[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"East Lancashire Hospitals NHS Trust\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":173},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,51,86,114,148],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100640122","exploration-of-acceptability-of-alcohol-interventions-100640122",false,"NCT07580378","Exploration of Acceptability of Alcohol Interventions","A Mixed-methods Study Exploring the Acceptability of Psychosocial Interventions and Social Determinants of Engagement With an NHS-led Alcohol Care Service.","Inclusion Criteria:\n\n* Clinical staff who worked in the ELHT alcohol care service, and received training in the delivery of psychosocial interventions using the ITEP Manual, and who are still employed by ELHT in other roles (following de-commissioning of the alcohol care service).\n* Patient data under part 2 of the study, who have not opted to have their data removed, in accordance with the NHS MESH, opt out scheme.\n\nExclusion Criteria:\n\n* Clinical staff who worked in the ELHT alcohol care service, but who no longer work for the trust, or are retired.\n* Clinical staff who did not receive training in the delivery of psychosocial interventions.\n* Any patient data under part 2 of the study, who have opted to have their data removed for use, under the NHS MESH protocols.",true,"ALL","18 Years","67 Years",{"count":21,"type":22},2000,"ESTIMATED","OBSERVATIONAL","This is a mixed-methods study consisting of a qualitative assessment the acceptability of psychosocial interventions, delivered by clinical staff. The study will also investigate the correlation between demographic variables and engagement with a North West England, NHS-led, alcohol care service, amongst the patient population.",[26,27,28,29,30,31,32,33,34,35,36,37],"Alcohol Misuse","Alcohol Use Disorder","Behaviour Change","Health Behaviour","Brief Intervention","Outcome Assessment","Social Determinants of Health","Psychosocial Intervention","Socioeconomic Factors","Primary Healthcare","Primary Heath Care","Problem Behavior","NOT_YET_RECRUITING","2026-05-05",{"date":41,"type":42},"2026-05-12","ACTUAL",{"date":44,"type":22},"2026-05-01",{"date":46,"type":22},"2026-06-10",{"name":48,"class":49},"East Lancashire Hospitals NHS Trust","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":50},"100635630","stick2it---understanding-why-people-do-or-do-not-stick-with-exercise-treatment-for-achilles-tendinopathy-100635630","NCT07555184","STICK2IT - Understanding Why People Do or Do Not Stick With Exercise Treatment for Achilles Tendinopathy","STICK2IT: Identifying and Prioritising Determinants of Adherence to Progressive Tendon-Loading Exercise in People With Achilles Tendinopathy","Inclusion Criteria:\n\n* • Adults aged 18 years or over with lived experience of Achilles tendinopathy (AT).\n\n  * Gender representation: A purposive sample including men and women, with inclusion of non-binary participants where self-identified, aiming for broad gender representation rather than fixed quotas.\n  * Ethnic and cultural diversity: Purposive sampling will seek representation from diverse ethnic and cultural backgrounds, informed by local population demographics and service user profiles.\n  * Socioeconomic diversity: Participants will be recruited across high, mid, and low socioeconomic deprivation groups, defined using postcode-derived Index of Multiple Deprivation (IMD) tertiles (lower, middle, upper thirds of national IMD distribution). Recruitment will aim for representation across all three IMD categories rather than predefined percentages.\n\nExclusion Criteria:\n\n* • Under 18 years of age\n\n  * Inability to confirm previous AT through either ELHT electronic medical records or through discussion with CI\n  * Individuals whose Achilles symptoms are due to a different primary pathology (e.g., Rheumatological, Achilles Rupture)\n  * Unable to provide informed consent\n  * Unable or unwilling to be audio-recorded.",{"count":59,"type":22},30,"Achilles tendinopathy is a common condition that causes pain and stiffness in the tendon at the back of the ankle. It can make walking, exercise, work, and everyday activities difficult. The main recommended treatment is a programme of progressive tendon-loading exercises, usually supported by an NHS physiotherapist. These exercises can help improve pain and function, but many people find them hard to continue over time. This means that, even though the treatment can work well, some people do not get the full benefit because they are unable to keep up with the exercise programme as advised.