[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Elsan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":638},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,48,74,103,125,148,168,194,226,257,291,318,337,363,386,407,432,459,481,507,528,549,571,596,617],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100642675","cost-utility-analysis-of-the-use-of-a-laser-fiber-in-the-management-of-non-abscessed-pilonidal-cyst-100642675",false,"NCT07652099","Cost-utility Analysis of the Use of a Laser Fiber in the Management of Non-abscessed Pilonidal Cyst","ACONIDAL","Inclusion Criteria:\n\n1. Male or female aged 18 years or older and younger than 80 years.\n2. Patient for whom excision of a non-abscessed pilonidal cyst by laser fiber or conventional surgery is indicated.\n3. Patient informed and having provided free, informed, written consent before any study-specific procedure.\n\nExclusion Criteria:\n\n1. Acute abscess.\n2. Contraindication to surgery and\u002For anesthesia.\n3. Need for urgent intervention for non-abscessed pilonidal cyst.\n4. Participation in another ongoing study or exclusion period.\n5. No health insurance coverage\u002Fprotection.\n6. Legal protection measure or deprived of liberty by judicial or administrative decision.\n7. Hospitalized without consent.","ALL","18 Years","79 Years",{"count":21,"type":22},150,"ESTIMATED","INTERVENTIONAL",[25],"NA","This multicenter, prospective, randomized, open-label trial compares laser fiber treatment with conventional surgery in adults with non-abscessed pilonidal cyst. The main objective is to evaluate the incremental cost-utility ratio of laser fiber versus conventional surgery over 12 months from a societal perspective. Secondary objectives include 3-month cost-utility, healing time, closure at 3 months, recurrence at 12 months, postoperative complications, treatment parameters, postoperative pain, and duration of sick leave.",[28],"Non-abscessed Pilonidal Cyst",[30,31,32,33,34],"Pilonidal disease","Pilonidal sinus","Laser fiber","Conventional surgery","Cost-utility","NOT_YET_RECRUITING","2026-06-11",{"date":38,"type":39},"2026-06-16","ACTUAL",{"date":41,"type":22},"2026-06-15",{"date":43,"type":22},"2029-12-15",{"name":45,"class":46},"Elsan","OTHER",2,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},"100555413","phase-3-anesthetic-block-of-the-erector-muscles-of-the-lumbar-spine-to-relieve-acute-lumbar-pain-pilot-study-100555413","NCT06511765","Anesthetic Block of the Erector Muscles of the Lumbar Spine to Relieve Acute Lumbar Pain: Pilot Study","Inclusion Criteria:\n\n1. Patient with lumbago lasting less than 7 days despite analgesic \u002F NSAID treatment.\n2. Patient with NS pain \\> 6\n3. Patient with Oswestry score \\> or equal to 30\n4. Patient informed of the trial and having signed the informed consent form prior to any trial-specific procedure,\n5. Patient willing and able to undergo all planned examinations and procedures in compliance with the clinical trial protocol,\n6. Patient affiliated to a social security or any health insurance.\n\nExclusion Criteria:\n\n1. Presence of \"red flag\" (non-disc lumbago):\n\n   * Motor deficit or signs of horsetail irritation\n   * Inflammatory pain waking up in the 2nd half of the night\n   * Tumoral context\n   * Infectious context or fever\n   * Altered general condition\n   * Traumatic context\n   * Osteoporotic context\n2. Risk of infection\n3. Patient with poor local skin condition\n4. Patient on AVK or anti-Xa anticoagulation, or bleeding disorder (antiaggregants authorized)\n5. Patients with hypersensitivity to Ropivacaine or any of its excipients: Sodium chloride, hydrochloric acid sodium hydroxide\n6. Patient with sciatica\n7. Patient with chronic respiratory insufficiency\n8. Patient with cardiac rhythm disorders\n9. Pregnant or breastfeeding woman or woman refusing effective contraception\n10. Patient deprived of liberty or under legal protection (guardianship or curator)\n11. Patient participating in another clinical research protocol involving a drug or medical device\n12. Patient unable to follow the protocol, as judged by the investigator\n13. Patient refusing to participate in the study",{"count":55,"type":22},40,[57],"PHASE3","This study concerns the treatment of recent lumbago and aims to evaluate the efficacy of an anesthetic block of the erector spinae muscles combining ropivacaine and dexamethasone. This treatment is routinely used in several institutions in France, but has never been the subject of a randomized placebo-controlled study to assess its efficacy at D4 of treatment.\n\nThe BLOCLOMB comparative, randomized, double-blind study aims to validate the efficacy, over the first 4 days, of anesthetic blocks of the erector spinae muscles, during recent lumbago, on the pain of muscular contractures.",[60],"Lumbago",[62,63],"anesthetic blocks","pain","RECRUITING","2026-06-08",{"date":67,"type":39},"2026-06-10",{"date":69,"type":39},"2026-03-24",{"date":71,"type":22},"2026-10-31",{"name":45,"class":46},1,{"id":75,"slug":76,"hasResults":12,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":12,"sex":17,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":73},"100597662","impact-of-a-multidisciplinary-rehabilitation-program-associated-with-the-doado-application-in-lowback-pain-management-100597662","NCT07061405","Impact of a Multidisciplinary Rehabilitation Program Associated With the Doado Application in Lowback Pain Management","Impact of a Multidisciplinary Rehabilitation Program and Doado Application on the Functional Disability of Patients With Low Back Pain at Risk of Chronicization, Compared With a Monodisciplinary Rehabilitation Program and Doado Application.","REEDUCALGIE","Inclusion Criteria:\n\nPatient:\n\n1. Suffering from acute common low back pain for less than 3 months at the time of the initial consultation\n2. With a prescription for physiotherapy\n3. Available for both programs\n4. Aged between 20 and 55\n5. Equipped with a smartphone compatible with the Doado application\n6. Having been informed and having signed the free and informed consent form prior to any specific study procedure\n7. Affiliated to a health insurance scheme\n\nExclusion Criteria:\n\nPatient:\n\n1. suffering from a first episode of acute common low back pain for less than one month at the time of the initial consultation\n2. With a history of spinal surgery:\n\n   1. For lumbar arthrodesis in the 12 months prior to inclusion\n   2. For lumbar arthroplasty in the 6 months prior to inclusion\n   3. For lumbar recalibration or lumbar disc herniation within 3 months of inclusion.\n3. With suspected specific low-back pain\n4. Suffering from radiculalgia of the lower limbs\n5. Suffering from sensory-motor disorders of the lower limbs\n6. Suffering from continuous low-back pain for at least 3 months\n7. Have severely impaired physical and\u002For psychological health, which in the investigator's opinion may affect the participant's compliance with the study.\n8. Participating in other interventional research\n9. In a period of exclusion from other research still in progress at the time of inclusion.\n10. Protected: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision.\n11. Pregnant, breast-feeding or parturient.","20 Years","55 Years",{"count":85,"type":22},84,[25],"This study is aimed at patients consulting a physiotherapist for acute low-back pain at risk of becoming chronic.\n\nThe goal of this study is to compare two types of rehabilitation programs for these patients, on their functional disability at 3 months:\n\n* A multidisciplinary program lasting two weeks, including physiotherapists, rheumatologists, physical medicine and rehabilitation specialists, occupational physicians, psychologists, etc.\n* A monodisciplinary physiotherapy rehabilitation program consisting of active treatment with a physiotherapist, with 2 to 3 sessions per week for 4 to 5 weeks, based on muscle-strengthening exercises for the trunk and lower limbs and stretching exercises for the back and lower limbs.\n\nPatients will be evaluated before treatment (baseline), and at 1, 3, 6 and 12 months to evaluate the following secondary outcomes: pain, absence of chronicity, evolution of functional disability, muscle endurance, flexibility, level of fear, apprehension and avoidance associated with low back pain over the time, return to work and to physical activities, painful relapses and analgesic treatment consumption.",[89],"Lumbar Pain Syndrome",[91,92,93,94],"rehabilitation","functional disability","multidisciplinary program","physiotherapy","2026-04-20",{"date":97,"type":39},"2026-04-23",{"date":99,"type":22},"2026-05",{"date":101,"type":22},"2028-11",{"name":45,"class":46},{"id":104,"slug":105,"hasResults":12,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":12,"sex":17,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":113,"phases":4,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":73},"100580817","descriptive-study-of-the-initial-management-of-young-children-with-moderate-acute-bronchiotitis-with-home-hospitalisation-100580817","NCT06842238","Descriptive Study of the Initial Management of Young Children With Moderate Acute BRONCHiotitis With Home Hospitalisation","BRONCHAD","Inclusion Criteria:\n\n* Any infant with moderate bronchiolitis according to the HAS definition (except for the SpO2 criterion which must be greater than or equal to 92% to avoid the patient being on oxygen therapy upon admission)\n* Age \\> 2 months and ≤ 2 years\n* Respiratory syndrome for 48 hours\n* Infant with a first