[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"EPC Education s.r.o.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":92},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100635992","monopolar-basivertebral-nerve-ablation-for-axial-low-back-pain-100635992",false,"NCT07559890","Monopolar Basivertebral Nerve Ablation for Axial Low Back Pain","Monopolar Basivertebral Nerve Ablation for Axial Low Back Pain - Single-Arm Proof-of-Concept Study","Inclusion Criteria:\n\n* Axial low back pain (with or without lateral component).\n* Presence of Modic type I or II changes at ≥ 1 level.\n* Age over 18 years.\n* Duration of pain ≥ 6 months.\n* Completion of full conservative management for ≥ 3 months.\n\nExclusion Criteria:\n\n* Coagulation disorders.\n* Platelet abnormalities.\n* Lack of informed consent.\n* Generalized solid tumor.\n* Hematopoietic malignancy.\n* Radicular pain.\n* Alternative primary pain generators other than axial low back pain.\n* Previous spinal surgery.\n* Targeted level located above L3\u002FL4\n* Osteoporosis","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","Determination of efficacy and safety of Monopolar Basivertebral Nerve Ablation for Axial Low Back Pain treatment, including the method optimization.",[26,27],"Chronic Back Pain","Basivertebral Nerve Ablation",[29,30,31],"chronic back pain","basivertebral nerve ablation","radiofrequency","RECRUITING","2026-06-04",{"date":35,"type":36},"2026-06-05","ACTUAL",{"date":38,"type":36},"2026-05-04",{"date":40,"type":20},"2029-05",{"name":42,"class":43},"EPC Education s.r.o.","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":51,"targetDuration":53,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},"100618935","opioidredoxstudyii-100618935","NCT07338084","OpioidRedoxStudyII","ORRS","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Receiving opioid therapy (tramadol, tapentadol, morphine, fentanyl, or buprenorphine) as part of routine clinical care\n* Stable opioid treatment for at least a predefined minimum period prior to enrollment (according to the study protocol)\n* Ability to provide written informed consent\n* Ability to comply with study procedures, including blood sampling and completion of questionnaires\n\nExclusion Criteria:\n\n* Acute opioid intoxication or withdrawal at the time of enrollment\n* Use of investigational drugs or participation in another interventional clinical trial that could interfere with study outcomes\n* Severe acute illness or unstable medical condition that, in the investigator's judgment, would interfere with study participation\n* Known pregnancy or breastfeeding\n* Inability to provide informed consent\n* Any condition that, in the opinion of the investigator, would make participation unsafe or compromise the quality of the collected data",{"count":52,"type":20},120,"3 Years","OBSERVATIONAL","This observational study aims to examine the relationship between opioid use and redox balance in adults. Redox balance reflects the level of oxidative stress in the body, which is known to play an important role in many biological processes and diseases.\n\nParticipants who use opioids will be included in the study. No experimental treatment or changes to current medical care will be provided as part of this study. Biological samples may be collected to assess redox-related biomarkers, and relevant clinical and demographic information will be recorded.\n\nThe results of this study are expected to improve understanding of how opioid exposure is associated with redox balance in adults. This information may help inform future research on the biological effects of opioids and potential strategies to reduce harm associated with long-term opioid use.",[57,58],"Oxidative Stress","Opioid Use","NOT_YET_RECRUITING","2026-01-03",{"date":62,"type":36},"2026-01-13",{"date":64,"type":20},"2026-06-30",{"date":66,"type":20},"2029-12-31",{"name":42,"class":43},1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":21,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":68},"100524658","thermovision-controlled-lumbar-sympathetic-blockade-in-chronic-limb-threatening-ischemia-treatment-100524658","NCT06111599","Thermovision-controlled Lumbar Sympathetic Blockade in Chronic Limb-threatening Ischemia Treatment","Tevi-LuSy","Inclusion Criteria:\n\n* Chronic limb-threatening ischemia-Patients with chronic leg pain for at least 6 months with intensity (VAS \\>=5)\n* those who (only if a signature was obtainable), or whose legal guardian,fully understood the clinical trial -details and signed the informed consent form\n\nExclusion Criteria:\n\n* Chronic Venous Insufficiency\n* women with positive a pregnancy tests before the trial or who planned to become pregnant within the following 3 years\n* other patients viewed as inappropriate by the staff\n* disagreement with participation in the study","20 Years","80 Years",{"count":79,"type":20},60,[23],"Thermovision-controlled lumbar sympathetic blockade in chronic limb-threatening ischemia treatment",[83],"Chronic Limb-Threatening Ischemia","2023-10-26",{"date":86,"type":36},"2023-11-01",{"date":88,"type":36},"2023-10-22",{"date":90,"type":20},"2026-08-31",{"name":42,"class":43},""]