[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Direction Centrale du Service de Santé des Armées\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":463},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,55,81,115,145,168,187,214,242,270,292,313,336,357,376,396,417,441],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":38,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100638153","study-of-the-effects-of-acute-exposure-to-moderate-altitude-hypoxia-on-prospective-memory-100638153",false,"NCT07585227","Study of the Effects of Acute Exposure to Moderate Altitude Hypoxia on Prospective Memory.","Etude Des Effets d'Une Exposition aiguë à l'Hypoxie d'Altitude modérée Sur la mémoire Prospective (HYPRO)","HYPRO","Inclusion Criteria:\n\n* Healthy volunteer\n* Has provided informed consent\n\nExclusion Criteria:\n\n* Individuals who do not understand French\n* Pregnant or breastfeeding women\n* Cardiovascular risk factor\n* Infectious disease within the last 4 weeks\n* Chronic cardiovascular, respiratory, hematological, neurological, psychiatric, or metabolic disease\n* History of epileptic seizures, convulsions, or loss of consciousness\n* Individuals with migraines\n* History of a bleeding disorder\n* History of high blood pressure\n* Current medication use (excluding contraception)\n* History of episodes of altitude intolerance\n* Stay at high altitude (\\> 3,500 m) within the last 3 months\n* Anxiety score on the Hospital Anxiety and Depression (HAD) scale \\> 7\n* Depression score on the HAD scale \\> 7\n* Uncontrollable claustrophobia or a history of panic attacks",true,"ALL","18 Years","45 Years",{"count":22,"type":23},50,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this study is to investigate whether prospective memory, i.e., memory for delayed intentions, is impaired at moderate altitude (4,000m).\n\nIt will also allow to study the effect of air and oxygen administration during hypoxia exposure.\n\nThe main questions it aims to answer are:\n\n* Does moderate acute hypoxia impair prospective memory ?\n* If so, does air or oxygen adminsitration induce a restoration of prospective memory? Researchers will compare cognitive performance during normobaric hypoxia exposure to cognitive performance during normoxia (control situation).\n\nParticipants will:\n\n* Session S0. Perform a battery of neuropsychological tests and questionnaires). EEG will be recorded during tests. A cheek swab will be performed.\n* Sessions S1 and S2. Perform several cognitive tasks while exposed to hypoxia and to normoxia (2 different sessions, randomized order) in a normobaric chamber. These are standardized cognitive tests administered on a computer and cognitive tests embedded in a flight simulator scenario. Various questionnaires will be performed on a regular basis. Several physiological measurements will be performed continuously: EEG, ECG, SpO2 and breathing rate. Blood pressure will be measured at the beginning and at the end of hypoxia\u002Fnormoxia exposure. A blood sample will also be performed. At last, participants will inhale air or oxygen through a mask while making a cognitive task in the chamber.",[29,30,31,32,33,34,35,36,37],"Hypoxia","Hypoxia Brain","Hypoxia Altitude Simulation Test","Hypoxia in Healthy Individuals","Hypoxia, Altitude","Hypoxia, Brain","Altitude","Altitude Hypoxia","Normobaric Hypoxia",[39,40,41],"prospective memory","working memory","flight simulator","NOT_YET_RECRUITING","2026-05-09",{"date":45,"type":46},"2026-05-13","ACTUAL",{"date":48,"type":23},"2026-05-06",{"date":50,"type":23},"2026-12-31",{"name":52,"class":53},"Direction Centrale du Service de Santé des Armées","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100620075","exploration-strategies-in-night-vision-sensors-100620075","NCT07352904","Exploration Strategies in Night Vision Sensors","STRAT-JVN","Inclusion Criteria:\n\n* Affiliated with social security;\n* Normal vision or vision corrected with lenses (far vision ≤ 0.03 log unit (≥ 9\u002F10) OD\u002FOG\u002Fbinocular);\n* No current or past ocular or binocular pathology: strabismus or amblyopia;\n* Signed non-objection form.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women;\n* Incapacitated adults;\n* Individuals who do not understand French (written or spoken).",{"count":63,"type":23},10,"OBSERVATIONAL","The main objective of this clinical trial is to identify a variation in visual strategy characterized by both head movements and eye movements of healthy volunteers during a target detection task when images simulating night vision goggles (NVG) are presented, compared to a situation in which the images simulate a natural environment.\n\nTo highlight changes in environmental scanning with simulated images from NVG, objective measurements will be collected:\n\n* eye movements characterized by saccades (speed, latency, and number) for each stimulus\n* head movements (horizontal angle of the participant's head) for each stimulus and throughout the exposure\n\nParticipants sit facing a screen (9.90 m x 2.10 m) onto which a virtual scene is projected. The objective is to correctly identify, as quickly as possible, a target stimulus (represented by a tank) that may appear in the scene. They must use the directional arrows on a game controller to indicate whether the tank is moving to the left or to the right.\n\nThere are four visits involving four viewing conditions in which the task remains the same:\n\n* With restricted field of view and a normal scene.\n* Without restricted field of view and a scene simulating the vision obtained by NVGs.\n* With restricted field of view and a scene simulating the vision obtained by NVGs.