[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Egymedicalpedia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":172},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,42,63,85,106,128,148],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100561488","the-effect-of-body-mass-index-on-short-term-results-of-hto-100561488",false,"NCT06590818","The Effect of Body Mass Index on Short-term Results of HTO","The Effect of Body Mass Index on Short-term Results of HTO for Treatment of OA With Varus Knee in Upper Egypt Population","Inclusion Criteria:\n\n* Meet the diagnostic criteria for knee osteoarthritis and only have one knee\n* No serious underlying medical disease\n* Conservative treatment is ineffective and there is a willingness for surgery\n* X-ray shows degeneration limited to the medial joint space (Ahlback grade ≥ grade II)\n* Knee flexion range of motion \\> 90°, varus deformity \\\u003C 15°, flexion contracture \\\u003C 5°.\n* Clinical examination shows intact anterior cruciate ligament and collateral ligament, tenderness point is limited to the medial joint space, and the lateral compartment and patellofemoral joint are intact.\n\nExclusion Criteria:\n\n* knee osteoarthritis caused by infection, blood-related or autoimmune diseases.\n* severe obesity (BMI\\>35 kg\u002Fm 2 ) or morbid obesity (obesity caused by diseases such as hypercortisolism and hypothyroidism, BMI≥30 kg\u002Fm 2 ).","ALL","40 Years","60 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The knee joint plays a major role in weight transmission of the body in day-to-day activities. The biomechanics of the knee and malalignment in lower limb anatomy are major risk factors for chronic knee pain, leaving Total Knee Arthroplasty (TKA) as the best and most successful option for patients with end-stage osteoarthritis (OA)",[27,28],"Osteo Arthritis Knee","Varus Knee","RECRUITING","2024-09-06",{"date":32,"type":33},"2024-09-19","ACTUAL",{"date":35,"type":33},"2024-07-10",{"date":37,"type":21},"2025-07-10",{"name":39,"class":40},"Egymedicalpedia","INDUSTRY",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":60,"leadSponsor":62,"locationsCount":41},"100560950","remifentanil-and-remimazolam-to-limit-patient-movement-100560950","NCT06583811","Remifentanil and Remimazolam to Limit Patient Movement","Remifentanil and Remimazolam to Limit Patient Movement During Long-Eye Surgeries Under Local Anesthesia","Inclusion Criteria:\n\n* Age \\> 40 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-III.\n* Undergoing long-eye surgeries under local anesthesia using peribulbar block with an expected surgical time of more than one hour.\n\nExclusion Criteria:\n\n* Patients on aspirin or anticoagulants.\n* Allergy to any study medication.\n* Drug abuse.\n* Uncontrolled hypertension.\n* Hyperthyroidism.\n* Frequent cough.\n* Impaired hearing.\n* Severe liver and kidney dysfunction.\n* Neurological or psychological disorders.\n* Partial or failed block.","50 Years",{"count":51,"type":21},70,[24],"Local anesthetics (LA) may be administered by injection (retrobulbar, peribulbar, subconjunctival, lid, or facial block) or by instillation (topical anesthesia), Considerable drawbacks of local anesthesia in these patients include the fact that a few patients can remain comfortable on an operating table for procedures that exceed two or three hours.\n\nSedation may be helpful with LA to decrease the experience of discomfort, movement and anxiety, which may in turn positively influence hemodynamic parameters, patient satisfaction, and overall improve surgical safety. Sedatives used in eye surgeries include benzodiazepines, opioids, alpha-adrenoceptor agonists, and propofol.",[55],"Long-Eye Surgeries","2024-08-31",{"date":58,"type":33},"2024-09-04",{"date":35,"type":33},{"date":61,"type":21},"2025-01-10",{"name":39,"class":40},{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":16,"minAge":70,"maxAge":17,"enrollmentInfo":71,"targetDuration":4,"studyType":22,"phases":73,"briefSummary":74,"conditions":75,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":41},"100556275","fractional-erbium-yag-laser-vs-intradermal-and-systemic-tranexamic-acid-100556275","NCT06522984","Fractional Erbium YAG Laser vs Intradermal and Systemic Tranexamic Acid","Fractional Erbium YAG Laser vs Intradermal and Systemic Tranexamic Acid in Combination With Topical Hydroquinone for Refractory Melasma","Inclusion Criteria:\n\n\\- Patients of both sexes with melasma.