[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"East Kent Hospitals University NHS Foundation Trust\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":98},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100608221","effect-of-virtual-reality-and-trans-auricular-x-vagus-nerve-stimulation-for-anxiety-and-depression-in-chronic-shoulder-pain-patients-100608221",false,"NCT07198737","Effect of Virtual Reality and Trans Auricular X-Vagus Nerve Stimulation for Anxiety and Depression in Chronic Shoulder Pain Patients","VIRTAX-ADSP","Inclusion Criteria:\n\n* Aged over 18.\n* Ability to understand English\n* Ability to provide informed consent and attend in-person sessions\n* Chronic shoulder pain (pain lasting for at least 6 months) waiting on surgical pathway.\n* Comorbid mild-to-moderate anxiety or depression\n* Referred by a consultant orthopaedic surgeon.\n* Unresponsive to conventional treatment for 6 months including antidepressants, physiotherapy, and\u002F or oral analgesics\n* Mean NRS pain score ≥ 5 on most or all days either continuously or in motion\n\nExclusion Criteria:● Inability to understand English and consent process\n\n* History of significant neurological or psychiatric conditions unrelated to chronic pain (e.g., epilepsy, psychosis, schizophrenia).\n* Skin lesions or piercing or extensive tattooing of the concha or Skin disease: infection, eczema or cancer of the ears or skin in region where VR headset or taVNS would sit\n* Presence of active implants (e.g. cochlear implant, implanted vagus nerve stimulator, cardiac pacemaker, implantable cardioverter defibrillator (ICD) deep brain stimulations or spinal cord stimulators, ventriculoperitoneal (VP) shunt).\n* Inability to tolerate VR (e.g., severe motion sickness, vertigo or balance issues, claustrophobia).\n* Fear of heights\n* Active infections, significant trauma, or other acute conditions affecting the shoulder.\n* Pregnancy and women trying actively to conceive\n* Pre-existing Persistent post-surgical pain-(\\>6 months) from surgeries other than shoulder replacements\n* On- going alcohol and\u002F or drug problem\n* Widespread chronic pain conditions (fibromyalgia, complex regional pain syndrome)\n* Involvement in any clinical studies within the last 28 days prior to assessment\n* Other therapies such as other psychological interventions for A\u002FD and pain in the shoulder are not allowed for the period of the study and follow up unless there is a psychiatric emergency. Participants may also not be involved in any trial on pain management or related to shoulders while participating in this VR\u002FVNS trial.","ALL","18 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"NA","Chronic shoulder pain is a debilitating condition that significantly impacts quality of life, daily functioning, and mental well-being. For individuals awaiting surgical intervention for a long period, prolonged pain often leads to heightened psychological distress, poor sleep quality, and reduced overall health outcomes. Innovative approaches are urgently needed to address these challenges and improve preoperative management.\n\nThis study will combine 2 technologies which have both been shown to help relax and calm users.\n\nTranscutaneous Auricular Vagus Nerve Stimulation (taVNS) is\n\n* a gentle non-invasive therapy that uses a small device to send tiny electrical pulses to a spot on your outer ear. The principle of using electrical pulses are similar to pacemaker or TENS machines.\n* These pulses help stimulate a special nerve called the vagus nerve, which is like a superhighway between your brain and your body\n\nYour vagus nerve helps control:\n\n* Your mood and anxiety levels\n* Healing of nerves and other organs in the body\n* How your body handles pain\n* Digestion, heart rate, and more By stimulating the vagus nerve, taVNS can help your body relax, reset, and feel better.\n\nWhile virtual reality (VR) has demonstrated effectiveness in distracting from pain and improving psychological resilience.\n\nThese two will be combined so that the participant experiences a relaxing VR environment that helps them control their breathing while receiving taVNS. With the aim of managing chronic pain by targeting both physical and psychological dimensions.