\n* Without restricted field of view and a normal scene. Regarding the content of the scene, half of the tests in each visit involve a so-called poor scene when fog is simulated, or an enriched scene when there is no fog. Each visit lasts approximately one hour and thirty minutes.",[67],"Visual Acuity",[69,70,71,72],"visual strategy","Night Vision Goggles","eyetracking","visual fatigue","2026-01-15",{"date":75,"type":46},"2026-01-20",{"date":77,"type":23},"2026-02-01",{"date":79,"type":23},"2026-12-25",{"name":52,"class":53},{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":91,"conditions":92,"keywords":101,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":4},"100613748","french-military-firefighters-to-assess-relationships-between-exposome-and-health-100613748","NCT07270627","French Military Firefighters to Assess Relationships Between Exposome and Health.","Cohorte Militaire et Son Exposome : étude Pilote rétrospective au Sein de la Population Des Sapeurs-pompiers (Actuellement en Exercice et Anciens Sapeurs-pompiers) de la Brigade Des Sapeurs Pompiers de Paris","COMITEX-BSPP","Inclusion Criteria:\n\n* Active-duty or veteran military personnel from French Paris firefighter brigade.\n* Aged at least 18.\n* Not opposed to participate to the study\n\nExclusion Criteria:\n\n* Opposition to participate\n* veterans under legal protection",{"count":90,"type":23},15000,"The aim of the study is to describe professional exposures and health events among French military firefighters (both active-duty personnel and veterans) and identify potential relationships between the exposome (the total history of occupational and personal exposures) and health status in these populations. The study is based on a self-administered questionnaire that collects retrospective and present information about exposures and health conditions.",[93,94,95,96,97,98,99,100],"Health Adult Subjects","Exposure Occupational","Health Behavior, Risky","Occupational Health","Exposure","Firefighters","Military Personnel","Observational Study",[102,103,104,105,106],"Occupational exposure","health","military","exposome","occupational","2025-11-26",{"date":109,"type":46},"2025-12-08",{"date":111,"type":23},"2026-01-01",{"date":113,"type":23},"2026-12",{"name":52,"class":53},{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":126,"conditions":127,"keywords":130,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":4},"100592657","attachment-and-post-traumatic-stress-disorder-in-military-personnel-characterization-of-the-french-military-population-exploration-of-biopsychosocial-factors-and-study-of-the-impact-of-security-priming-on-emotional-contagion-capacities-100592657","NCT06996275","Attachment and Post-Traumatic Stress Disorder in Military Personnel: Characterization of the French Military Population, Exploration of Biopsychosocial Factors, and Study of the Impact of Security Priming on Emotional Contagion Capacities","Attachment and Post-traumatic Stress Disorder in Military Personnel: Characterisation of the French Military Population, Exploration of Biopsychosocial Factors and Study of the Impact of Reassuring Primers on Emotional Contagion Skills.","AT-HOME","Inclusion Criteria:\n\nInclusion Criteria Common to Both Groups:\n\n* Volunteers who agreed to participate in the study and provided written consent\n* Affiliated with social security\n* Proficient in the French language\n\nInclusion Criteria Specific to the \"Military Personnel with PTSD\" Group:\n\n* Military personnel diagnosed with post-traumatic stress disorder related to their duties\n* Participants in activities offered by the wounded service support units\n\nExclusion Criteria:\n\n* Adults subject to a protective measure\n* Refusal to participate in the study\n* Unrectified Legionnaires","65 Years",{"count":125,"type":23},94,"Post-traumatic stress disorder (PTSD) is a pathology that impairs the quality of life of sufferers. In military personnel, it can lead to military incapacity. This psychopathology is characterized by confrontation with one or more traumatic events in the individual's life history. Symptoms include cognitive and mood disorders, avoidance, hyperactivation (hypervigilance and anger) and intrusions (flashbacks and nightmares).\n\nStudies show that the prevalence of PTSD in military personnel fluctuates considerably from one situation to another (pre-deployment\u002Fpost-deployment, etc.). In these at-risk populations, the often more complex PTSD clinic may also account for the heterogeneity of prevalences observed. Nevertheless, PTSD tends to become chronic in military personnel, making it particularly difficult to return to a \"previous\" state. In French casualties, beyond the symptoms already mentioned, complaints focus on difficulties in social interaction situations involving others in social life (attachment style to others) and in everyday life (public transport, supermarket shopping, social interactions, presence of crowds...).\n\nIn the context of post-traumatic stress disorder, we would like to explore the processes of social cognition that enable people to interact in their environment, in relation to biological, psychosocial and physiological variables that may constitute risk or maintenance factors for the pathology.",[128,129],"Post-traumatic Stress Disorder (PTSD)","Emotional Contagion",[131,132,133,134,135,136],"PTSD","complex PTSD","military veteran","emotional contagion","oxytocin","vasopressine","2025-05-21",{"date":139,"type":46},"2025-05-30",{"date":141,"type":23},"2025-05-27",{"date":143,"type":23},"2025-12-31",{"name":52,"class":53},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":154,"conditions":155,"keywords":4,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":54},"100581096","measurement-of-intestinal-permeability-in-intensive-care-patients-with-single-or-multiple-organ-failure-100581096","NCT06845865","Measurement of Intestinal Permeability in Intensive Care Patients With Single or Multiple Organ Failure","BLUE-REA","Inclusion Criteria:\n\nPatient with single organ failure, secondary to sepsis, hospitalized in intensive care for a foreseeable duration of \\> 48 hours\n\n* SAPS2 between 20 and 40 at the sixth hour after the diagnosis of organ failure.\n* Consent from the patient or their trusted person.\n* Affiliation to a social security system.\n* Functional digestive tract and possible feeding (per os or via a nasogastric tube whose indication was determined independently of the study's needs).\n\nSecond group of patients with multi-organ failure:\n\n* Multi-organ failure syndrome with at least 2 organ failures, secondary to sepsis.\n* SAPS2 between 60 and 80 at the sixth hour after the diagnosis of organ failure.\n* Consent from the patient or their trusted person.\n* Affiliation to a social security system.