[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dr. Rebecca Schule\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100361063","phenotypes-biomarkers-and-pathophysiology-in-hereditary-spastic-paraplegias-and-related-disorders-100361063",false,"NCT03981276","Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders","HSP-PBP","Inclusion criteria:\n\n* One of the following:\n\n  1. Primary participant: Clinical or genetic diagnosis of HSP or a related disorder\n  2. Secondary participant: Unaffected family member (1st or 2nd degree relative) of primary participant (with the above-mentioned restrictions for special populations) able to give informed consent\n  3. Unrelated healthy control able to give informed consent\n\n     AND\n* Written informed consent\n\nAND\n\n\\- Participants are willing and able to comply with study procedures\n\nExclusion criteria:\n\n* Missing informed consent of primary or secondary participant\u002F healthy control\u002F legal representatives\n* For controls: evidence of a neurodegenerative disease or movement disorders; inability to give informed consent",true,"ALL",{"count":19,"type":20},2000,"ESTIMATED","20 Years","OBSERVATIONAL","The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias (HSP) and related disorders in a prospective multicenter natural history study, identify digital, imaging and molecular biomarkers that can assist in diagnosis and therapy development and study the genetic etiology and molecular mechanisms of these diseases.",[25],"Hereditary Spastic Paraplegia",[25,27,28,29],"Biomarker","Genetic etiology","Molecular mechanisms","RECRUITING","2021-05-18",{"date":33,"type":34},"2021-05-19","ACTUAL",{"date":36,"type":34},"2019-10-14",{"date":38,"type":20},"2041-08",{"name":40,"class":41},"Dr. Rebecca Schule","OTHER",13,""]