[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dentsply Sirona Implants and Consumables\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":85},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,62],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100642378","clinical-performance-of-ah-plus-jet-root-canal-sealers-in-single-cone-protocols-100642378",false,"NCT07642284","Clinical Performance of AH Plus Jet® Root Canal Sealers in Single-cone Protocols","A Prospective, Parallel-group, Randomized Clinical Investigation Evaluating Performance and Safety of the AH Plus Jet® Sealing Materials Used in Single-cone Technique for Single Visit Endodontic Treatment. A 2-year Follow-up Study","Inclusion Criteria:\n\n1. Adult aged 18-75 at time of informed consent.\n2. Subject willing to participate in the clinical investigation and able to understand the content of the clinical investigation.\n3. Subject willing to return for follow-up visits.\n4. Subject has signed and dated the informed consent form.\n5. Subject in need of one or two primary root canal treatment on mature permanent anterior (incisor or canine) or premolar tooth.\n6. Planned study tooth has a favorable prognosis for the next 2 years.\n\nExclusion Criteria:\n\n1. History of allergic reaction to epoxy resins or amines or any of the other product components.\n2. Subject has significant systemic health issues or chronic conditions (American Society of Anesthesiologists (ASA) class 3-6).\n3. Known pregnancy or is breastfeeding at time of enrolment or at the RCT visit.\n4. Subject unlikely to comply with investigational procedures, as judged by the Investigator.\n5. Sign of sinus tract or gingival swelling in the planned study position.\n6. Previous enrolment in the present clinical investigation.\n7. Involvement in the planning and conduct of the clinical investigation (applies to both Dentsply Sirona personnel and the clinical investigation site).\n8. Participation in another clinical investigation that may interfere with the present clinical investigation.\n9. Subject experiencing an intraoperative condition that may interfere with the evaluation of the investigational root canal sealer.","ALL","18 Years","75 Years",{"count":20,"type":21},130,"ESTIMATED","INTERVENTIONAL",[24],"NA","A prospective, parallel-group, randomised, post-market clinical follow-up investigation evaluating the performance and safety of the modified formula of the AH Plus Jet® Endodontic Sealer (also referred to as ES) and the predicate AH Plus Jet® Root Canal Sealing material (also referred to as RCS). Around 150 teeth will be randomly assigned to receive either ES or RCS root canal treatment using the single-cone technique. A maximum of 2 teeth per participant will be included and \"tooth\" will be considered the statistical unit and hence considered independent even if the teeth are in the same participant. Participants will be followed up for a period of 24 months to assess the outcomes.",[27],"Root Canal Treatment","NOT_YET_RECRUITING","2026-06-15",{"date":31,"type":32},"2026-06-16","ACTUAL",{"date":34,"type":21},"2026-05-30",{"date":36,"type":21},"2029-03-30",{"name":38,"class":39},"Dentsply Sirona Implants and Consumables","INDUSTRY",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":59,"leadSponsor":61,"locationsCount":40},"100642830","clinical-outcomes-of-3d-printed-and-milled-complete-dentures-100642830","NCT07586774","Clinical Outcomes of 3D Printed and Milled Complete Dentures","An Open, Single-center, Prospective, Randomized, Two-armed, Interventional, Post-market Clinical Investigation of 3D Printed Complete Dentures and Milled Complete Dentures During a 5-year Follow-up Period","Inclusion Criteria:\n\n* Adult aged 18 years or above at time of informed consent.\n* Subject willing to participate in the clinical investigation and able to understand the content of the clinical investigation.\n* Subject willing to comply with investigational related procedures and to return for follow-up visits for a period of 5 years.\n* Subject has signed and dated the informed consent form.\n* Subjects in need of complete dentures in maxilla and mandible.\n* Prosthodontic Diagnostic Index (PDI) Completely edentulous classification (Class 1-3).\n* History of edentulism of at least 1 year.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to any of the components.\n* Subjects with significant systemic health issues or chronic conditions (American Society of Anesthesiologists (ASA) class 3-6 ).\n* Known pregnancy at time of enrolment.\n* Subjects unlikely to comply with investigational procedures, or unlikely to come back for follow-up visits, as judged by the Investigator.\n* Previous enrolment in the present clinical investigation.\n* Involvement in the planning and conduct of the clinical investigation (applies to both Dentsply Sirona personnel and the clinical investigation site).\n* PDI Completely edentulous classification (Class 4)\n\n  * Presence of severely atrophied ridge.\n  * Presence of severe ridge undercuts.\n  * Clinically severe Xerostomia.\n  * Absence of hard or soft tissue pathology that precludes denture therapy.\n  * Maxillofacial defects.\n* Uncontrolled pathological process in the oral cavity, as judged by the Investigator.