[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Elazıg Fethi Sekin Sehir Hastanesi\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":416},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,46,82,113,141,164,190,218,241,269,293,322,345,370,394],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100644264","ai-based-prediction-of-difficult-airway-in-bariatric-surgery-100644264",false,"NCT07666074","AI-Based Prediction of Difficult Airway in Bariatric Surgery","Artificial Intelligence-Based Prediction of Difficult Airway in Bariatric Surgery: A Prospective Evaluation of Preoperative Airway Predictors","AI-Airway","Inclusion Criteria:\n\n1. Adult patients aged 18 to 65 years.\n2. Scheduled for elective bariatric surgery under general anesthesia.\n3. Body Mass Index (BMI) ≥ 35 kg\u002Fm².\n4. Consenting to participate in the study.\n\nExclusion Criteria:\n\n1. Patients with known upper airway anatomical deformities, head and neck tumors, or a history of head\u002Fneck radiotherapy.\n2. History of maxillofacial, airway, or cervical spine surgery.\n3. Emergency surgeries.\n4. Patients requiring planned awake fiberoptic intubation based on obvious preoperative clinical indicators.",true,"ALL","18 Years","65 Years",{"count":22,"type":23},340,"ESTIMATED","OBSERVATIONAL","The aim of this prospective study is to evaluate the accuracy of artificial intelligence (AI) and machine learning algorithms in predicting difficult airways in patients undergoing bariatric surgery. Preoperative airway assessments, including the Upper Lip Bite Test (UBLT), Mallampati score, Body Mass Index (BMI), thyromental distance (TMD), and sternomental distance (SMD), will be recorded. The study investigates whether AI models can provide higher sensitivity and specificity in predicting difficult intubation compared to traditional clinical scoring systems in the obese patient population.",[27],"Obesity Difficult Airway Airway Management",[29,30,31,32],"Artificial Intelligence","Airway Management","Obesity","Machine Learning","RECRUITING","2026-06-18",{"date":36,"type":37},"2026-06-24","ACTUAL",{"date":39,"type":37},"2026-05-21",{"date":41,"type":23},"2026-10-15",{"name":43,"class":44},"Elazıg Fethi Sekin Sehir Hastanesi","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":45},"100641481","qr-code-video-education-for-icu-family-members-100641481","NCT07660705","QR Code Video Education for ICU Family Members","Effect of a QR Code-Based Digital Information Video on Knowledge and Anxiety Among Family Members of Intensive Care Unit Patients: A Prospective Randomized Controlled Trial","QR-ICU","Inclusion Criteria:\n\n* Age 18 years or older\n* First-degree family member of a patient admitted to the intensive care unit\n* Able to read and understand Turkish\n* Able to use a smartphone\n* Able to access QR code-based educational materials\n* Willing to participate and provide written informed consent\n\nExclusion Criteria:\n\n* History of a diagnosed psychiatric disorder\n* Current use of anxiolytic or antidepressant medication\n* Visual or hearing impairment preventing participation in video-based education\n* First-degree family member who is an active healthcare professional involved in patient care\n* Inability to complete study questionnaires or follow-up assessments\n* Refusal to participate in the study",{"count":55,"type":23},150,"INTERVENTIONAL",[58],"NA","This prospective randomized controlled study aims to evaluate the effect of a QR code-based digital information video on knowledge level and anxiety among family members of intensive care unit (ICU) patients. Participants will be randomly assigned to either a control group receiving routine verbal information or an intervention group receiving routine verbal information plus access to a standardized QR code-based educational video. Knowledge level, anxiety, and satisfaction with information will be assessed at baseline, within 24 hours after the intervention, and 72 hours later. The study will determine whether digital video-based information improves understanding of the ICU environment and reduces anxiety among family members.",[61,62,63],"Anxiety","Health Education","Family Members of Intensive Care Unit Patients",[65,66,67,68,69,61,70,71,72],"Intensive Care Unit","ICU Family Members","QR Code","Digital Education","Video-Based Education","Health Communication","Family-Centered Care","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-06-16",{"date":76,"type":37},"2026-06-22",{"date":78,"type":23},"2026-06-17",{"date":80,"type":23},"2026-07-17",{"name":43,"class":44},{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":90,"minAge":19,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":56,"phases":93,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":45},"100643009","video-versus-verbal-preoperative-education-in-elective-cesarean-delivery-100643009","NCT07647601","Video Versus Verbal Preoperative Education in Elective Cesarean Delivery","Effects of Verbal and Video-Based Preoperative Education on Anxiety and Serum Cortisol Response in Women Scheduled for Elective Cesarean Delivery: A Prospective Randomized Controlled Trial","VIDEO-CS","Inclusion Criteria:\n\n* Female participants aged 18 years or older\n* Scheduled for