[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"East Carolina University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":231},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,45,67,97,128,165,188,209],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100424331","pregnancy-exercise-mode-effect-on-childhood-obesity-100424331",false,"NCT04805502","Pregnancy Exercise Mode Effect on Childhood Obesity","Effect of Exercise Modality During Pregnancy on Childhood Obesity Risk","Inclusion Criteria:\n\n* Age: 18 to 40 years old\n* BMI between ≥ 25\n* Pregnancy: Singleton; ≤ 16 weeks gestation\n* Clearance by Obstetric provider for exercise\n\nExclusion Criteria:\n\n* Age: ≤ 17.9 or ≥ 41 years of age\n* BMI \\\u003C25\n* Multi fetal pregnancy\n* Obstetric Provider does not provide clearance for exercise\n* Unable or Unwilling to provide consent\n* Inability to communicate with members of study team, despite use of interpreter\n* Medical Conditions (e,g. HIV\u002FAids, Cancer, Type 1 or 2 Diabetes, Untreated Hypertension, Thyroid Disorders)\n* Use of tobacco products, alcohol, recreational drugs, or medications (oral hypertensive, insulin)\n* Unable to provide phone or email contact",true,"FEMALE","18 Years","45 Years",{"count":21,"type":22},300,"ESTIMATED","INTERVENTIONAL",[25],"NA","The overall objective of this proposal is to conduct a longitudinal prospective study of overweight\u002Fobese (OW\u002FOB) pregnant women and their offspring to determine which prenatal exercise mode will have the greatest impact on maternal and infant cardiometabolic health. This information may lead to clinical practice recommendations that improve childhood health. This randomized controlled trial will recruit 284 OW\u002FOB pregnant women randomized to an exercise intervention (aerobic (AE), resistance (RE), or aerobic+resistance exercise (AERE)) or to no exercise; their infants will be measured at 1, 6, and 12 months of age. This design will test our central hypothesis that AERE and RE training during pregnancy will improve maternal and offspring cardiometabolic outcomes to a greater extent than AE alone. This hypothesis will be tested with two specific aims:\n\nAim 1. Determine the influence of different exercise modes during OW\u002FOB pregnancy on infant cardiometabolic health and growth trajectories. Hypothesis: AE, RE, and AERE by OW\u002FOB pregnant women will improve offspring neuromotor and cardiometabolic measures at 1, 6, and 12 months postpartum (e.g. decreased %body fat, BMI z-score, heart rate \\[HR\\], non-HDL, and C-Reactive Protein (CRP); increased insulin sensitivity) compared to infants of OW\u002FOB pregnant women that do not exercise; AERE and RE will have the greatest impact on improving infant measures.\n\nAim 2. Determine the most effective exercise mode in OW\u002FOB pregnancy on improving maternal cardiometabolic health outcomes. Hypothesis: AE, RE, and AERE by OW\u002FOB pregnant women will improve both maternal cardiometabolic health measures (e.g. decreased BMI z-score, non-HDL, % body fat, HR, weight gain) across pregnancy (16-36 weeks' gestation) and overall pregnancy outcomes (e.g. lower incidence of gestational diabetes, pre-eclampsia, hypertension during gestation) compared to OW\u002FOB pregnant women that do not exercise; AERE and RE will have the greatest impact on improving maternal health measures, with the AERE group having the highest compliance.\n\nThe proposed study will be the first to provide an understanding of the influence of maternal exercise modes on the cardiometabolic health and growth trajectories of offspring who are at increased risk due to maternal OW\u002FOB. This work will have a significant impact on reducing the cycle of OB, potentially providing the earliest and most efficacious intervention to decrease or prevent OB in the next generation.",[28,29],"Pregnancy","Overweight and Obesity",[31],"exercise modes, exercise intervention","RECRUITING","2026-06-02",{"date":35,"type":36},"2026-06-04","ACTUAL",{"date":38,"type":36},"2021-10-18",{"date":40,"type":22},"2027-08-30",{"name":42,"class":43},"East Carolina University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":44},"100633323","prenatal-choline-and-infant-outcomes-study-100633323","NCT07525193","PREnatal