","effects-of-intermitted-theta-burst-stimulation-itbs-on-motor-recovery-of-upper-extremity-in-chronic-stroke-patients-100598573","NCT07073248","Effects of Intermitted Theta Burst Stimulation (iTBS) on Motor Recovery of Upper Extremity in Chronic Stroke Patients","Neuroplastic Changes and Effects of Intermittent Theta Burst Stimulation (iTBS) on Motor Recovery of Upper and Lower Extremity in Chronic Stroke Patients","NIMBLE","Inclusion Criteria:\n\n* Age over 18\n* Chronic stroke (\\>6 months)\n* Residual hemiparesis FM-UE\\>17\n\nExclusion Criteria:\n\n* Metal implants\n* Epilepsy\u002Fseizures\n* Pregnancy\n* Claustrophobia (related to MRIs exams)\n* Severe cognitive impairment\n* Untreated or unstable depression\u002Fanxiety\n* Other disabilities prohibiting intensive physical training",{"count":104,"type":21},48,[24],"This study aims to evaluate the effects and clinical feasibility of non-invasive brain stimulation protocols, specifically intermittent Theta Burst Stimulation, as part of rehabilitation interventions for motor recovery of upper extremity in the chronic phase after stroke.\n\nIt also seeks to explore the underlying mechanisms by investigating changes of functional and structural brain networks.",[108,109,110,111,112],"Stroke","Hemiplegia","Hemiparesis After Stroke","Hand Functionality","Chronic Stroke Patients",[114,115,116,117,118,119,120,121,122],"stroke","iTBS","TMS","Motor cortex","chronic stroke patients","hand dexterity","Hemiparesis","Transcrania Magnetic Stimulation","intermittent Theta Burst Stimulation","2025-11-20",{"date":125,"type":40},"2025-11-21",{"date":127,"type":21},"2025-11",{"date":129,"type":21},"2030-12",{"name":46,"class":47},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":100,"acronym":101,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":152,"leadSponsor":153,"locationsCount":48},"100598572","effects-of-intermittent-theta-burst-stimulation-itbs-on-motor-recovery-of-lower-extremity-in-chronic-stroke-patients-100598572","NCT07073235","Effects of Intermittent Theta Burst Stimulation (iTBS) on Motor Recovery of Lower Extremity in Chronic Stroke Patients","Inclusion Criteria:\n\n* Age over 18\n* Chronic stroke (\\>6 months)\n* Residual hemiparesis FAC ≥3\n\nExclusion Criteria:\n\n* Metal implants\n* Epilepsy\u002Fseizures\n* Pregnancy\n* Claustrophobia (related to MRIs exams)\n* Severe cognitive impairment\n* Untreated or unstable depression\u002Fanxiety\n* Other disabilities prohibiting intensive physical training",{"count":138,"type":21},56,[24],"This study aims to evaluate the effects and clinical feasibility of non-invasive brain stimulation protocols, specifically intermittent Theta Burst Stimulation, as part of rehabilitation interventions for motor recovery of lower extremity in the chronic phase after stroke.\n\nIt also seeks to explore the underlying mechanisms by investigating changes of functional and structural brain networks.",[108,110,112,109,142],"Ambulatory Difficulty",[114,115,116,144,145,146,147,148,120,122],"Trancranial Magnetic Stimulation","Cerebellum","Chronic stroke patients","Balance","Walking",{"date":150,"type":40},"2025-11-25",{"date":127,"type":21},{"date":129,"type":21},{"name":46,"class":47},{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":163,"conditions":164,"keywords":169,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":183},"100576395","community---the-covid-19-immunity-study-100576395","NCT06784739","COMMUNITY - the COVID-19 Immunity Study","COMMUNITY","Inclusion Criteria:\n\n* Health care workers: Employment at Danderyd hospital at time of enrollment\n* COVID-19 patients: Admitted to Danderyd Hospital with confirmed SARS-CoV-2 infection at time of enrollment\n\nExclusion Criteria:\n\n* No exclusion criteria",{"count":162,"type":21},5500,"The principal aim of the COMMUNITY study is to investigate immune responses following SARS-CoV-2 infection and\u002For vaccination in healthcare workers and hospitalized COVID-19 patients. The study aims to enroll a total of 5,000 healthcare workers and 500 COVID-19 patients. All participants are enrolled at Danderyd Hospital in Stockholm, Sweden. Participants will be followed every four months with blood and mucosal sampling in addition to demographic and clinical data provided by the participants and from national registries.