[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"El Katib Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":103},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100601993","endoscopic-band-ligation-for-type-2-diabetes-mellitus-endoband-dm-100601993",false,"NCT07117721","Endoscopic Band Ligation for Type 2 Diabetes Mellitus (ENDOBAND-DM)","Evaluation of Endoscopic Band Ligation for Treatment of Type 2 Diabetes: A Single-Center Interventional Study","ENDOBAND-DM","Inclusion Criteria:\n\n* Age between 18 and 70 years\n* Confirmed diagnosis of type 2 diabetes mellitus\n* HbA1c between 7.5% and 10.5% at screening\n* Body Mass Index (BMI) between 27 and 40 kg\u002Fm²\n* Stable use of oral antidiabetic medications for ≥3 months prior to enrollment\n* Willingness to undergo endoscopic procedure and attend all follow-up visits\n* Signed informed consen\n\nExclusion Criteria:\n\n* Use of insulin therapy\n* Previous bariatric or gastrointestinal surgery\n* Diagnosis of type 1 diabetes mellitus\n* Known gastrointestinal obstruction, ulcers, or active GI bleeding\n* History of pancreatitis, biliary disease, or abnormal anatomy in duodenum\n* Pregnancy or breastfeeding\n* Severe comorbidities (e.g., uncontrolled cardiovascular disease, advanced kidney or liver disease)\n* Use of GLP-1 receptor agonists within 3 months prior to enrollment\n* Inability or unwillingness to comply with the study protocol","ALL","18 Years","70 Years",{"count":21,"type":22},10,"ESTIMATED","INTERVENTIONAL",[25],"NA","This is a pilot clinical study evaluating the safety and feasibility of Endoscopic Band Ligation (ENDOBAND-DM) applied to the second through fourth parts of the duodenum - from just distal to the ampulla of Vater to the ligament of Treitz - in patients with type 2 diabetes mellitus (T2DM). The goal is to induce mucosal remodeling in this duodenal segment, potentially enhancing gut hormone signaling and improving glycemic control. Participants will be monitored for changes in HbA1c, fasting glucose, and insulin sensitivity over 6-12 months.",[28],"Type 2 Diabetes Mellitus (T2DM)",[30,31,32,33,34,35,36,37,38],"Endoscopic band ligation","Duodenal intervention","Metabolic endoscopy","GLP-1","GIP","Insulin resistance","HbA1c","Non-surgical diabetes treatment","Duodenal mucosal modulation","NOT_YET_RECRUITING","2025-08-12",{"date":42,"type":43},"2025-08-15","ACTUAL",{"date":45,"type":22},"2026-01-01",{"date":47,"type":22},"2028-01-01",{"name":49,"class":50},"El Katib Hospital","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},"100525770","endoscopic-band-ligation-for-treating-reflux-disease-100525770","NCT06126055","Endoscopic Band Ligation for Treating Reflux Disease","EndoBand: Endoscopic Band Ligation for Treating Reflux Disease (GERD)","Inclusion Criteria:\n\n* Symptomatic GERD\n\nExclusion Criteria:\n\n* Any previous surgery for GERD",true,"50 Years",{"count":21,"type":22},[25],"GERD is a chronic disease the require different treatment modalities; non have proven long term efficacy with concerns about their safety. The use of band ligation in endoscopy appears safe, repeatable with short learning curve. Placing multiple bands at the Z-line can create a fibrous ring in the distal esophagus acting as a barrier against reflux of gastric content.",[64],"GERD",[64,66,67,68],"GastroEsophageal Reflux","Band Ligation","EndoBand","2025-08-05",{"date":71,"type":43},"2025-08-08",{"date":73,"type":22},"2025-12-01",{"date":75,"type":22},"2027-12-01",{"name":49,"class":50},1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":77},"100395602","endo-band-endoscopic-band-ligation-for-weight-loss-100395602","NCT04431232","Endo-Band: Endoscopic Band Ligation for Weight Loss","Endoscopic Band Ligation for Weight Loss","Inclusion Criteria:\n\n* BMI \\> 27\n\nExclusion Criteria:\n\n* Any contraindication for endoscopy\n* Any gastric bleeding lesions\n* Uncontrolled use of anticoagulants or NSAID's","65 Years",{"count":87,"type":22},5,[25],"To the best of our knowledge, this is the first study to use endoscopic band ligation for weight loss. All ligatures will be performed in the gastric body starting at the distal body; 5 parallel rows, with the last one in the proximal body.The entire procedure can be completed in 30 min. Oxygen is used for endoscopic air insufflation.Endoscopy is performed using propofol for sedation.",[91],"Obesity",[91,93],"BMI","RECRUITING","2024-08-26",{"date":97,"type":43},"2024-08-27",{"date":99,"type":43},"2020-02-01",{"date":101,"type":22},"2026-03-07",{"name":49,"class":50},""]