Choline and Infant Outcomes Study","PRECIOUS","Inclusion Criteria:\n\n* Healthy pregnant individual\n* Singleton pregnancy\n* 18-40 years of age\n* Pre-pregnancy BMI ≥ 18.5\n\nExclusion Criteria:\n\n* Any non-pregnancy-related illness or chronic condition that may impact fetal development (i.e., HIV, cancer, heart disease, pre-existing diabetes) or known fetal anomaly\n* Food allergy to choline-rich foods (i.e., eggs)\n* Multi fetal pregnancy\n* \\>40 years of age","40 Years",{"count":54,"type":22},102,[25],"Less than 10% of pregnant women consume adequate levels of choline, an essential nutrient for maternal lipid metabolism, placental efficiency, and fetal development. Most prenatal vitamins do not contain choline; a research survey shows that only 6% of OB\u002FGYNs were likely to recommend choline-rich foods to pregnant women. Nutrition education grounded in the Health Belief Model (HBM) has high efficacy among pregnant women; therefore, it is likely that HBM-driven choline education intervention will increase maternal choline levels. No studies have evaluated the influence of prenatal choline education intervention on maternal, placental, and neonatal outcomes. Our preliminary data suggest that increased choline intake corresponds with lower maternal body fat percentage (BF%), infant 1-month BF%, and MSC lipid accumulation, as well as increased placental efficiency. The central hypothesis is that choline education will increase maternal choline levels and improve placental function and infant health. We will test this hypothesis with three aims: to determine the influence of choline education intervention on maternal choline intake, placental efficiency, and infant health at the whole-body and cellular levels. The proposed study will be the first to provide a critical translational understanding of the influence of prenatal choline education intervention on maternal, placental, and child health.",[58],"Nutrition During Pregnancy","2026-04-06",{"date":61,"type":36},"2026-04-13",{"date":63,"type":36},"2025-05-15",{"date":65,"type":22},"2027-05-14",{"name":42,"class":43},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":23,"phases":79,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":44},"100622987","remote-ischemic-conditioning-and-spinal-reflex-modulation-in-children-with-cerebral-palsy-100622987","NCT07390760","Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy","Effects of Remote Ischemic Conditioning (RIC) Combined With Balance Training on Spinal Reflex Modulation in Children With Cerebral Palsy","Inclusion Criteria:\n\n* Children diagnosed with cerebral palsy (CP) between the ages 8-17 years\n* Gross motor function classification system levels I-III\n* Mainstream in school and has sufficient cognition to follow the experiment instructions\n\nExclusion Criteria:\n\n* Children with other developmental disabilities such as autism and developmental coordination disorders\n* Children with cognitive deficits such as inability to understand and follow commands, substantially lower performance at grade level in school, and\u002For communication problems\n* Children with balance disorders such as vestibular disorders, posterior fossa tumor etc.\n* Children with known cardiorespiratory dysfunctions\n* Children with sickle cell disease\n* Children who are receiving other adjunct therapies such as transcranial magnetic stimulation, transcranial direct current stimulation, or vagal nerve stimulation\n* Presence of lower extremity condition, injury, or surgery within last three months which could compromise conditioning and training.\n* Participants who are pregnant.","ALL","8 Years","17 Years",{"count":78,"type":22},16,[25],"Remote ischemic conditioning (RIC) is a clinically feasible intervention involving brief, sublethal periods of ischemia followed by reperfusion that has been shown to enhance motor performance, strength, and balance when combined with training in healthy adults and individuals with neurological conditions. Although RIC is thought to influence neuroplasticity through neural, metabolic, and humoral pathways, its effects on spinal-level mechanisms remain poorly understood. Emerging evidence indicates that neuroplastic adaptations occur not only at the cortical level but also within