elective cesarean delivery\n* Planned to undergo spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I or II\n* Able to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Emergency cesarean delivery\n* History of psychiatric disease\n* Current use of anxiolytic or antidepressant medications\n* Endocrine disorders, including adrenal or thyroid disease\n* Current corticosteroid therapy\n* Previous surgery performed under spinal anesthesia\n* Cognitive impairment or communication difficulties that may interfere with completion of anxiety assessments\n* ASA physical status III, IV, or V","FEMALE",{"count":92,"type":23},140,[58],"This prospective randomized controlled trial aims to evaluate the effects of verbal and video-based preoperative education on anxiety levels and serum cortisol response in women scheduled for elective cesarean delivery under spinal anesthesia.\n\nEligible participants will be randomly assigned to receive either standard verbal education or a standardized video-based educational intervention before surgery. Anxiety levels will be assessed using the State-Trait Anxiety Inventory (STAI-S), and serum cortisol levels will be measured before and after the educational intervention.\n\nThe primary objective is to compare the effectiveness of the two educational methods in reducing preoperative anxiety and physiological stress response.",[96,97,98],"Preoperative Anxiety","Cesarean Delivery","Stress Response",[100,69,101,102,103,61,104,105,72],"Preoperative Education","Verbal Education","Cesarean Section","Spinal Anesthesia","Serum Cortisol","STAI","2026-06-13",{"date":74,"type":37},{"date":109,"type":23},"2026-06-10",{"date":111,"type":23},"2026-07-20",{"name":43,"class":44},{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":56,"phases":123,"briefSummary":124,"conditions":125,"keywords":129,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":136,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":140,"locationsCount":45},"100642020","qr-code-based-video-supported-anesthesia-information-and-preoperative-anxiety-100642020","NCT07647588","QR Code-Based Video-Supported Anesthesia Information and Preoperative Anxiety","The Effect of QR Code-Based Video-Supported Anesthesia Information on Preoperative Anxiety, Comprehensibility of Information, and Patient Satisfaction: A Prospective Randomized Controlled Study","QR-AID","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective surgery\n* Evaluated in the anesthesia outpatient clinic\n* Able to understand the study information and questionnaires\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Emergency surgery\n* Impaired consciousness\n* Advanced dementia\n* Severe psychiatric illness\n* Severe visual, hearing, or cognitive impairment\n* Inability to understand the digital educational content\n* Refusal to participate\n* Inability to read or understand Turkish",{"count":122,"type":23},284,[58],"This study aims to evaluate the effects of QR code-based video-supported anesthesia information on preoperative anxiety, comprehensibility of information, and patient satisfaction in adult patients undergoing elective surgery.\n\nParticipants will be randomly assigned in a 1:1 ratio to either a control group receiving standard written informed consent and routine verbal anesthesia information or an intervention group receiving the same standard information plus a standardized video-based educational intervention accessed through a QR code.\n\nThe primary outcome is the change in the Amsterdam Preoperative Anxiety and Information Scale (APAIS) anxiety score before and after the information process. Secondary outcomes include comprehensibility of information and patient satisfaction assessed using a structured Likert-type questionnaire.\n\nThe findings may contribute to the standardization of patient information processes in anesthesia outpatient clinics through a low-cost and easily implementable digital educational approach.",[96,126,127,128],"Anesthesia","Informed Consent","Patient Education",[67,130,131,132,133,134,127,72,135,96],"Video-Supported Education","Amsterdam Preoperative Anxiety and Information Scale","APAIS","Anesthesia Information","Patient Satisfaction","Digital Health",{"date":74,"type":37},{"date":109,"type":23},{"date":139,"type":23},"2026-07-10",{"name":43,"class":44},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":149,"conditions":150,"keywords":152,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":45},"100632366","preoperative-distress-and-postoperative-delirium-in-elderly-patients-undergoing-major-orthopedic-surgery-100632366","NCT07512752","Preoperative Distress and Postoperative Delirium in Elderly Patients Undergoing Major Orthopedic Surgery","The Association Between Preoperative Distress and Postoperative Delirium, Pain, and Length of Hospital Stay in Elderly Patients Undergoing Major Orthopedic Surgery","Inclusion Criteria\n\n* Age ≥65 years\n* Undergoing major orthopedic surgery, including:\n* Hip fracture surgery\n* Primary or revision hip arthroplasty\n* Primary knee arthroplasty\n* Ability to provide informed consent or availability of a legally authorized representative\n\nExclusion Criteria\n\n* Known diagnosis of severe dementia or significant cognitive