\n\nThis study aims to evaluate the feasibility and safety, of a trial of taVNS paired with VR looking at trial recruitment, retention and compliance. Secondary to this the study will look to see if there is evidence of taVNS +VR in reducing pain, enhancing psychological well-being, and improving quality of life for individuals with chronic shoulder pain awaiting surgery. It will provide critical insights into the potential of this combined intervention as a preoperative and potentially post operative pain management strategy.",[26],"Chronic Pain (Back \u002F Neck)",[28],"VR VNS","NOT_YET_RECRUITING","2025-09-22",{"date":32,"type":33},"2025-09-30","ACTUAL",{"date":35,"type":20},"2025-11-01",{"date":37,"type":20},"2026-08-01",{"name":39,"class":40},"East Kent Hospitals University NHS Foundation Trust","OTHER_GOV",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":41},"100508025","trial-of-an-exercise-intervention-for-children-with-haemophilia-100508025","NCT05895032","Trial of an Exercise Intervention for Children With Haemophilia","Development Of a haemophiLia PHysiotherapy INtervention for Optimum Musculoskeletal Health in Children (DOLPHIN-II) - a Randomised Controlled Trial","DOLPHIN-II","Inclusion Criteria:\n\n• Children aged 6-12 years, with severe or moderate haemophilia A or B\n\nExclusion Criteria:\n\n* von Willebrand disease\n* past history of fracture or trauma to the lower limb\n* orthopaedic surgery\n* acquired brain injury or any other disturbance of the central nervous system; joint or muscle bleed in the lower limb in the past 6 weeks\n* presence of lower limb pain or unable to fully comply with verbal instructions.","MALE","6 Years","12 Years",{"count":54,"type":20},132,[23],"\"Being able to participate in games and activities with their friends\" is one of the things that matters most to boys with haemophilia. At present, there is a lack of robust evidence to determine whether muscle strengthening exercise can improve or negatively affect outcomes for young children with haemophilia. With the help of boys with haemophilia, their parents and physiotherapists the investigators have developed an exercise programme designed to increase muscle strength. Using this intervention the investigators will undertake a single-blinded, two-arm pragmatic randomised controlled trial (RCT) of a 12-week intervention verses usual care of boys with haemophilia aged 6-12 years of age.",[58,59,60],"Hemophilia","Child, Only","Musculoskeletal Diseases or Conditions",[62,63,64],"Physical Therapy","Exercise","Muscle strength","RECRUITING","2024-08-29",{"date":68,"type":33},"2024-08-30",{"date":70,"type":33},"2021-05-06",{"date":72,"type":20},"2025-06-30",{"name":39,"class":40},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":41},"100495536","influence-of-gut-microbiome-in-gallstone-disease-100495536","NCT05732480","Influence of Gut Microbiome in Gallstone Disease","Understanding Changes in the Gut Microbiome in Patients With Gallstone Disease and Its Impact on Patient Outcomes","Inclusion Criteria:\n\n* All adults (age \\>18 years of age) patients diagnosed with gallstone disease following confirmatory imaging at an East Kent University Foundation Trust Hospital. Patients of any gender, ethnicity or socio-economic background are eligible as well as pregnant women. Patients undergoing both open and laparoscopic cholecystectomy will be included.\n\nExclusion Criteria:\n\n* Patients less than 18 years of age and patients who do not have capacity to consent to involvement in the study.",{"count":82,"type":20},75,"OBSERVATIONAL","The goal of this prospective observational study is to explore the role of the gut microbiome in patients with gallstone disease.\n\nThe main question\\[s\\] it aims to answer are:\n\n* if there is a relationship between the gut microbiome and the development of complications associated with gallstone disease (such as pancreatitis and acute cholecystitis)\n* if there are changes in the gut microbiome following cholecystectomy and the relationship with patient outcomes.\n\nParticipants will be asked to provide stool samples at fixed time points (recruitment, pre- and post-cholecystectomy if applicable and at 6 months and 3 years. They will also be asked to provide stool samples if they represent to hospital with complications associated with their gallstone disease.",[86,87,88,89],"Gall Stone","Gall Stones, Common Bile Duct","Pancreatitis","Acute Cholecystitis","2024-02-22",{"date":92,"type":33},"2024-02-23",{"date":94,"type":33},"2023-05-30",{"date":96,"type":20},"2026-11-13",{"name":39,"class":40},""]