the spinal cord. Moreover, altered spinal reflex excitability is associated with spasticity, balance impairments, and functional limitations in children with cerebral palsy (CP), yet the role of spinal reflex modulations in response to RIC and balance training remains under expplored in this population. Therefore, this study aims to investigate the effects of RIC combined with balance training on spinal reflex modulation in children with CP.",[82],"Children With Cerebral Palsy",[84,85,86,87,88],"Remote Ischemic Conditioning","Cerebral Palsy","Spinal Reflex Modulation","H-reflex","Balance Training","2026-03-23",{"date":91,"type":36},"2026-03-24",{"date":93,"type":36},"2025-07-28",{"date":95,"type":22},"2026-12-31",{"name":42,"class":43},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":74,"minAge":18,"maxAge":4,"enrollmentInfo":105,"targetDuration":107,"studyType":108,"phases":4,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":44},"100627322","prospective-analysis-of-arteriovenous-access-ava-use-for-continuous-renal-replacement-therapy-crrt-100627322","NCT07447128","Prospective Analysis of Arteriovenous Access (AVA) Use for Continuous Renal Replacement Therapy (CRRT)","Prospective Analysis of Arteriovenous Access Use in Continuous Renal Replacement Therapy, a Feasibility Project","CRRT","Inclusion Criteria:\n\n* Age 18 years or older\n* Diagnosis of End-Stage Kidney Disease (ESKD) receiving maintenance chronic hemodialysis\n* Admission to the Intensive Care Unit (ICU)\n* Presence of a functioning arteriovenous fistula (AVF) or arteriovenous graft (AVG)\n* Clinical indication for Continuous Renal Replacement Therapy (CRRT)\n* Score of ≥16 points on the study enrollment screening tool\n\nExclusion Criteria:\n\n* Age under 18 years\n* Arteriovenous access thrombectomy within 30 days prior to study enrollment\n* Documented prolonged bleeding from arteriovenous access within 30 days prior to study enrollment\n* Current dialysis via temporary or tunneled hemodialysis catheter\n* International Normalized Ratio (INR) \\> 3.0\n* Acute liver failure, defined as AST \\> 1000 U\u002FL and\u002For ALT \\> 1000 U\u002FL\n* Platelet count \\\u003C 50,000\u002FµL\n* Evidence of disseminated intravascular coagulation (DIC)\n* Pregnant patients\n* Patients actively attempting to become pregnant",{"count":106,"type":22},50,"30 Days","OBSERVATIONAL","Arteriovenous fistula or graft are the ideal hemodialysis access. Nonetheless the most common access type used for Continuous Renal Replacement Therapy (CRRT) is either a temporary or permanent hemodialysis catheter. Recommendations for the use of catheters to deliver CRRT in end stage kidney disease (ESKD) patients are lacking on data and subjective to anecdotal experiences and expert consensus. The repetitive placement of catheters in ESKD patients have shown to increase the chances of central vascular stenosis which is one of the main risk factors that lead to access failure. Also, the repetitive use of dialysis catheters increases the risk for catheter associated infections. Dedicated studies demonstrating the safety and feasibility of using arteriovenous access (AVA) for CRRT are scarce. No screening criteria or algorithm exists to determine the adequate patient and clinical scenario to use AVA for CRRT.\n\nGoals of the study:\n\n1. To develop a standard operating procedure for the use of AVA in CRRT.\n2. Evaluate the safety and efficacy of using AVA for CRRT.",[111,112],"Continuous Renal Replacement Therapy (CRRT)","End Stage Kidney Disease (ESRD)",[114,115,103,116,117,118],"Arteriovenous access","Continuous Renal Replacement Therapy","AVA","ESKD","End Stage Kidney Disease","NOT_YET_RECRUITING","2026-02-27",{"date":122,"type":36},"2026-03-03",{"date":124,"type":22},"2026-03",{"date":126,"type":22},"2026-09",{"name":42,"class":43},{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":74,"minAge":136,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":23,"phases":140,"briefSummary":141,"conditions":142,"keywords":148,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":164},"100606257","optimizing-the-aya-survivors-coping-and-emotional-needs-toolkit-100606257","NCT07173205","Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit","R00 Full Factorial Trial: