[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dominique JANUEL\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":109},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,82],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100578593","theta-burst-stimulation-with-an-8-coil-versus-h1-coil-for-resistant-depression-100578593",false,"NCT06813313","Theta Burst Stimulation With an 8-Coil Versus H1-Coil for Resistant Depression","Randomized Controlled Trial of Two Accelerated Transcranial Magnetic Stimulation Methods in the Treatment of Resistant Depression: Intermittent Theta Burst Stimulation With an 8-Coil Versus H1-Coil","rTBShTBS","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Presenting a major depressive episode according to the DSM-5-TR criteria, occurring as part of major depressive disorder (unipolar depression)\n* The major depressive episode must meet the criteria for treatment resistance, defined by a lack of response to at least two different antidepressant treatments prescribed at an effective dose for a duration of 6 weeks or more\n* Stable treatment for at least 6 weeks\n* Affiliation with a social security system or State Medical Assistance (Aide Médicale d'État)\n* Patient agrees to participate in the study and has signed an informed consent form\n\nExclusion Criteria:\n\n* Presence of a contraindication to TMS: epilepsy, intracranial foreign body, cochlear implant, retinal implant, pacemaker\n* Presence of a bipolar disorder according to DSM-5-TR criteria\n* Presence of catatonic or psychotic features during the current episode\n* Presence of severe psychiatric disorders other than a major depressive episode\n* Presence of neurological disorders\n* Unstable epilepsy\n* Current moderate to severe addiction disorders other than caffeine and\u002For tobacco\n* Current suicidal ideation\n* Use of any brain stimulation treatment (ECT, rTMS, tDCS) for the current episode\n* Pregnancy or breastfeeding\n* Women of childbearing potential without effective contraception\n* Persons under guardianship or legal protection","ALL","18 Years",{"count":20,"type":21},108,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare response rates after treatment with Figure Eight-Coil TMS versus H-Coil TMS on the prefrontal cortex left dorsolateral, in patients suffering from depression resistant. The main question it aims to answer is:\n\nrTBS (accelerated neuronavigated intermittent Theta Burst Stimulation) is more effective than hTBS (accelerated deep intermittent Theta Burst Stimulation) in the treatment of resistant depression in terms of response rate.?\n\nResearchers will compare Figure Eight-Coil TMS (rTBS) versus H-Coil TMS (hTBS) to see if rTBS is more effective than hTBS.\n\nParticipants will:\n\n* Receive, for each stimulation method, 8 sessions per day spaced 50 minutes apart, over 5 days.\n* Have visit all day of stimulation for checkups and tests.\n* Have a a research MRI before and after treatment.\n* Have follow-up visits at 1 month, 2 months, 3 months, 6 months, and 12 months post-treatment, via teleconsultation.",[27,28,29],"Treatment of Resistant Depression","H1-Coil","Theta Burst Stimulation",[31,28,32,33,34,35],"Resistant Depression","Theta burst stimulation","TMS","Accelerated Transcranial Magnetic Stimulation","Intermittent Theta Burst Stimulation with an 8-Coil versus H1-Coil","NOT_YET_RECRUITING","2025-02-03",{"date":39,"type":40},"2025-02-06","ACTUAL",{"date":42,"type":21},"2025-02-16",{"date":44,"type":21},"2028-11-18",{"name":46,"class":47},"Dominique JANUEL","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},"100562146","evaluation-of-the-efficacy-of-transcranial-magnetic-stimulation-on-resistant-auditory-hallucinations-in-schizophrenia-100562146","NCT06599372","Evaluation of the Efficacy of Transcranial Magnetic Stimulation on Resistant Auditory Hallucinations in Schizophrenia","Treatment of Resistant Auditory Hallucinations in Schizophrenia by Repetitive Transcranial Magnetic Stimulation. Naturalistic Study","HRRENAT","Inclusion Criteria:\n\n* Patient over 18 years of age\n* Patient diagnosed with schizophrenia according to DSM-V criteria (Diagnostic and Statistical Manual of Mental Disorder V5, 2013)\n* Presence of auditory hallucinations: Resistant auditory hallucinations: resistance to treatment with 2 different well-conducted antipsychotics.