[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dr. Kerstin de Wit\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":119},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,73,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100644557","superficial-vein-thrombosis-testing-in-the-emergency-department-100644557",false,"NCT07671300","Superficial Vein Thrombosis Testing in the Emergency Department","Evaluating Superficial Vein Thrombosis in the Emergency Department.","SVTest","Inclusion Criteria:\n\n* Aged ≥ 18\n* Tested for superficial vein thrombosis in the emergency department or urgent care centre\n* Patients tested for SVT at all sites, including arms, legs and torso\n\nExclusion Criteria:\n\n* Patient opted out of research at the participating site\n* Patient included in the study in the last 90 days","ALL","18 Years",{"count":20,"type":21},400,"ESTIMATED","OBSERVATIONAL","Superficial vein thrombosis (SVT) occurs when blood in a vein directly under the skin clots. SVT causes vein tenderness, pain, and skin discolouration. Over time, the vein hardens into a firm, nontender, easily palpable lump. SVT commonly occurs in the veins of the leg. Each year, 1 per 1000 people over the age of 18 have a superficial vein thrombosis (SVT). SVT is painful but usually gets better within a month. Four in 100 people with SVT develop progressively worse blood clotting involving the deep veins or lungs.\n\nIf a deep vein clot in the leg occurs it can cause permanent disability with post-thrombotic syndrome (long-term leg pain and swelling) and reduced quality of life. If a pulmonary embolism occurs it may causes chest pain, breathlessness, pulmonary hypertension, psychological distress, and potentially death.\n\nRisk factors for SVT include varicose veins, pregnancy, cancer, the use of intravenous catheters, a history of venous thromboembolism, age, and thrombophilia.\n\nGuidelines tell doctors to use ultrasound scanning to decide whether SVT needs treatment with a blood thinner or not. Blood thinners prevent the clot from worsening.\n\nMany people who have SVT go to the emergency department. Scanning is limited to the daytime so often people have multiple trips to the emergency department for their scan and they spend many hours waiting for a doctor to see them.\n\nOur research group developed simple ways to limit the need for scans for other types of blood clots, like blood clots in the lungs or in the deep veins. We use a simple blood test called D-dimer. We believe we may be able to use D-dimer to help limit the need for SVT scanning.\n\nThis is an exploratory study to document what happens to patients tested for SVT in the emergency department, and to see if the D-dimer blood test might be useful in reducing scans. We will review the emergency department charts for patients who came to the emergency department with SVT. Our results will tell us whether further studies would be helpful.",[25,26],"Superficial Vein Thrombosis","D-dimer",[26,28,29,30],"Superficial vein thrombosis","Emergency Medicine","diagnostic","NOT_YET_RECRUITING","2026-06-22",{"date":34,"type":35},"2026-06-26","ACTUAL",{"date":37,"type":21},"2026-07-15",{"date":39,"type":21},"2029-07",{"name":41,"class":42},"Dr. Kerstin de Wit","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},"100634224","falls-validation-study-100634224","NCT07536906","Falls Validation Study","Validation of the Falls Decision Rule for Diagnosing Intracranial Bleeding in Older Adults After a Fall","Inclusion Criteria:\n\n* Age 65 or older\n* Present to the emergency department within 48 hours of having a fall\n* Fall from standing, from a chair, toilet seat, or bed\n\nExclusion Criteria:\n\n* Transferred from another hospital organization after brain imaging\n* Leave the emergency department prior to completion of their medical assessment\n* Previously enrolled\n* Lives outside the hospital catchment area","65 Years",{"count":53,"type":21},4000,"Each year, one in three adults over the age of 65 has a fall. These falls lead to half a million Canadian emergency department patient visits annually and falls in older adults account for more than 3% of all emergency department visits.