[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"David Krpata\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":66},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100514148","mesh-vs-pledgets-for-repair-of-paraesophageal-hernia-100514148",false,"NCT05974722","Mesh Vs Pledgets for Repair of Paraesophageal Hernia","A Randomized, Blinded, Parallel-group Trial Evaluating Mesh Versus Pledgeted Sutures in Paraesophageal Hernia Recurrence","Inclusion Criteria:\n\n* 18 years of age or older\n* Willing and able to provide informed consent\n* Willing and able to participate in long-term follow up including study visits and surveys\n* Type II, III, or IV hiatal hernia \\> 5 cm, confirmed via upper GI studies, CT, or MRI 5 cm or greater hernia confirmed intraoperatively\n\nExclusion Criteria:\n\n* Pregnancy\n* BMI \\>45\n* Allergy to any components of mesh\n* Patients undergoing PEHR with a concurrent bariatric procedure or other procedure to reduce stomach volume (sleeve gastrectomy, roux-en-y gastric bypass, duodenal switch, single-anastomosis gastric bypass, and partial or total gastrectomy)\n* Patients who have undergone previous hiatal hernia repair","ALL","18 Years",{"count":19,"type":20},164,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at the Cleveland Clinic. The main questions it aims to answer are:\n\n* Determine whether there is a difference in 2-year rates of radiographic recurrence with Ovitex versus pledgeted sutures in paraesophageal hernia repair.\n* Assess patient quality of life (QOL) after paraesophageal hernia repair with pledgets and mesh. A two-tailed research hypothesis will be used to determine whether there are differences between the two arms",[26,27],"Paraesophageal Hernia","GERD","RECRUITING","2025-10-02",{"date":31,"type":32},"2025-10-07","ACTUAL",{"date":34,"type":32},"2023-09-11",{"date":36,"type":20},"2028-12",{"name":38,"class":39},"David Krpata","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":40},"100476492","mesh-removal-versus-no-mesh-removal-for-chronic-groin-pain-after-inguinal-hernia-repair-100476492","NCT05484635","Mesh Removal Versus No Mesh Removal for Chronic Groin Pain After Inguinal Hernia Repair","Mesh Removal Versus No Mesh Removal for Chronic Groin Pain After Minimally Invasive Inguinal Hernia Repair: A Randomized Controlled Trial","Inclusion Criteria:\n\n* \\> 18 years of age\n* CPIP lasting \\> 6 months after laparoscopic or robotic inguinal hernia repair with pre-peritoneal mesh\n* Must exhibit 1 or more of the following characteristics of nociceptive pain:\n\nHistory:\n\n* Pain while sitting in a chair for prolonged periods of time with relief when extending the hip or lying supine to straighten the leg\n* Severe pain when crossing the affected leg over the contralateral leg\n* \"Foreign body sensation\" or \"tightness\" in the groin\n\nExam:\n\n-Diffuse tenderness with deep palpation along the inguinal ligament (over the mesh)\n\nSomatosensory mapping:\n\n* Does not have a maximum trigger point for pain\n* Lacks characteristics of neuropathic pain (sharp, burning, shooting, paresthesias, allodynia, hyperalgesia, etc.)\n\n  * Moderate to severe pain \\[4-10\\] when moving from supine to standing on NRS\n\nExclusion Criteria:\n\n* No characteristics of nociceptive groin pain\n* Zero or mild pain \\[0-3\\] when moving from supine to standing on NRS\n* Recurrent inguinal hernia detected on clinical exam\n* Large, femoral, direct or indirect inguinal hernia (F2-3, M2-3, L2-3) on diagnostic laparoscopy as defined by European Hernia Society (EHS) classification\n* Prior open (anterior) approach to inguinal hernia repair (i.e. Lichtenstein)\n* Prior mesh plugs or Prolene Hernia Systems\n* History of prostatectomy or vascular procedures in the pelvis or groin",true,{"count":50,"type":20},70,[23],"This study is evaluating the management of chronic post-operative inguinal hernia pain and the impact of hernia mesh removal after previous minimally invasive inguinal hernia repairs.\n\nThe study aims are to evaluate the change in chronic (\\>6 months), nociceptive, postoperative inguinal pain after mesh removal compared to no mesh removal in patients who have previously undergone minimally invasive inguinal hernia repair with pre-peritoneal mesh.",[54,55],"Chronic Groin Pain","Hernia, Inguinal",[57,55,58],"Chronic groin pain","Chronic pain groin",{"date":60,"type":32},"2025-10-06",{"date":62,"type":32},"2022-07-25",{"date":64,"type":20},"2028-07-01",{"name":38,"class":39},""]