[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dow University of Health Sciences\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":435},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,48,72,98,128,153,182,205,246,275,305,331,359,388,408],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100642334","comparison-of-high-intensity-interval-training-with-moderate-intensity-continuous-training-in-chronic-non-specific-low-back-pain-patients-100642334",false,"NCT07645859","Comparison of High-Intensity Interval Training With Moderate-Intensity Continuous Training in Chronic Non-Specific Low Back Pain Patients","Comparison of High-Intensity Interval Training With Moderate-Intensity Connuous Training In Chronic Non-Specific Low Back Pain Patients: Randomized Clinical Trial","Inclusion Criteria:\n\n* Referred patients of back pain persisting for \\> 12 weeks with no identifiable specific cause or underlying pathology from DUH OPD who meet the eligibility criteria.\n* Age group 20-48 with either gender.\n* NPRS score ranging between 3 and 5 (mild to moderate).\n* Modified ODI score is mild to moderate.\n\nExclusion Criteria:\n\n* Any client with a specific cause of LBP (neurological problems, fractures, malignancy, infections, or rheumatic diseases such as RA or ankylosing spondylitis).\n* Any client with cardiopulmonary problems (recent myocardial infarction, uncontrolled hypertension, asthma, COPD).\n* Any client with musculoskeletal disorders \\[injuries limiting exercises, spine injuries, recent trauma (fracture), scoliosis by Forward Adam's test\\].\n* Any client with metabolic conditions (thyroid problems, uncontrolled diabetes).\n* Pregnancy \u002F first 3-6 months postpartum.\n* Recent surgery.","ALL","20 Years","48 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare the HIIT with MICT in chronic non-specific low back pain patients. The main questions it aims to answer are:\n\n* The broad aim of the study is to compare HIIT with MICT in pain reduction in chronic non-specific low back pain patients.\n* The purpose of this research is to compare HIIT with MICT on disability and quality of life among chronic non-specific low back pain patients.\n* It also attempts to investigate the relationship between the baseline attributes and outcome variables.\n\nResearcher will compare the HIIT to MICT to see the effects on CNSLBP\n\nParticipants will be:\n\n* Allocated to HIIT or MICT group for 6 weeks.\n* Assessed pre and post intervention.\n* Continuously monitored during treatment sessions.",[27],"Chronic Non-Specific Low Back Pain",[29,30,27,31,32,33,34],"High-Intensity Interval Training","Moderate-Intensity Continuous Training","Aerobic","Heart rate","Body composition","Anaerobic","RECRUITING","2026-06-10",{"date":38,"type":39},"2026-06-12","ACTUAL",{"date":41,"type":39},"2026-05-14",{"date":43,"type":21},"2026-12",{"name":45,"class":46},"Dow University of Health Sciences","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":47},"100640075","the-effect-of-palatal-rugae-design-in-complete-denture-on-patient-satisfaction-and-quality-of-life-100640075","NCT07579377","The Effect of Palatal Rugae Design in Complete Denture on Patient Satisfaction and Quality of Life","Inclusion Criteria:\n\n1. Patients seeking conventional complete dentures.\n2. Aged 40-80 years.\n3. Both genders (male and female).\n4. Patient's must be willing to participate in the study and able to attend follow-up appointments\n\nExclusion Criteria:\n\n1. Patients with severe underlying medical conditions and mental conditions.\n2. Neuromuscular dysfunction.\n3. Oral diseases such as denture stomatitis and oral submucous fibrosis\n4. Xerostomia and tied tongue condition.\n5. Flabby and Atrophic Ridges.",true,"40 Years","80 Years",{"count":58,"type":21},90,[24],"The goal of this clinical trial is to learn whether different palatal rugae designs in complete dentures can improve comfort, function, and overall oral health-related quality of life in edentulous adults aged 40 to 80 years. The main questions it aims to answer are:\n\nDo roughened or vacuum-formed thermoplastic sheet palatal rugae designs lead to higher patient satisfaction than the traditional polished design?\n\nDo these designs improve oral health-related quality of life, including chewing, speaking, and overall comfort?\n\nResearchers will compare three denture designs-a polished palatal surface, a roughened palatal surface, and a vacuum-formed thermoplastic sheet rugae design-to see which design provides better comfort, function, and quality of life for patients.\n\nParticipants will:\n\nReceive complete maxillary dentures made with one of the three palatal rugae designs\n\nAttend follow-up assessments at 1 week, 1 month, and 3 months after denture insertion (in person or by phone)\n\nComplete the OHIP-EDENT questionnaire and a Visual Analog Scale (VAS) to report satisfaction, comfort, and oral health-related quality of life.",[62,63],"Edentulism","Complete Dentures","2026-05-07",{"date":66,"type":39},"2026-05-12",{"date":68,"type":39},"2025-10-20",{"date":70,"type":21},"2026-12-30",{"name":45,"class":46},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":79,"maxAge":55,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},"100630139","short-term-comparative-assessment-of-mta-and-biodentine-in-complete-pulpotomy-for-symptomatic-irreversible-pulpitis-100630139","NCT07483788","Short Term Comparative Assessment of MTA and Biodentine in Complete Pulpotomy for Symptomatic Irreversible Pulpitis","Short Term Outcome of Complete Pulpotomy Using MTA vs Biodentine in Symptomatic Irreversible Pulpitis - A Randomized Controlled Trial","Inclusion Criteria:\n\nTeeth of generally healthy patients having following criteria will be included:\n\n1. Age between 18-40 years of both males and females\n2. Carious