\n\nExclusion Criteria:\n\n* Pregnancy\n* Lactation\n* Administration of oral contraceptive pills or any phototoxic drug within 1 month prior to study\n* Patients with a history of thrombosis, abnormal bleeding profile, known hypersensitivity to TA or HQ, and endocrinal disease.","18 Years",{"count":72,"type":21},45,[24],"Melasma is a common acquired disorder of hyperpigmentaion caused by increased melanin production by melanocytes.\n\nMelasma is a name derived from the Greek word melas meaning black.It is characterized by the appearance of brownish or grayish symmetrical patches on sun-exposed skin, most commonly on the face. Compared to men, women are more likely to be affected.",[76],"Refractory Melasma","2024-07-23",{"date":79,"type":33},"2024-07-26",{"date":81,"type":33},"2024-06-01",{"date":83,"type":21},"2025-06-10",{"name":39,"class":40},{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":16,"minAge":70,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":41},"100542073","value-of-laboratory-biomarkers-in-prediction-of-outcome-in-septic-patients-100542073","NCT06338124","Value of Laboratory Biomarkers in Prediction of Outcome in Septic Patients","Inclusion Criteria:\n\n\\- patients whom will be diagnosed with sepsis\n\nExclusion Criteria:\n\n* patients diagnosed by hematological disease\n* patients refused to participate in the research\n* patients less than 18 years","70 Years",{"count":93,"type":21},100,"OBSERVATIONAL","Sepsis is defined as a dysregulated host response to infection . Despite ongoing efforts, both the incidence and mortality of sepsis have demonstrated limited reductions over the past years,There are several biomarkers that have already been studied for the early diagnosis of sepsis. Some of these markers can be used in risk prediction and monitoring the outcome of sepsis .\n\nSome of these markers as procalcitonin and CD14, are costly and not feasible options for low- and middle-income countries . While other biomarkers are feasible and accessible to be evaluated as Triglyceride\\\\glucose index (TyG) , Relative Distributive Width of red blood corpuscles to albumin ratio (RAR), C-reactive protein,Neutrophile \\\\Lympocyte ratio and serum lactate levels .",[97],"Sepsis","2024-07-09",{"date":100,"type":33},"2024-07-11",{"date":102,"type":33},"2024-04-01",{"date":104,"type":21},"2025-04-01",{"name":39,"class":40},{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":113,"maxAge":49,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":41},"100551759","dexmedetomidine-versus-midazolam-fentanyl-for-analgesia-and-sedation-100551759","NCT06464263","Dexmedetomidine Versus Midazolam-Fentanyl for Analgesia and Sedation","Comparative Study Between Dexmedetomidine Versus Midazolam-Fentanyl for Analgesia and Sedation After Adult Valvular Cardiac Surgeries; a Prospective Randomized Blinded Clinical Trial","Inclusion Criteria:\n\n\\- This study will include patients undergoing elective adult valvular cardiac surgeries\n\nExclusion Criteria:\n\n* Patient refusal.\n* Emergent valve cardiac surgeries.\n* Patients with known hypersensitivity to study drugs.\n* History of uncontrolled diabetes or hypertension.\n* Impaired kidney or liver functions.\n* Perioperative hemodynamic instability.","21 Years",{"count":115,"type":21},60,[24],"Postoperative sedation is an essential component in recovery of the patient undergoing cardiac surgery. It facilitates the patient's unawareness of the environment as well as reduce the discomfort and anxiety caused by surgery, intubation, mechanical ventilation, suction, and physiotherapy.