impairment\n* Presence of preoperative delirium or an active diagnosis of delirium\n* Severe hearing or visual impairment preventing effective communication\n* History of intracranial surgery or neurological diseases significantly increasing the risk of delirium (e.g., advanced Parkinson's disease, severe stroke sequelae)\n* Planned postoperative sedation in the intensive care unit",{"count":55,"type":23},"Postoperative delirium is a common and serious complication in elderly patients undergoing major orthopedic surgery and is associated with increased morbidity, prolonged hospital stay, and higher healthcare costs. Preoperative psychological distress has been suggested as a potential risk factor influencing postoperative outcomes; however, its relationship with delirium and other clinical outcomes remains insufficiently explored.\n\nThis prospective observational study aims to investigate the association between preoperative distress levels and postoperative delirium, pain intensity, and length of hospital stay in elderly patients undergoing major orthopedic surgery. Preoperative distress will be assessed using validated tools, and postoperative outcomes including delirium incidence, pain scores, and hospital stay duration will be recorded and analyzed.\n\nThe findings of this study are expected to contribute to improved perioperative risk stratification and may support the development of targeted interventions to reduce postoperative complications in this vulnerable patient population.",[151],"Postoperative Delirium",[151,153,154,155],"Preoperative Distress","Pain","Length of Hospital Stay","2026-06-09",{"date":158,"type":37},"2026-06-11",{"date":160,"type":37},"2026-02-19",{"date":162,"type":23},"2026-06",{"name":43,"class":44},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":173,"conditions":174,"keywords":178,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":45},"100626451","long-term-health-effects-of-previous-coronavirus-disease-2019-covid-19-in-patients-undergoing-preoperative-anesthesia-evaluation-100626451","NCT07435805","Long-Term Health Effects of Previous Coronavirus Disease 2019 (COVID-19) in Patients Undergoing Preoperative Anesthesia Evaluation","Long-Term Clinical and Health Effects of Previous Coronavirus Disease 2019 (COVID-19) in Patients Presenting for Preoperative Anesthesia Evaluation","Inclusion Criteria:\n\n* Age ≥18 years\n\nPresentation to the preoperative anesthesia clinic\n\nSelf-reported history of laboratory-confirmed COVID-19 infection\n\nAbility to provide informed consent\n\nWillingness to complete the post-COVID clinical questionnaire\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n\nNo history of COVID-19 infection\n\nRefusal to participate or incomplete questionnaire\n\nCognitive impairment or communication difficulties preventing reliable data collection",{"count":172,"type":23},400,"The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in persistent health problems in a significant proportion of individuals after recovery from the acute infection. These long-term manifestations, commonly referred to as post-COVID-19 condition or long COVID, may involve respiratory, cardiovascular, neurological, psychological, and general health domains. Understanding these sequelae is particularly important in patients undergoing preoperative anesthesia evaluation, as residual symptoms may influence perioperative risk assessment and clinical decision-making. This cross-sectional observational study aims to evaluate the long-term clinical and health effects of previous COVID-19 infection in adult patients presenting to the preoperative anesthesia clinic. Patients aged 18 years and older who report a history of confirmed COVID-19 infection will be included. Clinical data related to the acute infection period (disease severity, hospitalization, intensive care unit (ICU) admission, oxygen therapy, and radiological findings) will be retrospectively obtained from hospital records. At the time of preoperative assessment, participants will complete a structured post-COVID-19 clinical questionnaire to evaluate persistent symptoms across multiple organ systems. The study seeks to determine the prevalence and characteristics of long-term post-COVID-19 symptoms and to explore potential associations between acute disease severity and ongoing health complaints. No additional medical intervention will be performed as part of this research.",[175,176,177],"Post-COVID Condition","Long COVID","Sequelae of COVID-19",[175,179,180,181],"Preoperative Assessment","Cross-Sectional Study","COVID-19 Sequelae","2026-06-02",{"date":184,"type":37},"2026-06-04",{"date":186,"type":37},"2025-12-01",{"date":188,"type":23},"2026-06-20",{"name":43,"class":44},{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":90,"minAge":19,"maxAge":198,"enrollmentInfo":199,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":201,"conditions":202,"keywords":205,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":45},"100618055","effect-of-gestational-weight-gain-on-spinal-anesthesia-in-elective-cesarean-delivery-100618055","NCT07326644","Effect of Gestational Weight Gain on Spinal Anesthesia in Elective Cesarean Delivery","Effect of Gestational Weight Gain on Regional Anesthesia in Cesarean Patients","GWG-CESA","Inclusion Criteria:\n\n* Pregnant women aged 18-45 years\n\n  * Single pregnancy\n  * Planned elective cesarean section\n  * Spinal anesthesia (regional anesthesia technique)\n  * Pre-pregnancy weight information available (maternal health record, e-Nabız or file record)\n  * Recorded pre-delivery weight information\n  * Gestational weight gain (GWG) calculable according to the IOM 2009 classification\n  * ASA I-II pregnant women\n  * Voluntary participation in the study and informed consent\n\nExclusion Criteria:\n\n* Pregnant women with preeclampsia, severe preeclampsia, eclampsia, or HELLP syndrome\n\n  * Pregnant women with a history of gestational diabetes or pregestational diabetes\n  * Multiple pregnancy (twins, triplets, etc.)