exposed maxillary and mandibular molars teeth\n3. Moderate to severe pain (VAS 4-10)\n4. Diagnosed with Symptomatic irreversible pulpitis on cold test and Electric pulp test (EPT)\n5. Periapical index of 1\n6. Hemostasis is achieved within 10 mins after full pulpotomy\n\nExclusion Criteria:\n\nTeeth of generally healthy patients having following criteria will be excluded:\n\n1. Any traumatic injury\n2. Non-restorable carious lesion\n3. Immature or Open apices of roots\n4. Internal or external Resorption\n5. Calcified canals","18 Years",{"count":81,"type":21},60,[24],"All Patients coming to the Operative Dentistry Department (DIDC-DUHS) with complain of pain in posterior teeth will be invited to participate. The treatment will be done by one dentist. Patient's medical and dental history will be recorded, and tooth will be checked for swelling, sensitivity, cavity type, and loosening of tooth. Special tests like the cold test, electric pulp test, and an X-ray will help assess the tooth's condition. Patient will also be asked to rate pain from 1-10. Before starting the treatment, the procedure will be explained to patient in detail, and written consent will be taken. The treatment will be done in two visits by one dentist. Patient will be given an injection to make tooth pain-free so that patient does not feel any discomfort during the treatment and the area will be kept clean using a rubber sheet. The dentist will remove the hole in tooth and remove the infected soft part of tooth and stop the bleeding. Then one of the two materials will be placed inside the tooth. A temporary filling will be placed first, and patient will come the next day for the final filling. An X-ray will be taken to check the result. If patient feel pain, may take ibuprofen (400 mg) as needed, and if the pain continues, please contact the dentist. Patient will be called for follow-ups after 1 day, 1 week, 1 month, and 3 months to make sure the tooth is healing properly.",[85],"Symptomatic Irreversible Pulpitis (SIP)",[87,88],"Symptomatic Irreversible Pulpitis","Complete pulpotomy","2026-03-16",{"date":91,"type":39},"2026-03-19",{"date":93,"type":39},"2024-11-02",{"date":95,"type":21},"2026-07-31",{"name":45,"class":46},2,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":79,"maxAge":55,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":106,"briefSummary":107,"conditions":108,"keywords":112,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":47},"100613303","this-clinical-trial-aims-to-compare-the-effectiveness-of-two-intra-pulpal-cryotherapy-techniques-endo-ice-and-ice-sticks-in-decreasing-intra-operative-pain-and-enhancing-the-success-of-local-anesthesia-during-pulpectomy-of-mandibular-molars-with-symptomatic-irreversible-pulpitis-100613303","NCT07264829","This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis.","Comparative Analysis of Intra-pulpal Cryotherapy Methods During Pulpectomy in Molars With Symptomatic Irreversible Pulpitis: A Randomized Control Trial","Inclusion Criteria:\n\n1. Individuals (Male and Female) aged 18 to 40 years.\n2. Healthy individuals with no significant present and past medical findings.\n3. Mandibular molars.\n4. Symptomatic irreversible pulpitis (moderate to severe pain according to VAS 4-10).\n5. Periapical index (PAI) Score: 1-3 on periapical radiograph.\n6. DAS-R: 4-14( mild to moderate anxiety)\n\nExclusion Criteria:\n\n1. Immature teeth with open apices.\n2. Calcified pulp chamber and canals.\n3. Periodontally compromised teeth.\n4. Individuals who had taken steroids, analgesics, or antibiotics within the last 48 hours.",{"count":58,"type":21},[24],"The goal of this clinical trail is to compare the analgesic effect of endo-ice and ice-sticks in reducing intra-operative pain during pulpectomy in molars with Symptomatic Irreversible Pulpitis. Principal Investigator will perform the procedure and outcome assessor will interview the participants as well as fill the pre-operative questionnaire. The patient will be instructed beforehand on how to score their pre-operative, intra-operative and post-operative intensity of pain according to Visual Analogue Scale.The Anxiety level of patient will also be recorded according to the Corah's Dental Anxiety Scale questionnaire and their level of anxiety before and after the intervention will be recorded by the outcome assessor.\n\nThe principal investigator will perform all endodontic procedures, with the outcome assessor blinded to the cryotherapy method. Prior to administering IANB, a topical anesthetic gel will be applied. A 27-gauge needle will deliver 1.8 ml of 2% lidocaine with 1:100,000 epinephrine at a rate of 1 ml\u002Fmin. After a 5-minute wait, anesthesia effectiveness will be confirmed through electric pulp testing (EPT) on a neighboring tooth, with two consecutive negative responses confirming success. Once adequate anesthesia is confirmed, an access opening will be made under rubber dam isolation for the procedure.\n\n1. CONTROL GROUP: After access opening and complete de-roofing of the pulp chamber, pulpectomy of the inflamed pulp will be performed under the given effective IANB with no additional intervention to control intra-operative pain.\n2. ENDO-ICE GROUP: After access opening, pulp will be exposed and de-roofing will be performed. Endo-ice with the help of cotton pellet will be applied inside the pulp chamber for 2min (8 consecutive applications, 15sec each) and pulpectomy of the inflammed pulp will be performed immediately.\n3. ICE-STICKS GROUP: Following the access opening and complete de-roofing of pulp chamber, four ice sticks will be placed inside the pulp chamber for 2 minutes (30 seconds each, using tweezer). Subsequently, pulpectomy of the inflamed pulp will be performed immediately.