\n\nPrimary outcome:\n\n\\- Antibody responses in blood and mucosa following SARS-CoV-2 infection and\u002For vaccination\n\nSecondary outcomes:\n\n* Cellular immune responses following SARS-CoV-2 infection and\u002For vaccination\n* Antibody responses in blood and mucosa following following Influenza A\u002FB infection and\u002For vaccination\n* Antibody responses in blood and mucosa following following RSV A\u002FB infection\n\nBlood and mucosal samples are collected every 4 months and at tighter intervals in sub studies. PCR testing is conducted upon symptoms of respiratory infections and with regular intervals regardless of symptomatology in sub studies. Participants provide detailed demographic and clinical data through a smart phone application-based questionnaire. Data on infection and vaccination history is collected from national registries",[165,166,167,168],"COVID 19","Respiratory Synctial Virus","Influenza Virus","SARS-CoV-2 Virus",[170,171,172,173,174],"COVID-19","Mucosal immunity","Pandemic","Vaccination","Secretory IgA","2025-01-16",{"date":177,"type":40},"2025-01-20",{"date":179,"type":40},"2020-04-15",{"date":181,"type":21},"2027-04",{"name":46,"class":47},2,{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":188,"acronym":4,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":16,"minAge":190,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":22,"phases":194,"briefSummary":195,"conditions":196,"keywords":4,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":183},"100537259","strokestop-iii---optimized-method-for-atrial-fibrillation-screening-100537259","NCT06275503","STROKESTOP III - Optimized Method for Atrial Fibrillation Screening","Inclusion Criteria:\n\n* Individuals aged 75\u002F76 in 2024 (born 1948, 1949)\n* Must reside in the region of Värmland\n* Must be listed at a primary care facility\n\nExclusion Criteria:\n\n* Treatment with oral anti coagulation treatment (OAC)\n* Contraindications for OAC treatment\n* Prior atrial fibrillation\n* Unable to provide consent","75 Years","76 Years",{"count":193,"type":21},2200,[24],"Atrial fibrillation is the most common sustained cardiac arrhythmia affecting more than 3% of the adult population. The symptoms of atrial fibrillation can range from asymptomatic to debilitating. It can be permanent in its nature, but also paroxysmal with only short bursts of atrial fibrillation randomly occurring and can therefore remain unnoticed. Atrial fibrillation increases the risk of stroke five fold if left untreated.\n\nScreening for atrial fibrillation in elderly populations above age 65 years can result in detection of new atrial fibrillation cases ranging from 0,5% new AF with a single time-point ECG, up to 30% AF if an implantable loop recorder is inserted for 3 years.\n\nCurrently opportunistic screening using pulse palpation, or a single time-point ECG is recommended by the European Society of Cardiology guidelines. Systematic screening in individuals aged 75 or above, or at a high stroke risk should be considered.\n\nOverall, participation in systematic atrial fibrillation screening trials has been shown to be relatively low with almost 50% non-participants. Participants are generally healthier, with higher socioeconomic status, hence the ones who would potentially benefit the most remain absent.\n\nOpportunistic screening has shown promising results with higher participation rates and the possibility of better outreach. There is a lack of data from randomized trials on the difference in participation rates in systematic and opportunistic screening approaches when screening with prolonged ECG monitoring.",[197,198],"Atrial Fibrillation","Atrial Fibrillation New Onset","2024-05-03",{"date":201,"type":40},"2024-05-06",{"date":203,"type":40},"2024-05-02",{"date":205,"type":21},"2026-06-30",{"name":46,"class":47},{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":215,"targetDuration":4,"studyType":22,"phases":217,"briefSummary":218,"conditions":219,"keywords":223,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":48},"100546015","robotic-assisted-versus-conventional-knee-endoprosthetic-techniques-100546015","NCT06389435","RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques","ROCKETS: RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques in a Randomized, Multicenter, Preference-tolerant Study","ROCKETS","Inclusion Criteria:\n\n* Adults aged 18 years and older.\n* Eligible for TKR according to local guidelines and routines.\n* Willingness to participate in the study.\n\nExclusion Criteria:\n\n* Patients with extreme malalignment necessitating special implants or techniques.\n* Patients unfit for surgery due to other medical reasons.\n* Patients who, for other reason such as alcohol or substance abuse, is deemed unsuitable to participate in the study.\n* Patients who, for other reasons can't fulfill the required patient recorded outcome measures",{"count":216,"type":21},250,[24],"Rationale for conducting the study:\n\nThe study aims to systematically evaluate the clinical and economic impacts of Robotic-Assisted Total Knee Replacement (RTKR) compared to conventional Total Knee Replacement (TKR). It focuses on the potential benefits of RTKR, including improved precision in surgery, potentially leading to better patient outcomes and reduced healthcare costs. Our primary endpoint is the Forgotten Joint Score (FJS), aimed at measuring patients awareness of their knee joint in everyday life, indicating the success of the knee replacement surgery in restoring natural joint function. Secondary endpoints include patient-reported outcome measures (PROMs), patient activity levels, the accuracy of implant positioning on x-ray, and the incidence of adverse events.