[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Edward Via Virginia College of Osteopathic Medicine\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":164},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,51,78,98,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100639618","exploring-how-osteopathic-manipulative-treatment-may-affect-spinal-fluid-flow-an-mri-study-100639618",false,"NCT07629765","Exploring How Osteopathic Manipulative Treatment May Affect Spinal Fluid Flow: An MRI Study","Exploring the Impact of Osteopathic Manipulative Treatment on CSF Dynamics: A Mechanistic MRI-Based Investigation","Inclusion Criteria:\n\n* Healthy adults between 18 and 80 years of age\n* Able and willing to provide informed consent\n* Able to safely undergo MRI procedures\n* Able to participate in osteopathic manipulative treatment (OMT)\n\nExclusion Criteria:\n\n* History of severe traumatic brain injury\n* Fibromyalgia\n* Epilepsy\n* Severe neurodegenerative disorders\n* Brain tumor or brain metastasis\n* Stroke or cerebrovascular disease\n* Hydrocephalus\n* Brain malformations\n* Demyelinating disorders\n* Congenital abnormalities affecting cerebrospinal fluid (CSF) flow\n* Spinal stenosis\n* Prior brain surgery\n* Chiari malformation\n* Syringomyelia\n* Other spinal conditions that may disrupt CSF flow\n* Manual therapy within the previous 2 weeks\n* Use of medications that affect CSF flow and\u002For production (including carbonic anhydrase inhibitors, furosemide, thiopental, desflurane, halothane, ketamine, etc.)\n* Uncontrolled hypertension\n* Uncontrolled diabetes\n* MRI contraindications, including implanted metallic\u002Felectronic devices or -severe claustrophobia\n* Pregnancy",true,"ALL","18 Years","80 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","his study aims to investigate whether Osteopathic Manipulative Treatment (OMT) affects cerebrospinal fluid (CSF) flow and glymphatic clearance in the human brain. CSF plays an important role in brain health by supporting nutrient delivery, waste removal, and pressure regulation. Aging and certain neurological conditions are associated with reduced CSF circulation and impaired brain waste clearance.\n\nParticipants will undergo magnetic resonance imaging (MRI) scans before and after a 30-minute OMT session to evaluate changes in CSF flow dynamics and brain physiology. The study will also examine whether age, cognition, sleep quality, physical function, anxiety, and depression are associated with changes in CSF flow following OMT.\n\nThe study will enroll healthy adults between 18 and 80 years of age. Data collected from MRI imaging and questionnaires may help improve understanding of the physiological effects of OMT and its potential role in supporting brain health",[28],"Osteopathic Manipulative Treatment (OMT) Effects on Cerebrospinal Fluid (CSF) Dynamics",[30,31,32,33,34,35,36,37],"Osteopathic Manipulative Treatment","Cerebrospinal Fluid","CSF Dynamics","Brain MRI","Glymphatic System","Aging Brain","Healthy Adults","Manual Therapy","NOT_YET_RECRUITING","2026-06-01",{"date":41,"type":42},"2026-06-05","ACTUAL",{"date":44,"type":22},"2026-06",{"date":46,"type":22},"2027-08",{"name":48,"class":49},"Edward Via Virginia College of Osteopathic Medicine","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":50},"100607796","how-osteopathic-treatment-affects-the-leg-and-foot-in-people-with-low-back-pain-100607796","NCT07193212","How Osteopathic Treatment Affects the Leg and Foot in People With Low Back Pain","Osteopathic Manipulation Treatment Effect on the Leg and Foot Myofascial System in Adults With Chronic Low Back Pain - Pilot Study","Inclusion Criteria:\n\n* male and female subjects 18-65 years old\n* presence of chronic low back \\> 3 months duration or pain present \\> 50% of the time within the previous 12 months\n\nExclusion Criteria:\n\n* prior surgery of the thoracic, lumbar or sacral spine, pelvis\n* diagnosis lumbar radiculopathy or pinched nerve in the neck\n* diagnosis of foot condition that alters gait\n* diagnosis of connective tissue or muscle disorders\n* diagnosis of cancer\n* previous spinal cord injury inflammatory arthritis and fibromyalgia\n* pregnancy\n* tobacco use\n* known diabetes or prediabetes\n* allergy to ultrasound gel (propylene glycol)\n* history of manual therapy treatment within the past 2 weeks\n* injection for