[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dr. Behcet Uz Children's Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":100},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100520033","decremental-esophageal-catheter-filling-volume-titration-for-transpulmonary-pressure-measurement-100520033",false,"NCT06051292","Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement","Decremental Esophageal Catheter Filling Volume Titration For Esophageal Pressure Measurement","DECFVTTPM","Inclusion Criteria:\n\n* Pediatric patients between 1 months and 18 years\n* Patients need mechanical ventilation support without modification of ventilation settings within the upcoming 2 hours\n* Informed consent was signed by next of kin\n* Requiring esophageal catheter application\n\nExclusion Criteria:\n\n* Patients eligible for extubation or modification of ventilation settings within the upcoming 2 hours\n* Patient included in another interventional study in the last 30 days\n* Patients unable to undergo esophageal catheter insertion due to congenital or acquired pathologies\n* Patient included in another interventional research study under consent\n* Patient already enrolled in the present study in a previous episode of acute respiratory failure","ALL","1 Month","18 Years",{"count":21,"type":22},27,"ESTIMATED","INTERVENTIONAL",[25],"NA","Mechanical ventilation is a critical intervention in the management of pediatric patients with respiratory distress. During this process, accurate measurement of transpulmonary pressure (PL) is essential to ensure the safety and efficacy of ventilation. PL is defined as the difference between alveolar pressure (Palv) and pleural pressure (Ppl). While the direct measurement of Ppl is possible, it poses a risk to tissue integrity. Thus, the primary surrogate for Ppl measurement today is esophageal pressure (Pes).\n\nHowever, the measurement of Pes is not without challenges. This abstract outlines the pitfalls associated with Pes measurement, emphasizing the importance of employing well-defined procedures to mitigate potential errors. These errors can range from underestimation of Pes due to underfilled catheters to overestimation resulting from overfilled catheters.\n\nTo address these challenges and optimize Pes measurement, various methods have been proposed for titrating the filling volume of the esophageal catheter. In this study, investigators aim to assess a faster decremental filling method and compare it to the traditionally accepted Mojoli method in the context of pediatric patients. This research seeks to enhance the intensivists' understanding of the most efficient and accurate approach to Pes measurement during mechanical ventilation in the pediatric population, ultimately contributing to improved patient care and outcomes",[28,29,30],"Pediatric Acute Respiratory Distress Syndrome (PARDS)","Acute Respiratory Failure","Acute Respiratory Distress Syndrome",[32,33,34],"Acute respiratory failure (ARF)","esophageal catheter","transpulmonary pressure","RECRUITING","2025-03-18",{"date":38,"type":39},"2025-03-20","ACTUAL",{"date":41,"type":39},"2023-09-18",{"date":43,"type":22},"2025-12-30",{"name":45,"class":46},"Dr. Behcet Uz Children's Hospital","OTHER",4,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":72,"locationsCount":73},"100495425","closed-loop-synchronization-versus-conventional-synchronization-100495425","NCT05731024","Closed-loop Synchronization Versus Conventional Synchronization","Protocol for Comparing Closed-loop syncHronization vErsuS convenTional Synchronization In sPontaneously Breathing Pediatric Patients (CHESTSIPP) - a Randomized Cross-over Study","CHESTSIPP","Inclusion Criteria:\n\n* Pediatric patients older than 1 month and younger than18 years of age\n* Hospitalized at the PICU with the intention of treatment with mechanical ventilation at least for the upcoming 3 hours with spontaneous breathing activity\n* Written informed consent signed and dated by the patient or one relative in case that the patient is unable to consent, after full explanation of the study by the investigator and prior to study participation\n\nExclusion Criteria:\n\n* Formalized ethical decision to withhold or withdraw life support\n* Patient included in another interventional research study under consent\n* Patient already enrolled in the present study in a previous episode of respiratory failure\n* Pregnant woman\n* Patients deemed at high risk for the need of transportation from PICU to another ward, diagnostic unit or any other hospital\n* Hemodynamic instability defined as a need of continuous infusion of epinephrine or norepinephrine \\> 1 mg\u002Fh\n* Not being able to obtain reference waveform",{"count":57,"type":22},15,[25],"A prior research indicated that asynchrony between the patient and ventilator occurred in 33 percent of 19,175 breaths, and was seen in every patient. The most prevalent kind of asynchrony was ineffective triggering (68%), followed by delayed termination (19%), double triggering (4%) and premature termination (3%). Asynchrony between the patient and ventilator increased considerably with decreasing levels of peak inspiratory pressure, positive end-expiratory pressure, and set frequency.Despite this, more asynchrony categories exist, and there is no widely accepted categorization. Major asynchronies, however, include auto trigger, ineffective effort, and double trigger, while minor asynchronies include early\u002Flate cycle, trigger delay, and spontaneous breaths during a mandatory breath. This study aims to compare the safety and efficacy of a closed-loop synchronization controller with conventional control of synchronization during invasive mechanical ventilation of spontaneous breathing of pediatric patients in a pediatric intensive care unit (PICU).",[29,61],"Pediatric Respiratory Distress Syndrome",[32,63,64,65,66],"Pediatric acute respiratory distress syndrome (PARDS)","Closed-loop","synchronization","patient ventilator asynchrony",{"date":68,"type":39},"2025-03-19",{"date":70,"type":39},"2023-02-06",{"date":43,"type":22},{"name":45,"class":46},5,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},"100527338","mobile-health-applications-in-pediatric-patient-management-clinicians-perceptions-expectations-and-experiences-100527338","NCT06146465","Mobile Health Applications in Pediatric Patient Management: Clinicians' Perceptions, Expectations and Experiences","Inclusion Criteria:\n\n* Being a medical doctor involved in the management of pediatric patients (0-18 years old)\n\nExclusion Criteria:\n\n* Other specialists outside of pediatrics and family medicine.",true,{"count":82,"type":22},368,"OBSERVATIONAL","The goal of this observational study is to to determine the perceptions, expectations and experiences of physicians involved in pediatric patient management about mHealth applications. The main questions it aims to answer are:\n\n* Is the use of mHealth applications in pediatric patient management different between pediatricians and other specialties?\n* What are the most commonly used mHealth applications in pediatric patient management? Participants will fill out an online survey form.",[86,87],"Mobile Health","Pediatrics",[89,90],"mobile health","pediatric","2024-08-05",{"date":93,"type":39},"2024-08-06",{"date":95,"type":39},"2023-10-01",{"date":97,"type":22},"2024-10-01",{"name":45,"class":46},1,""]