\n* Functional digestive tract and possible feeding (conscious patient able to swallow or with a nasogastric tube whose indication was determined independently of the study's needs).\n\nExclusion Criteria:\n\n* Pregnant and breastfeeding women;\n* Minors;\n* Persons under administrative and judicial supervision;\n* Absence of a functional digestive tract (patient unable to swallow and absence of a nasogastric tube, contraindication to enteral feeding);\n* Patients with gastroparesis;\n* Refusal of the patient or their trusted person;\n* Patient with a SAPS2 at the sixth hour after the diagnosis of organ failure \\\u003C 20 or between 40 and 60 or \\> 80.",{"count":153,"type":23},126,"Multivisceral failure syndrome (MVFS) in humans is associated with a very high risk of mortality, ranging between 30 and 50%. This syndrome is associated with significant systemic inflammation and a high risk of bacteremia, the origin of which is not always identified. Among the possible causes of bacteremia, digestive translocation is the most probable but has not been formally proven to date. This translocation is made possible by the numerous cellular and metabolic alterations secondary to MVFS, which can lead to increased intestinal barrier permeability. Intestinal permeability is currently not systematically evaluated in clinical practice in humans.\n\nThis increased intestinal permeability, associated with the presence of inflammatory markers and a septic state, has been studied in several animal models ranging from the fruit fly (Drosophila) to the mouse. These studies have shown a high risk of mortality associated with increased intestinal permeability.\n\nWe propose to use this methodology in intensive care patients with at least one organ failure to investigate the link between increased intestinal permeability and survival chances.",[156,157,158],"Multivisceral Failure Syndrome","Monovisceral Failure","Infection in ICU","RECRUITING","2025-04-29",{"date":162,"type":46},"2025-05-02",{"date":164,"type":46},"2025-02-20",{"date":166,"type":23},"2029-04-30",{"name":52,"class":53},{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":123,"enrollmentInfo":175,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":54},"100579899","validation-and-standardisation-of-a-neuralix-digital-ecological-battery-100579899","NCT06830291","Validation and Standardisation of a \"Neuralix\" Digital Ecological Battery","VANOLIX","Inclusion Criteria:\n\n* French-speaking subject aged 18 to 65 years old\n* Signed consent to participate\n* History of head trauma of moderate to severe intensity, i.e. having presented the high risk criteria of the study by Masters et al. (1987) at the time of the head trauma, and occurred a maximum of 5 years after inclusion in the VANOLIX study\n\nExclusion Criteria:\n\n* Visual or hearing or motor deficit disrupting the taking of cognitive tests\n* Subject with insufficient knowledge of counting (up to 25), the alphabet, reading, or French writing\n* Subject with a severe intellectual disability\n* Subject with past psychiatric or behavioral disorders requiring a stay \\>2 days in a specialized environment or requiring current treatment other than a single anxiolytic\n* Current treatment with antidepressant\n* Current treatment with antipsychotic or multiple anxiolytics\n* Single anxiolytic treatment initiated or increased for less than 1 month or current antiepileptic treatment\n* Subject with a neurological condition or a history leading to cerebral dysfunction likely to interfere with the cognitive assessment",{"count":176,"type":23},800,"The management of head trauma patients requires the assessment of cognitive disorders using standardized neuropsychological tests and questionnaires. However, the evaluation tools currently available present well-identified limitations limiting the accuracy of the measurements (in a non-exhaustive manner, let us cite for example the absence of control of the rate of \"false positives\" or even the impossibility of measuring the improvement or decline in performance over time). In order to overcome these limitations, the Neuralix battery was created with particular attention to the assessment of memory and executive functions largely impacted after head trauma. The Neuralix battery comes in the form of a digital application accessible online and allowing a global assessment of cognitive functions in adults. In addition, the processing of results includes the operationalization of decision criteria taking into account the limitations cited above in order to improve the sensitivity of the evaluation.\n\nThe VANOLIX study proposes the validation of the Neuralix cognitive battery with head trauma patients of moderate to severe intensity as well as its standardization with healthy volunteers, these two steps being essential to making the tool available to clinician-researchers.",[179],"Traumatic Brain Injuries",{"date":181,"type":46},"2025-04-30",{"date":183,"type":46},"2025-03-11",{"date":185,"type":23},"2027-03",{"name":52,"class":53},{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":123,"enrollmentInfo":195,"targetDuration":197,"studyType":64,"phases":4,"briefSummary":198,"conditions":199,"keywords":201,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":54},"100585796","wear-and-tear-on-military-personnel-post-caledonian-crisis-100585796","NCT06907030","Wear and Tear on Military Personnel Post Caledonian Crisis","Evaluation of Operational Wear and Tear Related to the Caledonian Crisis on Military Personnel","U-CARE","Inclusion Criteria:\n\n* be a member of the military\n* be permanently posted to NC at the time of the study\n\nExclusion Criteria:\n\n* Be on temporary assignment in NC at the time of the study\n* Subjects covered by articles L1121-5 to 1121-8 of the Public Health Code, i.e. :\n\n  * Pregnant women, women in labour and nursing mothers\n  * Persons deprived of their liberty by judicial or administrative decision\n  * Persons subject to psychiatric monitoring under articles L3212-1 and L3213-1 who are not covered by the provisions of article L1121-8\n  * Persons of full age who are the subject of a legal protection measure or who are unable to express their consent.",{"count":196,"type":23},200,"2 Months","Since May 2024, New Caledonia has been experiencing a period of crisis. The organisation of the work of military personnel on the ground has been heavily impacted, with longer working hours, shorter rest periods and increased stress levels (uncertainty about the situation, lack of visibility, etc.).