\n  * Preterm pregnancy (\\\u003C37 weeks)\n  * Failure of spinal anesthesia or need for conversion to general anesthesia\n  * Lack of pre-pregnancy weight information or weight gain data during pregnancy\n  * Pregnancies with fetal anomalies\n  * Morbid obesity (BMI ≥ 45 kg\u002Fm²)","45 Years",{"count":200,"type":23},200,"This prospective, observational, non-interventional study aims to evaluate the effect of gestational weight gain on regional anesthesia characteristics in pregnant women undergoing elective cesarean delivery. No additional intervention, medication, or procedure beyond routine clinical care will be performed. Participants will be classified according to gestational weight gain categories based on the Institute of Medicine (IOM) 2009 guidelines, and spinal anesthesia block characteristics, hemodynamic responses, and perioperative outcomes will be assessed.",[203,204,97],"Gestational Weight Gain","Regional Anesthesia",[206,207,208,209],"Gestational weight gain","Spinal anesthesia","Cesarean delivery","Hemodynamic response","2026-04-20",{"date":212,"type":37},"2026-04-23",{"date":214,"type":37},"2025-12-05",{"date":216,"type":23},"2026-05-10",{"name":43,"class":44},{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":90,"minAge":19,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":56,"phases":226,"briefSummary":227,"conditions":228,"keywords":231,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":4},"100633046","effect-of-video-based-versus-verbal-preoperative-information-on-anxiety-and-cortisol-levels-in-elective-cesarean-section-100633046","NCT07521592","Effect of Video-Based Versus Verbal Preoperative Information on Anxiety and Cortisol Levels in Elective Cesarean Section","The Effect of Video-Based Versus Verbal Preoperative Information on Anxiety and Serum Cortisol Levels in Elective Cesarean Section: A Prospective Randomized Controlled Study","Inclusion Criteria:\n\n* Pregnant women aged 18 years or older\n* Scheduled for elective cesarean delivery\n* Planned to receive spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Emergency cesarean delivery\n* History of psychiatric disorders\n* Current use of anxiolytic or antidepressant medications\n* Endocrine disorders, particularly adrenal or thyroid disease\n* Current corticosteroid therapy\n* History of previous surgery under spinal anesthesia\n* Cognitive impairment preventing effective communication or completion of the assessment scales\n* American Society of Anesthesiologists (ASA) physical status III-V",{"count":92,"type":23},[58],"Preoperative anxiety is a common problem in patients undergoing elective cesarean section and may negatively affect perioperative outcomes through activation of the stress response, including increased cortisol levels. Effective preoperative information is considered a key non-pharmacological strategy to reduce anxiety; however, the optimal method of information delivery remains unclear. This prospective randomized controlled trial aims to compare the effects of video-based versus verbal preoperative information on anxiety levels and serum cortisol response in patients scheduled for elective cesarean delivery under spinal anesthesia. Anxiety will be assessed using the State-Trait Anxiety Inventory (STAI), and serum cortisol levels will be measured before and after the intervention. The findings of this study are expected to provide evidence for improving patient-centered preoperative education strategies in obstetric anesthesia.\"",[96,102,229,230],"Surgical Stress Response","Cortisol",[96,97,232],"Cortisol Biomarker","2026-04-08",{"date":235,"type":37},"2026-04-13",{"date":237,"type":23},"2026-04-02",{"date":239,"type":23},"2026-07",{"name":43,"class":44},{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":248,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":250,"conditions":251,"keywords":254,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":45},"100629903","systemic-inflammation-thyroid-autoimmunity-and-neuroretinal-changes-in-graves-disease-100629903","NCT07480720","Systemic Inflammation, Thyroid Autoimmunity and Neuroretinal Changes in Graves Disease","Relationship Between Systemic Inflammation, Thyroid Autoimmunity, and Neuroretinal Structures in Graves Disease","Inclusion Criteria:\n\n* Age ≥ 18 years\n\nDiagnosis of Graves' disease (for the patient group)\n\nNo known thyroid disease in healthy control participants\n\nAvailability of optical coherence tomography (OCT) measurements and laboratory data\n\nTime interval between OCT examination and blood sampling ≤ 10 days\n\nExclusion Criteria:\n\n* Presence of glaucoma, optic neuropathy, or retinal vascular diseases\n\nMacular diseases, uveitis, or severe refractive error (high myopia \\>6 diopters)\n\nDiabetic retinopathy\n\nHistory of previous intraocular surgery\n\nHistory of active infection, malignancy, or systemic inflammatory disease\n\nPoor-quality OCT measurements (segmentation errors or low signal strength)",{"count":249,"type":23},100,"This retrospective observational study aims to evaluate the relationship between systemic inflammatory parameters, thyroid autoimmunity markers, and neuroretinal structures in patients with Graves disease. Medical records of patients diagnosed with Graves disease and healthy control subjects evaluated at Elazığ Fethi Sekin City Hospital between August 2018 and January 2026 will be reviewed. Optical coherence tomography (OCT) measurements, including macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness, will be analyzed. Laboratory parameters such as complete blood count-derived inflammatory indices, C-reactive protein, thyroid function tests, and thyroid autoantibodies will also be recorded. The study will compare neuroretinal parameters between healthy controls, Graves disease patients without ophthalmopathy, and Graves disease patients with ophthalmopathy, and will investigate potential associations between systemic inflammation, thyroid autoimmunity, and neuroretinal structural changes.",[252,253],"Graves Disease","Graves Ophthalmopathy",[255,256,257,258,259,260],"Graves disease","Thyroid autoimmunity","Systemic inflammation","Optical coherence tomography","Retinal nerve fiber layer","Graves ophthalmopathy","2026-03-14",{"date":263,"type":37},"2026-03-18",{"date":265,"type":37},"2026-03-01",{"date":267,"type":23},"2026-05-01",{"name":43,"class":44},{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":276,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":278,"conditions":279,"keywords":283,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":4},"100626458","impact-of-information-and-participation-on-decision-time-for-tracheostomy-or-peg-in-icu-families-100626458","NCT07435896","Impact of Information and Participation on Decision Time for Tracheostomy or PEG in ICU Families","Impact of Information and Participation Strategies on Decision Time for Tracheostomy or PEG Among Family Members of Intensive Care Patients","Inclusion Criteria:\n\n* First-degree relative of an ICU patient with an indication for tracheostomy and\u002For percutaneous endoscopic gastrostomy (PEG)\n* Age ≥ 18 years\n* Able to understand and communicate in Turkish\n* Provides written informed consent\n* Responsible for or involved in the medical decision-making process\n\nExclusion Criteria:\n\n* Cognitive impairment or psychiatric condition interfering with questionnaire completion\n* Refusal to participate\n* Prior participation in this study\n* Inability to complete study questionnaires",{"count":277,"type":23},60,"Decisions regarding tracheostomy and percutaneous endoscopic gastrostomy (PEG) in the intensive care unit (ICU) are frequently associated with substantial uncertainty, decisional conflict, and psychosocial burden among patients' relatives. Inadequate or non-tailored information may negatively influence anxiety levels, decision satisfaction, and subsequent adaptation to care responsibilities. Differences in communication patterns and educational background may further affect how families perceive the risks, benefits, and long-term implications of these procedures.\n\nThis prospective study aims to evaluate the impact of relatives' educational level and different information delivery methods on anxiety, decision satisfaction, and the overall decision-making process related to tracheostomy and PEG in the ICU setting. The findings are expected to contribute to the development of structured, education-level-tailored information strategies to improve shared decision-making and family-centered care in critical care practice.",[280,281,282],"Intensive Care Unit (ICU) Admission","Tracheostomy","Percutaneous Endoscopic Gastrostomy (PEG)",[284,281,65],"Percutaneous Endoscopic Gastrostomy","2026-02-21",{"date":287,"type":37},"2026-02-27",{"date":289,"type":23},"2026-03-15",{"date":291,"type":23},"2026-06-15",{"name":43,"class":44},{"id":294,"slug":295,"hasResults":11,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":299,"eligibilityCriteria":300,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":301,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":302,"conditions":303,"keywords":308,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":319,"leadSponsor":321,"locationsCount":45},"100619036","incidence-and-determinants-of-joint-contractures-in-mechanically-ventilated-icu-patients-100619036","NCT07339397","Incidence and Determinants of Joint Contractures in Mechanically Ventilated ICU Patients","Incidence and Determinants of Joint Contractures in Mechanically Ventilated Intensive Care Unit Patients: a Prospective Cohort Study","ICU-CONTRACT","Inclusion Criteria:\n\n* • Adult patients aged 18 and over\n\n  * Patients on mechanical