[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Denver Health and Hospital Authority\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":118},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,67,95],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100626440","optimizing-heart-failure-therapies-among-patients-with-limited-access-in-denver-100626440",false,"NCT07435662","Optimizing Heart Failure Therapies Among Patients With Limited Access in Denver","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosis of HFrEF (EF ≤ 40%)\n* Receiving care within DHHA system\n\nExclusion Criteria:\n\n* Estimated glomerular filtration rate (eGFR) \\\u003C 25 mL\u002Fmin\u002F1.73 m² or receiving dialysis.\n* Cirrhosis\n* Inability to consent\n* Non-English or non-Spanish speaking","ALL","18 Years",{"count":18,"type":19},40,"ESTIMATED","INTERVENTIONAL",[22],"NA","Numerous pharmacotherapies have been proven to reduce mortality and hospitalization rates for heart failure with reduced ejection fraction (HFrEF) patients. However, these are underutilized clinically, preventing realization of proven benefits. Simplified patient education tools and multidisciplinary teams including pharmacists have been used to improve medication optimization but in predominantly private payer groups. This study will translate these evidence-based interventions to patients with limited access to care. In this randomized, prospective study, patients with HFrEF at a local hospital dedicated to care for participants with limited access will receive either pharmacist-directed medication adjustment visits with patient education materials or standard of care. This study will assess the hypothesis that the implementation of the intervention is feasible in this population, as demonstrated by the number of visits and proportion of visits with medication adjustments. Further, medication dosing in each arm will be evaluated via the Kansas City Medication Optimization (KCMO) score, which will average the percentage of maximal doses of appropriate HFrEF medication classes a patient is on. The change in KCMO scores over the course of the pilot in the two arms will then be compared to assess the hypothesis that the intervention will better increase patients' KCMO scores than the standard of care. The findings of this study will help address knowledge gaps in the care of patients not well represented previously in the literature. This proposal addresses the translational science roadblock of recruitment and engagement of participants with limited access to care.",[25,26],"Heart Failure","Medication Optimization",[28,29],"heart failure","limited access to care","RECRUITING","2026-02-23",{"date":33,"type":34},"2026-02-27","ACTUAL",{"date":36,"type":34},"2025-10-01",{"date":38,"type":19},"2026-07-01",{"name":40,"class":41},"Denver Health and Hospital Authority","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":20,"phases":51,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":42},"100609016","emergency-department-linkage-to-care-for-patients-experiencing-homelessness-100609016","NCT07209072","Emergency Department Linkage to Care for Patients Experiencing Homelessness","Inclusion Criteria:\n\n1. adult (≥18 years of age) DHMC ED patient,\n2. currently unsheltered, defined as living on the streets, in a vehicle, or in another place not fit for human habitation,\n3. anticipating ED discharge, with\n4. a diagnosis listed below that requires short-term follow up:\n\n   * COPD or asthma exacerbation\n   * Bacterial or viral pneumonia\n   * CHF with volume overload\n   * SSTI\n   * Dehydration requiring IV fluids\n   * Hyperglycemia secondary to DM\n   * Frostbite\n   * First- and second-degree burns\n   * Bacterial ENT infections\n   * Diabetic foot infection\n   * Traumatic head injury\n   * Pregnancy\n   * Opioid overdose\n5. a stable location (i.e., an intersection, landmark, or encampment where they can be located by the street medicine team) within Denver County for at least 2 weeks.\n\nExclusion Criteria:\n\n1. have altered mentation (e.g., intoxication, or secondary to medical, psychiatric, or behavioral conditions) that are unable to communicate their location, contact information, or agree to follow up.\n2. are prisoners,\n3. previously enrolled.",{"count":50,"type":19},390,[22],"In an effort to improve access to primary care at time of discharge, patients who are homeless will be given either enhanced follow up through a street medicine team or routine follow up in clinic.",[54],"Homelessness",[56,57,58],"primary care","emergency department","homelessness","2026-01-27",{"date":61,"type":34},"2026-01-28",{"date":63,"type":34},"2025-12-05",{"date":65,"type":19},"2027-12",{"name":40,"class":41},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":77,"phases":4,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},"100557024","barretts-esophagitis-in-anorexia-nervosa-bingepurge-subtype-100557024","NCT06532734","Barrett's Esophagitis in Anorexia Nervosa Binge\u002FPurge Subtype","Presence of Barrett's Esophagitis in a Cohort of People With Eating Disorders Who Engage in Purging Behaviors: A Pilot Study","Inclusion Criteria:\n\n* Patients diagnosed with an eating disorder diagnosis that includes purging history\n* Ages 18-65\n* Purging history =\\>5 years\n* Purging or rumination at a minimum of once daily upon admission.\n* Admission to the ACUTE Center for Eating Disorders and Severe Malnutrition\n\nExclusion Criteria:\n\n* Any eating disorder diagnosis that does not include purging behaviors\n* Ages under 18 and over 65\n* Patients who otherwise meet the current ACG screening guidelines (chronic GERD and 3 or more risk factors for Barrett's mentioned in the Background)\n* Received mandated care at time of enrollment\n* Inability to consent to participate in the research","65 Years",{"count":76,"type":19},25,"OBSERVATIONAL","To better define the presence of Barrett's esophagus (BE) via non-endoscopic testing in an eating disorder cohort with purging (vomiting\u002Frumination) behaviors",[80,81,82,83,84,85],"Barrett Esophagus","Anorexia Nervosa, Binge Eating\u002FPurging Type","Rumination","Vomiting","Eating Disorders","Esophageal Adenocarcinoma","2025-12-03",{"date":88,"type":34},"2025-12-10",{"date":90,"type":34},"2024-11-12",{"date":92,"type":19},"2026-11",{"name":40,"class":41},3,{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":102,"sex":15,"minAge":16,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":20,"phases":105,"briefSummary":106,"conditions":107,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":42},"100554203","blood-flow-restriction-training-in-patients-with-lower-extremity-fractures-100554203","NCT06496035","Blood Flow Restriction Training in Patients With Lower Extremity Fractures","Blood Flow Restriction Training Versus Traditional Rehab in Patients With Lower Extremity Fractures: Effect on Fracture Healing, Muscle Strength and Girth, and Return to Function","Inclusion Criteria:\n\n* Adult with closed tibial shaft fracture\n* Ability to begin physical therapy treatment within 2 weeks post-operatively\n\nExclusion Criteria:\n\n* History of osteoporosis or osteopenia\n* Impaired circulation in the limb\n* Active deep vein thrombosis\n* Clotting disorders or other elevated risk of embolism\n* Sickle cell anemia\n* Infection in extremity\n* Renal compromise\n* Severe uncontrolled hypertension (SBP\\>180)\n* Lymphedema\n* Under age 18\n* Pregnancy\n* Prisoner",true,"100 Years",{"count":18,"type":19},[22],"This study will look at the effect of using a blood flow restriction device during low load strengthening exercises on patients with tibial shaft fractures, compared to patients performing exercise without the device. The study will compare muscle strength, muscle size, fracture healing, and return to normal function between the two groups.",[108,109],"Tibial Fractures","Lower Extremity Fracture","2025-11-18",{"date":112,"type":34},"2025-11-21",{"date":114,"type":34},"2024-11-01",{"date":116,"type":19},"2026-05-31",{"name":40,"class":41},""]