pain within the past 1 month\n* currently taking muscle relaxers","65 Years",{"count":60,"type":22},20,[25],"This pilot study will examine whether osteopathic manipulative treatment (OMT) can improve both physical and psychological aspects of chronic low back pain by focusing on the interconnected myofascial system of the back, legs, and feet. Twenty adults with chronic low back pain will receive four OMT sessions over 5-7 weeks. Before and after treatment, the investigators will measure muscle stiffness with ultrasound, plantar pressure during walking with a pressure plate, and patient-reported outcomes on pain, disability, sleep quality, stress, anxiety, depression, pain catastrophizing, and pain self-efficacy using surveys. By linking these objective and subjective measures, the study aims to provide early evidence of how OMT may influence musculoskeletal function, daily activity, and overall well-being, helping to guide future larger studies on treatment strategies for low back pain",[64],"Chronic Low Back Pain (CLBP)",[66,67,68],"chronic low back pain","myofascial systems","omt","RECRUITING","2026-05-12",{"date":72,"type":42},"2026-05-14",{"date":74,"type":42},"2025-11-05",{"date":76,"type":22},"2026-12",{"name":48,"class":49},{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":58,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":50},"100552310","the-effect-of-osteopathic-treatment-on-craniocervico-mandibular-dysfunction-100552310","NCT06471426","The Effect of Osteopathic Treatment on Craniocervico-Mandibular Dysfunction","Inclusion Criteria:\n\n* male and female subjects 19-65 years old\n* neck pain and\u002For headaches of \\> 1 month duration\n\nExclusion Criteria:\n\n* prior cervical or thoracic spinal surgery\n* diagnosis cervical radiculopathy or pinched nerve in the neck\n* diagnosis of jaw disease or dysfunction\n* diagnosis of connective tissue or muscle disorders\n* diagnosis of cancer\n* previous spinal cord injury\n* Inflammatory arthritis and fibromyalgia\n* eye movement disorder\n* known pregnancy (hormonal changes affecting tissues could be a confounding variable)\n* tobacco use\n* known diabetes or prediabetes\n* allergy to ultrasound gel (propylene glycol)\n* history of manual therapy treatment within the past 2 weeks\n* history of injection for pain within the past month\n* currently taking muscle relaxers","19 Years",{"count":21,"type":22},[25],"The goal of this clinical trial is to measure the effects of osteopathic manipulative treatment (OMT) on tissues of the craniocervico-mandibular unit (CCMU) in individuals with neck pain and headaches.\n\nThe main questions to answer are:\n\n1. How does OMT affect CCMU muscle stiffness\n2. How does OMT affect jaw motion\n3. How does OMT affect autonomic function\n4. Is pain pressure threshold affected by OMT of the CCMU\n\nParticipants will undergo the following interventions:\n\n1. Photos taken to measure head and neck angles\n2. Ultrasound\n3. Smooth Pursuit Neck Torsion Test\n4. Motion Capture\n5. Autonomic Protocol\n6. Algometry\n7. Surveys",[89,90],"Headache","Neck Pain","2026-05-11",{"date":72,"type":42},{"date":94,"type":42},"2024-04-22",{"date":96,"type":22},"2026-09-22",{"name":48,"class":49},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":108,"briefSummary":109,"conditions":110,"keywords":114,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":50},"100578967","physical-exam-static--dynamic-ultrasound-assessment--treatment-of-thoracolumbar-fascia-tlf-mediated-low-back-pain-100578967","NCT06818175","Physical Exam, Static & Dynamic Ultrasound Assessment, & Treatment of Thoracolumbar Fascia (TLF) Mediated Low Back Pain","Machine Learning Analysis of Ultrasound Images for the Investigation of Thoracolumbar Myofascial Pain and Therapeutic Efficacy of Hydrodissection (DoD) and Osteopathic Manipulative Treatment (AOA) for Thoracolumbar Fascia Glide Impairment","Inclusion Criteria:\n\n* ALL 18-50 year olds with No Low Back Pain (LBP); Acute LBP (\\\u003C 3 months); or Chronic LBP (\\> 3 months)\n\nExclusion Criteria:\n\n* Allergy to ultrasound gel - relative, consider alternatives\n* BMI: \\> 30\n* Pregnancy or Breastfeeding: current or remote, within the past 6 months\n* Spinal Surgery: history of lower thoracic or lumbar spine: within the past year, of more than a single level of hardware. (prior single level microdiscectomy, laminectomy, or