[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dr. Grace Parraga\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":95},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100603994","paxt-pulmonary-imaging-of-mild-asthma-using-129xe-mri-and-tc-99-labeled-carbon-imaging-tc99cimaging-100603994",false,"NCT07143747","PAXT: Pulmonary Imaging of Mild Asthma Using 129Xe MRI and Tc-99-Labeled-Carbon-Imaging (Tc99CImaging)","PAXT","Inclusion Criteria:\n\nParticipants eligible for inclusion in this study must meet all of the following criteria:\n\n1. Participant diagnosed with mild (GINA1) asthma by physician\n2. Participant understands study procedures and is willing to participate in the study as indicated by the participant's signature\n3. Provision of written, informed consent prior to any study specific procedures\n4. Males and females 17 to 35 years of age\n5. Women of childbearing potential (after menarche) must ensure that they are using an effective form of birth control for at least 2 months prior to each imaging visit. Examples of effective birth control include:\n\n   1. True sexual abstinence\n   2. A vasectomized sexual partner\n   3. Implanon®\n   4. Female sterilization by tubal occlusion\n   5. Effective intrauterine device (IUD)\u002Flevonogestrel intrauterine system (IUS)\n   6. Depo-Provera™ injections\n   7. Oral contraceptive\n   8. Evra Patch™\n   9. Nuvaring™\n\nExclusion Criteria:\n\nParticipants fulfilling any of the following criteria are not eligible for inclusion in this study:\n\n1. Participant has an implanted mechanically, electrically, or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and\u002For ear implants) (at the discretion of the MRI Technologist)\n2. In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, CT, or Tc99CImaging, such as severe claustrophobia\n3. Participants who are pregnant, breastfeeding or have a positive pregnancy test at initial screening visit\n4. Participant is unable to perform spirometry or plethysmography maneuvers\n5. Participant is unable to perform MRI and CT breath-hold maneuvers","ALL","17 Years","35 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to better understand how asthma affects the lungs in young adults (ages 17-35) with mild asthma. The main questions it aims to answer are:\n\n* Can advanced imaging detect abnormal airway function in people with mild asthma?\n* Do changes in ventilation imaging correlate with asthma symptoms or quality of life? Researchers will compare hyperpolarized xenon-129 MRI and Technegas (Tc-99m) imaging to see if these techniques reveal more detailed lung abnormalities than standard lung function tests.\n\nParticipants will:\n\n* Complete a single 2-hour visit\n* Undergo two types of lung imaging: Hyperpolarized xenon-129 MRI (to visualize how air moves in the lungs), Technegas (Tc-99m) imaging (to assess airflow using nuclear medicine)\n* Perform spirometry and other breathing tests\n* Answer questionnaires about asthma symptoms and quality of life This study is designed to improve our understanding of subtle changes in lung function that may not be detected by standard tests in people with mild asthma. The findings may lead to better diagnostic tools and more personalized treatment strategies in the future.",[25],"Mild Asthma",[27,28,29,25,30],"Hyperpolarized 129Xe MRI","Technegas Ventilation Imaging","Pulmonary Function Testing","Ventilation Defects","NOT_YET_RECRUITING","2025-08-19",{"date":34,"type":35},"2025-08-27","ACTUAL",{"date":37,"type":21},"2025-09",{"date":39,"type":21},"2028-12",{"name":41,"class":42},"Dr. Grace Parraga","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":71,"locationsCount":43},"100236070","structure-and-function-mri-of-asthma-100236070","NCT02351141","Structure and Function MRI of Asthma","Inclusion Criteria:\n\n* Subjects male and female aged 18-60 with a clinical diagnosis of asthma\n* Smoking history ≤ 1 pack\u002Fyear\n* Subject understands the study procedures and is willing to participate in the study as indicated by signature on the informed consent\n* Subject is judged to be in otherwise stable health on the basis of medical history\n* Subject able to perform reproducible pulmonary function testing (i.e., the 3 best acceptable spirograms have FEV1 values that do not vary more than 5% of the largest value or more than 100 ml, whichever is greater.)\n* FEV1 \\>60% predicted\n\nExclusion Criteria:\n\n* Patient is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand the written material\n* Patient is unable to perform spirometry or plethysmography maneuvers\n* Subject has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and\u002For ear implants.) (At the discretion of the MRI Technologist\u002F3T Manager)\n* In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia.\n* Patient is pregnant","18 Years","60 Years",{"count":53,"type":21},200,"INTERVENTIONAL",[56],"NA","The investigators will apply 129Xenon and\u002For 3He image acquisition and analysis methods in 200 asthma patient volunteers in order to characterize and probe the relationship between lung structure and function using imaging.",[59],"Asthma",[61,62,63],"Noble Gas MRI","Pulmonary Function","Quality of Life Questionnaires","RECRUITING","2025-08-08",{"date":67,"type":35},"2025-08-11",{"date":69,"type":35},"2015-01",{"date":39,"type":21},{"name":41,"class":42},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":54,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":43},"100230571","longitudinal-study-of-helium-3-and-xenon-129-magnetic-resonance-imaging-100230571","NCT02279329","Longitudinal Study of Helium-3 and Xenon-129 Magnetic Resonance Imaging","Longitudinal Study of 3He and 129Xe Magnetic Resonance Imaging in Chronic Obstructive Pulmonary Disease","Inclusion Criteria:\n\n* Subjects male and female aged 50-85 with either A) a clinical diagnosis of COPD or Bronchiectais or B) \\>10 pack\u002Fyear smoking history\n* Subject understands the study procedures and is willing to participate in the study as indicated by signature on the informed consent\n* Subject must be able to perform a breathhold for 16s.\n* Subject is judged to be in otherwise stable health on the basis of medical history\n* Subject is ambulatory and can perform the 6MWT\n* Subject able to perform reproducible pulmonary function testing (i.e., the 3 best acceptable spirograms have FEV1 values that do not vary more than 5% of the largest value or more than 100 ml, whichever is greater.)\n* FEV1 \\>25% predicted\n* FVC \\> 25% predicted and \\>0.5L\n\nExclusion Criteria:\n\n* Patient is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand the written material.\n* Subject has a daytime room air oxygen saturation \\\u003C90% while lying supine.\n* Patient is unable to perform spirometry or plethysmography maneuvers\n* Patient is pregnant\n* In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia.\n* Subject has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and\u002For ear implants.)","50 Years","85 Years",{"count":53,"type":21},[56],"Subjects male and female aged 50-85 with a clinical diagnosis of chronic obstructive pulmonary disease (COPD) or Bronchiectasis, or those with ≥ 10 pack\u002Fyears smoking history will be imaged with CT and MRI for the development of tools to quantify and validate longitudinal in vivo magnetic resonance imaging phenotypes of COPD and Bronchiectasis.",[85,86],"COPD","Bronchiectasis","2024-06-12",{"date":89,"type":35},"2024-06-13",{"date":91,"type":35},"2009-05",{"date":93,"type":21},"2025-02",{"name":41,"class":42},""]