[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dr. Joachim Enax\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100598185","comparative-study-of-caries-preventive-effects-2-calcium-hypophosphite-toothpaste-vs-sodium-fluoride-toothpaste-1450ppm-f-100598185",false,"NCT07068204","Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)","Caries-preventing Effect of 2% Calcium Hypophosphite Toothpaste Compared to a Sodium Fluoride Toothpaste (1450ppm F) in Adults","Inclusion Criteria:\n\n* A minimum of 10 healthy molars and premolars (DMFS of these teeth = 0)\n* Willingness to use an electric (powered) toothbrush\n* Willingness to use interdental floss\n* Willingness to have bitewing radiographs taken\n* Willingness to undergo an oral examination by an intraoral camera (DIAGNOcam)\n\nExclusion Criteria:\n\n* Untreated caries \\[clinical investigation and analysis with an intraoral camera (DIAGNOcam)\\] (→ unsuitable subjects with one or two untreated caries in need of a restoration can become eligible after restorative therapy. If there are three or more untreated caries patients will be excluded)\n* Xerostomia (medication, radiation, disease induced)\n* Chemo\u002Fradiation therapy\n* Physical or mental disability which prevents proper oral health care\n* Orthodontic treatment\n* Severe periodontitis at the Baseline Visit (pocket depth on at least one tooth ≥ 5.5 mm)\n* Known hypersensitivity to one of the ingredients of the toothpastes to be tested\n* Regular medication intake interfering with salivary function or flow\n* Current pregnancy, the wish to become pregnant, the suspicion of being pregnant, or breastfeeding or in the course of the study\n* 3 or more carious lesions\u002Frestorations in last 36 months until Baseline Visit\n* Teeth missing due to caries in last 36 months until Baseline Visit",true,"ALL","18 Years","45 Years",{"count":21,"type":22},164,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of the study is to compare the caries-preventive effect of the test and control toothpaste in order to proof the non-inferiority of the test toothpaste compared to the control.",[28,29,30],"Caries, Dental","Calcium Hypophosphite","Fluoridation","RECRUITING","2026-04-10",{"date":34,"type":35},"2026-04-13","ACTUAL",{"date":37,"type":35},"2026-01-22",{"date":39,"type":22},"2028-01",{"name":41,"class":42},"Dr. Joachim Enax","INDUSTRY",2,""]