\n\nPatients will be asked to rate their level of pain to the outcome assessor at four specific intervals during the trial, i.e., pre-operative (before local anesthesia), pre-operative (after local anesthesia), during pulpectomy and immediately after pulp extirpation and it will be recorded in a proforma by the blinded outcome assessor.\n\nPain and Anxiety Scores will be compared to asses either cryotherapy or which method of cryotherapy found to be effective in reducing intra-operative pain.",[109,110,87,111],"Root Canal Treatment","Intra-operative Pain","Cryotherapy Effect",[113,114,115,116,117,118,87],"Cryotherapy","Endodontic treatment","Intra-operative pain","Pulpectomy","Endo-ice","Ice-sticks","NOT_YET_RECRUITING","2026-03-11",{"date":122,"type":39},"2026-03-13",{"date":124,"type":21},"2026-04-15",{"date":126,"type":21},"2026-10-30",{"name":45,"class":46},{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":136,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":152,"locationsCount":47},"100613304","phase-2-triple-antibiotic-paste-vs-simvastatin-for-lesion-sterilization-and-tissue-repair-in-primary-molars-100613304","NCT07264842","Triple Antibiotic Paste vs Simvastatin for Lesion Sterilization and Tissue Repair in Primary Molars.","Triple Antibiotic Paste Versus Simvastatin for LSTR Treatment of Primary Molars With Pulp Necrosis: A Randomized Controlled Trial","LSTR","Inclusion Criteria:\n\n* Young, healthy patient, ranging in age from 5-8 years.\n* Has parents\u002F guardians who give consent to allow their minor to participate in the study and willing to monitor their progress.\n* Having maxillary and mandibular primary molars with:\n\n  * Spontaneous pain or tenderness to percussion.\n  * Deep cavity extending to the pulp chamber.\n  * Chronic Abscess or draining sinus.\n  * Restorable.\n  * To be kept for less than a year.\n  * Irregular mobility that is not related to exfoliation.\n\nExclusion Criteria:\n\n* Uncooperative patients.\n* Children with a history of allergic reaction with antibiotics.\n* Teeth with physiological root resorption but root length is more than two thirds, root canal obliteration, severe internal resorption, internal calcifications, or piercing into the bifurcation.","5 Years","8 Years",{"count":81,"type":21},[140],"PHASE2","This randomized, double-blinded, parallel-controlled clinical trial aims to compare the effectiveness of Triple Antibiotic Paste (TAP) and Simvastatin in Lesion Sterilization and Tissue Repair (LSTR) of primary molars with pulp necrosis.\n\nA total of 60 children (aged 5-8 years) with non-vital primary molars will be recruited from the Department of Operative Dentistry and Endodontics, Dow International Dental College, Karachi. Participants will be randomly assigned to one of two groups:\n\nGroup 1 (Control): LSTR using Triple Antibiotic Paste (Ciprofloxacin + Metronidazole + Cefixime).\n\nGroup 2 (Intervention): LSTR using Simvastatin paste.\n\nBoth materials will be placed after non-instrumentation cleaning and sealed with glass ionomer cement, followed by stainless steel crown placement. Patients will be evaluated clinically and radiographically at 1, 2, and 3 months post-treatment.\n\nPrimary outcomes include clinical success (absence of pain, swelling, or sinus tract) and radiographic success (reduction or absence of periapical radiolucency). Data will be analyzed using SPSS v26, with chi-square and t-tests applied as appropriate; p \\\u003C 0.05 will be considered significant.\n\nThis study seeks to determine whether Simvastatin, owing to its antibacterial, anti-inflammatory, and regenerative properties, can serve as a viable alternative to antibiotic-based LSTR in managing necrotic primary teeth.",[143],"Pulpal Necrosis",[145],"Lesion Sterilization and Tissue Repair","2026-03-08",{"date":148,"type":39},"2026-03-10",{"date":150,"type":39},"2024-06-26",{"date":95,"type":21},{"name":45,"class":46},{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":54,"sex":16,"minAge":79,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":22,"phases":163,"briefSummary":165,"conditions":166,"keywords":170,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":47},"100619429","phase-4-cure-h-pylori-a-trial-on-the-combination-of-anti-ulcerants-and-levofloxacin-based-therapy-for-helicobacter-pylori-eradication-100619429","NCT07344506","CURE-H. Pylori: A Trial on the Combination of Anti-Ulcerants and Levofloxacin-Based Therapy for Helicobacter Pylori Eradication","Evaluating the Effectiveness of Anti- Ulcerants (Dexlansoprazole, Lansoprazole, and Vonoprazan) With Levofloxacin-based Triple Therapy for Helicobacter Pylori Eradication - A Three-arm Randomized Controlled Trial","CURE-H Pylori","Inclusion Criteria:\n\nAdult patients of both sexes, presenting to the out-patient departments of the participating healthcare centres, and diagnosed through a UBT to have H.Pylori infection by their physician will be eligible for enrolment in the study, but are currently not receiving any treatment for H.Pylori infection.\n\nExclusion Criteria:\n\n1. Those who will not provide written consent for the study.\n2. Patients with severe mental disability,\n3. pregnant or lactating women,\n4. those who are already on treatment for H.Pylori infection, and\n5. those who have received any antibiotic within the last two weeks of enrolling in this study will be excluded.