\n\nDespite the advances in anesthesia and surgical techniques, the duration of mechanical ventilation (MV) may be prolonged after cardiac surgery, due to the classic high-dose narcotic-based cardiac anesthesia.",[119],"Valvular Cardiac Surgeries","2024-06-12",{"date":122,"type":33},"2024-06-18",{"date":124,"type":33},"2024-02-10",{"date":126,"type":21},"2026-02-10",{"name":39,"class":40},{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":16,"minAge":70,"maxAge":18,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":138,"conditions":139,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":145,"leadSponsor":147,"locationsCount":41},"100544530","effect-of-early-administration-of-albumin-20-versus-crystalloid-100544530","NCT06370078","Effect of Early Administration of Albumin 20% Versus Crystalloid","Effect of Early Administration of Albumin 20% Versus Crystalloid During Resuscitation of Patient With Septic Shock: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Presence of septic shock that meets all the following Criteria: Clinically possible, probable, or microbiologically confirmed infection according to the definitions of the International-Sepsis- Forums (ISF), Despite adequate volume therapy, vasopressors are required to maintain mean arterial pressure (MAP) ≥ 65 mmHg for at least 1 hour, Serum lactate concentration \\> 2 mmol\u002Fl (18 mg\u002Fdl) despite adequate volume therapy.\n* Onset of septic shock less than 24 h prior to study inclusion.\n* Women of childbearing age: negative pregnancy test\n\nExclusion Criteria:\n\n* Moribund conditions\n* End of life decisions\n* Previous participation to this trial or any other interventional clinical trial\n* Known hypersensitivity to albumin or any component of the trial drug\n* Clinical conditions, where albumin administration may be unfavourable\n* Breast feeding",{"count":136,"type":21},46,[24],"Sepsis and septic shock are global health problems, leading to a high mortality rate. They are often associated with extremely low blood pressure and multiple organ dysfunctions, which are the main causes of death in critically ill patients. Fluid resuscitation is one of the most critical treatments for patients with sepsis and septic shock.\n\nAn early administration of an appropriate fluid to patients is considered the most effective way to increase blood pressure, improve tissue perfusion, and save their lives. Crystalloid fluids are a subset of intravenous solutions composed of mineral salts and other small, water-soluble molecules, including normal, isotonic or hypertonic saline, and various buffered solutions.",[140],"Septic Shock","2024-06-04",{"date":143,"type":33},"2024-06-06",{"date":81,"type":33},{"date":146,"type":21},"2024-11-30",{"name":39,"class":40},{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":155,"minAge":156,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":41},"100497344","ivficsi-outcome-in-women-with-polycystic-ovary-syndrome-100497344","NCT05756023","IVF\\ICSI Outcome in Women With Polycystic Ovary Syndrome","IVF\\ICSI Outcome in Women With Polycystic Ovary Syndrome Compared With Non Polycystic Ovary Syndrome Women","Inclusion Criteria:\n\n* Oligo-ovulation or anovulation.\n* Clinical and\u002For biochemical hyper androgenesim.\n* Polycystic ovaries.\n\nExclusion Criteria:\n\n1. Androgen-secreting tumors (ovarian or adrenal).\n2. Adult-onset congenital adrenal hyperplasia.\n3. Thyroid diseases.\n4. Cushing's syndrome.\n5. Diabetes Mellitus.\n6. recurrent ICSI failure\n7. endocrine, hematologic and autoimmune disorders\n8. Non chromosomal and genetic abnormalities\n9. Major uterine anomalies, bad surgical history, sever endometriosis, , hydrosalpinx, uterine fibroids\n10. Azospermia","FEMALE","20 Years","35 Years",{"count":159,"type":21},156,[24],"Polycystic ovarian syndrome (PCOS) occurs in 5% to 10% of all women of reproductive age and 50% of women who present with sub-fertility due to anovulatory infertility . Clear diagnostic criteria for this condition were identified at the consensus meeting of the European Society of Human Reproduction and Embryology and the American Society for Reproductive Medicine .",[163],"PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries","2023-10-17",{"date":166,"type":33},"2023-10-19",{"date":168,"type":33},"2023-06-01",{"date":170,"type":21},"2026-12-15",{"name":39,"class":40},""]