ventilation and monitored in the intensive care unit for at least 7 days\n  * Glasgow Coma Score ≤10\n  * Patients monitored immobile in the intensive care unit\n  * Situations where informed consent can be obtained from the patient's legal representative\n\nExclusion Criteria:\n\n* • Presence of pre-existing joint contracture, ankylosis, or amputation\n\n  * Patients with severe burns, fractures, or surgical reasons preventing joint movement\n  * Patients with a history of neuromuscular disease or spasticity\n  * Patients who were immobilized for ≥1 week prior to admission to the intensive care unit\n  * Hemodynamic instability situations where measurement is unreliable",{"count":55,"type":23},"This prospective observational cohort study aims to evaluate the incidence and determinants of joint contracture development in mechanically ventilated adult patients admitted to the intensive care unit (ICU). Prolonged immobilization, deep sedation, and neuromuscular blockade are common in critically ill patients and may contribute to musculoskeletal complications, including joint contractures, which can adversely affect functional outcomes and rehabilitation after ICU discharge.\n\nAdult patients who are mechanically ventilated, immobilized, and have impaired consciousness will be consecutively enrolled and followed during their ICU stay. Joint range of motion will be assessed using standardized passive range of motion (PROM) measurements performed with a goniometer at predefined intervals by trained assessors. Joint contracture will be defined as a reduction of at least 33% in passive joint range of motion compared with normal reference values.\n\nThis study is non-interventional, and all patients will receive routine ICU care and standard physiotherapy according to institutional protocols. No additional procedures or interventions will be applied for research purposes. Demographic characteristics, clinical variables, and ICU-related factors will be recorded to explore potential associations with contracture development.\n\nThe findings of this study are expected to provide prospective data on the burden of joint contractures in mechanically ventilated ICU patients and to identify modifiable risk factors that may inform future preventive and rehabilitative strategies in critical care practice.",[304,305,306,307],"Joint Contractures","Critical Illness","Mechanical Ventilation","INTANSIVE CARE",[309,310,311,312,313,314],"Joint contracture","Intensive care unit","Mechanical ventilation","Passive range of motion","Musculoskeletal complications","Physiotherapy","2026-01-13",{"date":317,"type":37},"2026-01-14",{"date":186,"type":37},{"date":320,"type":23},"2026-05",{"name":43,"class":44},{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":11,"sex":90,"minAge":19,"maxAge":198,"enrollmentInfo":329,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":330,"conditions":331,"keywords":333,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":45},"100606926","postoperative-recovery-quality-after-cesarean-section-comparing-erector-spinae-and-retrolaminar-blocks-using-turkish-version-of-the-obstetric-quality-of-recovery-score-in-a-turkish-cohort-obsqor-11t-100606926","NCT07181902","Postoperative Recovery Quality After Cesarean Section: Comparing Erector Spinae and Retrolaminar Blocks Using Turkish Version of the Obstetric Quality-of-Recovery Score in a Turkish Cohort (ObsQoR-11T)","Postoperative Recovery Quality After Cesarean Section: Comparing Erector Spinae and Retrolaminar Blocks Using Turkish Version of the Obstetric Quality-of-Recovery Score (ObsQoR-11T) in a Turkish Cohort","Inclusion Criteria\n\n* Women aged 18-45 years, scheduled for elective cesarean delivery under spinal anesthesia.\n* Gestational age ≥37 weeks, singleton pregnancy.\n* Undergoing either ESP or RLB for postoperative analgesia.\n* ASA Physical Status II-III.\n* Ability to understand and complete ObsQoR-11T questionnaire.\n* Provided written informed consent prior to participation. Exclusion Criteria\n* Emergency cesarean delivery.\n* Multiple pregnancy, preterm delivery (\\\u003C37 weeks),\n* Severe maternal or obstetric complications (e.g., preeclampsia, placenta previa, placenta accreta spectrum), regardless of urgency.\n* BMI ≥40 kg\u002Fm²\n* Significant systemic diseases (e.g., severe cardiac, respiratory, renal, or hepatic disease).\n* Fetal or placental anomalies.\n* History of chronic pain syndromes, opioid dependence, or long-term analgesic use.\n* Neurological, psychiatric, or cognitive disorders that may interfere with pain perception or questionnaire completion.\n* Patients who declined participation or did not provide informed consent.",{"count":277,"type":23},"Study Design This retrospective observational study aims to evaluate and compare the effects of two regional anesthesia techniques, Erector Spinae Plane (ESP) block and Retrolaminar Block (RLB), on postoperative recovery quality in women undergoing elective cesarean section (CS). Postoperative pain after CS is common, particularly in the first 24-72 hours, and can affect mobility, breastfeeding, and overall well-being. Effective pain management is therefore critical for both patient comfort and maternal-infant bonding.