episode of bronchiolitis\n* Referral of the general practitioner\u002Ftreating pediatrician for home hospitalisation care\n* Parents' agreement for the choice of home hospitalisation care\n* Non-opposition or free and informed consent of both parents to the use of the child's health data\n\nExclusion Criteria:\n\n* Patient not receiving health protection\n* Comorbidities: congenital heart disease with shunt, chronic pulmonary pathology including bronchopulmonary dysplasia, neuromuscular pathology, immune deficiency, multiple disabilities Congenital heart disease\n* Refusal of one or both parents for the proposed pathway\n* Doubts about the parents' understanding of the nature of home hospitalisation care\n* Severe bronchiolitis or with saturation \\\u003C 92%\n\n  * Moderate bronchiolitis but evolving for less than 48 hours\n  * Cases of psychiatric pathologies or depressive syndrome diagnosed in the parents.","2 Months","2 Years",{"count":55,"type":22},"OBSERVATIONAL","The occurrence of a first episode of acute bronchiolitis in an infant or young child (3 months-2 years) always represents a medical event that generates stress for parents and in some cases for the primary care physician when it is necessary to decide on the child's orientation for treatment. Each year, during the winter season, this pathology affects 30% of infants under two years old (480,000 annual cases in France), generates approximately 30,000 hospitalizations and exposes to an overall mortality risk of 0.08%.\n\nAccording to the recommendations of the HAS (2019), moderate bronchiolitis does not require systematic hospitalization and can be managed in a Home Hospitalization (HAD) context.\n\nWhen the child's examination data do not find signs of severity, the SpO2 measurement is greater than 92% and the family context allows for return home, HAD management is a reasonable option and represents an alternative to the classic scheme of assessing the level of severity by the emergency department and subsequent hospitalization if necessary. HAD management is carried out within the framework of a very structured \"patient pathway\", codified and supervised by the pediatric teams and doctors of this department. This patient pathway concerns children with a moderate form of bronchiolitis without oxygen requirements at the time of inclusion. This must be 48 hours from the onset of the child's respiratory clinical signs.\n\nThe main objective of this study is to describe the need for oxygen therapy for a young child with moderate acute bronchiolitis syndrome during home hospitalization (HAD) care.",[116,117],"Bronchiolitis","Bronchiolitis Acute",{"date":119,"type":39},"2026-04-21",{"date":121,"type":39},"2025-06-14",{"date":123,"type":22},"2027-03-14",{"name":45,"class":46},{"id":126,"slug":127,"hasResults":12,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":23,"phases":135,"briefSummary":136,"conditions":137,"keywords":139,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":142,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":73},"100544045","a-study-to-assess-the-ability-of-stereotactic-radiotherapy-to-restore-the-efficacy-of-immunotherapy-in-patients-with-metastatic-cancer-100544045","NCT06363773","A Study to Assess the Ability of Stereotactic Radiotherapy to Restore the Efficacy of Immunotherapy in Patients With Metastatic Cancer.","Pilot, Exploratory, Prospective Study to Assess the Ability of Stereotactic Radiotherapy to Restore the Efficacy of Anti-PD1 Immunotherapy in Initially Long-responder Patients With Metastatic Progression.","RESTO-IMMUNO","Inclusion Criteria:\n\n1. Male or female, 18 years of age or older,\n2. Patient with a metastatic solid tumor,\n3. Patient with at least one target lesion (for radiotherapy) together with other secondary lesions that must be measurable,\n4. Measurable disease according to RECIST 1.1 and iRECIST criteria,\n5. Patient undergoing anti-PD1 immunotherapy as part of standard of care treatment,\n6. Disease progression with immunotherapy (progression assessed by iRECIST criteria) but having received at least 6 months of immunotherapy,\n7. Performance Status (PS) of 0 or 1,\n8. Patient eligible for stereotactic radiotherapy,\n9. Patient affiliated to or benefiting from a social security scheme,\n10. Patient having been informed of the investigation and having signed the informed consent form prior to any study-specific procedures,\n11. Patient willing and able to undergo all examinations and procedures in accordance with the clinical investigation plan.\n\nExclusion Criteria:\n\n1. Patient having received previous radiotherapy since the start of immunotherapy,\n2. Patient for whom first disease progression (pre-inclusion stage) is not confirmed secondarily (inclusion stage),\n3. Patient with an active implantable medical device (e.g. pacemaker) or an active medical device worn on the body that could interact adversely with stereotactic radiotherapy treatment,\n4. Patient with hematological cancer,\n5. Symptomatic patient requiring a rapid change of systemic line according to the investigator's judgment,\n6. Concurrent participation in another clinical trial, or patient having received an investigational product within 30 days prior to inclusion,\n7. Pregnant or breast-feeding women,\n8. Patient under legal protection.",{"count":134,"type":22},35,[25],"This study aims at enrolling patients with solid tumors at metastatic stage, considered long responders to immunotherapy (\\> 6 months) and displaying disease progression.\n\nIn this study, the investigator wants to evaluate specific modalities of stereotactic radiotherapy, with 3 sessions, each of 8 Gy, lasting 20 minutes and spaced 72 hours apart (Day 1, Day 4, Day 7). The radiotherapy device itself is not the subject of this study and will be used in accordance with its CE mark and indications.\n\nThe objective of the study is to assess the ability of stereotactic radiotherapy to restore the lost efficacy of immunotherapy. In particular, the abscopal effect will be assessed, i.e. the action of irradiating a particular target lesion and observing an effect on other distant metastases.",[138],"Metastatic Cancer",[140,141],"stereotactic radiotherapy","immunotherapy",{"date":97,"type":39},{"date":144,"type":39},"2026-01-27",{"date":146,"type":22},"2028-01",{"name":45,"class":46},{"id":149,"slug":150,"hasResults":12,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":156,"targetDuration":4,"studyType":23,"phases":158,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":162,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":47},"100444464","efficacy-of-aponeurectomy-on-the-2-year-recurrence-rate-of-dupuytrens-disease-100444464","NCT05067764","Efficacy of Aponeurectomy on the 2-year Recurrence Rate of Dupuytren's Disease","Multicenter, Randomized, Open-label Study Evaluating the Efficacy of Aponeurectomy Associated With Adipose Tissue Grafting Compared to Aponeurectomy Alone, on the 2-year Recurrence Rate of Dupuytren's Disease (REMEDY).","REMEDY","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Carrier of Tubiana stage II-IV Dupuytren's disease on at least one or more rays, not previously operated\n* Indication of a surgery by aponeurectomy\n* Skin pinch of the posterior aspect of the arm of more than 1cm\n* Affiliation to a social security system\n* Patient informed of the study and having given informed consent\n\nExclusion Criteria:\n\n* Previous surgery of any kind for Dupuytren's disease\n* Involvement on the thumb only\n* Need for a total skin graft or a pedicle flap on all the rays to be treated\n* Active autoimmune disease\n* Previous treatment with collagenase\n* Pregnant and breastfeeding women\n* Patient under legal protection\n* Contraindications to MRI (criteria applicable only for patients from the coordinating center, not applicable for other centers)",{"count":157,"type":22},172,[25],"Dupuytren's disease is a frequent hereditary disease in Northern Europe. It is a degenerative disease affecting the palmar aponeurosis of the hand. It develops a progressive contractile fibrosis which cuts the hypodermic fatty tissue, adheres to the skin and the phalanges, gradually bending the affected rays, resulting in significant functional impotence.