\n\nPeople with Achilles tendinopathy often describe worries about making the tendon worse, uncertainty about whether pain during exercise is safe, low confidence, slow progress, and difficulty fitting exercises into daily life. These challenges may be even greater for people from underserved groups, including those living with long-term health conditions, financial pressures, language barriers, or other forms of disadvantage. At present, there is limited research exploring these experiences in a structured way, especially in routine NHS care.\n\nThe aim of this study is to understand what helps or makes it harder for people to stick with NHS-prescribed progressive tendon-loading exercises for Achilles tendinopathy. The study will focus particularly on the experiences of people who may be at higher risk of poor outcomes or reduced access to support.\n\nUp to 30 adults with experience of Achilles tendinopathy and previous NHS physiotherapy treatment will take part in a one-to-one interview. Interviews will last up to 45 minutes and can take place in person, online, or by telephone, depending on what suits the participant best. Participants will be asked about their experiences of living with Achilles tendon pain, being given exercise treatment, and trying to follow that treatment in everyday life.\n\nThe information from these interviews will be analysed to identify the main barriers and supports affecting exercise adherence. The findings will be used to build a clearer understanding of the behavioural factors that influence whether people are able to continue with treatment. This will help inform the future development of a targeted support approach to improve adherence to exercise-based rehabilitation for Achilles tendinopathy in NHS practice.\n\nThe long-term goal of the study is to help make treatment more effective, more personalised, and more suitable for people from a wide range of backgrounds, including those whose needs are often overlooked in research and healthcare design.",[62,63,64,28],"Achilles Tendinopathy (AT)","Musculoskeletal Diseases or Conditions","Adherence",[66,67,68,69,70,71,72,73,74,75,76,77,78],"Achilles tendinopathy","Theoretical Domains Framework","Qualitative","Adherence to prescribed exercise","Tendon loading exercise","Musculoskeletal physiotherapy","Behaviour change","Underserved populations","Health inequalities","Multimorbidity","Socioeconomic deprivation","Semi-structured interviews","thematic analysis","2026-04-21",{"date":81,"type":42},"2026-04-29",{"date":44,"type":22},{"date":84,"type":22},"2027-05-01",{"name":48,"class":49},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":113,"locationsCount":4},"100627146","how-does-pre-operative-biliary-drainage-in-pancreatic-adenocarcinoma-affect-surgical-outcomes-in-pancreatic-cancer-surgery-100627146","NCT07444840","How Does Pre-operative Biliary Drainage in Pancreatic Adenocarcinoma Affect Surgical Outcomes in Pancreatic Cancer Surgery","Pre-operative Biliary Drainage in Pancreatic Adenocarcinoma and Its Effect on Surgical Oncological Outcomes","PBDSOO","Inclusion Criteria:\n\n* Procedure - Pancreaticoduodenectomy\n* Histology - Pancreatic ductal adenocarcinoma at East Lancashire Hospitals NHS Trust\n* Age \\> 18 years\n\nExclusion Criteria:\n\nPatients \\\u003C 18 years of age Patients who had pancreaticoduodenectomy for benign disease Patients who had pancreaticoduodenectomy with any histology other than pancreatic ductal adenocarcinoma Patients who underwent any other procedure for head of pancreas pancreatic ductal adenocarcinoma Patients who have opted out from being part of research as per the MESH database",{"count":95,"type":22},90,"Pre-operative biliary drainage (PBD) is a procedure used to relieve bile duct obstruction, a common issue in patients with pancreatic cancer. The obstruction occurs when a tumor blocks the bile duct, leading to jaundice and other complications. While PBD can help resolve jaundice and improve liver function, its impact on the overall outcomes of pancreatic cancer surgery is still debated.\n\nRecent research has focused on whether PBD before surgery improves patient outcomes, such as surgical success, recovery time, and long-term survival. Some studies suggest that draining the bile before surgery might reduce complications like infections, liver dysfunction, and jaundice-related risks. On the other hand, other research indicates that PBD could increase the chances of infection, delays in surgery, or complications from the procedure itself, such as bile leakage or inflammation.\n\nThis study will look at patients undergoing pancreaticoduodenectomy to remove their head of pancreas pancreatic ductal adenocarcinoma over 8 years, and will compare the tumour characteristics of patients who have had PBD vs those who have not. Data will be gathered from the already available histological characteristics. No treatment would be affected and no tissue would be affected.