\n\nParticipants and Methods Medical records of adult women aged 18-45 years, with a singleton pregnancy at ≥37 weeks, who underwent elective CS under spinal anesthesia in our clinic, were retrospectively reviewed. Patients who had received either ESP or RLB immediately after surgery were included. Both blocks had been performed under ultrasound guidance at the T9 level using 20 mL of 0.25% bupivacaine, according to institutional practice. Standard perioperative care and analgesia protocols were applied to all patients.\n\nOutcomes The primary outcome was postoperative recovery quality, assessed 24 hours after surgery using the Turkish version of the Obstetric Quality-of-Recovery Score (ObsQoR-11T), a validated tool addressing physical, emotional, and functional aspects of recovery. Secondary outcomes included postoperative pain intensity (Visual Analog Scale), opioid consumption, adverse events, and patient satisfaction, as documented in patient files.\n\nConclusion This retrospective study will provide evidence on which block technique more effectively improves recovery quality after CS and may help optimize postoperative analgesia strategies in Turkish obstetric populations.",[332],"Postoperative Pain Management",[102,334,335,336],"Retrolaminar Block","ObsQoR-11T","Erector Spinae Plane Block","2025-09-24",{"date":339,"type":37},"2025-09-30",{"date":341,"type":23},"2025-10-01",{"date":343,"type":23},"2025-12-15",{"name":43,"class":44},{"id":346,"slug":347,"hasResults":11,"nctId":348,"briefTitle":349,"officialTitle":350,"acronym":4,"eligibilityCriteria":351,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":352,"targetDuration":354,"studyType":24,"phases":4,"briefSummary":355,"conditions":356,"keywords":358,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":45},"100606597","retrolaminar-block-analgesia-and-patient-comfort-during-prone-eswl-100606597","NCT07177625","Retrolaminar Block Analgesia and Patient Comfort During Prone ESWL","Assessment of Patient Comfort and Analgesic Efficacy of Retrolaminar Block During Extracorporeal Shock Wave Lithotripsy : An Observational Prospective Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* ASA Physical Status I-III\n* Undergoing ESWL in prone position\n* Provided written informed consent\n\nExclusion Criteria:\n\n* ASA Physical Status IV or higher\n* Allergy to local anesthetics or sedatives\n* Coagulopathy or anticoagulant use\n* Local infection at injection site\n* Severe spinal deformity or anatomical abnormality preventing block\n* Cognitive impairment or inability to use VAS\n* Pregnancy\n* Chronic opioid use or chronic pain medication\n* Emergency ESWL\n* Previous open surgery at block site\n* Intraoperative hemodynamic instability or severe complications",{"count":353,"type":23},90,"1 Day","The purpose of this prospective, observational study is to evaluate the effect of retrolaminar block (RLB) on patient comfort and analgesic effectiveness during extracorporeal shock wave lithotripsy (ESWL) procedures. The main questions the study aims to answer are:\n\nDoes retrolaminar block reduce pain intensity during ESWL?\n\nDoes retrolaminar block improve patient comfort during ESWL?\n\nParticipants will undergo the following interventions:\n\nRLB Group: Retrolaminar block performed under ultrasound guidance prior to ESWL.\n\nSedation Group (S): Standard sedoanalgesia administered.\n\nControl Group (C): No additional regional block or sedoanalgesia applied.\n\nParticipants will be monitored for pain levels, procedural duration, hemodynamic parameters, and the need for additional analgesics. The study aims to determine whether retrolaminar block can serve as a safe and effective analgesic method during ESWL procedures.",[357],"Urolithiasis",[359,360,361],"Extracorporeal Shock Wave Lithotripsy","Retrolaminar block","Prone position","2025-09-16",{"date":364,"type":37},"2025-09-17",{"date":366,"type":23},"2025-09-15",{"date":368,"type":23},"2025-11-30",{"name":43,"class":44},{"id":371,"slug":372,"hasResults":11,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":376,"eligibilityCriteria":377,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":378,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":379,"conditions":380,"keywords":382,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":393,"locationsCount":45},"100605900","effect-of-tap-block-on-gi-function-after-sleeve-gastrectomy-using-pro-digi-scale-and-perlas-score-100605900","NCT07168538","Effect of TAP Block on GI Function After Sleeve Gastrectomy Using PRO-diGI Scale and Perlas Score","Effect of Transversus Abdominis Plane (TAP) Block on Postoperative Gastrointestinal Function After Laparoscopic Sleeve Gastrectomy: Evaluation Using the PRO-diGI Scale and Perlas Score (Prospective Clinical Study)","TAP","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* Scheduled for primary laparoscopic sleeve gastrectomy (LSG)\n* Body Mass Index (BMI) ≥ 35 kg\u002Fm²\n* ASA Physical Status II-III\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Previous major abdominal surgery\n* Known allergy to local anesthetics\n* Severe hepatic or renal dysfunction\n* Pregnancy or breastfeeding\n* Conversion to open surgery during the procedure\n* Patients refusing TAP block or general anesthesia",{"count":277,"type":23},"This prospective clinical study aims to evaluate the effect of Transversus Abdominis Plane (TAP) block on postoperative gastrointestinal function in patients undergoing laparoscopic sleeve gastrectomy. Gastrointestinal recovery plays a crucial role in patient outcomes after bariatric surgery, and regional anesthesia techniques such as TAP block have been suggested to reduce postoperative pain and opioid consumption, which may influence gut motility.