\n\nA rapid, simple bedside test (known as a decision rule) to guide emergency physicians on when older adults should have a brain scan to diagnose traumatic brain bleeding was created. This decision rule will be checked to see if it works well in guiding who needs a brain scan.",[56,57],"Intracranial Bleed","Falls",[57,59,60,61,62],"Intracranial Bleeding","Head CT","Computed Tomography","Clinical Decision Rule","RECRUITING","2026-05-21",{"date":66,"type":35},"2026-05-27",{"date":68,"type":35},"2026-05-01",{"date":70,"type":21},"2030-12-30",{"name":41,"class":42},7,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":5},"100540699","emergency-medicine-pulmonary-embolism-testing-multicentre-study-100540699","NCT06320236","Emergency Medicine Pulmonary Embolism Testing Multicentre Study","EMPET","Inclusion Criteria:\n\n* Emergency department patient who is tested by an emergency physician for PE\n\nExclusion Criteria:\n\n* Patient is \\\u003C 18 years of age\n* No documentation of whether PE is the most likely diagnosis\n* D-dimer is not tested or else not resulted during the emergency visit\n* The D-dimer level is known before documentation of whether PE is the most likely diagnosis\n* The D-dimer is ordered prior to the physician assessing the patient\n* The patient has previously registered that they opt out of all research at the participating site\n* The patient leaves against medical advice\n* The patient has had PE or deep vein thrombosis imaging (CT pulmonary angiogram, ventilation-perfusion scan or lower limb ultrasound) within prior 30 days\n* There is a new (non-PE) indication for anticoagulation\n* The patient was initiated on treatment for presumed PE prior to PE testing\n* The patient has previously been enrolled into the study\n* The patient has a prior history of lower extremity deep vein thrombosis without availability of a baseline ultrasound scan\n* The patient was transferred from another hospital organization\n* The patient does not reside in Ontario\n* The patient has no valid Ontario Health Insurance Plan card",{"count":53,"type":21},"It is important to diagnose pulmonary embolism in a timely manner to prevent death and long-term disability. More than half a million people (4-5% of emergency department patients) are tested for pulmonary embolism, although the positive rate is low. Imaging for PE testing exposes patients to radiation, is expensive, adds time to the emergency visit, and can lead to a false positive diagnoses. Existing protocols aimed at reducing unnecessary pulmonary embolism imaging are complex and seldom used by emergency physicians. Too many patients undergo unnecessary pulmonary embolism imaging.\n\nA new tool (called Adjust-Unlikely) could safely reduce pulmonary embolism imaging in Canada. A research group composed of researchers, emergency physicians, and patients developed the Adjust-Unlikely clinical decision rule: a rule which has been customized for emergency physicians and emergency patients. Adjust-Unlikely is highly sensitive at the bedside, meaning there are very few false negative results.\n\nThe study aim is to prospectively validate Adjust-Unlikely pulmonary embolism testing in emergency patients with suspected pulmonary embolism.",[83,26,84],"Pulmonary Embolism","Diagnosis",[26,83,86,87,29],"Adjust-Unlikely","Diagnostic","2026-04-15",{"date":90,"type":35},"2026-04-20",{"date":92,"type":35},"2024-01-01",{"date":94,"type":21},"2027-09-30",{"name":41,"class":42},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":104,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":106,"conditions":107,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":118,"locationsCount":72},"100467283","selective-ct-for-anticoagulated-head-injured-patients-100467283","NCT05364749","Selective CT for Anticoagulated Head Injured Patients","Selective Neuroimaging for Head-injured Emergency Patients Who Take Anticoagulant Medication","Can-SCAHn","Inclusion Criteria:\n\n* Age ≥16 years\n* Presents to the emergency department after a head injury\n* Patient has a head CT in the emergency department\n* Is a current anticoagulant user\n\nExclusion Criteria:\n\n* Head injury occurred \\>48 h before patient's arrival to the emergency department\n* Penetrating head injury\n* Previously enrolled\n* Patient resides outside of the hospital's catchment area\n* Patient was transferred from another emergency department following neuroimaging\n* Patient was not managed by the emergency or trauma physician in the emergency department\n* Leaves the emergency department prior to completion of their medical assessment","16 Years",{"count":53,"type":21},"The goal is to derive and a clinical decision rule for safe exclusion of traumatic brain injury without neuroimaging in head-injured ED patients who take anticoagulant medications.\n\nThe objectives are to:\n\n1. Derive and externally validate a new highly sensitive and maximally specific clinical decision rule for the exclusion of traumatic brain injury in head-injured ED patients who take anticoagulant medications; and,\n2. Estimate the sensitivity and specificity of existing head injury clinical decision rules in head-injured ED patients who take anticoagulant medications.",[108,109,110,111],"Head Injury","Traumatic Brain Injury","Intracranial Hemorrhage, Traumatic","Blunt Head Injury","2026-04-11",{"date":114,"type":35},"2026-04-14",{"date":116,"type":35},"2022-02-01",{"date":94,"type":21},{"name":41,"class":42},""]