\n6. Patients with known previous documented drug allergies for the current regime will be excluded from the trial",{"count":162,"type":21},942,[164],"PHASE4","This study, titled CURE-H. Pylori, is a three-arm, parallel-group, open-label, randomized controlled trial designed to evaluate the effectiveness of Dexlansoprazole, Lansoprazole, and Vonoprazan in combination with Levofloxacin and Amoxicillin for Helicobacter pylori eradication. H. pylori infection is a significant health issue worldwide, with an estimated prevalence of 44% globally and around 60% in Pakistan, leading to gastritis, peptic ulcer disease, and increased risks of gastric cancer and mucosa-associated lymphoid tissue lymphoma. Despite the widespread use of PPI-based triple therapies, treatment efficacy has decreased due to increasing antibiotic resistance, especially to Clarithromycin and Metronidazole. This study aims to assess the eradication rate of H. pylori in patients receiving either Dexlansoprazole 60mg, Lansoprazole 30mg, or Vonoprazan 20mg, each combined with Levofloxacin 500mg and Amoxicillin 1g for 14 days. Participants will be randomized into three arms (314 participants per arm) and assessed for H. pylori eradication using a Urea Breath Test (UBT) at follow-up, which will serve as the primary endpoint. Secondary objectives include assessing symptom improvement using the Gastrointestinal Symptom Rating Scale (GSRS), measuring symptoms such as reflux, abdominal pain, indigestion, diarrhea, and constipation. The study will enroll adult patients diagnosed with H. pylori via UBT and who are not currently receiving treatment for the infection. The study will be conducted at healthcare centers in major cities across Pakistan, including Peshawar, Faisalabad, Rawalpindi, Multan, Lahore, Karachi, and Quetta, over a 12-month period. All participants will sign informed consent forms before enrollment, ensuring they understand the study's procedures and risks. Statistical analysis will be performed using SPSS version 26, with categorical variables analyzed using the Chi-square or Fisher's exact test and continuous variables using descriptive statistics. The primary outcome is the H. pylori eradication rate, and secondary outcomes include the improvement in gastrointestinal symptoms. This study is significant because it aims to compare three different PPI-based therapies in the context of H. pylori eradication in a high-resistance population, providing much-needed data for tailoring treatment strategies in regions with high antibiotic resistance like Pakistan. The results could enhance the effectiveness and cost-efficiency of treatment regimens for H. pylori, ultimately improving patient outcomes and reducing the burden of gastric diseases. Ethical approval has been obtained from the Institutional Review Board (IRB) of Dow University of Health Sciences, Karachi, and all procedures will adhere to the principles of human subjects protection. This study will provide valuable insights into the comparative efficacy of different proton pump inhibitors when combined with Levofloxacin-based triple therapy, potentially leading to more effective treatment options for H. pylori infections in Pakistan and similar regions. The total required sample size for this study is 942 participants, with a 20% expected dropout rate. Data collection will be conducted at baseline and six weeks post-treatment, with the aim of addressing the region-specific challenges in H. pylori treatment and contributing to the global knowledge on optimal therapeutic strategies for this infection. Additionally, the trial's findings may contribute to the broader understanding of how regional antibiotic resistance patterns affect treatment outcomes and help shape future guidelines for H. pylori management in endemic areas. This trial will also help assess the safety and tolerability of the different therapies, providing a comprehensive evaluation of both therapeutic efficacy and patient quality of life post-treatment.",[167,168,169],"H. Pylori Gastrointestinal Disease","H.Pylori Infection","H.Pylori Eradication Rate",[171,172,173],"Helicobacter pylori, Peptic ulcer disease, Combination Triple regime, Dexlansoprazole, Lansoprazole, Vonoprazan, Eradication therapy, Treatment Efficacy","Randomized Controlled Trial","Three Arm","2026-01-07",{"date":176,"type":39},"2026-01-15",{"date":178,"type":39},"2025-05-01",{"date":180,"type":21},"2026-08-01",{"name":45,"class":46},{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":54,"sex":16,"minAge":79,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":22,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":47},"100612622","phase-4-comparison-of-effectiveness-of-gingival-displacement-using-retraction-cord-and-aluminum-chloride-gel-100612622","NCT07255976","Comparison of Effectiveness of Gingival Displacement Using Retraction Cord and Aluminum Chloride Gel","Inclusion Criteria:\n\n1. age ranges from 18 to 50 years a fixed prosthesis with minimum of two abutments.\n2. minimum of two abutments\n3. Finishing line margins will be Equiogingival\n4. Clinically healthy gingiva and periodontium.\n\nExclusion Criteria:\n\n* 1\\. Sub-gingival or supra-gingival margins 2 Periapical pathosis 3. inadequate obturated root canals 4. bleeidng disorder 5.uncontrolled diabetes, 6.hypertension 7.neurological disease","50 Years",{"count":190,"type":21},66,[164],"This study aims to compare the horizontal gingival displacement by using a retraction cord and aluminum chloride gel, and also to determine the time taken for placement and hemorrhage after the procedure by using a retraction cord and aluminum chloride gel. Patients of both genders, age ranges from 18 to 50 years, will be selecting requiring fixed prosthesis with of minimum two abutments. This study divided in two parallel groups of 33 patients in each group.",[194,195,196],"Gingival Bleeding","Prosthesis Failure, Dental","Tissue Injury","2025-11-27",{"date":199,"type":39},"2025-12-01",{"date":201,"type":39},"2024-09-11",{"date":203,"type":21},"2025-12-30",{"name":45,"class":46},{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":16,"minAge":213,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":22,"phases":217,"briefSummary":218,"conditions":219,"keywords":223,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":245,"locationsCount":47},"100612671","non-surgical-periodontal-therapy-and-kidney-outcomes-in-type-2-diabetes-mellitus-100612671","NCT07256613","Non-surgical Periodontal Therapy and Kidney Outcomes in Type 2 Diabetes Mellitus","Outcomes of Non-surgical Periodontal Therapy on Urea and Creatinine Levels in Type-2 Diabetes Mellitus Patients","KIDPER","Inclusion Criteria:\n\nAdults between 30 and 65 years of age.