[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dr. Negrin University Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":196},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,74,102,125,147,168],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100581992","post-icu-syndrome-over-time-in-patients-with-respiratory-failure-100581992",false,"NCT06857513","Post-ICU Syndrome Over Time in Patients With Respiratory Failure","PICUS2","Inclusion Criteria:\n\n* Patients admitted to the ICU between January 2021 and December 2023 who have required invasive mechanical ventilation for a period of more than 48 hours.\n* Patients who give their informed consent to participate in the study.\n* Patients aged 18 years or older\n\nExclusion Criteria:\n\n* Patients who have been subjected to mechanical ventilation for less than 48 hours during their stay in the ICU between January 2021 and December 2023.\n* Patients who do not give their informed consent and, therefore, do not agree to participate in the interview.\n* Patients who have died during their stay in the ICU or in the period between 2021 and 2024.\n* Patients under 18 years of age.\n* Patients in whom it is not possible to collect all the information necessary to adequately assess post-ICU syndrome.","ALL","18 Years",{"count":19,"type":20},90,"ESTIMATED","OBSERVATIONAL","Intensive Care Units (ICU) stabilize and maintain vital functions in critically ill patients, optimizing their survival. However, patients with prolonged stays may develop Post-ICU syndrome , characterized by physical, cognitive and psychological dysfunctions. This syndrome considerably affects the quality of life of patients. The risk of post-ICU syndrome is associated with factors such as advanced age, delirium, prolonged sedation and mechanical ventilation.\n\nThe main objective of this study is to assess the temporal evolution of post-ICU syndrome in patients who required mechanical ventilation for more than 48 hours, analyzing its incidence, associated risk factors and the impact on their long-term quality of life.\n\nThis cross-sectional study evaluates the presence of post-ICU syndrome in 2025 in patients who have been admitted to the ICU during 2021 and 2024 who required invasive mechanical ventilation for more than 48 hours. Of this total, deceased persons, those who did not give their consent, and minors will not be included.",[24,25],"Post-Intensive Care Syndrome","Quality of Life",[27,28,29],"risk factors","intensive care unit","comorbidities","NOT_YET_RECRUITING","2025-09-02",{"date":33,"type":34},"2025-09-08","ACTUAL",{"date":36,"type":20},"2025-10-01",{"date":38,"type":20},"2026-01-30",{"name":40,"class":41},"Dr. Negrin University Hospital","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},"100404354","phase-4-efficacy-of-dexamethasone-in-patients-with-acute-hypoxemic-respiratory-failure-caused-by-infections-100404354","NCT04545242","Efficacy of DEXamethasone in Patients With Acute Hypoxemic REspiratory Failure Caused by INfEctions","Efficacy of Higher vs. Lower Doses of Dexamethasone in Patients With Acute Hypoxemic Respiratory Failure (Including ARDS) Caused by Infections (Including COVID-19)","DEXA-REFINE","Inclusion Criteria:\n\n* age 18 years or older;\n* intubated and mechanically ventilated;\n* acute onset of AHRF (as defined by a PaO2\u002FFiO2 ≤300 mmHg during at least 6 hours from diagnosis. For the measurement of PaO2 and calculation of PaO2\u002FFiO2 ratio, the minimum accepted value for PEEP is 5 cmH2O and for FiO2 is 0.3. ARDS is defined by Berlin criteria,4 which includes: (i) having pneumonia or worsening respiratory symptoms, (ii) bilateral pulmonary infiltrates on chest imaging (x-ray or CT scan), (iii) absence of left atrial hypertension or no clinical signs of left heart failure, and (iv) hypoxemia, as defined by a PaO2\u002FFiO2 ≤300 mmHg on positive end-expiratory pressure (PEEP) of ≥5 cmH2O, regardless of FiO2.\n* Pulmonary or systemic infectious etiology of AHRF.\n\nExclusion Criteria:\n\n* Patients with a known contraindication to corticosteroids,\n* Patient included in another therapeutic clinical trial\n* Lack of informed consent",{"count":52,"type":20},980,"INTERVENTIONAL",[55],"PHASE4","Background: There are no proven therapies specific for pulmonary dysfunction in patients with acute hypoxemic respiratory failure (AHRF) caused by infections (including Covid-19). The full spectrum of AHRF ranges from mild respiratory tract illness to severe pneumonia, acute respiratory distress syndrome (ARDS), multiorgan failure, and death. The efficacy of corticosteroids in AHRF and ARDS caused by infections remains controversial.\n\nMethods: This is a multicenter, randomized, controlled, open-label clinical trial testing dexamethasone in mechanically ventilated adult patients with established AHRF (including ARDS) caused by confirmed pulmonary or systemic infections, admitted in a network of Spanish ICUs. Eligible patients will be randomly assigned to receive dexamethasone: either 6 mg\u002Fd x 10 days or 20 mg\u002Fd x 5 days followed by 10 mg\u002Fd x 5 days. The primary outcome is 60-day mortality. The secondary outcome is the number of ventilator-free days at 28 days. All analyses will be done according to the intention-to-treat principle.",[58],"Acute Hypoxemic Respiratory Failure",[60,61,62,63],"Acute respiratory failure","ARDS","Mechanical ventilation","Infection","RECRUITING","2025-08-20",{"date":67,"type":34},"2025-08-26",{"date":69,"type":34},"2021-07-06",{"date":71,"type":20},"2026-12-30",{"name":40,"class":41},40,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":42},"100576445","influence-of-preoperative-fear-on-pain-and-postoperative-outcomes-100576445","NCT06785389","Influence of Preoperative Fear on Pain and Postoperative Outcomes","POSPoFe","Inclusion Criteria:\n\n* All patients older than 18 years old scheduled for surgery with admission during the study period will be included.