\n* Patient agreeing to participate in the study and having signed an informed consent\n* Patient with French language skills\n* Affiliation to a social security system\n* Women of childbearing age must be on contraception and have a negative pregnancy test (βHCG)\n\nExclusion Criteria:\n\n* Have a contraindication to MST: intracranial foreign body, unstabilized epilepsy, cochlear implant\n* Presence of an unstabilized medical condition\n* Pregnant woman (Women of childbearing age without effective contraception)\n* Current or less than one month old engagement in another research protocol\n* A person who is subject to a safeguard of justice measure\n* An adult under curatorship\n* Minor patients with mental health problems\n* Pregnant or breastfeeding women\n* A person in a social fragility (Persons deprived of liberty by a judicial or administrative decision, hospitalized persons)\n* Persons incapable or unable to give consent",{"count":57,"type":21},30,[24],"This open naturalistic study aims to evaluate the efficacy of rTMS in routine practice on auditory resistant hallucinations (AHR) of patients with schizophrenia. To this end, two stimulation methods will be offered to patients: the rTMS stimulation method and the cTBS stimulation method.We principally use the AHRS scale to evaluate the effectiveness of rTMS on RAH in patients with schizophrenia. Our main hypothesis is that rTMS used under naturalistic conditions, in addition to antipsychotics, would allow a relative improvement of resistant auditory hallucinations assessed by the AHRS scale between baseline and end of treatment in patients with schizophrenia.",[61,62,63],"Schizophrenia","Transcranial Magnetic Stimulation","Hallucinations, Verbal Auditory",[65,66,67,33,68,69,32,70,71],"hallucinations","resistant auditory hallucinations","schizophrenia","Transcranial magnetic stimulation","TBS","a improvement","real-life conditions","RECRUITING","2024-09-12",{"date":75,"type":40},"2024-09-19",{"date":77,"type":40},"2022-07-11",{"date":79,"type":21},"2027-11",{"name":46,"class":47},1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":90,"minAge":18,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},"100395625","emdr-pre-treatment-yoga-for-complex-trauma-100395625","NCT04431531","EMDR Pre-treatment Yoga for Complex Trauma","EMDR Pre-treatment Yoga for Complex Trauma Randomized Controlled Comparative Study","YOGA-EMDR","Inclusion Criteria:\n\n. Women\n\n* Meets diagnostic criteria for Complex Post-traumatic Stress Disorder according to ICD-11 criteria, related to childhood sexual abuse\n* PCL-5 must be at least 45\n* Age between 18 and 70.\n* Free, informed and signed consent.\n\nExclusion Criteria:\n\nNeurological disorders\n\n* Pregnant women\n* Severe and\u002For unstable somatic diseases\n* Diseases resulting in serious motor disorders (e.g. people paralyzed)\n* Patient not affiliated with social security, State Medical Aid (AME)\n* Patient hospitalized under stress in psychiatric care at the decision of the state representative or in psychiatric care at the request of a third party,\n* Patient under guardianship, curatorship and protection of justice\n* Patient participating in parallel biomedical research\n* French language not mastered\n* Persons unable to give consent","FEMALE","70 Years",{"count":93,"type":21},66,[24],"yoga is a technique of hope. Indeed, it is a practice that specifically combines postures, breathing technique and a state meditative. The combination of these elements produces multiple effects that are exposed to detailed in the publications of Bessel Van der Kolk (Price et al., 2017; Rhodes, Spinazzola, \\& van der Kolk, 2016; Van der Kolk, 2014; Van Der Kolk et al., 2014) and whose four main effects are summarized here:\n\n* A regulation of the level of vigilance\n* An improvement in self-awareness\n* An increased sense of self-efficacy\n* Improved metacognition, awareness and regulation emotional",[97],"Trauma, Psychological",[99],"Yogatherapy-EMDR-psychiatry","2024-03-03",{"date":102,"type":40},"2024-03-06",{"date":104,"type":40},"2016-09-20",{"date":106,"type":21},"2026-09-06",{"name":46,"class":47},2,""]