\n\nMen and women previously diagnosed with type 2 diabetes mellitus for at least one year.\n\nParticipants with uncontrolled diabetes, defined as HbA1c ≥ 7%.\n\nPresence of moderate to severe gum disease (Stage II or Stage III periodontitis) as determined by a dental examination.\n\nEstimated glomerular filtration rate (eGFR) of 60 mL\u002Fmin\u002F1.73 m² or higher.\n\nWilling and able to provide written informed consent.\n\nExclusion Criteria:\n\nCritically ill individuals or those unable to communicate effectively.\n\nPregnant or breastfeeding women.\n\nWomen currently using hormone replacement therapy or oral contraceptives within the past six months.\n\nIndividuals taking steroidal, nonsteroidal anti-inflammatory drugs (NSAIDs), or other anti-inflammatory medications within the past three months (except low-dose aspirin up to 75 mg daily).\n\nParticipants with a recent history of major blood loss, trauma, or gastrointestinal bleeding.\n\nUse of antibiotics within the last month.\n\nHistory of fever or vomiting lasting more than one week within the last month.\n\nRegular tobacco or alcohol users.\n\nIndividuals with any other chronic disease or condition that could interfere with study outcomes.\n\nIndividuals unwilling or unable to comply with study procedures or follow-up visits.","30 Years","65 Years",{"count":216,"type":21},46,[24],"Brief Summary (Lay Description)\n\nThis research study is being conducted to understand whether treating gum disease (periodontitis) can help improve kidney health in patients who have type-2 diabetes mellitus (T2DM). Both diabetes and gum disease are common long-term conditions that often occur together. People with uncontrolled diabetes are at risk of developing kidney problems due to damage in the small blood vessels of the kidneys - a condition known as diabetic nephropathy.\n\nScientific evidence has already shown that treating gum disease can help improve blood sugar control in diabetic patients. However, it is still unclear whether gum treatment can also help reduce the risk or severity of kidney-related complications. This study aims to find out if non-surgical periodontal therapy (NSPT), which includes scaling and root planing (deep dental cleaning), has any effect on blood markers of kidney function - specifically urea, creatinine, and estimated glomerular filtration rate (eGFR) - in patients with uncontrolled type-2 diabetes.\n\nThe study will be conducted as a randomized controlled trial involving 46 patients with uncontrolled T2DM (HbA1c ≥ 7%) who also have moderate to severe gum disease. Participants will be divided randomly into two groups:\n\nTest Group: Will receive full-mouth non-surgical periodontal therapy (scaling and root planing) and oral hygiene instructions.\n\nControl Group: Will receive oral hygiene instructions only and will get the same gum treatment later (after 90 days, as delayed therapy).\n\nAll participants will have their gum health examined, and blood tests will be done at the start and again after 90 days to measure urea, creatinine, and eGFR levels. These tests help determine how well the kidneys are working. The changes in these values before and after gum treatment will show whether improving oral health has any beneficial impact on kidney function in diabetics.\n\nThe study is expected to take one year and will be conducted at Dow University of Health Sciences, Karachi. All participants will receive standard dental and laboratory assessments at no cost. The results may help improve future strategies for managing diabetic patients by integrating oral health care with medical care.\n\nPurpose:\n\nTo determine whether treating gum disease (through non-surgical periodontal therapy) can improve kidney function markers - urea, creatinine, and eGFR - in patients with uncontrolled type-2 diabetes mellitus.\n\nQuestion being answered:\n\nDoes non-surgical periodontal therapy have a positive effect on kidney function in uncontrolled type-2 diabetic patients by reducing urea and creatinine levels and improving eGFR?",[220,221,222],"Type 2 Diabetes Mellitus MeSH:D003924","Periodontitis MeSH:D010518","Diabetic Nephropathies MeSH:D003928",[224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239],"Type 2 Diabetes Mellitus","Uncontrolled Type 2 Diabetes","Diabetes-related nephropathy","Chronic kidney disease (CKD)","Diabetic nephropathy","periodontitis","non surgical periodontal therapy","scaling","root palnning","serum creatinine","blood urea nitrogen","BUN","eGFR","MDRD GFR euation","oral hygiene instruction(OHI)","Randomised control trial","2025-11-20",{"date":199,"type":39},{"date":243,"type":39},"2025-08-15",{"date":124,"type":21},{"name":45,"class":46},{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":252,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":254,"enrollmentInfo":255,"targetDuration":4,"studyType":22,"phases":257,"briefSummary":258,"conditions":259,"keywords":262,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":47},"100586705","comparative-effectiveness-of-myofacial-release-vs-cupping-therapy-on-quality-of-life-in-restless-leg-syndrome-with-knee-oa-100586705","NCT06918847","Comparative Effectiveness of Myofacial Release vs Cupping Therapy on Quality of Life in Restless Leg Syndrome With Knee O.A.","Comparative Effectiveness of Myofacial Release vs Cupping Therapy on Quality of Life in Restless Leg Syndrome With Knee O.A.A