\n* Participation in another clinical investigation that may interfere with the present clinical investigation.",{"count":49,"type":21},68,[24],"This is a two-armed, single-center clinical study evaluating performance, efficacy and safety of three dimensional (3D) printed complete dentures and milled complete dentures during a 5-year follow-up period. The primary objective of this clinical investigation is to evaluate survival rate, i.e. subjects with survived dentures in both upper and lower jaw, of 3D printed complete dentures and milled complete dentures after 1 year (in each of the groups separately).",[53,54],"Edentulous Mouth","Edentulous Jaw","2026-06-05",{"date":57,"type":32},"2026-06-08",{"date":34,"type":21},{"date":60,"type":21},"2032-10-30",{"name":38,"class":39},{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":69,"targetDuration":4,"studyType":22,"phases":71,"briefSummary":72,"conditions":73,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},"100615298","a-prospective-multicenter-clinical-investigation-evaluating-the-accuracy-of-the-trimline-design-when-treated-with-suresmile-aligners-100615298","NCT07290790","A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSmile® Aligners.","A Prospective, Multicenter, Randomized, Post-market Clinical Investigation to Assess the Accuracy of Different Tooth Movements for Patients Undergoing Clear Aligner Therapy (CAT) With SureSmile® Clear Aligners With Three Different Trimlines.","Inclusion Criteria:\n\n* Subject willing to participate in the clinical investigation, able to understand the intent risks and benefits of the clinical investigation as well as associated time commitment and follow-ups visits.\n* Subject has signed and dated the informed consent form (ICF) .\n* Subject aged 18 years or above at time of informed consent.\n* Subject has permanent dentition (i.e., all 2nd molars).\n* Subject with a dental malocclusion, consistent with Levels 1 and 2 case complexity and within the clinical references as defined in the SureSmile Case Selection Guide.\n\n  * Crowding or spacing must be ≤6mm present in one or both arches consistent with level 1 and 2 of case complexity.\n  * Midline deviation must be ≤3 mm consistent with level 1 and 2 of case complexity.\n  * Overjet must be ≤4 mm consistent with level 1 and 2 case complexity.\n  * Overbite must be ≤3 mm consistent with level 1 and 2 case complexity.\n  * Anterior open bite must be ≤1 mm, consistent with level 1 and 2 case complexity.\n* Intermaxillary elastics may be included within the treatment plan to support sagittal, vertical, or transverse correction within the limits defined under exclusion criteria.\n\nExclusion Criteria:\n\n* Subjects unlikely to comply with investigational procedures, or unlikely to come back for follow-up visits, as judged by the Investigator.\n* Subject that presents a dental malocclusion classified as level 3 case complexity, as defined in the SureSmile Case Selection Guide.\n* Subjects who have completed aligner therapy within the last 12 months or who are in active orthodontic treatment.\n* Subjects with active periodontal disease or other unresolved dental conditions such as active cavities, active periodontal disease.\n* Subjects with treatment plans requiring transverse correction requiring expansion greater than 4 mm per arch or 2 mm per quadrant, or any skeletal transverse correction.\n* Treatment plans requiring sagittal correction exceeding a half-cusp discrepancy (i.e., \\>½ unit) in molar or canine relationships.\n* Subjects with treatment plans require vertical correction beyond Level 1 and 2 thresholds (i.e., overbite \\>3 mm or anterior\u002Fposterior open bite \\>1 mm), or vertical elastics exceeding 3 mm.\n* TMJ (Temporo-Mandibular Join) disorders or history of headaches or migraines.\n* Participants with known history of plastic allergies.\n* Subjects with presence of skeletal discrepancies necessitating orthognathic surgery, rapid palatal expansion, other orthopedic intervention, unilateral or bilateral cross-bites, mandibular deviations in association with the diagnosed malocclusion\n* The use of TADs (Temporary Anchor Devices), plates, other fixed anchorage ancillaries or the use of functional appliances (distalizers, growth modification devices), any approach involving orthopedic or skeletal sagittal correction or the use of hybrid fixed appliances are not considered part of the scope of this clinical investigation and these subjects are not eligible.\n* Uncontrolled para-functional habits, e.g., bruxism.\n* Any other condition that would make the subject unsuitable for participation, including but not limited to:\n\n  * Unstable psychiatric illness.\n  * Recent myocardial infarction (\\\u003C 3 months\\*).\n  * Recent cerebrovascular accident (\\\u003C 3 months\\*).\n  * Recent cardiac-valvular prosthesis placement (\\\u003C 3 months\\*).\n  * Hemorrhagic diathesis.\n  * Severe liver dysfunction.\n  * Known or suspected current malignancy.\n* Known pregnancy at the time of enrolment.\n* Previous enrolment in the present clinical investigation.\n* Involvement in the planning and conduct of the clinical investigation (applies to both Dentsply Sirona personnel and the clinical investigation site).\n* Participation in another clinical investigation that may interfere with the present clinical investigation.",{"count":70,"type":21},90,[24],"This is a three-armed, multicenter clinical study evaluating the SureSmile clear aligner medical device. The primary objective is to confirm the safety and assess the accuracy of different tooth movements. In addition, the study will investigate and compare three different trimline designs: Scalloped, Straight, and Straight Extended.",[74],"Malocclusion","RECRUITING","2026-03-06",{"date":78,"type":32},"2026-03-09",{"date":80,"type":32},"2026-01-29",{"date":82,"type":21},"2028-02-01",{"name":38,"class":39},6,""]