\n\nProlonged exposure to stress is accompanied by neuronal damage (Ramdani et al., 2024) and operational fatigue, a mindset that results from reversible neuronal damage and appears to be distinct from exhaustion. The aim of this study is to assess the impact of the crisis on the level of operational fatigue. In addition, identifying the organisational and human factors (Jaspers et al., 2024) that may have been protective against operational fatigue could help to optimise the way in which these factors are taken into account in the event of future crises, in order to promote resilience.",[200],"Chronic Stress Disorder",[202,203,204,205],"operational wear and tear","resilience","organisational and human factor","psychosocial risk","2025-04-07",{"date":208,"type":46},"2025-04-09",{"date":210,"type":46},"2025-04-03",{"date":212,"type":23},"2026-04",{"name":52,"class":53},{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":222,"enrollmentInfo":223,"targetDuration":225,"studyType":64,"phases":4,"briefSummary":226,"conditions":227,"keywords":231,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":4},"100580049","cognitive-load-assessment-of-helicopter-pilots-in-training-100580049","NCT06832241","Cognitive Load Assessment of Helicopter Pilots in Training","ÉVALUATION DE LA CHARGE COGNITIVE DES PILOTES D'HÉLICOPTÈRES EN FORMATION \"ECCOLicoF\"","ECCOLicoF","Inclusion Criteria:\n\n* Being a trainee at the Instructional center of helicopter crews\n* Being more than 18 years old\n* Being insured under the French social security system\n* Having the bases to pilot helicopters\n* Having signed the non-opposition form\n\nExclusion Criteria:\n\n* Being minor or an incapacitated adult\n* Being in a motor handicap situation\n* Having a cardiac pathology\n* Having a visual pathology that is uncorrected by glasses or lens\n* Having a bad audition\n* Having a psychiatric disorder, a neurologic or organic disorder requiring a medical treatment\n* Taking psychotropics\n* Drinking more than 28 units of alcohol per week\n* Being epileptic","50 Years",{"count":224,"type":23},32,"3 Years","The aim of this study is to identify the effect of the increase of the situation demands, with or without a thread, on military helicopter pilot's cognitive load, depending on their skills acquisition (at the beginning, midway and end of training course). This study is carried out on a simulator, in virtual reality and allows to identify the moments of cognitive load enhancement and the associated indicators such as subjective, physiological and behavioural indicators. Recommendations will be done to go towards an individualization of the lessons during the pilots education, by anticipating an overload which has a deleterious effect on learning.",[228,229,230],"Cognitive Impairment","Situational Anxiety","Skills, Coping",[232,233],"Cognitive load","Military helicopter pilots","2025-02-12",{"date":236,"type":46},"2025-02-18",{"date":238,"type":23},"2025-03",{"date":240,"type":23},"2028-01",{"name":52,"class":53},{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":250,"enrollmentInfo":251,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":253,"conditions":254,"keywords":256,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":4},"100578284","assessment-of-the-effects-of-acute-exposure-to-cold-and-heat-on-appetite-100578284","NCT06809296","Assessment of the Effects of Acute Exposure to Cold and Heat on Appetite","Evaluating the Effects of Acute Exposure to Cold and Heat on Appetite: Impact of Serving Food Temperature (Hot and Cold Meals)","TEMPCA2","Inclusion Criteria:\n\n* Active (\\>3 h\u002Fw of physical activites)\n* Affiliated to the social security\n* Usual breakfast eaters\n\nExclusion Criteria:\n\n* Unusual or irregular meal pattern\n* Too high dietary restrictive profile assessed by the TFEQ-21\n* Bad sleepers (\\\u003C 6h\u002Fnight)\n* Presenting a metabolic condition\n* BMI lower than 18 or higher than 30\n* Chronic medication (at the exception of the contraceptive pills)\n* Regular smoker (more than 2 cigarettes per day)\n* Regular alcohol consumer (more then 1 glass per day)\n* Vegetarian\n* Following a confessional diet (hallal, casher)\n* Do not speak fluently French","40 Years",{"count":252,"type":23},40,"Military personnel and athletes have a very high energy expenditure, which is increased during certain key periods (intense training, competition and missions). Compensating for this expenditure through adequate energy intake can be complicated by physiological ingestive limits and logistical and organizational constraints (number of meals, food availability), leading these populations to regularly find themselves in an energy deficit situation (intake below requirements). If this situation persists, it could impair physical and cognitive performance, as well as major physiological functions. Among the many constraints to which military personnel and athletes are subjected (stress, sleep deprivation, travel, etc.) that can increase the risk of energy deficiency, the impact of thermal environmental constraints is very imperfectly known. Seasonal impact and travel to countries with very different thermal environments from temperate countries can lead these populations to work in cold and hot conditions for long periods.\n\nUnderstanding how exposure to hot and cold alters appetite and energy intake is therefore of the high importance. Our previous \"TEMPCA\" study highlighted a modulation of preferences for warm or cold foods depending on the exposure environment. By being able to adapt their food intake to these preferences, subjects were able to maintain a decent energy intake.\n\nThe primary objective of this study is to determine the effect of the temperature of the food served (hot or cold) on changes in food intake during acute exposure to hot and cold. We hypothesized that adapting the temperature of the food served according to the exposure environment (hot in a cold environment and cold in a hot environment) would enable adequate levels of energy intake.