RCT","RCT","Inclusion Criteria:\n\n1. grade 2, 3 and 4 knee OA by the Kellgren Lawrence classification\n2. Bilateral or unilateral both knee OA\n3. Age 40 to 70 years\n4. Patients who were meeting the International Restless Leg Syndrome Study Group (IRLSSG) eligibility criteria\n\nExclusion Criteria:\n\n1. patients with cognitive dysfunction\n2. Rheumatoid arthritis\n3. patients with neurological disorders\n4. Medical conditions covering (cardiovascular disease, neurological disorders, severe psychiatric illness or pregnancy)","70 Years",{"count":256,"type":21},54,[24],"The aim of this study is to determine effectiveness of Myofascial Release and Cupping Therapy on Quality of Life in Restless Leg Syndrome with knee Osteoarthritis. Holding this aim, a Randomized control trial will be conducted at physiotherapy out patient department of Dow Institute of Physical Medicine and Rehabilitation.\n\nThe subjects will first be screened by the principal investigator, physiotherapist, using the criteria of International Restless Leg Syndrome Study Group (IRLSSG). Each selected subject will go for random allocation in one of the two treatment groups with different interventions with the help of a computer-generated randomization sheet. The group A will be provided with myofacial release whereas the group B will receive cupping therapy while cryotherapy and passive lower limb stretches (hamstring and calf muscles) will be applied to both the groups as standard treatment. Assessment will be done at baseline and will re-evaluate at the post intervention session through an assessment form. Physical therapist but not the principal investigator will assess who will be unaware to the type of intervention administered.\n\nOutcome measures will be Pittsburgh sleep quality index, Visual Analog Scale for pain assessment, Restless leg syndrome Quality of life questionnaire (RLS-QOL), International Restless leg syndrome Study Group Rating Scale (IRLSSG RS) and passive straight leg raise (PSLR). Total 12 sessions will be given for duration of 4weeks on alternate days.",[260,261],"Restless Leg Syndrome With Knee OA","Sleep Disorder",[263,264,265,266],"Restless leg syndrome","knee OA","cupping therapy","myofacial release","2025-10-02",{"date":269,"type":39},"2025-10-07",{"date":271,"type":39},"2025-05-05",{"date":273,"type":21},"2026-07",{"name":45,"class":46},{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":11,"sex":16,"minAge":79,"maxAge":282,"enrollmentInfo":283,"targetDuration":4,"studyType":22,"phases":285,"briefSummary":287,"conditions":288,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":47},"100515275","phase-2-outcomes-of-high-volume-saline-irrigation-vs-povidone-iodine-solution-cleaning-of-iowi-in-preventing-ssis-in-emergency-laparotomies-100515275","NCT05989386","Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies","Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of Intraoperative Incision Wound in Preventing Surgical Site Infections in Emergency Laparotomies: A Randomized Controlled Trial","Inclusion Criteria:\n\n* • Patients undergoing emergency laparotomy under the care of surgical-6 unit of Dr. Ruth K. M. Pfau Civil Hospital Karachi\n\n  * The age of patients should be between 18-60 years old.\n\nExclusion Criteria:\n\n* Diabetic patients\n* Immune-suppressed patients\n* Patients taking steroids\n* Patients undergoing chemo-radiotherapy.\n* Pregnant females\n* Previous abdominal surgery within the last 30 days.\n* Presence of concurrent abdominal wall infections.\n* Trauma Laparotomies\n* Large Bowel perforations","60 Years",{"count":284,"type":21},200,[140,286],"PHASE3","The goal of this clinical trial is to compare the outcomes of High-volume saline irrigation vs Povidone-iodine solution cleaning of the intraoperative incision wound in preventing superficial surgical site infections in patients undergoing emergency laparotomies. The main question it aims to answer are:\n\n* Incidence of SSI after intervention\n* Length of hospital stay\n\nParticipants will be randomly assigned to two groups receiving either of the two groups:\n\nGroup A: 1000ml of IOWI with saline solution prior to incision closure Group B: The incisional wound will be closed conventionally without irrigation.\n\nResearchers will compare groups A( experimental group) and B (control group) to compare the incidence of superficial surgical site infections after intervention.",[289,290,291,292,293,294,295,296],"Surgical Site Infection","Surgical Wound","Surgical Incision","Emergency Laparotomies","Laparotomies","Post Operative Wound Infection","Wound Infection","Seroma","2025-06-14",{"date":299,"type":39},"2025-06-18",{"date":301,"type":39},"2023-04-29",{"date":303,"type":21},"2025-12-29",{"name":45,"class":46},{"id":306,"slug":307,"hasResults":11,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":311,"eligibilityCriteria":312,"healthyVolunteers":54,"sex":16,"minAge":313,"maxAge":188,"enrollmentInfo":314,"targetDuration":4,"studyType":22,"phases":315,"briefSummary":316,"conditions":317,"keywords":322,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":47},"100529360","phase-4-a-randomized-controlled-trial-of-vitamin-d-supplementation-on-salivary-biomarkers-and-cariogenic-oral-microbiome-100529360","NCT06172764","A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome","Effect of Vitamin D Supplementation on Salivary Biomarkers; Certain Proteins and Cariogenic Oral Microbiome for Medical Management of Dental Caries: A Randomized Controlled Trial","Incipient","Inclusion Criteria:\n\n* Patients of all genders and ages ranging from 12-50 years, having at least two teeth with clinically diagnosed Initial Carious Lesions at Moderate Risk of Dental Caries, after written informed consent.\n* Patients having vitamin D deficiency.