[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Daniel A Tonetti, MD\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100620740","phase-2-localized-injection-of-lidocaine-via-the-middle-meningeal-artery-for-intractable-headache-treatment-100620740",false,"NCT07361549","Localized Injection of Lidocaine Via the Middle Meningeal Artery for Intractable Headache Treatment","Localized Injection of Lidocaine Via the Middle Meningeal Artery for Intractable Headache Treatment: A Randomized, Double-Blinded, Parallel Phase 2 Clinical Trial","LIGHT 2","Inclusion Criteria:\n\n* Age 18 years or above\n* Referred for diagnostic angiography\n* Diagnosis of intractable migraine\n* Written informed consent able to be obtained from subject\n\nExclusion Criteria:\n\n* Baseline HIT-6 score less than 60 (severe)\n* Pregnant, breastfeeding, or unwilling to practice contraception during participation in the study\n* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data\n* Concomitant intracranial pathology (eg, intracranial malignancy)\n* Known hypersensitivity and\u002For contraindication to lidocaine or local anesthetics of the amide type\n* Taking chronic medications that, when co-administered with lidocaine and other local anesthetics, are at increased risk of developing methemoglobinemia (nitrates\u002Fnitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, acetaminophen, metoclopramide, quinine, sulfasalazine)\n* Known contraindications for angiography (eg, ESRD not requiring hemodialysis). Patients with contrast allergy with be premeditated with diphenhydramine and steroids.\n* Contraindication to anesthetic agents used for conscious sedation\u002Fmonitored anesthesia care (MAC)\n* Concurrent participation in another research protocol for investigation of an experimental therapy\n* Per DSA imaging, presence of a cerebrovascular pathology known to cause headache (eg, arteriovenous malformation, dural arteriovenous fistula)\n* Per DSA imaging, presence of anastomosis or anatomical variation (eg, branches of middle meningeal artery) that could lead to increased procedural risk\n* Per DSA imaging, lack of endovascular access to either middle meningeal artery, or origin of the middle meningeal artery other than from the external carotid artery\n* Known or suspected inability to adhere to study protocol or protocol requirements, as per discretion of the Investigator or treating provider","ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)",[27,28],"Refractory Migraine","Headache",[30,31,32,33],"headache","migraine","lidocaine","middle meningeal artery","NOT_YET_RECRUITING","2026-01-21",{"date":37,"type":38},"2026-01-23","ACTUAL",{"date":40,"type":21},"2026-03",{"date":42,"type":21},"2031-07",{"name":44,"class":45},"Daniel A Tonetti, MD","OTHER",""]