\n\nThis research study will focus on oncological characteristics such as tumour progression and lymphatic spread, with overall patient survival as secondary outcome measures.",[98,99],"Pancreatic Ductal Adenocarcinoma (mPDAC)","Pancreatic Ductal Adenocarcinoma (PDAC)",[101,102,103,104,105,106],"pancreatic ductal adenocarcinoma","biliary drainage","oncology","T stage","perineural invasion","lymphovascular invasion","2026-02-25",{"date":109,"type":42},"2026-03-03",{"date":111,"type":22},"2026-03-01",{"date":44,"type":22},{"name":48,"class":49},{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":124,"phases":125,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":138,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":147},"100513336","phase-3-the-mantra-trial-mandibular-trauma-and-antibiotic-use-100513336","NCT05964140","The MANTRA Trial (MANdibular TRauma and Antibiotic Use)","Should we Use Post-operative Antibiotics Following Surgery for Patients With Mandible Fractures? The MANTRA Trial (MANdibular TRauma and Antibiotic Use)","MANTRA","All adult patients aged 18 years or over with mandible fractures requiring surgery. Most of these patients will be identified from the A\\&E department via the on-call OMFS team or seen in dedicated OMFS trauma clinics. A small proportion of our study population will be seen in an OMFS clinic following referral from GP\u002FGDP.\n\nInclusion Criteria:\n\n* Ability to provide written informed consent\n* Age≥18 years\n* Hospital episode of mandible fracture(s)\n* Planned treatment is surgery - (ORIF with titanium miniplates)\n\nExclusion Criteria:\n\n* Isolated mandibular condylar fractures\n* Existing fracture site infection\n* Immunocompromised (transplant patients, haematological malignancies, HIV\u002FAIDS) - a clear definition will be provided in the protocol\n* Pathological fracture (e.g., malignancy, osteoradionecrosis, cysts, Medication-Related Osteonecrosis of the Jaws \\[MRONJ\\])\n* Fractures open to skin\n* Inability to provide written informed consent\n* Other injuries or infections mandating ongoing post-operative antibiotics (e.g., panfacial fractures with mandible fracture component)\n* Patients allergic to first and second-line antibiotic prophylaxis (as outlined above)",{"count":123,"type":22},2841,"INTERVENTIONAL",[126],"PHASE3","1. FULL TITLE OF THE PROJECT Should we use post-operative antibiotics following surgery for patients with mandible fractures? The MANTRA trial (MANdibular TRauma and Antibiotic use)\n2. SUMMARY OF RESEARCH (ABSTRACT) Research Question: Are post-operative antibiotics required following surgery for patients with mandible fractures? Background: Mandible fractures are the commonest facial fractures needing surgery and account for a significant percentage of the acute workload in Oral \\& Maxillofacial Surgery (OMFS) units. The UK records over 6000 new cases per year. Patients having surgery for mandible fractures have a theoretical risk of developing surgical site infection, due to the proximity of the fracture lines to the oral cavity microbes and the presence of foreign body (titanium fixation miniplates). For this reason, clinicians often prescribe antibiotics after surgery, to reduce the risk of infection. Previous systematic reviews and a multicentre cohort study performed by this team, revealed significant clinical variation in post-operative antibiotic prescription amongst UK OMFS clinicians and the presence of clinical equipoise. Antibiotic overuse can lead to antibiotic resistance and other antibiotic-related side effects; judicious antibiotic use and stewardship is of paramount importance.\n\nAim: To determine whether post-operative antibiotics are required at all, following surgery for mandible fractures, and, if so, what is the most clinically- and cost-effective regimen\n\nObjectives:\n\nPrimary Objective To conduct a Randomized Controlled Trial (MANTRA) in order to establish the non-inferiority (or not) of not giving post-operative antibiotics versus 2 other post-operative antibiotic regimens. An internal pilot phase will optimise recruitment and retention.\n\nSecondary Objectives\n\n* Measure the cost-effectiveness of the proposed antibiotic pathways\n* Assess patient and clinician acceptability to change clinical practice\n* Process evaluation to inform dissemination and implementation Methods: The investigators designed and propose the MANTRA RCT to compare 3 post-operative antibiotic approaches to prevent Surgical Site Infections (SSIs) following surgery for mandible fractures. The MANTRA trial is a large open label, multicentre study in NHS OMFS units. The 3 study arms represent the most common clinical pathways in the UK based on previous work; the control group is the approach prescribed by most UK OMFS clinicians. All patients will receive 1 dose of IV antibiotics (co-amoxiclav 1.2g, if no penicillin allergy, which is the most commonly used prophylactic antibiotic currently) on induction of anaesthesia, prior to their surgery.