\n\nExclusion Criteria:\n\n* Patients who have heavy calculus, gingivitis, or periodontitis.\n* Patients using desensitizing toothpaste or mouthwash up to six weeks before the study.\n* Patients who have severe intestine or kidney disease, malabsorption syndrome, or any other conditions affecting vitamin D metabolism.\n* Patients on antibiotics or probiotics therapy for the last month\n* Pregnant females.\n* Patients with poor oral hygiene and with excessive dietary exposure to acids and carbohydrates.","12 Years",{"count":58,"type":21},[164],"The goal of this clinical trial is to compare the treatment effect of vitamin D supplementation and topical fluorides in the population having vitamin D deficiency and Initial Carious Lesions (ICL) on the progression of ICL in teeth. This study aims to observe the changes in the International Caries Detection and Assessment System (ICDAS) scores, the concentration of salivary proteins, and cariogenic microbes, six months after the interventions.\n\n* Group A will get vitamin D supplements and oral hygiene instructions (OHI).\n* Group B will get vitamin D supplements, topical fluorides, and OHI.\n* Group C (Control), the vitamin D sufficient group will get topical fluorides and OHI.",[318,319,320,321],"Dental Caries","White Spot Lesion","Initial Caries","Incipient Enamel Caries",[318,319,320,321],"2025-03-08",{"date":325,"type":39},"2025-03-11",{"date":327,"type":39},"2023-12-12",{"date":329,"type":21},"2025-12",{"name":45,"class":46},{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":4,"eligibilityCriteria":337,"healthyVolunteers":11,"sex":338,"minAge":79,"maxAge":55,"enrollmentInfo":339,"targetDuration":4,"studyType":22,"phases":341,"briefSummary":342,"conditions":343,"keywords":345,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":47},"100580414","comparison-between-efficacy-of-norepinephrine-and-phenylephrine-boluses-for-prevention-of-spinal-anaesthesia-induced-hypotension-in-obstetrical-patients-undergoing-emergency-cesarean-section-a-double-blind-randomized-controlled-trial-100580414","NCT06836986","COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial","COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES FOR PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION- A Double Blind Randomized Controlled Trial","Inclusion Criteria:\n\n1. American society of anesthesiologists II and III patients\n2. Age 18-40years\n3. Gestational age 32 weeks and above\n\nExclusion Criteria:\n\n1. Patients with hypertensive disorders of pregnancy having baseline systolic blood pressure greater than 160 mmHg and diastolic blood pressure greater than 99 mmHg.\n2. Baseline mean arterial pressure less than 70 mmHg.\n3. Antepartum hemorrhage\u002Fintraoperative blood loss greater than 1000ml\n4. history indicative of cardiovascular or neurological disease.\n5. known fetal abnormality.\n6. Patients taking serotonin reuptake inhibitor, Tricyclic antidepressants,monoamine oxidase inhibitors.\n7. Maternal situations requiring immediate administration of general anesthesia","FEMALE",{"count":340,"type":21},124,[24],"The goal of this clinical trial is to learn if norepinephrine is more effective than phenylephrine for prevention of spinal anesthesia induced hypotension. The main questions it aims to answer are:\n\nDoes norepinephrine lower the incidence of spinal anesthesia induced hypotension in emergency obstetrical patients? We will compare effectiveness of norepinephrine and phenylephrine for the prevention of spinal anesthesia induced hypotension.\n\nParticipants will:\n\nBe administered prophylactic boluses of both drugs right after spinal anesthesia induction and maternal hemodynamic parameters and neonatal APGAR scores will be recorded",[344],"Spinal Anesthesia Induced Hypotension",[346,347,348,349,350],"Spinal anesthesia induced hypotension","Emergency lower segment cesarean section","Norepinephrine bolus","Prophylactic","Phenylephrine","2025-02-16",{"date":353,"type":39},"2025-02-20",{"date":355,"type":39},"2024-12-31",{"date":357,"type":21},"2025-03-31",{"name":45,"class":46},{"id":360,"slug":361,"hasResults":11,"nctId":362,"briefTitle":363,"officialTitle":364,"acronym":4,"eligibilityCriteria":365,"healthyVolunteers":54,"sex":16,"minAge":79,"maxAge":366,"enrollmentInfo":367,"targetDuration":4,"studyType":22,"phases":369,"briefSummary":370,"conditions":371,"keywords":373,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":381,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":387,"locationsCount":47},"100559337","phase-4-comparing-trypsin-chymotrypsin-and-naproxen-sodium-for-post-endodontic-treatment-pain-100559337","NCT06562816","Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-endodontic Treatment Pain","Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-endodontic Treatment Pain: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Both male and female, healthy patients (ASA class 1).\n* Patients between the age group of 18-45 years.\n* Patients who are appointed for endodontic treatment.\n* Maxillary or mandibular teeth diagnosed with symptomatic irreversible pulpitis based on delayed responses to vitality tests.\n\nExclusion Criteria:\n\n* Patients who will require emergency dental treatment.\n* Teeth with any form of peri-apical lesion will be excluded.\n* Patient who have taken analgesics within 24 hours prior to the treatment.\n* Patients with known hypersensitivity or allergy to any of the study medications.\n* Patients with any systemic disease such as uncontrolled diabetes, gastric ulcers, bleeding disorders, or cardiovascular problems.