\n\nSecondary objectives are to determine the influence of the environment on the levels of interstitial glucose during the preprandial period and to investigate the impact of thermal exposure (modulation of core temperature) on the modulation of quantities consumed and energy produced by digestion (postprandial thermogenesis). Forty participants (between 18 and 40 yo, male or female, active, lean, and healthy) will carry out 3 experimental sessions in which only the thermal environment will differ: cold condition (15°C), neutral condition (25°C) and warm condition (35°C). They will be divided into two groups, the first of which will be offered a cold meal during the three sessions (Cold Meal - CM) and the second a warm meal during the three sessions (Warm Meal - WM). They will all wear the same outfit designed to be offer perfect thermal comfort at 25 °C.\n\nBriefly, each session will start at 8:30am after eating a standardized breakfast. Body mass and ad libitum water intake will be frequently monitored to identify possible dehydration. Thermal comfort and sensation and subjective appetite will be regularly assessed using visual analog scale.\n\nFrom 11:00am to 01:00pm, all participants will be isolated and all temporal cues will be removed. At 01:00pm, an ad libitum meal (warm or cold) will be served in large quantities. The dishes will be weighed before and after the meal to assess energy intake. Before and after the meal, resting metabolism will be measured during 30 min in a supine position using indirect calorimetry and food preferences for high-fat\u002Flow-fat, savory\u002Fsweet, warm\u002Fcold foods, and fluid\u002Fsolid foods will be assessed using the Leeds Food Preference Questionnaire.",[255],"Appetite",[255,257,258,259,260,261],"food intake","Thermal exposure","Cold","Heat","Energy intake","2025-01-30",{"date":264,"type":46},"2025-02-05",{"date":266,"type":23},"2025-02",{"date":268,"type":23},"2027-04",{"name":52,"class":53},{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":276,"eligibilityCriteria":277,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":278,"targetDuration":280,"studyType":64,"phases":4,"briefSummary":281,"conditions":282,"keywords":4,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":54},"100553741","diagnostic-of-various-ototoxicity-induced-by-cancer-treatment-100553741","NCT06490029","Diagnostic of Various Ototoxicity Induced by Cancer Treatment","Evaluation of Hidden Hearing Loss and Vestibular Damage Induced by Anti-cancer Treatments","BIO-OTOTOX","Inclusion Criteria:\n\n* Age 18 and over\n* Registered with social security\n* Signed consents\n* Absence of presbycusis prior to cancer treatment (groups A and C)\n* No known presbycusis (group B)\n* Previous exposure to an ototoxic\u002Fneurotoxic agent (group A)\n* Indication for initiation of ototoxic\u002Fneurotoxic therapy (group C)\n\nExclusion Criteria:\n\n* \\- Subjects deprived of liberty\n* Subjects unable to read or write the French language\n* Pregnant and breast-feeding women\n* Previous treatment for ototoxicity\n* History of bilateral auditory pathology, in particular otosclerosis, perilymphatic fistula, ruptured tympanic membrane, autoimmune hearing loss, acoustic neuroma.\n* History of severe head trauma (Glasgow Coma Score \\\u003C= 8)\n* Abnormal otoscopy or tympanometry In addition for group B\n* Previous chemotherapy\n* Previous ENT radiotherapy\n* Ongoing ototoxic drug therapy (quinine, diuretics, aminoglycosides, aspirin, NSAIDs) or corticosteroid therapy",{"count":279,"type":23},540,"39 Months","• Visit the clinic once every 2 weeks for checkups and tests The goal of this clinical trial is to learn if systematic hearing tests (eg fonctional assesment, electrophysiology and seric biomarkers) can diagnose hidden hearing loss or vestibular troubles in a population of patients treated for cancer; population study will include different population in terms of sex\u002Fgender, age, medical condition (cancer patients treated with surgery alone and\u002For radiotherapy and\u002For chemotherapy, and healthy volunteers).\n\nThe main question it aims to answer is:\n\n• To assess the ototoxicity of anticancer drugs using a combination of auditory functional tests (including speech audiometry in noise), vestibular test , plasmatic samples and electrophysiological measures.\n\nParticipants will be studied:\n\nEither only after exposition (single visit) Or before, during and after the exposition to potential otototoxic agents with a 4 times Visit the clinic checkups and tests (one before, two while ongoing potential ototoxic agents and 1 post exposition)\n\nParticipants will complete questionnaires, undergo audiometric and electrophysiological tests, and their routine biomedical data will be studied, without any modification of the routine care (planned cancer treatment)",[283],"Ototoxicity, Drug-Induced","2024-06-28",{"date":286,"type":46},"2024-07-08",{"date":288,"type":46},"2024-06-19",{"date":290,"type":23},"2027-09-19",{"name":52,"class":53},{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":296,"acronym":297,"eligibilityCriteria":298,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":299,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":300,"conditions":301,"keywords":303,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":54},"100504373","study-of-thermoregulation-in-exercise-heat-stroke-in-the-military-environment-100504373","NCT05847465","Study of Thermoregulation in Exercise Heat Stroke in the Military Environment","EXPLO-MITO","Inclusion Criteria:\n\n* Be included in the main EXPLO-CCE study;\n* Subject trained or re-trained at 2 aerobic sessions per week;\n* At least 2 months from the exercise heat stroke experience\n\nExclusion Criteria:\n\n* Subject with a current medication treatment (for the control group only),\n* Subject with a contraindication to the ingestion of a thermal capsule, namely:\n\n  * Weight less than 37 kg\n  * Inflammatory, motor or obstructive disease of the digestive tract\n  * History of digestive surgery\n  * Participant requiring a CT or MRI scan prior to removal of the thermal capsule (scheduled scan)\n  * Presence of an implantable electronic device (e.g. pacemaker)",{"count":22,"type":23},"The EXPLO-MITO study is an ancillary study from the main EXPLO-CCE study (NCT04593316; IDRCB: 2020-A01967-32).