\n\nVarious medical and surgical treatments are available.",[161],"Dupuytren's Disease",{"date":97,"type":39},{"date":164,"type":39},"2022-09-29",{"date":166,"type":22},"2030-03-29",{"name":45,"class":46},{"id":169,"slug":170,"hasResults":12,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":12,"sex":176,"minAge":18,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":113,"phases":4,"briefSummary":179,"conditions":180,"keywords":182,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":187,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":193},"100411481","comparison-of-radical-prostatectomy-performed-by-robot-assisted-laparoscopy-or-conventional-laparoscopy-or-by-laparotomy-100411481","NCT04638088","Comparison of Radical Prostatectomy Performed by Robot-assisted Laparoscopy or Conventional Laparoscopy or by Laparotomy","Comparison of Radical Prostatectomy for the Treatment of Prostate Cancer, Performed by Robot-assisted or Standard Laparoscopy or by Laparotomy : a Multicentric Prospective Study.","EMUPRO","Inclusion Criteria:\n\n* patient hospitalized for a planned radical prostatectomy\n\nExclusion Criteria:\n\n* Consent refusal from the patient\n* Patients protected by law (Art.L 1121-5, 1121-6, 1121-8 du Code de la santé publique)\n* Absence of a French Health Care Insurance coverage","MALE",{"count":178,"type":22},2000,"Minimally invasive surgery has developed widely since the 1980s and has revolutionized the practices of surgeons. In urology, the development of laparoscopy and then robot-assisted surgery has considerably improved the management of pathologies. In France, as in all the countries concerned, the spread of robotic surgery has taken place without prior studies validating this new technology, nor organizational rules in terms of quality and access to care. The report of the Haute Autorité de Santé dated November 2016 underlines the weakness of the methodological quality of studies and meta-analyzes evaluating robot-assisted total prostatectomy compared to other surgical techniques by laparotomy or conventional laparoscopy. It therefore appears important to evaluate in a large study the interest of this technique in order to help the authorities to decide on the real benefit of this technology and to provide reliable answers to the patients.",[181],"Prostate Cancer",[183,184,185,186],"robot-assisted laparoscopy","laparotomy","conventional laparoscopy","prostatectomy",{"date":119,"type":39},{"date":189,"type":39},"2021-03-08",{"date":191,"type":22},"2030-04-30",{"name":45,"class":46},30,{"id":195,"slug":196,"hasResults":12,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":23,"phases":204,"briefSummary":205,"conditions":206,"keywords":209,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":73},"100628670","comparing-dual-mobility-cups-versus-unipolar-cups-for-unselected-primary-total-hip-arthroplasty-by-direct-anterior-approach-100628670","NCT07464665","Comparing Dual-mobility Cups Versus Unipolar Cups for Unselected Primary Total Hip Arthroplasty by Direct Anterior Approach","Monocentric Randomised Controlled Trial Comparing Dual-mobility Cups Versus Unipolar Cups for Unselected Primary Total Hip Arthroplasty by Direct Anterior Approach","DUALSIM-THA","Inclusion Criteria:\n\n* men and women aged ≥18 years old\n* set to undergo elective primary THA via direct anterior approach (DAA)\n* affiliated with a social security scheme\n* able to answer questionnaires and to communicate freely in French\n* who have been informed and have provided free, informed, and written consent (no later than the day of inclusion and before any examination required by the study)\n\nExclusion Criteria:\n\n* with prior ipsilateral hip surgery\n* with prior contralateral hip surgery\n* that require acetabular cup diameters ≤50mm (because DM cups are not available from the same manufacturer for diameters ≤50mm, and UP cups require head diameters of 36mm and thus minimum cup diameters of 52mm)\n* undergoing emergency or trauma surgery (e.g. femoral neck fractures)\n* with any concomitant disease or disorder which, in the opinion of the surgeon, may put the patient at risk, notably of hip instability or dislocation (hip dysplasia, neuromuscular deficit, fracture sequelae…) or may influence the result of the study\n* that are pregnant or breastfeeding\n* under legal protection (guardianship or curatorship or deprived of liberty).",{"count":203,"type":22},300,[25],"THA comprises the replacement of the damaged bone and cartilage with prosthetic components. The proximal end of the femur is replaced with a stem and ball\u002Fhead, while the acetabulum is most commonly replaced with a unipolar cup (UP) that consists of a liner inside of a metal shell. UP cups are associated with risks of dislocations, especially in elderly and female patients, as well as in patients with lumbar stiffness or operated for femoral neck fractures. In fact, one of the most common reasons for early revision of UP cups are dislocations.\n\nDual-mobility (DM) cups were introduced in the 1970s by the French surgeon Gilles Bousquet, as an alternative to UP cups. They are made up of two articulations, a femoral head moving inside a mobile polyethylene liner, which in turn moves inside a metal shell. This design allows for a greater jump distance and range of motion (ROM) compared to UP cups, thus resulting in reduced rates of dislocation.\n\nA recent systematic review that evaluated 5 case-control studies (549 DM cups vs 649 UP cups) and 3 registry studies (5935 DM cups vs 217362 UP) found that in case-control studies, the dislocation rates were 0.2% for DM cups versus 7.1% for UP cups (p=0.009). Furthermore, in registry studies the revision rates due to dislocation were 0.2% for DM cups versus 0.5% for UP cups (p=0.050).\n\nNonetheless, there have been some concerns associated with the use of DM cups, including intra-prosthetic dislocations (IPD), polyethylene wear, and iliopsoas impingement. Since the early 2000s, new improvements in the design of DM cups have nearly eliminated the risk of IPD, and the use of ultra-high molecular weight polyethylene (UHMWPE) has greatly reduced wear rates, even in young and active patients. Lastly, although some studies have reported iliopsoas impingement with DM cups, the impingement is usually against the optional fixations, and not against the mobile polyethylene insert.\n\nThe hypothesis of the present interventional randomised controlled trial (RCT) is that THA using DM cups will not provide inferior outcomes compared to THA using UP cups, in terms of hip awareness measured using the forgotten joint score (FJS).",[207,208],"Primary Total Hip Arthroplasty","Primary Total Hip Replacement",[210,211,212,213,214,215,216,217],"total hip arthroplasty","THA","total hip replacement","THR","randomised controlled trial","RCT","unipolar cup","dual-mobility cup","2026-03-06",{"date":220,"type":39},"2026-03-11",{"date":222,"type":22},"2026-06-01",{"date":224,"type":22},"2030-06-01",{"name":45,"class":46},{"id":227,"slug":228,"hasResults":12,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":232,"eligibilityCriteria":233,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":234,"targetDuration":4,"studyType":23,"phases":236,"briefSummary":237,"conditions":238,"keywords":242,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":73},"100583759","comparing-articular-noise-and-its-perception-between-two-different-types-of-total-knee-arthroplasty-100583759","NCT06880497","Comparing Articular Noise and Its Perception Between Two Different Types of Total Knee Arthroplasty","Monocentric, Randomized Study, Comparing Articular Noise and Its Perception Between Two Different Types of Total Knee Arthroplasty","NATKA","Inclusion Criteria:\n\n* Adult patients receiving a primary TKA\n* Signed informed consent\n* Patients affiliated to a social security scheme\n* Patients willing and able to comply with study protocol requirements based on the investigator's judgment.\n\nExclusion Criteria:\n\n* History of knee surgery on the concerned\u002Fstudied knee (except arthroscopic surgery)\n* Patients presenting coronal deformities \\> 20°, varus laxity \\> 10° and\u002For valgus laxity \\> 15°\n* Patients receiving revision TKA\n* Pregnancy or breast-feeding\n* Patients with protected status under articles L1121-6, LL121-8 and L1122-2 of the French Public Health Code\n* Unable to comply with study procedures, based on the investigator's judgment.",{"count":235,"type":22},170,[25],"Some patients complain of articular noise (such as clicking, snapping, cracking or popping) after a total knee replacement. Controversy remains about whether there is a correlation between articular noise and worse outcomes following a knee replacement. A study by Nam et al. on 1540 patients revealed an association between noise and residual symptoms 30 days after they received a total knee replacement. Conversely, a study by Kuriyama et al. on 60 patients revealed no correlation between noise and patient satisfaction after 1 year of receiving a total knee replacement. The incidence of noise following a knee replacement has rarely been studied as a primary outcome. Like pain, it could be considered an important patient-reported outcome to assess patient satisfaction. The study aims to compare the prevalence of patient-perceived noise of an ultra-congruent total knee prosthesis (Score 2, Amplitude) versus a posterior-stabilized total knee prosthesis (Anatomic, Amplitude).",[239,240,241],"Knee Osteoarthristis","Knee Replacement Arthroplasty","Knee Replacement, Total",[243,244,245,246,247,248],"Noise","Articular noise","Total Knee Arthroplasty","TKA","Total Knee Replacement","TKR","2026-03-02",{"date":251,"type":39},"2026-03-04",{"date":253,"type":39},"2025-12-24",{"date":255,"type":22},"2028-12",{"name":45,"class":46},{"id":258,"slug":259,"hasResults":12,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":265,"sex":17,"minAge":266,"maxAge":267,"enrollmentInfo":268,"targetDuration":4,"studyType":23,"phases":270,"briefSummary":271,"conditions":272,"keywords":277,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":47},"100613012","comparison-of-two-early-treatments-for-premature-babies-and-their-effects-over-time-100613012","NCT07261046","Comparison of Two Early Treatments for Premature Babies and Their Effects Over Time","Comparison of the Impact of Two Early Interventions on the Development of Premature Infants: a Clinical Study of Short- and Long-term Effects","PREMOTSENS","Inclusion Criteria:\n\n1. For premature infants: birth between 30 and 34 weeks of gestation plus 6 days, and weighing more than 1800 g at the start of the trial.\n2. For full-term infants: pregnancy and birth without complications at or after 37 weeks of gestation, with an Apgar score ≥7 at 10 minutes after birth.