Optimizing ASCENT","ASCENT","Inclusion Criteria:\n\n* Age at enrollment (adolescents 15-17, emerging adults 18-25, young adults 26-39)\n* Age at diagnosis (adolescents 12-17, emerging adults 15-25, young adults 15-39)\n* Time since completion of treatment: 1 month to 5 years\n* Language: Fluent in English (spoken and written)\n* Technology: Own smart phone with data plan\n\nExclusion Criteria:\n\n* Mental Health: Current diagnosis of severe or persistent mental illness\n* Suicidality: Severe suicidal ideation (including plan and intent)","15 Years","39 Years",{"count":139,"type":22},208,[25],"Our team has developed a digital intervention that aims to help adolescent and young adult cancer survivors (AYAs) manage symptoms of depression. This tool includes one psychoeducation component and four components that are based on evidence-based interventions for depression. The goal of this study is to test which component or combination of components meaningfully contribute to improvements in depressive symptoms among AYAs.",[143,144,145,146,147],"Depression","Cancer","Adolescent","Young Adult","Adult",[149,150,151,152,153,154,155],"AYA","Adolescent and Young Adult","Cancer Survivorship","Depressive Symptoms","Digital Mental Health","Multiphase Optimization Strategy","Full Factorial Trial","2026-01-05",{"date":158,"type":36},"2026-01-07",{"date":160,"type":36},"2025-10-25",{"date":162,"type":22},"2027-03",{"name":42,"class":43},2,{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":74,"minAge":18,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":108,"phases":4,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":44},"100387094","metabolic-inflexibility-is-related-to-elevated-muscle-anaerobic-glycolysis-100387094","NCT04320264","Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis","Inclusion Criteria:\n\n* 18-50 years old\n* BMI of 25 - 30 kg\u002Fm2\n* BMI \\> 40kg\u002Fm2\n* Lactate levels in top and lower 25%\n\nExclusion Criteria:\n\n* Pregnant women\n* Mentally disabled\n* Prisoners\n* Smokers\n* Subjects with heart disease\n* Type 1 and 2 diabetes\n* Endocrine disease\n* Hypertension\n* Musculoskeletal disease\n* Peripheral occlusion\n* Hepatic disease\n* Have had weight fluctuations exceeding + 3% in the previous 12 months\n* On medications which alter carbohydrate metabolism will not be studied","50 Years",{"count":173,"type":22},100,"The focus of this proposal is on overweight (25\\>BMI\\\u003C30 kg\u002Fm2) subjects, as these individuals exhibit a high risk of becoming obese and\u002For developing metabolic diseases. We hypothesize that in some overweight individuals there is a \"metabolic program\" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.",[176],"Metabolic Inflexibility",[176,178,179],"Obesity","Anaerobic glycolysis","2025-08-04",{"date":182,"type":36},"2025-08-07",{"date":184,"type":36},"2020-03-03",{"date":186,"type":22},"2025-12",{"name":42,"class":43},{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":194,"targetDuration":4,"studyType":23,"phases":196,"briefSummary":197,"conditions":198,"keywords":200,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":207,"leadSponsor":208,"locationsCount":44},"100562048","mama-tot---healthy-weight-parallel-study-100562048","NCT06598098","MAMA Tot - Healthy Weight Parallel Study","Inclusion Criteria:\n\n* Age: 18 to 40 years old\n* BMI 18.5 to 24.4\n* Pregnancy: Singleton; ≤ 16 weeks gestation\n* Clearance by Obstetric provider for exercise\n\nExclusion Criteria:\n\n* Age: ≤ 17.9 or ≥ 41 years of age\n* BMI ≥25\n* Multi fetal pregnancy\n* Obstetric Provider does not provide clearance for exercise\n* Unable or Unwilling to provide consent\n* Inability to communicate with members of study team, despite use of interpreter\n* Medical Conditions (e,g. HIV\u002FAids, Cancer, Type 1 or 2 Diabetes, Untreated Hypertension, Thyroid Disorders)\n* Use of tobacco products, alcohol, recreational drugs, or medications (oral hypertensive, insulin)\n* Unable to provide phone or email contact",{"count":195,"type":22},268,[25],"The overall objective of this proposal is to conduct a longitudinal prospective study of healthy pregnant women and their offspring to determine which antenatal maternal exercise mode(s) will have the greatest impact on maternal and