\n\nStudy design:\n\nMulticentre,, preference-tolerant, randomized, controlled, superiority trial with two treatment arms that compares the outcomes of RTKR with traditional TKR techniques.\n\nStudy population:\n\nAdult patients aged 18 years and older who are eligible for TKR as per local guidelines and who have given informed consent to participate in the study.\n\nNumber of patients:\n\n400\n\nInclusion criteria:\n\nPatients must be adults aged 18 years and older, eligible for TKR according to local guidelines, and willing to participate in the study.\n\nExclusion criteria:\n\nPatients with extreme malalignment requiring special implants or techniques, patients unfit for surgery due to medical reasons, and those deemed unsuitable to participate in the study for other reasons.\n\nPrimary outcome variables:\n\nThe Forgotten Joint Score (FJS) at 2 years after surgery",[220,221,222],"Knee Arthroplasty, Total","Robotic-assisted","Osteoarthritis of the Knee",[224,225,226],"Knee arthroplasty","Robotic assisted","Osteoartritis","2024-04-26",{"date":229,"type":40},"2024-04-29",{"date":231,"type":40},"2024-03-04",{"date":233,"type":21},"2028-01",{"name":46,"class":47},{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":244,"conditions":245,"keywords":4,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":48},"100543390","medeca---markers-in-early-detection-of-cancer-100543390","NCT06355245","MEDECA - Markers in Early Detection of Cancer","MEDECA","Inclusion Criteria:\n\n\\- Age above 18 years\n\nOne or more of the following symptoms\u002Fclinical signs:\n\n* General malaise\n* Severe tiredness\n* Unintentional weight loss\n* Fever of unknown cause\n* Uncharacteristic pain for \\>4 weeks\n* Abnormal laboratory tests (e.g., anemia, elevated alkaline phosphatase levels, erythrocyte sedimentation rate (ESR), calcium etc.)\n* Diffuse pain without explanation\n* Marked increase in drug usage\n* Increasing health service seeking behavior\n* Radiological findings suggestive of metastasis without known primary tumor or suspicion\n\nExclusion Criteria:\n\n* Unwillingness to participate in the study\n* Age below 18 years",{"count":243,"type":21},1500,"Early diagnosis of cancer is key for improving patient outcomes, but cancers are difficult to diagnose if patients present with unspecific symptoms. The principal objective of the MEDECA (Markers in Early Detection of Cancer) study is to identify a multi-analyte blood test that can detect and map occult cancer within a mixed population of patients presenting with serious but unspecific symptoms. The study will include 1500 patients referred to the Diagnostic Center at Danderyd Hospital (DC DS), a multidisciplinary diagnostic center referral pathway for patients with radiological findings suggestive of metastasis without known primary tumor or suspicion of serious but unspecific symptoms. Blood samples are collected prior to a standardized and extensive cancer diagnostic work-up, including an expanded panel of biochemical analyses and extensive imaging such as computed tomography or magnetic resonance investigations. In collaboration with world-leading international scientists, the blood samples will be analyzed for a panel of novel and established blood biomarkers predictive of an underlying cancer, including markers of neutrophil extracellular traps, circulating tumor DNA, platelet mRNA profiling, affinity-based proteomics and nuclear magnetic resonance metabolomics. The diagnostic accuracy of the blood biomarkers with respect to cancer detection during the diagnostic work-up will be analyzed through machine learning.",[246,247],"Cancer","Diagnosis","2024-04-03",{"date":250,"type":40},"2024-04-09",{"date":252,"type":40},"2018-03-01",{"date":254,"type":21},"2026-12",{"name":46,"class":47},{"id":257,"slug":258,"hasResults":11,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":262,"eligibilityCriteria":263,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":22,"phases":267,"briefSummary":268,"conditions":269,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":4},"100542690","impact-of-bariatric-surgery-on-heart-disease-compared-to-standard-care-100542690","NCT06346145","Impact of Bariatric Surgery on Heart Disease Compared to Standard Care","A Randomized Controlled Trial Comparing Metabolic Surgery to Standard Care in Patients With Severe Obesity and Established Cardiovascular Disease","MIMS","Inclusion Criteria:\n\n* MI (as defined by the universal definition of MI) at least 1 year before inclusion.