\n* Pregnant or lactating women and pediatric patients.","45 Years",{"count":368,"type":21},100,[164],"This study aims to compare the pain reduction efficacy of Trypsin-Chymotrypsin and Naproxen sodium after root canal treatment in patients with symptomatic irreversible pulpitis. A lot of patients suffer greatly from post endodontic treatment pain and have a fear of dental treatments due to the pain. Patients refuse to go to the dentists and neglect oral hygiene care. That's why it is very important to find an effective drug regimen to reduce this post treatment pain. The null hypothesis is that there will be no difference between the efficacy and mean pain scores of Trypsin-chymotrypsin and Naproxen Sodium for post-endodontic treatment pain. Conducted as a triple-blinded, parallel, randomized controlled trial, 100 patients will be randomly assigned to receive either Trypsin-Chymotrypsin or Naproxen sodium following standard root canal therapy. Pain levels will be assessed using a numerical rating scale at 1, 6, 12, and 24 hours post-treatment to evaluate the effectiveness of these two pain management modalities.",[372],"Effect of Drug",[374,375,87,376,377,378,379],"Trypsin-Chymotrypsin","Naproxen Sodium","Acute Irreversible Pulpitis","Post-endodontic treatment pain","Root canal treatment","Proteolytic Enzyme","2024-10-31",{"date":382,"type":39},"2024-11-04",{"date":384,"type":39},"2024-08-16",{"date":386,"type":21},"2025-01-31",{"name":45,"class":46},{"id":389,"slug":390,"hasResults":11,"nctId":391,"briefTitle":392,"officialTitle":392,"acronym":4,"eligibilityCriteria":393,"healthyVolunteers":54,"sex":16,"minAge":79,"maxAge":366,"enrollmentInfo":394,"targetDuration":4,"studyType":22,"phases":395,"briefSummary":397,"conditions":398,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":47},"100564810","phase-1-evaluation-of-effect-of-platelet-rich-fibrin-on-orthodontic-tooth-movement-a-split-mouth-randomised-controlled-trial-100564810","NCT06634017","Evaluation of Effect of Platelet-Rich Fibrin on Orthodontic Tooth Movement: a Split Mouth Randomised Controlled Trial","Inclusion Criteria:\n\n* Patients who give written consent to participate in the research\n* Orthodontic patients with good oral hygiene\n* Patients with periodontal probing depths≤3 mm with no bone loss\n* Patients undergoing orthodontic treatment with fixed appliance and requiring upper first premolar extraction followed by canine retraction\n* Patients treated with canine retraction utilizing maximum anchorage in the maxillary arch from trans-palatal arch anchorage device\n* Patients with mild to moderate crowding in maxillary arch\n* Patients with no previous history of orthodontic treatment\n\nExclusion Criteria:\n\n* patients who are smokers, health compromised (such as diabetics, with bone disorders, immunocompromised, known with blood dyscrasias) will be excluded from the trial. Patients with drug history of non-steroidal anti-inflammatory drugs, anti-inflammatory (in last 30 days), antibiotic therapy in last 3 months and those women who are pregnant will also be excluded.\n\nOther exclusion criteria will be patients with hypodontia, impacted\u002Fectopic canines, extracted first molars, and patients who may discontinue the trial with or without assigning any reasons and those not consenting to participate in the research.",{"count":5,"type":21},[396,140],"PHASE1","it is a randomized control trial and aims at investigating the effects of PRF on rate of tooth movement and root length to be tested on larger sample size of pakistani population",[399],"Rate of Tooth Movement in Orthodontic Patients","2024-10-07",{"date":402,"type":39},"2024-10-09",{"date":404,"type":39},"2024-04-25",{"date":406,"type":21},"2025-04-24",{"name":45,"class":46},{"id":409,"slug":410,"hasResults":11,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":4,"eligibilityCriteria":414,"healthyVolunteers":54,"sex":16,"minAge":415,"maxAge":214,"enrollmentInfo":416,"targetDuration":4,"studyType":22,"phases":418,"briefSummary":419,"conditions":420,"keywords":424,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":427,"lastUpdatePostDateStruct":428,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":47},"100551734","a-clinical-trial-to-compare-lasotronix-alone-or-in-combination-with-cpp-acp-to-treat-dh-100551734","NCT06463938","A Clinical Trial to Compare Lasotronix Alone or in Combination With CPP-ACP to Treat DH","A Clinical Study to Evaluate the Effectiveness of Casein Phosphopeptide, Amorphous Calcium Phosphate Paste (CPP-ACP) Used Alone or in Combination With Lasotronix (Diode Laser) to Treat Dentin Hypersensitivity","Inclusion criteria:\n\n* Patients of either gender, with ages between 25-65 years\n* should have at least more than one hypersensitive and vital tooth without any carious lesion or defective restoration\n\nExclusion criteria:\n\n* History of desensitizing therapy on the affected tooth\u002Fteeth in last six months (use of desensitizing toothpaste)\n* use of antibiotics \u002Fanalgesic\u002Fanti-inflammatory drugs\n* history of smoking\n* pregnancy\n* those who are not willing to participate or give follow-ups","25 Years",{"count":417,"type":21},120,[24],"Dentin hypersensitivity (DH) is defined as sharp pain of a shorter duration arise from exposed dentin in response to several chemicals and thermal or tactile stimuli that cannot be ascribed to other dental defects\". DH has a prevalence rate ranging from 1.3% to 92.1%, commonly affecting old ages. The use of laser has opened new dimensions in the treatment of DH. To the author's knowledge, not much research work has been conducted using LASOTRONIX as a treatment modality with CPP-ACP. Therefore, this research aims to determine the effectiveness of Casein phospho peptide paste (CPP-ACP) used alone or combined with a diode laser (LASOTRONIX).",[421,422,423],"Dentin Sensitivity","Hypersensitivity","Cervical Lesion",[421,425,426],"Lasotronix","Diode laser","2024-07-25",{"date":429,"type":39},"2024-07-26",{"date":431,"type":39},"2024-05-12",{"date":433,"type":21},"2024-10-10",{"name":45,"class":46},""]