\n\nThe Heat Tolerance Test (HTT) is a physiological exploration that has several advantages for use in research and clinical settings. Unlike the walk-run test, it is performed under controlled conditions, both environmentally (temperature control, humidity, etc.) and in terms of effort intensity. In addition, there are published interpretation criteria for this test allowing to characterize thermoregulation profiles and to distinguish between Heat Intolerant (HI) and Heat Tolerant (HT) patients.\n\nThe reproducibility of this test and its performance in a climatic chamber allows a true comparison of thermophysiological responses (heart rate, rectal and skin temperatures, skin blood flow and sweat loss), which was not possible with the run-walk test, which was more a field test validating a physical aptitude for recovery (so-called \"occupational\" test) than a physiological exploration evaluating a response to stress by comparing it with the expected response in a population of young, healthy, properly trained subjects. Moreover, the HTT is a much less physiologically demanding test than the 8-km run. The HTT, which corresponds to a 2-hour walk at 5 km\u002Fh with a 2% slope at 40°C and 40% relative humidity, is a so-called \"compensable\" thermal stress; that is, under these conditions of exercise and environment, when the individual has normal thermoregulatory capacities, a thermal equilibrium plateau is reached during the second hour, when the individual's thermolysis capacities make it possible to compensate for the production of heat by the exercise and the gain of heat related to the environment. On average, this plateau is between 38° and 39°C. This is clearly not the case with our experience of physiological monitoring of the 8-km walk-run which rarely allows a temperature plateau to be reached and is accompanied by a temperature rise constantly above 39°C. In addition to being performed in the laboratory, this test is therefore completely safe.\n\nFor all these reasons (reproducibility, relevance, predictive value of recurrence), this test has been used for more than 30 years by the Israeli army for the assessment of these cases of exercise heat stroke before their return to work. There is therefore a fair amount of published data and hindsight on the use and interest of this test. The Israeli test has the highest level of recommendation (Grade A) of all the other published heat tolerance tests. Also, the availability of a climatic chamber means that this test can now be proposed as one of the explorations available to clinicians who have to decide on the fitness of soldiers after exercise heat stroke.",[302],"Heat Stroke",[304],"Heat tolerance test","2023-08-01",{"date":307,"type":46},"2023-08-02",{"date":309,"type":46},"2023-05-09",{"date":311,"type":23},"2027-05",{"name":52,"class":53},{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":317,"acronym":318,"eligibilityCriteria":319,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":320,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":322,"conditions":323,"keywords":326,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":54},"100507835","covid-19-early-detection-of-worsening-by-voice-and-respiratory-pattern-characteristics-100507835","NCT05892549","COVID-19: Early Detection of Worsening by Voice and Respiratory Pattern Characteristics","COVOICE","Inclusion Criteria:\n\n* French speaking\n* Affiliated to a social security system\n* Owning a mobile phone capable of accessing the COVOICE application\n\nExclusion Criteria:\n\n* Incapable adults\n* People deprived of their liberty\n* People under administrative or judicial supervision\n* Patients intubated or hospitalized in intensive care unit",{"count":321,"type":23},1188,"In some clinical forms of COVID-19, an uncontrolled hyper-inflammatory reaction known as a \"cytokine storm\" appears abruptly, around day 7, and is associated with rapid respiratory deterioration, requiring hospitalization in an intensive care unit (ICU).\n\nAt present, although risk factors for this severe form have been described, there are no validated criteria for determining which individual patients will develop this aggravation.\n\nThe study of respiratory sounds (amplitude, frequency, ...) has made it possible in other respiratory pathologies (e.g., chronic obstructive pulmonary disease) to predict exacerbations several days in advance.\n\nHaving a predictive respiratory pattern for worsening in COVID-19 would make it possible to anticipate the need for intensive care hospital beds, by means of a tool easily available on a mobile phone.",[324,325],"Sars-CoV-2 Infection","COVID-19",[327],"Voice","2023-06-13",{"date":330,"type":46},"2023-06-15",{"date":332,"type":46},"2023-06-12",{"date":334,"type":23},"2026-07",{"name":52,"class":53},{"id":337,"slug":338,"hasResults":11,"nctId":339,"briefTitle":340,"officialTitle":340,"acronym":341,"eligibilityCriteria":342,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":343,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":345,"conditions":346,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":356},"100488063","chronic-anterior-shoulder-instability-in-the-military-100488063","NCT05635240","Chronic Anterior Shoulder Instability in the Military","EPAULUX","Inclusion Criteria:\n\n* Military member with a first episode of true anterior glenohumeral shoulder dislocation,\n* Male or female,\n* Major,\n* Having a sufficient level of reading\u002Fwriting of the French language,\n* Did not object to participating in the study.