\n* Verbal and written informed consent.\n\nExclusion Criteria:\n\n* Minors\n* Cognitive impairment\n* Patients not being able to understand and respond to preoperative questionnaires\n* Patients not being able to respond to postoperative pain assessment\n* Patients not giving informed consent.",{"count":82,"type":20},138,"Fear of anesthesia plays a crucial role in the perioperative setting and can negatively affect recovery. The main objective is to assess the relationship between fear of anesthesia, surgeries, and hospitals and poorer postoperative pain control in patients undergoing scheduled surgery, as well as to relate preoperative anxiety to postoperative analgesic assessment in this population.\n\nThis is a prospective observational study including 138 patients scheduled for surgery.",[85,86,87,88],"Fear","Pain Management","Anxiety","Complications of Surgical Procedures or Medical Care",[90,91,92,93],"preoperative fear","postoperative pain","postoperative outcomes","preoperative anxiety","2025-08-19",{"date":96,"type":34},"2025-08-24",{"date":98,"type":34},"2025-01-22",{"date":100,"type":20},"2025-12-15",{"name":40,"class":41},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":111,"conditions":112,"keywords":115,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":118,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},"100545780","residual-neuromuscular-block-in-the-post-anesthetic-unit-and-postoperative-complications-100545780","NCT06386354","Residual Neuromuscular Block in the Post-Anesthetic Unit and Postoperative Complications","Porcerito","Inclusion Criteria:\n\n* Patient undergoing surgical intervention under general anesthesia that requires the use of neuromuscular block during the study time and that required hospital admission.\n* Informed consent signature.\n\nExclusion Criteria:\n\n* Neuromuscular disease\n* Not having received neuromuscular block during the intervention\n* Admission to the outpatient surgery unit\n* Admission to the postoperative intensive care unit\n* Patients who signed informed consent, but postoperative data could not be collected upon arrival at the PACU.",{"count":110,"type":20},296,"The use of neuromuscular blockers (NMB) is essential to optimize surgical conditions, ensure patient immobility during the intervention and prevent complications derived from involuntary movements. Intraoperative monitoring of neuromuscular relaxation allows the depth of neuromuscular blockade to be accurately evaluated, guaranteeing ideal conditions for the surgical team. Residual neuromuscular blockade (RNMB) is the persistence of muscle paralysis after the administration of NMB during a surgical intervention. The appearance of RNMB poses substantial challenges in the postoperative period, as it has negative repercussions for the safety and well-being of the patient.",[113,114],"Postoperative Neuromuscular Block","Postoperative Complications",[116,117],"General Anesthesia","Neuromuscular block",{"date":96,"type":34},{"date":120,"type":34},"2024-05-01",{"date":122,"type":20},"2025-10-30",{"name":40,"class":41},2,{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":16,"minAge":133,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":135,"conditions":136,"keywords":138,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":141,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":42},"100507895","frailty-in-the-perioperative-period-100507895","NCT05893342","Frailty in the Perioperative Period","Perioperative Frailty and Postoperative Complications: a Prospective Study","Frail-Negrin","Inclusion Criteria:\n\n* Patients over 65 years old undergoing urgent or scheduled surgery\n\nExclusion Criteria:\n\n* Language barrier\n* Cognitive impairment or inability to assist in clinical assessment during the study\n* Refusal to participate in the study","65 Years",{"count":82,"type":20},"The presence of frailty is associated with a high risk of complications in the perioperative period, increasing morbidity and mortality, hospital stay, and loss of quality of life. In this prospective observational study, an evaluation of frailty was performed in patients older than 65 years old who undergo scheduled and urgent surgery. 138 patients are being included. The main objective is to evaluate the prevalence of frailty in patients older than 65 years undergoing surgery in our hospital and its association with postoperative mortality.",[137],"Frailty",[139,140],"Preoperative frailty","Postoperative complications",{"date":96,"type":34},{"date":143,"type":34},"2024-03-01",{"date":145,"type":20},"2025-09-30",{"name":40,"class":41},{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":154,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":156,"conditions":157,"keywords":159,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":4},"100603031","changes-in-portal-vein-pulsatility-variability-during-a-tidal-volume-challenge-can-predict-fluid-tolerance-100603031","NCT07131228","Changes in Portal Vein Pulsatility Variability During a Tidal Volume Challenge Can Predict Fluid Tolerance","SERLU","Inclusion Criteria:\n\nParticipants must meet all of the following:\n\nAge ≥ 18 years at the time of enrollment.