\n\nThe participants will be randomised to the following (1:1:1):\n\nGroup A: No further antibiotics Group B: 2 further postoperative IV doses of co-amoxiclav 1.2g Group C: 2 further postoperative IV doses (as above), followed by a 5-day course of oral co-amoxiclav 625mg every 8 hours if no penicillin allergy (Control).\n\nTrial processes will be optimised by an internal pilot phase ensuring we recruit, randomise, and retain participants with clear progression criteria. We will also conduct cost-effectiveness analyses and process evaluation for dissemination and implementation\n\nTimeline:\n\nStart of grant: 1st July 2023 Start of RCT \u002F pilot: 1st January 2024 End of pilot: 30th June 2024 End of recruitment: 31st December 2026 End of follow-up: 30th June 2027 Completion: 31st December 2027\n\nImpact and dissemination:\n\n* Practice changing outputs that standardise the use of antibiotics in mandible fractures in the NHS and provide a framework for other surgical prophylaxis research\n* A bespoke clinical dissemination plan via an engagement and training legacy\n* Cost-effectiveness data to inform policy making\n* A research legacy and change of culture in the specialty of OMFS",[129,130],"Mandible Fracture","Post-operative Antibiotics",[132,133,134,135,136,137],"Mandible fractures","Antibiotics","Open Reduction and Internal Fixation","Co-amoxiclav","Antibiotic Resistance","Surgical Site Infection","RECRUITING","2026-01-21",{"date":141,"type":42},"2026-01-22",{"date":143,"type":42},"2024-12-06",{"date":145,"type":22},"2027-12-31",{"name":48,"class":49},2,{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":17,"minAge":155,"maxAge":156,"enrollmentInfo":157,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":138,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":50},"100523802","exercise-engagement-in-people-over-60-at-risk-of-falls-100523802","NCT06100445","Exercise Engagement in People Over 60 at Risk of Falls","Barriers and Facilitators to Exercise Engagement in People Over 60 at Risk of Falls: an Exploratory Study","Inclusion Criteria:\n\n* Aged 60 years or over\n* At risk of falls or had a fall due to a musculoskeletal cause (pain, muscle weakness, balance issue)\n* Has capacity to consent, as deemed by the direct care team and researcher\n* Can communicate in English OR the use of a translation service - Able to independently participate in an interview either face-to-face or via remote means OR can use a translation service\n\nExclusion Criteria:\n\n\\- Aged under 60\n\n* Have a medical cause of falls OR currently under investigation for a medical cause of falls (eg\u002F dizziness, cardiac, visual impairment reported as being the cause of the fall as opposed to weakness or pain in lower limbs\u002Fbalance issues or unsteady on feet)\n* Moderate to severe cognitive impairment impairing capacity to consent","60 Years","95 Years",{"count":158,"type":22},10,"It is a qualitative study, using semi structured interviews to explore patient's experiences of falls and their perceptions on facilitators and barriers to exercise.\n\nAim: To explore reasons for and against engaging with exercises at home in participants over the age of 60 at risk of falls.\n\nTo explore:\n\n1. Patients' preferences to exercise format and type eg\u002F leaflet, online, access, such as the Chartered Society of Physiotherapy (CSP) chair exercises leaflet or individual personalized rehabilitation programme handouts\n2. The ability to discuss falls risk with health professionals.\n3. If health inequalities exist with people at risk of falls and exercising.\n4. Sustainability of exercise, in order to reduce the risk of falls in this population.\n5. The need to develop MSK internal and external facing falls management pathways.\n\nSuitability: Patients over the age of 60, who have been identified at risk of falls, having been referred to MSK Physiotherapy in Rossendale.\n\n'Risk of falls' is defined as: patient self-reports they are unsteady, had one or more fall in the last 6 months, or clinician identified a slow\u002Funsteady gait pattern on examination.\n\nSemi structured interviews on up to ten participants. It is anticipated that this sample size will give adequate data saturation. Approximately 12 months from participant recruitment to analysis of findings.",[161,162,163,164],"Musculoskeletal Injury","Frailty","Physical Inactivity","Health Behavior","2024-06-20",{"date":167,"type":42},"2024-06-21",{"date":169,"type":42},"2024-01-26",{"date":171,"type":22},"2024-12-31",{"name":48,"class":49},""]