\n* BMI ≥35 kg\u002Fm2\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Any condition that may influence the patient's ability to comply with study protocol.\n* Earlier MBS or operation for gastric or duodenal ulcer or reflux disease\n* Other condition that makes patient not suitable for MBS according to responsible surgeon and anesthesiologist\n* Unable to understand Swedish.","70 Years",{"count":266,"type":21},500,[24],"Obesity is associated with type 2 diabetes (T2D) and cardiovascular disease (CVD). Metabolic and bariatric surgery (MBS) has in several randomized controlled trials (RCT) been shown to be superior to best medical therapy in the treatment of T2D. In the area of CVD, RCT after MBS are lacking. It was recently demonstrated in a cohort study that MBS in patients with severe obesity and a previous myocardial infarction (MI) was associated with a 50% reduction in the risk of death and new MI. The aim of this proposal is to confirm this in a nationwide RCT. Using the nationwide SWEDEHEART database patients with severe obesity and a previous MI will be identified. They will be contacted and offered participation. After informed consent the patients will be randomized to MBS or optimized care (including visit with a cardiologist and optimization of secondary preventive measures and referral to dietician\u002Fphysiotherapist). The primary outcome measure is a major cardiovascular adverse event (MACE). Secondary outcome measures include mortality, new MI, stroke, heart failure and atrial fibrillation. Tertiary outcome measures include health related quality of life and surgical complications. Patients will be followed in the nationwide metabolic surgery register SOReg, the national inpatient register, national cause of death register, the Swedish prescribed drug register, and the Swedish population register. If positive results these can be included in guidelines for MBS.",[270,271,272],"Obesity, Morbid","Bariatric Surgery Candidate","Heart Diseases","2024-03-28",{"date":248,"type":40},{"date":276,"type":21},"2024-05-01",{"date":278,"type":21},"2030-05-01",{"name":46,"class":47},{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":288,"conditions":289,"keywords":291,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":183},"100345732","identification-of-novel-biomarkers-to-aid-in-the-detection-of-occult-cancer-in-patients-with-venous-thromboembolism-100345732","NCT03781531","Identification of Novel Biomarkers to Aid in the Detection of Occult Cancer in Patients With Venous Thromboembolism","Inclusion Criteria:\n\n* Venous thromboembolism (thrombosis in the deep venous system of upper or lower extremities or iliac veins and\u002For pulmonary embolism) as detected by ultrasonography, phlebography, computer tomography, or angiography;\n* \\> 18 years or older;\n* Written informed consent\n\nExclusion Criteria:\n\n* \\> 2 days after VTE diagnosis;\n* No blood withdrawal at baseline",{"count":287,"type":21},1000,"Venous thromboembolism is a common and serious complication in cancer, and is associated with a substantially increased morbidity and mortality. Furthermore, VTE may be the earliest sign of cancer. Recent studies, however, fail to show a clinical benefit of extended cancer screening in this patient population. Better risk prediction models are therefore warranted to identify VTE patients who would benefit from a rapid and extensive cancer screening. Inflammation and hypercoagulability are considered hallmarks of cancer, and emerging light is being shed on the potential of various markers of inflammation and coagulation in cancer diagnostics and prognostics. Among the inflammatory and thrombotic processes linked to cancer is the neutrophil release of web-like nuclear chromatin (DNA and histones), referred to as neutrophil extracellular traps (NETs). Driven by the tumor environment, NETs have recently been shown to play a central role in tumor progression, metastasis, and tumor-associated thrombosis.\n\nThe investigators hypothesize that an enhanced inflammatory state may be predictive of an underlying cancer in patients presenting with VTE. The present study is an ongoing prospective study with the primary aim to investigate the diagnostic potential of markers of inflammation, including markers of NETs, in detecting occult cancer in patients presenting with VTE. Secondary aims are to include other biomarkers of cancer, and to assess whether any or a combination of these biomarkers may be prognostic of occult cancer, recurrent thrombotic events, mortality, or cancer disease progression in VTE patients with an underlying malignancy.",[246,290],"Venous Thromboembolism",[292,293,294,295,296],"Occult cancer","Venous thromboembolism","Biomarkers","Early diagnosis","Neutrophil extracellular traps","2018-12-18",{"date":299,"type":40},"2018-12-20",{"date":301,"type":40},"2017-03-01",{"date":303,"type":21},"2028-12-31",{"name":46,"class":47},""]