\n\nExclusion Criteria:\n\n* Patient with a history of homolateral shoulder dislocation or surgery on the affected shoulder,\n* Collagen disease confirmed by genetic testing,\n* Inflammatory arthropathy,\n* History of rotator cuff injury,\n* Insufficient French reading\u002Fwriting skills,\n* Under legal protection,\n* Objection to participating in the study.",{"count":344,"type":23},120,"Anterior shoulder instability is a chronic condition that occurs after an anteromedial dislocation. Its prevalence is high in athletes but has been little studied in the armed forces. In general, patients with a first episode of dislocation have a 1 in 2 chance of experiencing at least one recurrence. The more recurrences there are, the more damage there is to the joint and the greater the disability for the patient. The decree determining the medical aptitude of military personnel emphasizes the need to have recourse to a specialized consultation to determine the classification of the soldier after a first episode of dislocation. In the absence of data collected specifically in the military population, classification is based on the surgeon's experience and extrapolation of results obtained in the general population.",[347],"Shoulder Dislocation","2023-04-27",{"date":350,"type":46},"2023-04-28",{"date":352,"type":23},"2023-09",{"date":354,"type":23},"2029-09",{"name":52,"class":53},2,{"id":358,"slug":359,"hasResults":11,"nctId":360,"briefTitle":361,"officialTitle":361,"acronym":362,"eligibilityCriteria":363,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":364,"targetDuration":4,"studyType":24,"phases":366,"briefSummary":367,"conditions":368,"keywords":4,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":370,"startDateStruct":371,"completionDateStruct":373,"leadSponsor":375,"locationsCount":54},"100423256","impact-of-hyperoxia-and-involvement-of-the-immune-system-in-diving-accident-100423256","NCT04791488","Impact of Hyperoxia and Involvement of the Immune System in Diving Accident","OXYDIVE","Inclusion Criteria:\n\n* Healthy subject with no contraindications to diving OR patient admitted to the hospital for suspicion of a diving accident OR patient admitted to the hospital for hyperbaric oxygen therapy\n\nExclusion Criteria:\n\n* Contraindication to diving or contraindication to hyperbaric oxygen therapy",{"count":365,"type":23},265,[26],"The impact of oxygen therapy in many pathologies has been subject of recent work, arguing both favourable and harmful effects. Consequently, one can wonder about the influence of hyperoxic gas mixture during diving on the genesis of decompression sickness, but also about the systematic application of normobaric and hyperbaric oxygen in case of proven decompression sickness.\n\nIn mammals, normoxic concentrations have been redefined at 20-100 mbars at the extracellular level and below 10 mbars in the mitochondria.\n\nUnder hyperbaric conditions, most of the oxygen being dissolved in blood plasma, a state of hyperoxia is established which escapes the usual delivery and regulation system represented by red blood cells.\n\nThe results of our team's previous work suggest a specific effect of diving on the levels of circulating mitochondrial DNA (mtDNA), suggesting cellular destruction linked to hyperoxia\u002Fhyperbaria. In fact, our studies, carried out on both animals and human divers, have shown that diving accident leads to an increase in mtDNA levels and an immune reaction through the mobilisation of leukocytes.\n\nThe main objective of this study is to compare the influence of oxygen partial pressure levels on the evolution of clinical and biological variables during hyperbaric oxygen therapy sessions in healthy versus injured divers.",[369],"Decompression Sickness",{"date":350,"type":46},{"date":372,"type":46},"2022-03-30",{"date":374,"type":23},"2028-03-30",{"name":52,"class":53},{"id":377,"slug":378,"hasResults":11,"nctId":379,"briefTitle":380,"officialTitle":380,"acronym":381,"eligibilityCriteria":382,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":383,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":385,"conditions":386,"keywords":4,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":54},"100440573","study-for-the-quantification-in-ecological-conditions-of-sensorimotor-and-dysexecutive-disorders-in-cerebral-palsy-patients-100440573","NCT05017051","Study for the Quantification in Ecological Conditions of Sensorimotor and Dysexecutive Disorders in Cerebral Palsy Patients","SDS2","Inclusion Criteria:\n\n* Patients with a dysexecutive syndrome OR healthy subjects\n* Over 18 years-old\n\nExclusion Criteria:\n\n* Patients\n\n  * Psychiatric pathology (except for Post-Traumatic Stress Disorder)\n  * Pregnant or breastfeeding woman\n* Healthy subjects\n\n  * Neurologic or psychiatric pathology\n  * Pregnant or breastfeeding woman",{"count":384,"type":23},442,"Executive functions are defined as the mental functions necessary for an individual to adapt to a complex or new environment that requires freedom from automatic and routine behavior. Deficits in executive functions are described under the term \"dysexecutive syndrome\", and call into question the quality of social and professional life as well as the autonomy of patients.\n\nThe usual methods of identifying dysexecutive syndrome are based essentially on batteries of neuropsychological tests known as \"paper and pencil\". However, these tests may lack sensitivity, in that they assess the patient in a very structured setting, very different from real life conditions, which are full of distractions and choices to be made.\n\nEvaluations on real tasks are more rarely used but have the advantage of observing the difficulties encountered by a patient in everyday life.\n\nTwo tests of this type have been set up in the Neurology Department of the Hôpital d'Instruction des Armées Percy, and are integrated into the routine care of patients with a dysexecutive syndrome.