\n3. For parents or legal guardians:\n\n   * Parents over the age of 18\n   * Parent agreeing to be filmed with their infant (parent who will be responsible for the treatment)\n   * Parents capable of understanding the information document\n   * Parent affiliated with or beneficiary of the French social security system\n   * Parents who have been informed and have freely given their informed written consent no later than the day of inclusion.\n\nExclusion Criteria:\n\n1. For premature infants:\n\n   * Birth before 30 weeks of gestation\n   * Weight less than 1800 g at the start of the trial\n   * Morbidities related to prematurity (necrotizing enterocolitis, cerebral parenchymal damage, stage III and IV intraventricular hemorrhages)\n   * Presence of a congenital malformation or chromosomal abnormality\n   * Known sensory, motor, or central nervous system impairment\n   * Patient receiving non-invasive ventilation at 34 weeks gestational age (CPAP and high-flow nasal cannula)\n2. For full-term infants:\n\n   * Birth before 37 weeks gestation\n   * Birth with complications\n3. For the parent providing the treatment and the infant:\n\n   * Presence of a known sensory, motor, or central nervous system impairment\n   * Presence of a congenital condition\n   * Presence of psychological distress in the parent\n4. For both parents:\n\n   * Under guardianship, conservatorship, or legal protection\n   * Situation of extreme psychosocial instability and\u002For mention of domestic and\u002For intra-family violence\n   * Illicit drug or alcohol use by the mother during the perinatal period\n   * Participant is in another study with an ongoing exclusion period during inclusion\n   * Involuntary hospitalization",true,"0 Weeks","4 Weeks",{"count":269,"type":22},90,[25],"According to the latest World Health Organization report, prematurity is a major health issue, recognized as a significant vulnerability factor contributing to the emergence of neurodevelopmental disorders. Of the various approaches adopted to limit its consequences, the control of the sensory environment and sensory-focused care are relatively recent. Although a number of sensory care approaches exist, few of them address the different sensory modalities jointly and have been scientifically validated. This research project aims to conduct a study in France on the effectiveness of multisensory ATVV (Auditory, Tactile, Visual, and Vestibular stimulation) treatment using a combination of short- and long-term clinical assessments. The research hypothesis is that ATVV care provided before term age will have a greater impact than \"Parental Singing\" care on the motor parameters and alertness level of premature infants. Given the importance of motor activity on child development, it is hypothesized here that from term age onwards, the development of children in the ATVV group will be less atypical, or even equivalent to that of the group of full-term infants for most of the parameters evaluated. Furthermore, this normalization of the developmental trajectory will be less pronounced for the \"Parental Singing\" group. However, the sessions for both treatments (Parental Singing and ATVV) should improve early interactions, sucking, and physiological parameters.",[273,274,275,276],"Premature - Weight 1000g-2499g or Gestation of 28-37weeks","Premature Baby 26 to 32 Weeks","Premature Baby 33 to 36 Weeks","Premature Between 32 and 36 Weeks of Amenorrhoea",[278,279,280,281,282],"ATVV","multisensory care","preterm outcome","sensory integration","NICU","2025-12-02",{"date":285,"type":39},"2025-12-03",{"date":287,"type":22},"2025-12",{"date":289,"type":22},"2027-09",{"name":45,"class":46},{"id":292,"slug":293,"hasResults":12,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":297,"eligibilityCriteria":298,"healthyVolunteers":12,"sex":299,"minAge":18,"maxAge":4,"enrollmentInfo":300,"targetDuration":4,"studyType":23,"phases":302,"briefSummary":303,"conditions":304,"keywords":306,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":73},"100613513","evaluation-of-the-added-value-of-logotherapy-in-the-psychological-support-of-patients-with-primary-breast-cancer-100613513","NCT07267572","Evaluation of the Added Value of Logotherapy in the Psychological Support of Patients With Primary Breast Cancer","Randomized, Comparative Study to Evaluate the Added Value of Logotherapy in the Psychological Support of Patients With Primary Breast Cancer","AELO","Inclusion Criteria:\n\nFemale patient:\n\n* With a first diagnosis of histologically proven breast cancer,\n* Affiliated to a health insurance scheme,\n* Having been informed and having given her free and informed consent prior to any procedure specific to the study.\n\nExclusion Criteria:\n\nFemale patient:\n\n* Unable to understand the study and to answer to the questionnaires\n* With an indication for neoadjuvant chemotherapy\n* Undergoing antidepressant treatment at the time of diagnosis\n* Presenting with alcohol or drug addiction at the time of diagnosis\n* Protected: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision.\n* Pregnant, breastfeeding, or in labor.","FEMALE",{"count":301,"type":22},66,[25],"The diagnosis of breast cancer in a woman can cause major psychological trauma with many destructive effects in all areas of life.\n\nDealing with this profound distress is often difficult, sometimes poorly defined between different professionals (psychiatrists, psychologists, psychotherapists, proponents of alternative therapies), leading to highly variable and difficult-to-measure results.\n\nSince the first French cancer plan (2003\u002F2007), facilities offering cancer care have been legally required to have a notification and support system in place. This consists of offering patients a range of supportive care throughout their cancer treatment (psychotherapy, physical activities, dietetics, pain management, etc.).\n\nIn recent years, logotherapy has been offered as part of psychological care. Logotherapy is a form of psychotherapy based on meaning, which has been offered for many years and aims to help patients create or discover meaning in their lives. Meaning serves as motivation to continue living despite illness by placing this ordeal in the context of existence.\n\nSuffering can thus be transformed into opportunity. The use of logotherapy gives the suffering person the ability to take an active part in their treatment and helps them to mobilize their personal resources to keep the disease at bay, stabilize it, or cure it.\n\nSeveral studies conducted on women with breast or gynecological cancer have shown that logotherapy can reduce the symptoms of traumatic stress and increase their ability to find meaning in their lives. However, these studies have certain limitations because they are not randomized.\n\nIn order to evaluate the short- and medium-term benefits of logotherapy in patients diagnosed with primary breast cancer, we propose a prospective, comparative, randomized study.",[305],"Breast Cancer",[307,308,309],"logotherapy","support","breast cancer","2025-11-25",{"date":312,"type":39},"2025-12-05",{"date":314,"type":22},"2026-02-01",{"date":316,"type":22},"2028-11-01",{"name":45,"class":46},{"id":319,"slug":320,"hasResults":12,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":325,"targetDuration":4,"studyType":23,"phases":326,"briefSummary":327,"conditions":328,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":73},"100612018","pilot-study-aimed-at-describing-in-myography-the-collapse-of-the-muscular-response-visualized-in-the-scratch-collapse-test-in-carpal-tunnel-syndrome-100612018","NCT07248124","Pilot Study, Aimed at Describing in Myography, the Collapse of the Muscular Response Visualized in the Scratch Collapse Test, in Carpal Tunnel Syndrome.","Pilot Study, Aimed at Describing in Myography, the Collapse of the Muscular Response Visualized in the Scratch Collapse Test, in Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Patient over 18 years old\n* Patient with clinical unilateral carpal tunnel syndrome diagnosed by history, clinical examination and electromyography,\n* Patient who has been informed and has given their free, informed, and written consent,\n* Patient affiliated with or beneficiary of a social security scheme.\n\nExclusion Criteria:\n\n* Other associated canal syndrome on either side (ulnar, defilement, lacertus),\n\n  * Rotator cuff pathology, insufficiency or rupture of the infraspinatus,\n  * Associated cervical pathology,\n  * Neuropathy, central or peripheral neurological disease,\n  * Diabetic patient,\n  * Patient with cognitive impairments that prevent the understanding of the study information,\n  * Refusal to participate in the study,\n  * Pregnant, parturient, or breastfeeding woman,\n  * Patient under legal protection,\n  * Patient not receiving health protection,\n  * Protected patient: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision",{"count":7,"type":22},[25],"The Scratch Collapse Test (SCT) is a neurocutaneous reflex used to detect peripheral nerve compression in nerve tunnel syndromes. It first involves applying a sensory stimulus to the skin over the suspected nerve compression point, then bilaterally testing the strength of a specific muscle in the patient. Compression is then manifested by a transient loss of strength in the muscle on the affected side, while it is preserved on the healthy side. This loss of strength is transient and disappears after a few seconds. This test can be performed during a patient's clinical examination, with the physician assessing strength or, conversely, muscle collapse. However, while several articles have described the relevance of this test, as well as its sensitivity and specificity, no study has specifically investigated and measured this observed loss of eccentric muscle tone and its unilateral and transient nature, even though the phenomenon of CSP (cutaneous silent period) has been described.