\n\nReceiving controlled mechanical ventilation with a baseline tidal volume of 6 mL\u002Fkg of predicted body weight.\n\nClinical indication for assessment of fluid responsiveness.\n\nAdequate acoustic window for ultrasound visualization of the portal vein.\n\nExclusion Criteria:\n\nParticipants will be excluded if they have any of the following:\n\nLiver cirrhosis.\n\nRight heart failure, defined as any of the following on prior echocardiography:\n\nTricuspid annular plane systolic excursion (TAPSE) \\\u003C 16 mm\n\nS' wave \\\u003C 10 cm\u002Fs\n\nRight ventricular fractional area change \\\u003C 35%\n\nLeft heart failure (left ventricular ejection fraction \\\u003C 50%).\n\nIntra-abdominal hypertension.\n\nAtrial fibrillation or other significant cardiac arrhythmias.\n\nTricuspid regurgitation.\n\nPoor echogenic window preventing adequate ultrasound assessment.\n\nPresence of spontaneous breathing activity.",{"count":155,"type":20},60,"In critically ill patients, appropriate fluid administration is one of the cornerstones of hemodynamic management, as both hypovolemia and fluid overload can negatively impact clinical outcomes.\n\nFor years, fluid responsiveness-defined as an increase in cardiac output following volume administration-has guided decision-making in the postoperative ICU. However, fluid responsiveness alone does not guarantee fluid tolerance, which refers to the venous system's ability to accommodate volume without developing venous congestion or adverse effects such as pulmonary edema, renal or hepatic dysfunction.\n\nThe tidal volume challenge (TVC)-which consists of a transient increase in tidal volume from 6 to 8 mL\u002Fkg-has been shown to predict fluid responsiveness by enhancing the hemodynamic interaction between the heart and lungs during the cardiac cycle, as measured through dynamic arterial indices such as pulse pressure variation (PPV) or stroke volume variation (SVV). However, these indices do not provide information about fluid tolerance or the state of venous congestion.\n\nDoppler ultrasound of the portal vein, specifically the portal pulsatility index (which under normal conditions presents as a continuous waveform due to the damping effects of the hepatic parenchyma and venous compliance), has been proposed as a non-invasive marker of systemic venous congestion. Studies have shown that an increase in the portal pulsatility index following volume loading may indicate the development of venous congestion and, therefore, poor fluid tolerance.\n\nSince the tidal volume challenge transiently increases intrathoracic pressure and allows dynamic evaluation of cardiovascular responses, we propose that this interaction be assessed not only through arterial dynamic indices (which assess responsiveness) but also through changes in venous flow patterns-specifically, variations in portal pulsatility-so that both fluid responsiveness and tolerance can be predicted with the same test.",[158],"Venous Congestion",[160],"Fluid Responsiveness Fluid Tolerance","2025-08-17",{"date":65,"type":34},{"date":164,"type":20},"2025-11-01",{"date":166,"type":20},"2026-11-30",{"name":40,"class":41},{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":53,"phases":178,"briefSummary":180,"conditions":181,"keywords":183,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":124},"100564956","ultrasound-to-check-the-position-of-the-nasogastric-tube-100564956","NCT06635915","Ultrasound to Check the Position of the Nasogastric Tube","Ultrasound to Check the Adequate Position of the Nasogastric Tube to Improve Patient Management and Safety","SONUS","Inclusion Criteria:\n\n* Patients classified as ASA I-IV according to the American Society of Anesthesiologists\n* Patients over 18 years old.\n* Informed consent signed by the patient or their family representatives\n\nExclusion Criteria:\n\n* Patients classified as ASA V.\n* Patients under 18 years old.\n* Refusal to participate in the study.\n* Contraindication for nasogastric tube placement: ingestion of caustics, nasal or skull fractures, and cervical surgery.\n* Patients with anatomical abnormalities at the cervical or pharyngoesophageal level.",{"count":177,"type":20},114,[179],"NA","The main objective of this study is to evaluate whether the use of ultrasound as a method of checking the normal positioning of the NGT is reliable, without requiring other diagnostic tests. Clinical trial that will include patients who had the NGT placed intraoperatively. 114 patients (57 with NGT and 57 without NGT) will be examined by ultrasound in the immediate postoperative period to diagnose the normal positioning of the NGT or its absence.\n\nCan ultrasound quickly and effectively diagnose the normal positioning of the NGT? Can chest X-ray be avoided by introducing ultrasound in the verification of the normal positioning of the NGT in the immediate postoperative period?",[182],"Nasogastric Tube Placement",[184,185,186,187],"nasogastric tube placement","ultrasound","postoperative diagnosis","monitoring","2024-12-20",{"date":190,"type":34},"2024-12-24",{"date":192,"type":34},"2024-10-15",{"date":194,"type":20},"2025-02-01",{"name":40,"class":41},""]