fusion, that is stable for 1 year or greater is NOT excluded)\n* Current Low Back Pain (LBP) or Injury: severe enough to 1) limits activities of daily living, 2) limits the ability to work to less than an 8-hour day, 3) unable to lie prone with a pillow under their abdomen\u002Fpelvis for 30-45 minute intervals\n* History of Spinal Pathology: ankylosing spondylitis, rheumatoid arthritis or other rheumatic diseases, spinal tumor, or spinal infection\n* Corticosteroids: Injections into the low back or systemic medication within the last 3 months. Must be able to cease injections and\u002For corticosteroid medication during the study\n* Medication Usage that cannot be discontinued for length study: anticoagulants, muscle relaxants\n* Physical or Manual Therapy Interventions: in the last 90 days: physical therapy, acupuncture or trigger point therapy, any type of manual medicine or other bodywork treatments","50 Years",{"count":107,"type":22},200,[25],"This Study is for our continued study of the Thoracolumbar Fascia (TFL) in patients with and without low back pain by our experienced multidisciplinary team:\n\nVincent Wang PhD, VT Biomedical Engineering \\& Mechanics (BEAM). Albert J Kozar DO, FAOASM, R-MSK. P. Gunnar Brolinson, DO, FAOASM, FAOCFP. David T. Redden PhD, VCOM Research Biostatistician. Matthew Chung DO, VCOM and Team Physician at Virginia Tech. Edward Magalhaes, PhD, LPC, Psychiatry and Neuro- Behavioral Sciences, VCOM.\n\nThis listing is specifically for our renewed efforts via two, Department of Defense (DoD) and American Osteopathic Association (AOA), extramurally, simultaneously funded grants for similar but distinct projects. Both funding sources are aware of each other's funding and have approved their grant study moving forward simultaneously with some integration.\n\nDoD: Machine Learning Analysis of Ultrasound Images for the Investigation of Thoracolumbar Myofascial Pain and Therapeutic Efficacy of Hydrodissection.\n\nThe primary objectives of the proposed project are to:\n\n1. develop reliable, quantitative image analysis approaches to objectively distinguish images from subjects with acute or chronic TLF pain from those without pain and\n2. to assess the preliminary clinical efficacy of hydrodissection of the TLF as a novel therapeutic treatment for chronic LBP.\n\nAOA: Assessment of the Therapeutic Efficacy of OMT on Chronic Low Back Pain: An Integrated Sonographic and Machine Learning Analysis of Thoracolumbar Fascia Glide Impairment.\n\nThe primary objectives of the proposed project are to:\n\n1. assess the preliminary clinical efficacy of OMT as a therapeutic treatment for CLBP of TLF origin and\n2. develop reliable, quantitative image analysis approaches to objectively distinguish images from subjects with TLF pain from those without pain.\n\nThese projects will share 50 no LBP subjects as controls. The DOD study will include 50 acute LBP and 50 CLBP. The AOA study will include 50 CLBP.\n\nThis project uses standard surveys, physical exam, functional tests, and ultrasound imaging to obtain both static images of the TLF at multiple transition zones. It further uses ultrasound to evaluate the dynamic gliding motion, via cine loops, of this fascia in 2 different body movements in subjects with acute low back pain (ALBP), with chronic low back pain (CLBP), and without low back pain (WLBP). All images will be clinically analyzed and further assessed by textural and machine learning analysis. Patients with CLBP (only) will choose to enter one of the two studies (DoD vs AOA) at the time of consent.\n\nAll images will be clinically analyzed and further assessed by textural and machine learning analysis. Patients with CLBP (only) that are found to have TLF glide impairment or positive physical exam maneuvers suggesting TLF as etiology will enter the treatment arm of the chosen study at the time of consent, either ultrasound guided hydrodissection (USGH), or Osteopathic Manipulative Therapy (OMT). After receiving 3 treatments utilizing one of these modalities, the CLBP participants will have repeat standard surveys, physical exam, functional tests, and ultrasound imaging assessments at 2,4,6,12, and 24 weeks post-treatment.