[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dr David Mathieu\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100519776","brain-low-risk-aneurysm-stereotactic-radiosurgical-trial-100519776",false,"NCT06047951","Brain Low-risk Aneurysm Stereotactic Radiosurgical Trial","Brain Low-risk Aneurysm Stereotactic Radiosurgical Trial: A Phase 2 Nonrandomized Controlled Trial","BLAST","Inclusion Criteria:\n\n* Medical imaging (CTA, MRA or digital substraction angiography) reveals the existence of an asymptomatic unruptured saccular anterior circulation intracranial aneurysm under 7 mm\n* Advised by a vascular neurosurgeon to observe rather than undergo endovascular or microsurgical management\n\nExclusion Criteria:\n\n* Prior history of aneurysmal rupture\n* Presence of symptoms that could be attributed to the aneurysm (severe headache, third cranial nerve deficits, or others)\n* Imaging features deemed to increase rupture risk as evaluated by the treating physician\n* Posterior circulation aneurysm\n* Fusiform aneurysm\n* Dissecting aneurysm\n* Mycotic aneurysm\n* Direct contact between the aneurysm and the optic pathways on medical imaging\n* Prior coils or clips in the targeted aneurysm or any other aneurysm\n* Patient unable to consent\n* Patient unable or unlikely to comply with the follow-up schedule","ALL","18 Years","75 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to confirm the feasibility and safety of performing radiosurgery on unruptured, low-risk aneurysms in humans.\n\nParticipants will choose if they want to undergo radiosurgery or not. Participants who choose not to have radiosurgery will be assigned to the observational group. Participants who choose to have radiosurgery performed will be assigned to the radiosurgery group. Participants in both groups will attend an initial exam session as well as four follow-up sessions:\n\nDay 0\n\n* Initial questionnaire\n* CTA scan\n* MRI\n* Radiosurgery performed on patients in the radiosurgery group\n\n  6 months\n* CTA scan\n* Follow-up questionnaire\n\n  12 months\n* CTA scan\n* MRI\n* Follow-up questionnaire\n\n  24 months\n* CTA scan\n* Follow-up questionnaire\n\n  36 months\n* CTA scan\n* MRI\n* Follow-up questionnaire\n\nResearchers will compare the observational group and the radiosurgery group to see if there is a difference in the incidence of aneurysm rupture during the study period (3 years). The hypothesis is that radiosurgery should not increase the risk of aneurysm rupture.",[28],"Intracranial Aneurysm",[30],"brain aneurysm, radiosurgery, intracranial aneurysm","NOT_YET_RECRUITING","2025-02-12",{"date":34,"type":35},"2025-02-14","ACTUAL",{"date":37,"type":22},"2025-06",{"date":39,"type":22},"2030-06",{"name":41,"class":42},"Dr David Mathieu","OTHER",""]