\n\nWe therefore propose to analyze the myographic tracing obtained in patients diagnosed with unilateral carpal tunnel syndrome. A transient loss of muscle tone is expected by selective needle myography on the pathological side after cutaneous sensory stimulation of the wrist, while cutaneous sensory stimulation on the healthy side does not alter the tracings obtained by myography.",[329],"Carpal Tunnel Syndrome (CTS)","2025-11-21",{"date":310,"type":39},{"date":333,"type":39},"2025-11-04",{"date":335,"type":22},"2026-05-05",{"name":45,"class":46},{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":12,"sex":17,"minAge":345,"maxAge":346,"enrollmentInfo":347,"targetDuration":4,"studyType":113,"phases":4,"briefSummary":349,"conditions":350,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":73},"100612380","identification-of-asymptomatic-patients-at-very-high-cardiovascular-risk-contribution-of-a-strategy-based-on-carotid-and-coronary-explorations-compared-to-simple-risk-calculation-using-the-european-score-2-algorithm-idea-cvr-100612380","NCT07252830","Identification of Asymptomatic Patients at Very High Cardiovascular Risk: Contribution of a Strategy Based on Carotid and Coronary Explorations, Compared to Simple Risk Calculation Using the European \"SCORE 2\" Algorithm. (IDEA-CVR)","Identification of Asymptomatic Patients at Very High Cardiovascular Risk: Contribution of a Strategy Based on Carotid and Coronary Explorations, Compared to Simple Risk Calculation Using the European \"SCORE 2\" Algorithm.","IDEA-CVR","Inclusion Criteria:\n\n* Age \\> 40 years and \\\u003C 80 years referred to general cardiology consultation\n* LDL-C level \\> 1.6 g\u002FL, or LDL-C level \\> 1.3 g\u002FL with at least one associated major cardiovascular (CV) risk factor (RCF) (smoking, hypertension, diabetes).\n* Coronary artery reserve assessment and EDTSA performed in a day hospital\n\nExclusion Criteria:\n\n* Known or suspected carotid atherosclerotic disease\n* Significant ischemic heart disease known or suspected at the time of the initial consultation\n* Protected adult patient (patient under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision)\n* Opposition expressed by the patient to the use of their health data.\n* Patient may have limited understanding of the information sheet","40 Years","80 Years",{"count":348,"type":22},1000,"To prevent myocardial infarction ( MI), coronary atheroma development by LDL-cholesterol deposition in the arterial wall is the basis. Since atheromatous plaques develop slowly before becoming symptomatic, their early detection in asymptomatic patients and the implementation of an effective strategy to prevent their progression constitute the most promising primary prevention strategy. In younger subjects, the main modifiable pro-atheromatous factors are smoking and an excessively high LDL-C level, partly genetically predetermined, but also favored by a diet too rich in saturated fats and a lack of physical activity. In the French national MI registry, the average age of patients is 62 years (Arch Cardiovasc Dis 2021 Oct;114(10):647-655). Half of MIs therefore occur at working age due to rupture of atheromatous plaques, which had developed during the months\u002Fyears preceding the acute event.\n\nAccording to the latest recommendations of the European Society of Cardiology (ESC) on CV prevention published in August 2021, the visualization of coronary or carotid atheromatous plaques justifies considering the patient as having atherosclerotic cardiovascular disease (ASCVD), and automatically places them in the \"very high CV risk\" category, with an LDL-cholesterol target of \\\u003C0.55 g\u002FL. However, these recommendations do not clearly define the criteria justifying the use of imaging in asymptomatic patients.\n\nIn current practice, CV risk stratification for asymptomatic patients with no prior CV disease is currently based on risk calculation using the European \"SCORE 2\" algorithm, available online. It allows the calculation of the absolute risk in % of occurrence of a fatal or non-fatal CV event (myocardial infarction, stroke) over 10 years.\n\nThe main objective of this study is to describe patients reclassified as \"very high CV risk\" following the detection of atheroma plaques formed in relation to their risk level estimated by SCORE2.",[351,352,353,354],"Myocardial Infarction","Atheroma","Cholesterol","Cardiovascular (CV) Risk","2025-11-19",{"date":357,"type":39},"2025-11-28",{"date":359,"type":39},"2021-09-12",{"date":361,"type":22},"2026-01-20",{"name":45,"class":46},{"id":364,"slug":365,"hasResults":12,"nctId":366,"briefTitle":367,"officialTitle":367,"acronym":368,"eligibilityCriteria":369,"healthyVolunteers":12,"sex":176,"minAge":18,"maxAge":4,"enrollmentInfo":370,"targetDuration":4,"studyType":23,"phases":372,"briefSummary":373,"conditions":374,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":384,"locationsCount":385},"100579296","prospective-comparative-study-evaluating-the-early-complications-of-robot-assisted-radical-prostatectomy-performed-as-an-outpatient-versus-an-inpatient-procedure-100579296","NCT06822452","Prospective Comparative Study Evaluating the Early Complications of Robot-assisted Radical Prostatectomy Performed as an Outpatient Versus an Inpatient Procedure.","PROSTAMBU","Inclusion Criteria:\n\n* Male, aged 18 and over\n* Patient with prostate cancer for which the multidisciplinary meeting has proposed radical prostatectomy as a therapeutic option (with or without lymphadenectomy)\n* Patient eligible for outpatient treatment :\n\n  1. The patient undertakes to comply with all medical instructions given during surgical consultations and the anaesthetic consultation.\n  2. The patient has access to personal transport allowing, if necessary, return to the facility or another approved facility (transport time and distance from the facility are not exclusion factors)\n  3. The patient has access to telephone communication facilities.\n  4. The patient undertakes not to drive a vehicle and to be accompanied on his return home and for the next 24 hours by a responsible person who will be familiar with the monitoring instructions.\n  5. The patient plans to remain in hospital overnight if this is deemed necessary by the department's doctors (operator and anaesthetist). The patient accepts this mode of care and its constraints.\n* Participant affiliated to or benefiting from a social security scheme\n* The participant has been informed and has given his\u002Fher free, informed and written consent (at the latest on the day of inclusion and before any examination required by the research).\n\nExclusion Criteria:\n\n* Patient already treated for prostatic carcinoma with brachytherapy, radiotherapy or focal therapy\n* Patient participating in ongoing research or in a period of exclusion at the time of inclusion\n* Refusal or inability to comply with the study protocol for any reason whatsoever\n* Protected participant: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision.",{"count":371,"type":22},510,[25],"The goal of this clinical trial is to demonstrate that outpatient management for robotic-assisted radical prostatectomy is not inferior to inpatient management in terms of the occurrence of early post-operative complications.\n\nResearchers will compare outpatient robot-assisted radical prostatectomy to inpatient procedure.\n\nParticipants will:\n\n* Visit the clinic after the operation once at 45 days, 6 months and once a year for up to 5 years for check-ups and tests.\n* Answer survey questions about urinary and erectil functions, stress and anxiety, satisfaction, quality of life for 6 months\n* Keep a diary to record procedures and treatments related to the care provided",[375,376,377],"Prostate Cancer Surgery","Ambulatory Care","Outpatient Surgery","2025-07-07",{"date":380,"type":39},"2025-07-08",{"date":382,"type":39},"2024-12-30",{"date":191,"type":22},{"name":45,"class":46},12,{"id":387,"slug":388,"hasResults":12,"nctId":389,"briefTitle":390,"officialTitle":390,"acronym":391,"eligibilityCriteria":392,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":393,"targetDuration":4,"studyType":23,"phases":394,"briefSummary":395,"conditions":396,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":406,"locationsCount":73},"100580322","comparative-3-year-study-of-nissen-sleeve-vs-sleeve-plus-cruroplasty-in-obese-patients-with-hiatal-hernia-100580322","NCT06835790","Comparative 3-year Study of Nissen-sleeve vs. Sleeve Plus Cruroplasty in Obese Patients With Hiatal Hernia","HH-N Sleeve","Inclusion Criteria:\n\n* Adult patient,\n* Patient with severe obesity (BMI \\>35) with comorbidity or morbidity (BMI \\>40),\n* Patient awaiting a sleeve gastrectomy,\n* Patient with a hiatal hernia \\\u003Cor= 4 cm,\n* Patient having undergone a gastroscopy,\n* Patient having undergone an esophagogastroduodenal transit (OGDT),\n* Patient having been informed and having given their free, informed and written consent,\n* Patient affiliated with or beneficiary of a social security scheme.