infant cardiometabolic health. This information may lead to modified clinical practice recommendations that improve health in childhood and possibly beyond. This randomized controlled trial will recruit 268 healthy pregnant women randomized to an exercise intervention (aerobic exercise, resistance exercise, aerobic and resistance exercise) or to no exercise (usual care); their infants will be measured at 1, 6, and 12 months of age. This rigorous design will test our central hypothesis that aerobic and resistance exercise and resistance exercise training during pregnancy will, in healthy weight BMI (HW) women, improve maternal and offspring cardiometabolic outcomes to a greater extent than AE alone. We will test this hypothesis with two specific aims:\n\nAim 1. Determine the influence of different exercise modes during HW pregnancy on infant cardiometabolic health and growth trajectories. Hypothesis: AE, RE, and AERE by HW pregnant women will improve offspring neuromotor and cardiometabolic measures at 1, 6, and 12 months postpartum (e.g. decreased % body fat, BMI z-score, heart rate, non-HDL, and C-Reactive Protein (CRP); increased insulin sensitivity) compared to infants of HW pregnant women that do not exercise; AERE and RE will have the greatest impact on improving infant measures.\n\nAim 2. Determine the most effective exercise mode in HW pregnancy on improving maternal cardiometabolic health outcomes. Hypothesis: AE, RE, and AERE by HW pregnant women will improve both maternal cardiometabolic health measures (e.g. decreased BMI z-score, non-HDL, % body fat, HR, weight gain) across pregnancy (16 to 36 weeks gestation) and overall pregnancy outcomes (e.g. lower incidence of gestational diabetes, pre-eclampsia, hypertension during gestation) compared to HW pregnant women that do not exercise; AERE and RE will have the greatest impact on improving maternal health measures, with the AERE group having the highest compliance.\n\nThe proposed innovative study will be the first to provide a critical understanding of the influence of antenatal exercise modes upon the cardiometabolic health and growth trajectories of offspring who may be at increased risk of poor outcomes. This work will have a significant impact on reducing the cycle of OB and CVD, potentially providing the earliest and most efficacious intervention to attenuate or prevent OB and CVD in the next generation.",[199],"Pregnancy Related",[201,202],"exercise modes","exercise intervention","2024-09-12",{"date":205,"type":36},"2024-09-19",{"date":38,"type":36},{"date":40,"type":22},{"name":42,"class":43},{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":217,"targetDuration":4,"studyType":23,"phases":219,"briefSummary":220,"conditions":221,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":44},"100540605","physical-activity-to-mitigate-preeclampsia-risk-100540605","NCT06319014","Physical Activity to Mitigate PreEclampsia Risk","Physical Activity to Mitigate PreEclampsia Risk (PAMPER)","PAMPER","Inclusion Criteria:\n\n* healthy women, age 18-40 years, \\\u003C16 weeks' gestation, with singleton pregnancy; women (BMI:18.5-45.0), sedentary, cleared by their obstetric provider.\n\nExclusion Criteria:\n\n* pre-existing chronic conditions such as HIV, lupus, etc.; taking medicines that affect fetal development; and\u002For lack of telephone or email contact information).",{"count":218,"type":22},224,[25],"The purpose of this study is to compare the effects of aerobic (AE), resistance (RE), and combination (AERE) exercise throughout pregnancy on selected maternal and fetal\u002Fneonatal physiological variables in women at-risk for preeclampsia. The central hypothesis of this project is that exercise will decrease severity and occurrence of preeclampsia symptoms, thus improving maternal, pregnancy, and birth outcomes.\n\nAim 1. Determine the influence of different exercise modes during pregnancy at risk of preeclampsia on maternal cardiometabolic health.\n\nAim 2. Determine the most effective exercise mode in pregnancy at risk of preeclampsia on improving birth and infant health outcomes.",[222],"Pre-Eclampsia","2024-06-28",{"date":225,"type":36},"2024-07-01",{"date":227,"type":36},"2024-06-24",{"date":229,"type":22},"2026-10-01",{"name":42,"class":43},""]