[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ditte Hansen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":69},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,38],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100340714","diagnosis-of-renal-osteodystrophy-in-patients-with-reduced-renal-function-100340714",false,"NCT03716128","Diagnosis of Renal Osteodystrophy in Patients With Reduced Renal Function","Diagnosis of Renal Osteodystrophy in Patients With Reduced Renal Function Can 18F-PET Replace Bone Histomorphometry","Patients with reduced renal function:\n\nInclusion Criteria:\n\n-≥ 18 years\n\n* estimated Glomerular Filtration Rate (eGFR) ≤ 20 ml\u002Fmin\u002F1,73m2\n* PTH \\\u003C 150 pg\u002Fml or PTH \\> 300 pg\u002Fml\n\nExclusion Criteria:\n\n* ongoing malignancy\n* Allergy towards tetracyclin\n* Pregnancy\n\nControl Group:\n\nInclusion Criteria:\n\n-≥ 18 years\n\n* eGFR \\>= 60 ml\u002Fmin\n* under examination for c prostata\n* Prostatic Specific Antigen (PSA) total \\\u003C40 µg\u002Fl\n\nExclusion:\n\n* Former kidney disease\n* ionized calcium or PTH outside normal range\n* Known metabolic bone disease\n* treatment with anticoagulants\n* Disturbed thrombosis and hemostasis","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","OBSERVATIONAL","The aim of the study is to\n\n1. To describe the bone morphology in patients with reduced renal function and high or low parathyroid hormone (PTH) respectively.\n2. To investigate if the non-invasive method 18-Fluoride Positron Emission Tomography (18F-PET) can describe the bone turnover and reflect the bone histomorphologic changes\n3. To investigate if non-oxidized PTH reflects bone turnover",[24],"Renal Osteodystrophy","RECRUITING","2025-03-14",{"date":28,"type":29},"2025-03-18","ACTUAL",{"date":31,"type":29},"2018-09-26",{"date":33,"type":20},"2027-10",{"name":35,"class":36},"Ditte Hansen","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":45,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":57,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},"100402619","phase-4-treatment-of-adynamic-bone-disorder-with-parathyroid-hormone-in-chronic-kidney-disease-100402619","NCT04522622","Treatment of Adynamic Bone Disorder With Parathyroid Hormone in Chronic Kidney Disease","Treatment of Adynamic Bone Disorder With Parathyroid Hormone in Patients With Chronic Kidney Disease","Inclusion Criteria:\n\n* Age ≥18 years\n* CKD stage 4-5D (eGFR ≤29 ml\u002Fmin) according to Kidney Disease Improving Global Outcomes(KDIGO) definition\n* DXA scan with a T-score at the total hip, femoral neck or lumbar spine (L1-4) ≤-2 (or Z-score ≤-2) in a minimum of 2 vertebraes (for patients with active oral prednisolone treatment ≥ 5 mg\u002Fday for minimum 3 months the T-score or Z-score limit i \\\u003C -1) and\u002For former fragility fracture (vertebral, hip, for- or upper arm, ankle) assessed with VFA or x-ray of the columna\n* Patients with expected adynamic bone disorder, based on BSAP≤21 µg\u002Fl or biopsy-verified low bone turnover\n\nExclusion Criteria:\n\n* Hypercalcemia defined as sustained ionized calcium \\>1.35 mmol\u002Fl\n* Previous fracture withon the last 6 months \\*Patients may be rescreened after the 6 months\n* Previous calciphylaxis\n* Thyroid disturbances not adequately treated based on the opinion by the clinician \\*Patients may be rescreened after treatment optimization\n* Treatment with digoxin\n* Paget's disease or other metabolic bone disorders\n* Antiresorptive or bone anabolic medication during the last 24 months (for bisphosphonates it is only during the last 12 months)\n* Former or present malignant disease (except skin basal or planocellular carcinoma)\n* Previous external beam or implant radiation therapy to the skeleton\n* Patients who have undergone a kidney transplantation within the last 12 months\n* 25 hydroxyvitamin D2 and D3 \\\u003C50 nmol\u002Fl \\*Patients may be rescreened after correction\n* Inability to administer teriparatide\n* Reduced liver function \\*Alanine Aminotransferase (ALAT) \\>3x upper limit of normal or bilirubin \\> 2x upper limit of normal\n* Pregnancy, lactation or fertile women (post-menopausal females are not considered fertile) not using safe anticonception (the following contraceptive methods are considered appropriate: Intrauterine device (IUD) or hormonal anticontraceptive (oral contraceptives, implant, transdermal patches, vaginal ring or depot injection)).\n* Hypersensitivity to the active substance in teriparatide or to any of the excipients or content\n* Inability to provide informed consent\n* Medical conditions or treatments that may interfere with assessments of the outcomes of the trial\n* Drug or alcohol abuse\n* Unable to participate in a clinical study based on the judgement by the local investigator\n* For those participating in the bone biopsy procedure: 1) Hypersensitivity to any of the tetracyclines or to any of the excipients or content, 2) Treatment with anticoagulants (vitamin K antagonists, Non-vitamin K Antagonist Oral Anticoagulants (NOAC), unfractionated or low-molecular heparin or antiplatelet agents that, due to clinical indication can't be paused, 3) Disturbances in thrombosis and\u002For haemostasis\n* For those participating in pulse wave measurements: 1) Atrial fibrillation, 2) Aorta stenosis","120 Years",{"count":47,"type":20},48,"INTERVENTIONAL",[50],"PHASE4","This study is a 1:1 randomized controlled trial with an intervention for 18 months and a follow up period of 12 months. The purpose of the study is to assess the safety and efficacy of recombinant human parathyroid hormone for treatment of adynamic bone disorder in patients with chronic kidney disease.",[53,54,55,56],"Adynamic Bone Disease","Chronic Kidney Diseases","Cardiac Disease","Chronic Kidney Disease-Mineral and Bone Disorder",[58,59],"Fracture risk","Teriparatide","2024-04-19",{"date":62,"type":29},"2024-04-23",{"date":64,"type":29},"2021-12-15",{"date":66,"type":20},"2027-09-01",{"name":35,"class":36},4,""]