\n\nExclusion Criteria:\n\n* Patient with poorly controlled diabetes,\n* Patient with major esophageal motility disorders,\n* Patient with a Hiatal Hernia \\> 4cm,\n* History of bariatric surgery, history of ring,\n* Patient refusing pH-metry examination,\n* Refusal to participate in the study,\n* Patient under legal protection,\n* Patient not benefiting from health protection,\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision.",{"count":21,"type":22},[25],"The success of laparoscopic sleeve gastrectomy (LSG) is not only due to its proven efficacy in the treatment of obesity and associated to comorbidities in the short and long term, but also because it is considered as less technically complicated compared to other malabsorptive procedures. Unfortunately, the main long-term side effect of LSG appears to be the development of severe gastroesophageal reflux (GERD). This problem is aggravated by the concomitant presence of a hiatal hernia at the time of surgery. Indeed, by causing laxity of the lower esophageal sphincter (LES), the hiatal hernia reduces the barrier functions of the esophageal-gastric junction against the reflux of gastric contents.\n\nThe classic combination of sleeve and hiatal hernia treatment by cruroplasty gives contradictory results and several surgeons prefer to perform only the sleeve without addressing the hiatal hernia especially if it is small (\\\u003C4 cm). For this reason a modification of the usual surgical technique of LSG has been proposed by adding a Nissen fundoplication-Nissen Sleeve (NS). The intentions of this technique were to minimize the rate of postoperative GERD especially for patients with hiatal hernia, to protect the staple line of the angle of His, and finally to provide a safe and effective alternative for patients with a contraindication to LRYGB due to GERD. Although the first results of the technique are encouraging, the realization of the Nissen valve remains a sensitive technical point that can transform a relatively simple procedure like LSG into a more complex procedure like NS. The only test able to directly identify and classify gastric reflux is pH-metry with or without esophageal manometry. Unfortunately, especially due to the difficulty of access to the examination, there are no studies with solid scientific bases that identify the correct conduct to adopt in the case of an obese patient with a hiatal hernia (with or without preoperative reflux).\n\nThe main objective of this study is to evaluate the occurence or worsening of GERD at 3 years following a Nissen-sleeve vs. sleeve plus cruroplasty intervention in patients with obesity and hiatal hernia.",[397,398],"Obesity","Hiatal Hernia","2025-02-18",{"date":401,"type":39},"2025-02-19",{"date":403,"type":22},"2025-03-02",{"date":405,"type":22},"2031-11-02",{"name":45,"class":46},{"id":408,"slug":409,"hasResults":12,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":413,"eligibilityCriteria":414,"healthyVolunteers":12,"sex":299,"minAge":18,"maxAge":415,"enrollmentInfo":416,"targetDuration":4,"studyType":113,"phases":4,"briefSummary":418,"conditions":419,"keywords":422,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":424,"lastUpdatePostDateStruct":425,"startDateStruct":427,"completionDateStruct":429,"leadSponsor":431,"locationsCount":4},"100520760","assessment-of-the-occurrence-of-obstructive-sleep-apnea-hypopnea-syndrome-osahs-in-women-suffering-from-endometriosis-100520760","NCT06060756","Assessment of the Occurrence of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) in Women Suffering from Endometriosis","Assessment of the Occurrence of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) in French Women Suffering from Endometriosis.","ENDOSAS","Inclusion Criteria:\n\n* Female patients aged between 18 and 50 years of age\n* Confirmed diagnostic of endometriosis (either through imaging procedure (ultrasound or RMI) or diagnostic coelioscopy)\n* Patient suffering from symptoms evocating Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and justifying a diagnosis process performed within Standard of Care practice\n* Patient who has been informed about the study and has signed the informed consent form prior to any study-specific procedures\n* Patient willing and able to perform all scheduled procedures in accordance with the study protocol\n\nExclusion Criteria:\n\n* Post menopausal patient\n* Ongoing treatment for OSAHS\n* Patient with Chronic Obstructive Pulmonary Disease (COPD) or unstabilized cardiac disorders\n* Concomitant participation in another clinical trial\n* Pregnant or breastfeeding woman\n* Patient under legal protection measure","50 Years",{"count":417,"type":22},80,"This observational study aims at establishing the proportion of patients suffering from endometriosis and for whom an Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) diagnosis is established.\n\nThe study participation will be offered to endometriosis patients displaying symptoms that may suggest an underlying OSAHS.\n\nOSAHS diagnosis will be made according to standard of care practice and patients will be followed up to 12 months after initiating the OSAHS treatment to fill in questionnaires assessing the impact of OSAHS treatment on various endometriosis-related symptoms",[420,421],"Endometriosis","Obstructive Sleep Apnea-hypopnea",[423,420],"observational","2024-09-02",{"date":426,"type":39},"2024-09-05",{"date":428,"type":22},"2024-10",{"date":430,"type":22},"2026-10",{"name":45,"class":46},{"id":433,"slug":434,"hasResults":12,"nctId":435,"briefTitle":436,"officialTitle":437,"acronym":438,"eligibilityCriteria":439,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":440,"targetDuration":4,"studyType":23,"phases":442,"briefSummary":443,"conditions":444,"keywords":447,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":455,"completionDateStruct":456,"leadSponsor":458,"locationsCount":4},"100542664","innovative-care-pathway-in-physical-activity-and-behavior-change-in-coronary-patients-post-cardiac-rehabilitation-100542664","NCT06345807","Innovative Care Pathway in Physical Activity and Behavior Change in Coronary Patients Post-cardiac Rehabilitation","Innovative Care Pathway in Physical Activity and Behavior Change in Coronary Patients Post Cardiac Rehabilitation","APIC","Inclusion Criteria:\n\n* Post-infarction coronary artery patient aged 18 years and older, with no gender difference.\n* Patients engaged in a follow-up care and cardiovascular rehabilitation program at the Supervaltech center.\n* Patient at low to moderate RARE risk of complication (RARE score 2 to 3)\n* Patients equipped with smartphones, laptops or other equipment compatible with downloading an application with their personal ID\n* Patient able to understand French for the purpose of conducting the study.\n* Affiliated member or beneficiary of a social security scheme.\n* Participant who has been informed and has given free, informed and written consent (no later than the day of inclusion and before any examination required by the research).\n\nExclusion Criteria:\n\n* Patients with a formal contraindication to physical activity such as: unstabilized coronary syndrome, decompensated heart failure, severe ventricular arrhythmias, intracardiac thrombus at risk embolic, PAH, moderate pericardial effusion, history of thrombophlebitis with or without pulmonary embolism, severe and\u002For symptomatic left ventricular ejection obstruction.\n* Patients with ongoing infectious disease\n* Participant whose physical and\u002For psychological health is severely impaired, which in the opinion of the investigator may affect the study participant's compliance.\n* Participant included in other research\n* Participant in a period of exclusion from another research still in progress at the time of inclusion.\n* Protected participant: an adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision.\n* Pregnant, breastfeeding or parturient women.\n* Participant hospitalized without consent.",{"count":441,"type":22},192,[25],"The objective of this 18-month research is to show the effectiveness of an individualized physical activity( PA) compared to standard PA management and voluntary PA, to achieve a change in the behavior of the coronary patient.",[445,446],"Individualised Physical Activity Program","Coronary Patient",[448,449,450,451],"cardiac rehabilitation","ischemic heart disease","physical activity","wearables","2024-08-30",{"date":454,"type":39},"2024-09-03",{"date":428,"type":22},{"date":457,"type":22},"2026-11",{"name":45,"class":46},{"id":460,"slug":461,"hasResults":12,"nctId":462,"briefTitle":463,"officialTitle":464,"acronym":465,"eligibilityCriteria":466,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":467,"enrollmentInfo":468,"targetDuration":4,"studyType":23,"phases":470,"briefSummary":471,"conditions":472,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":474,"lastUpdatePostDateStruct":475,"startDateStruct":477,"completionDateStruct":479,"leadSponsor":480,"locationsCount":73},"100404710","computed-tomography-scan-in-complex-chronic-total-occlusion-percutaneous-coronary-intervention-100404710","NCT04549896","Computed Tomography Scan in Complex Chronic Total Occlusion Percutaneous Coronary Intervention;","Interest of Coronary CT Scan Before Complex Chronic Total Occlusion (CTO) Percutaneous Coronary Intervention (PCI).","CTS-C-CTOPCI","Inclusion Criteria:\n\n1. Male or female ≥ 18 years old and ≤ 90 years old,\n2. BMI ≤ 40 kg\u002Fm²,\n3. Dated and signed informed consent, before any study-related procedures\n4. Ability to understand and comply with the study procedures,\n5. Affiliate or recipient of a social security scheme,\n6. Coronary artery chronic total occlusion (TIMI 0 flow from \\> 3 months) associated with myocardial viability (intended like normokinetic\u002Fhypokinetic wall motion or instrumental data in favor of viability) associated with ≥ CCS2 angina or ≥ NHYA2 dyspnea or documented ischemia or ejection fraction \\\u003C50%.