\n\nAt the conclusion of this project, the investigators expect to have developed, refined, and implemented robust and feasible experimental and computational approaches which can be further expanded in larger-scale studies. The development of our data-driven computer models for the objective analysis of sonographic images of the TLF has high potential impact as it seeks to transform the assessment of TLF integrity, injury and healing via establishment of reliable US imaging biomarkers. The investigators anticipate that the tools developed will have broad utility to assess a variety of clinical treatments for the TLF. The investigators also hope to validate physical exam maneuvers that may predict TLF mediated LBP and have preliminary evidence of the efficacy of hydrodissection and OMT in TLF mediated LBP.\n\nIn pursuit of these objectives, the investigators will adopt an innovative approach featuring a robust integration of clinical imaging, physical exam, pain and functional outcomes, quantitative image analysis, and machine learning analyses.\n\nSpecific Aim 1: Compare sonographic TLF imaging characteristics in individuals with acute versus chronic pain to those without low back pain.\n\nSpecific Aim 2: Develop a machine learning (ML) classification algorithm to reliably distinguish abnormal myofascial tissue in acute versus chronic pain stages from healthy tissue.\n\nSpecific Aim 3:\n\nDoD Study: Assess the preliminary therapeutic efficacy of hydrodissection as a novel treatment for TLF pain using quantitative US imaging and ML tools.\n\nAOA Study: Assess the preliminary therapeutic efficacy of OMT as a treatment for CLBP using quantitative US imaging and ML tools.",[111,112,113],"Low Back Pain","Chronic Low-back Pain","Acute Low Back Pain",[115,116,117,118,119,120,121,122],"Diagnostic Ultrasound","Machine Learning","Shear Wave Elastography","Osteopathic Manipulative Treatment (OMT)","Hydrodissection","Physical Exam","Fascia","Thoracolumbar Fascia","2026-03-11",{"date":125,"type":42},"2026-03-13",{"date":127,"type":42},"2023-09-01",{"date":129,"type":22},"2026-12-31",{"name":48,"class":49},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":139,"maxAge":19,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":142,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":50},"100557071","vcom-pain-free-research-collaborative-100557071","NCT06533345","VCOM Pain Free Research Collaborative","MERCI Chronic Pain Research Clinic (Medical Education and Research in Compassionate Integration\u002FIntervention)","MERCI","Inclusion Criteria:\n\n* Those experiencing chronic pain, i.e., ongoing pain not relevant to an acute perturbation (e.g., recent injury).\n\nExclusion Criteria:\n\n* Those subjects seeking pharmaceutical intervention\n* Those whose myofascial pain is deemed functional (normal response to acute injury or ongoing pathology","21 Years",{"count":141,"type":22},120,[25],"Studies estimate that 30% of people worldwide experience chronic pain. The mechanisms causing this pain can vary: a neuropathic offender, such as nerve compression; a structural offender, such as long-term effects of soft tissue damage and repair; or nociplastic, dysfunctional offenders, such as fibromyalgia. The type of pain experienced influences diagnostic and treatment choice. In theory, there's a significant blending of these pain types within individuals and across patients, leading many specialists to view pain classification as a spectrum. Multidisciplinary pain management (MPM) is a standard model for addressing and treating different mechanisms of chronic pain using multiple interventions from different disciplines. Although many clinics employing these strategies have resulted in positive and clinically effective outcomes, the creation and implementation of such facilities have not been widespread. With increasing focus on psychosocial factors that impact pain in conjunction with structural and biomechanical offenders, a need for a whole-person, integrated approach to chronic pain management is needed. We propose an observational study to gather data that will inform the design, implementation, and operation of such a chronic pain research clinic.",[145],"Chronic Pain",[147,148,30,149,150,151,152,153,154,155],"Autonomic Dysfunction","Sympathetic Dominance","Dry Needling","Nutrition","Lifestyle","Group Therapy","Therapy","Trauma","Flourishing","2026-02-18",{"date":158,"type":42},"2026-02-20",{"date":160,"type":42},"2024-08-30",{"date":162,"type":22},"2027-08-01",{"name":48,"class":49},""]