\n\nIn this study, postoperative gastrointestinal function will be assessed using the validated Patient-Reported Outcome for Dysfunctional Gastrointestinal Motility (PRO-diGI) scale. Additionally, gastric ultrasound will be performed to calculate the Perlas score as an objective marker of gastric emptying and residual volume. These assessments will allow a comprehensive evaluation of both subjective and objective gastrointestinal recovery parameters.\n\nThe study will include adult patients scheduled for elective laparoscopic sleeve gastrectomy at Elazığ Fethi Sekin City Hospital. Participants will receive standard general anesthesia with or without ultrasound-guided TAP block, and their postoperative recovery will be monitored. Primary outcomes include PRO-diGI scores at defined postoperative intervals, while secondary outcomes include Perlas scores obtained via gastric ultrasonography.\n\nThe findings from this research are expected to provide valuable insights into the potential benefits of TAP block on gastrointestinal motility and overall recovery after bariatric surgery.",[31,381],"Postoperative Gastrointestinal Dysfunction",[383,384,385,386],"TAP Block","Gastrointestinal Motility","PRO-diGI Scale","Sleeve Gastrectomy","2025-09-09",{"date":389,"type":37},"2025-09-11",{"date":391,"type":23},"2025-09-01",{"date":368,"type":23},{"name":43,"class":44},{"id":395,"slug":396,"hasResults":11,"nctId":397,"briefTitle":398,"officialTitle":399,"acronym":4,"eligibilityCriteria":400,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":401,"targetDuration":354,"studyType":24,"phases":4,"briefSummary":402,"conditions":403,"keywords":407,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":415,"locationsCount":4},"100598093","measurement-of-intraocular-pressure-in-patients-undergoing-laminectomy-in-the-prone-position-100598093","NCT07067008","Measurement of Intraocular Pressure in Patients Undergoing Laminectomy in the Prone Position","Measurement of Intraocular Pressure (With Non-contact Tonometer) in Patients Undergoing Laminectomy in the Prone Position: A Clinical Study","Inclusion Criteria:\n\n* Patients scheduled for laminectomy surgery under general anesthesia\n\nPatients with ASA physical status I-II-III\n\nPatients who can cooperate postoperatively\n\nPatients without eye diseases or conditions affecting eye physiology (such as glaucoma)\n\nPatients who have not undergone eye surgery\n\nPatients who consent to participate in the study\n\nExclusion Criteria:\n\n* Patients scheduled for laminectomy surgery but not receiving general anesthesia\n\nPatients with ASA physical status IV-V\n\nPatients who do not consent to participate in the study\n\nPatients who cannot cooperate postoperatively\n\nPatients with eye diseases or conditions affecting eye physiology (such as glaucoma)\n\nPatients who have undergone eye surgery\n\nPatients from whom consent cannot be obtained",{"count":277,"type":23},"Laminectomy surgeries, typically performed for lumbar disc herniation and spinal disorders, are often lengthy surgical procedures requiring patients to be in the prone position. While this position provides better visibility of the surgical field, it can lead to physiological changes in intraocular pressure (IOP) in anesthetized patients. An increase in IOP, though rare, has the potential to cause severe ocular complications such as postoperative vision loss (POVL), which is one of the most feared complications after spinal surgery.\n\nOne of the main mechanisms of IOP elevation in the prone position is the impediment of venous return in the head and neck region due to gravity, leading to an increase in episcleral venous pressure. Additionally, direct mechanical pressure on the face and globe can also increase IOP. Anesthesia management can also play a role in IOP dynamics by affecting intrathoracic pressure and venous return. This complex interaction necessitates careful monitoring of eye health in anesthetized patients in the prone position. Non-contact tonometers offer a non-invasive, rapid, and reliable method for IOP measurement. They are particularly advantageous for repeated measurements in anesthetized patients. This clinical study aims to evaluate changes in IOP using a non-contact tonometer in patients undergoing laminectomy in the prone position and to identify anesthesia- and patient-related factors influencing these changes. The data obtained will contribute to the development of anesthesia and positioning strategies aimed at reducing the risk of ocular complications.",[404,405,406],"Laminectomy","Intraocular Pressure","Prone Position",[406,405,404],"2025-07-15",{"date":410,"type":37},"2025-07-18",{"date":412,"type":23},"2025-08-15",{"date":414,"type":23},"2025-10-30",{"name":43,"class":44},""]