\n7. Coronary angiography J-CTO score ≥ 2 (complex cases)\n\nExclusion Criteria:\n\n1. Pregnant or breastfeeding woman,\n2. Adults patients protected by law,\n3. Very frequent and irregular cardiac rhythm (\\>100\u002Fmin.),\n4. More than one CTO to be treated by PCI,\n5. Coronary angiography J-CTO (Japan Chronic Total Occlusion) score 0\u002F1\n6. Hemodynamic instability,\n7. Anemia \\\u003C 9g\u002Fdl,\n8. Gastrointestinal bleeding,\n9. Thrombocytopenia with \\\u003C 50 000\u002Fmm3 platelets count,\n10. Severe valvular disease associated\n11. CT-Scan performed as part of the standard of care pathology diagnosis, before the inclusion","90 Years",{"count":469,"type":22},130,[25],"The chronic total occlusion of a coronary artery is the most frequent cardiac disease in the developped countries. The percutaneous coronary intervention is one of the existing treatments. This procedure is long, expensive and uses a lot of contrast medium and X ray. With this study, the investigators want to adress the impact of CT scan performed before the surgical procedure. A better knowledge of the patient's anatomy could lead to a better success rate of the operation, with a lower radiation, lower contrast injection, and a faster and more cost-efficient procedure.",[473],"Total Occlusion of Coronary Artery","2024-06-25",{"date":476,"type":39},"2024-06-26",{"date":478,"type":39},"2022-06-01",{"date":287,"type":22},{"name":45,"class":46},{"id":482,"slug":483,"hasResults":12,"nctId":484,"briefTitle":485,"officialTitle":486,"acronym":487,"eligibilityCriteria":488,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":489,"targetDuration":4,"studyType":23,"phases":491,"briefSummary":492,"conditions":493,"keywords":495,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":506},"100535911","unexpected-positive-cultures-in-rotator-cuff-revision-surgery-100535911","NCT06257979","Unexpected Positive Cultures in Rotator Cuff Revision Surgery","Unexpected Positive Cultures in Rotator Cuff Revision Surgery: Significance and Influence on Outcomes and Tendon Healing","POCICO","Inclusion Criteria:\n\n* Patient, male or female, aged 18 or over\n* Patient requiring re- intervention for Rotator Ruff Revision Surgery for non-healing of the same tendons after a first intervention (delay \\\u003C2 years)\n* Patient requiring arthroscopy\n* Patient having had realized a MRI of the shoulder in the 6 previous months\n* Affiliate participant or beneficiary of a social security scheme\n* Participant having been informed and not having objected to the use of their data\n\nExclusion Criteria:\n\n* Patient with at least one clinical sign of infection (fever, redness)\n* Patient with a new distant rupture on a healed cuff (\\> 3 years)\n* Patient with a history of shoulder surgery other than initial Rotator Ruff Surgery\n* Patient having received antibiotic treatment in the 2 weeks preceding inclusion\n* Participant in another research\n* Participant in a period of exclusion from another research still in progress at the time of inclusion\n* Protected participant: an adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision\n* Pregnant, breastfeeding or parturient woman\n* Participant hospitalized without consent",{"count":490,"type":22},132,[25],"In the context of rotator cuff re-intervention, the impact of Unexpected Positive Cultures (UPC) is not documented, and their management has not been studied, particularly regarding indications for antibiotic therapy, which is currently not a consensus.\n\nA prospective interventional study will be implemented to compare the results of non-randomized patient samples, whether positive or negative, taken during rotator cuff re-intervention. The objective is to assess whether these samples do not affect clinical outcomes and tendon healing rates.",[494],"Rotator Cuff Repair",[496,497],"Unexpected Positive Cultures (UPC)","Revision cuff repair surgery (RCR)","2024-06-17",{"date":500,"type":39},"2024-06-18",{"date":502,"type":39},"2024-02-27",{"date":504,"type":22},"2028-03-15",{"name":45,"class":46},8,{"id":508,"slug":509,"hasResults":12,"nctId":510,"briefTitle":511,"officialTitle":512,"acronym":4,"eligibilityCriteria":513,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":514,"targetDuration":4,"studyType":23,"phases":516,"briefSummary":517,"conditions":518,"keywords":520,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":522,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":527,"locationsCount":73},"100457233","total-knee-arthroplasty-and-augmented-reality-based-navigation-system-100457233","NCT05233930","Total Knee Arthroplasty and Augmented Reality-based Navigation System","Does an Augmented Reality-based Navigation System in Total Knee Arthroplasty Allow a Better Alignment of the Lower Limb and Does it Improve Functional Results ? An Equivalence, Monocentric, Prospective and Randomized Study","Inclusion Criteria:\n\n1. Gonarthrosis on a varum knee requiring a Total Knee Replacement\n2. Female or male, 18 years of age or older\n3. Affiliation to a social security scheme\n4. Patient has been informed of the study and has signed an informed consent form\n\nExclusion Criteria:\n\n1. Osteonecrosis,\n2. Post traumatic osteoarthritis with femoral or tibial callus,\n3. History of tibial or femoral osteotomy,\n4. Valgum knee,\n5. Isolated patellofemoral osteoarthritis,\n6. Significant hip dysplasia or other excessive pelvic deformity,\n7. Patient already equipped with medical devices that may conflict with the instrumentation required for augmented reality navigation,\n8. Pregnant or breastfeeding women,\n9. Patients under legal protection.",{"count":515,"type":22},88,[25],"The purpose of Total Knee Replacement (TKR) is to remove worn cartilage surfaces and replace them with artificial parts of the same shape. TKR can be used in cases of osteoarthritis, inflammatory rheumatism, bone necrosis of the knee or following malformative or traumatic sequelae.\n\nImplant alignment is paramount in TKR and the last years have seen a proliferation of alignment techniques following the introduction of computer and robotic-assisted surgery. Among Computer-assisted surgery, the augmented reality-based navigation system can be an option to improve accuracy in orthopaedic surgery.\n\nThe hypothesis of this study is: the use of augmented reality-based navigation system allows a prosthesis alignment and positioning that is at least as good as with the traditional mechanically aligned technique, and therefore improves knee functional results. This study also aims at assessing the cost-effectiveness of this new technology.",[519],"Gonarthrosis",[521],"TKR: total knee replacement",{"date":500,"type":39},{"date":524,"type":22},"2024-09",{"date":526,"type":22},"2025-10",{"name":45,"class":46},{"id":529,"slug":530,"hasResults":12,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":534,"eligibilityCriteria":535,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":536,"enrollmentInfo":537,"targetDuration":4,"studyType":23,"phases":539,"briefSummary":540,"conditions":541,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":543,"startDateStruct":544,"completionDateStruct":546,"leadSponsor":548,"locationsCount":47},"100431298","efficacy-and-safety-of-radiofrequency-versus-hal--rar-doppler-in-hemorrhoidal-pathology-100431298","NCT04896268","Efficacy and Safety of RAdiofrequency Versus HAL- RAR DOppler in Hemorrhoidal Pathology","Prospective, Multicentric, Randomized, Open-label Study Comparing the Efficacy, in Terms of Quality of Life, and Safety of RAdiofrequency Versus HAL- RAR DOppler in Hemorrhoidal Pathology","RADO","Inclusion Criteria:\n\n* Male or Female consulting for hemorrhoidal pathology (grade II or III) after failure of medico-instrumental treatments.\n* Age ≥ 18 years and \\\u003C 75 years\n* Mandatory affiliation to a health insurance system.\n* Patient having been informed of the study and having given informed consent\n\nExclusion Criteria:\n\n* Patients with chronic inflammatory bowel disease\n* Patients with suspected gastro-colic pathology\n* Haematological diseases\n* Anal fistulas\n* Patients unable to discontinue anti-vitamin K or oral anticoagulants\n* Associated anal fissure\n* External haemorrhoidal disease\n* Pregnant or breastfeeding women\n* Patients under legal protection","75 Years",{"count":538,"type":22},100,[25],"Haemorrhoids are composed of tissue rich in blood vessels and are present in all individuals inside the anus (internal haemorrhoids) or under the skin of the anus (external haemorrhoids). Haemorrhoidal disease (HD) occurs when haemorrhoids become troublesome and cause symptoms such as pain, bleeding, prolapse or oozing. In case of failure of medical treatment, instrumental procedures or extensive disease, surgical treatment can be considered. There are two classic surgical techniques. The first is the pedicle haemorrhoidectomy of the Milligan and Morgan type. The second classic surgical technique is the Longo stapled anopexy. Recently, less invasive surgical techniques such as arterial ligation (HAL, with or without Doppler) followed by recto-anal repair (RAR for \"Recto Anal Repair\") and sometimes associated with mucopexy, which allows the excess mucosa to be ligated and the muco-haemorrhoidal tissue to be fixed to the rectal wall, have developed. The