\n\nFor this purpose, a room in the department has been set up as a studio in order to reproduce as much as possible an everyday life environment, in which executive functions, fine motor skills, neurovegetative functions, emotional state, posture, locomotor skills and visual information capture can be measured ecologically.",[387],"Dysexecutive Syndrome","2022-12-20",{"date":390,"type":46},"2022-12-21",{"date":392,"type":46},"2021-10-13",{"date":394,"type":23},"2028-10",{"name":52,"class":53},{"id":397,"slug":398,"hasResults":11,"nctId":399,"briefTitle":400,"officialTitle":400,"acronym":401,"eligibilityCriteria":402,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":403,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":405,"conditions":406,"keywords":408,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":411,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":356},"100430317","study-of-the-role-of-the-induced-membrane-in-the-reconstruction-of-bone-loss-in-the-limbs-100430317","NCT04883502","Study of the Role of the Induced Membrane in the Reconstruction of Bone Loss in the Limbs","MEMBRAN","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patient with traumatic bone loss\n* Patient eligible for the induced membrane technique\n\nExclusion Criteria:\n\n* Patients with post-tumor bone loss\n* Patients who are immunocompromised or under immunosuppressive treatment\n* Patients with chronic inflammatory disease (diabetes, inflammatory bowel disease)\n* Patients with collagenosis\n* Patient with a contraindication to sampling\n* Pregnant or breastfeeding women",{"count":404,"type":23},80,"Masquelet's induced membrane technique is a two-stage reconstructive surgery for severe bone fractures commonly used by military orthopedists. The particularity of this technique relies on the synthesis of a biological membrane induced by the transient implantation of a surgical cement (= 1st stage surgery). The presence of the induced membrane in the reconstruction space defines a microenvironment or \"biological chamber\" favourable to osteogenesis, positively influencing the repair of the lesion after implantation of an autologous bone graft (= 2nd stage of surgery).\n\nIn view of the excellent clinical results obtained with this procedure, the Masquelet technique has gradually become a reference treatment in the field of orthopedic and trauma surgery.\n\nHowever, orthopedic surgeons sometimes observe failures in bone consolidation. To our knowledge, the role played by induced membrane in these therapeutic failures has never been studied.",[407],"Bone Loss",[409,410],"Masquelet technique","Induced membrane technique",{"date":390,"type":46},{"date":413,"type":46},"2021-10-29",{"date":415,"type":23},"2028-04",{"name":52,"class":53},{"id":418,"slug":419,"hasResults":11,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":423,"eligibilityCriteria":424,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":123,"enrollmentInfo":425,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":427,"conditions":428,"keywords":430,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":438,"leadSponsor":440,"locationsCount":4},"100481158","neural-bases-of-phantom-pain-after-amputation-100481158","NCT05545358","Neural Bases of Phantom Pain After Amputation","Experimental Study of the Neural Bases of Phantom Pain After Amputation and Their Modification by Proprioceptive Training: MRI Study of the Brain and Spinal Cord","Phantom limb","Inclusion Criteria:\n\n* Between 18 and 65 years old\n* For the \"amputees with phantom pain\" group: patients who have been amputated for more than 2 years and have chronic phantom pain\n* For the \"amputees without phantom pain\" group: patients who have been amputated for more than 2 years and do not have chronic phantom pain\n* For the \"healthy participants\" group: healthy participants with no neurological history\n\nExclusion Criteria:\n\n* Clinically significant pathology (gastrointestinal, renal, hepatic, endocrine, cardiovascular or respiratory)\n* Progressive psychiatric or neurological pathology\n* On psychotropic medication\n* Pregnant or nursing woman\n* Inadequate level of French language",{"count":426,"type":23},75,"The amputation of a limb results in chronic pain associated with the lost limb in the majority of patients, which persists over time. Despite a large number of studies conducted in an attempt to elucidate the neural basis of phantom pain, these are still not elucidated and current treatments often fail to relieve patients' pain.",[429],"Phantom Pain",[431,432],"fMRI","spinal fMRI","2022-09-16",{"date":435,"type":46},"2022-09-19",{"date":437,"type":23},"2022-10",{"date":439,"type":23},"2026-10",{"name":52,"class":53},{"id":442,"slug":443,"hasResults":11,"nctId":444,"briefTitle":445,"officialTitle":445,"acronym":446,"eligibilityCriteria":447,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":448,"enrollmentInfo":449,"targetDuration":4,"studyType":24,"phases":451,"briefSummary":452,"conditions":453,"keywords":4,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":455,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":462,"locationsCount":356},"100443092","screening-for-individual-susceptibility-factors-to-immersion-pulmonary-edema-100443092","NCT05049889","Screening for Individual Susceptibility Factors to Immersion Pulmonary Edema","RFSI-OPI","Inclusion Criteria:\n\n* Military or civilian diver with at least 100 dives\n* Between the ages of 18 and 60\n* Good physical condition (able to run\u002Fswim for 30 minutes at a constant pace).\n\nExclusion Criteria:\n\n* Divers with a current temporary medical incapacity to dive\n* Persons with contraindications to physical exercise and\u002For scuba diving\n* Pregnant or breastfeeding women","60 Years",{"count":450,"type":23},63,[26],"Immersion Pulmonary Edema (IPE) is a relatively new form of hemodynamic pulmonary edema. The number of cases has been increasing over the last ten years and it has become the second most common cause of hospitalization for military divers, after decompression sickness. The pathophysiological mechanisms of IPE are not completely known. Its occurrence is linked to a combination of factors related to the environmental constraints of diving, as well as to the diver's equipment. The main external factors are increased hydrostatic pressure, cold, intense effort and emotional stress. The impact of internal factors is not known. At this time, no severe forms of IPE have been identified in the military. However, it is important to identify this pathology at an early stage, even if the signs appear minor, because the continuation of underwater activity can significantly worsen the clinical picture. The risk of recurrence (greater than 15%) could result in a severe or even lethal accident.",[454],"Pulmonary Edema","2022-09-13",{"date":457,"type":46},"2022-09-14",{"date":459,"type":46},"2022-08-17",{"date":461,"type":23},"2026-08",{"name":52,"class":53},""]