use of radiofrequency current (Rafaelo technique) in the treatment of haemorrhoidal disease is an innovative technique of haemorrhoidal thermocoagulation. It is a mini-invasive technique, which can be performed under sedation or short general anaesthesia (GA), with little pain, allowing a rapid return to normal life and a short time off work. Although this technique is already used in other European countries: Poland, Germany, Belgium, Great Britain (UK), there is now a Polish, German, Spanish and English study in the process of publication. There have been no studies in France to evaluate this new technique and assess its good tolerance, the duration of work stoppage, the improvement in quality of life and the evaluation of its effectiveness.",[542],"Hemorrhoids",{"date":500,"type":39},{"date":545,"type":39},"2023-01-03",{"date":547,"type":22},"2025-08",{"name":45,"class":46},{"id":550,"slug":551,"hasResults":12,"nctId":552,"briefTitle":553,"officialTitle":554,"acronym":555,"eligibilityCriteria":556,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":557,"targetDuration":4,"studyType":23,"phases":558,"briefSummary":559,"conditions":560,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":570},"100504443","rotator-cuff-repair-under-isolated-loco-regional-anesthesia-100504443","NCT05848375","Rotator Cuff Repair Under Isolated Loco-regional Anesthesia","Rotator Cuff Repair Under Isolated Loco-regional Anesthesia Versus General Anesthesia Combined With Loco-regional Anesthesia: Randomized Controlled Trial of Superiority.","AGORA","Inclusion Criteria:\n\n* Patient, male or female, aged 18 and over\n* Patient with a supraspinatus lesion or supraspinatus and infraspinatus lesions requiring surgery for arthroscopic rotator cuff repair, with a non-retracted or minimally retracted tendon (lower stage or = 2 according to the Patte score) and a muscle with little or no fat infiltration (fatty infiltration less than or = 2 according to the Goutallier classification)\n* Affiliated participant or beneficiary of a social security scheme.\n* Participant having been informed and having given their free, informed and written consent (at the latest on the day of inclusion and before any examination required by the research).\n\nExclusion Criteria:\n\n* Patient with a history of surgery for the operated shoulder\n* Patient with stage \\>1 glenohumeral osteoarthritis according to the Samilson classification\n* Patient requiring associated subscapularis repair\n* Patient with a contraindication to LRA or a contraindication to GA\n* Patient wishing a type of anesthesia\n* Patient with a contraindication to day surgery\n* Patient with neuropathy\n* Patients with a history of vagal, emotional or stress-prone discomfort\n* Participant whose physical and\u002For psychological health is severely impaired, which according to the investigator may affect the participant's compliance with the study.\n* Patients participating in another research\n* Participant in period of exclusion from another research still in progress at the time of inclusion.\n* Protected participant: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision.\n* Pregnant, breastfeeding or parturient woman.\n* Participant hospitalized without consent.",{"count":417,"type":22},[25],"Damage to the tendons of the shoulder, called rotator cuff, causes pain and loss of strength that may require surgery. This operation is performed under general anesthesia combined with loco-regional anesthesia of the shoulder. Indeed, this loco-regional anesthesia makes it possible to specifically suppress the sensation of pain in the shoulder for several hours after surgery. General anesthesia is produced by injecting drugs intravenously and breathing anesthetic vapors. Repair of the rotator cuff under loco-regional anesthesia alone is performed by several surgeons in France and is recommended by international experts. If blood pressure is artificially lowered during general anesthesia, loco-regional anesthesia alone allows maintenance of blood pressure and real-time clinical assessment since the patient is conscious.\n\nThe purpose of the research is to compare the blood pressure measured during surgery of patients operated under loco-regional anesthesia alone or associated with general anesthesia, two common practices of surgical teams.",[561],"Shoulder Cuff Surgical Repair","2024-06-12",{"date":564,"type":39},"2024-06-13",{"date":566,"type":39},"2023-11-13",{"date":568,"type":22},"2025-07",{"name":45,"class":46},4,{"id":572,"slug":573,"hasResults":12,"nctId":574,"briefTitle":575,"officialTitle":576,"acronym":577,"eligibilityCriteria":578,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":579,"enrollmentInfo":580,"targetDuration":4,"studyType":23,"phases":582,"briefSummary":583,"conditions":584,"keywords":585,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":589,"lastUpdatePostDateStruct":590,"startDateStruct":592,"completionDateStruct":593,"leadSponsor":595,"locationsCount":73},"100512586","study-assessing-the-contribution-of-telemedicine-monitoring-in-addition-to-standard-follow-up-of-an-obesity-program-100512586","NCT05954377","Study Assessing the Contribution of Telemedicine Monitoring in Addition to Standard Follow-up of an Obesity Program","Prospective, Single-center, Randomized, Open Label Study Assessing the Contribution of Telemedicine Monitoring in Addition to Standard Follow-up, Strengthening an Obesity Program in Berry (FRANCE)","STROBERRY","Inclusion Criteria:\n\n* Woman or Male aged from 18 to 60 years old included\n* Patient in obesity (BMI\\> or = 30)\n* Patient who has completed a multidisciplinary medical program for obesity management, as a first- or second-line intention (after initial obesity management) at the investigating center\n* Affiliation to a social security scheme\n* Patient informed of the study and who had signed the informed consent form\n\nNon Inclusion Criteria:\n\n* Management of obesity within the framework of an exclusively interventional program, without redirection to a medical program\n* Managing obesity as part of a post-operative program\n* Pregnant or breastfeeding women\n* Patients deprived of liberty\n* Patients under legal protection","60 Years",{"count":581,"type":22},116,[25],"STROBERRY Study is a Prospective, monocentric, randomized, open-label study assessing the contribution of telemedicine, in addition to standard follow-up, strengthening an Obesity program in Berry (France). The principal objective is to study the effectiveness of a follow-up reinforced with telemedicine in addition to the standard multidisciplinary annual follow-up on the rate of patients lost to follow-up after initial or second line management in a multidisciplinary bariatric medical program",[397],[586,587,588],"obesity","public health","telemedicine","2024-04-23",{"date":591,"type":39},"2024-04-24",{"date":524,"type":22},{"date":594,"type":22},"2030-03",{"name":45,"class":46},{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":601,"acronym":602,"eligibilityCriteria":603,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":346,"enrollmentInfo":604,"targetDuration":4,"studyType":23,"phases":606,"briefSummary":607,"conditions":608,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":589,"lastUpdatePostDateStruct":610,"startDateStruct":611,"completionDateStruct":613,"leadSponsor":615,"locationsCount":616},"100459608","pulmonary-vein-isolation-alone-or-in-combination-with-substrate-modulation-after-electric-cardioversion-failure-100459608","NCT05264831","Pulmonary Vein Isolation Alone or in Combination With Substrate Modulation After Electric Cardioversion Failure","Pulmonary Vein Isolation Alone or in Combination With Substrate Modulation After Electric Cardioversion Failure in Patients With Persistent Atrial Fibrillation: a Randomized, Multicentric, and Comparative Study","PACIFIC","Inclusion criteria:\n\nCriteria to be validated for patients included before performing electric cardioversion:\n\n1\\) Persistent AF (continuous for at least 7 days without interruption according to information transmitted by the cardiologist and the patient), symptomatic and resistant to at leat one anti-arrhythmic drug treatment including amiodarone;\n\nCriteria to be validated for patients included after performing electric cardioversion :\n\n1. Patient treated by electric cardioversion for persistent AF, symptomatic and resistant to anti-arrhythmic treatment including amiodarone and whom ablative procedure is planned in the following 4-6 weeks after electric cardioversion\n\n   Criteria to be validated for all patients included:\n2. Life expectancy \\> 5 years;\n3. Female or male between 18 and 80 years of age at the electric cardioversion time\n4. Affiliation to a health insurance system;\n5. Patient informed of the study and having signed informed consent\n\n   Criteria to be validated prior to randomization on the day of ablation (these patients may be randomized):\n6. Patient with failed electric cardioversion i.e. in AF, confirmed by ECG.\n\nExclusion criteria:\n\nCriteria to be validated before or after performing electric cardioversion (the study cannot be proposed to patients corresponding to these criteria):\n\n1. Current hyperthyroidism;\n2. Pregnant or breastfeeding woman;\n3. Patient with a Body Mass Index (BMI) greater than 35;\n4. Patient with severe Chronic Obstructive Pulmonary Disease (COPD);\n5. Patient with hypertrophic heart disease;\n6. Patient with a mechanical or biological mitral valve;\n7. Contraindications to anticoagulants;\n8. Transient Ischemic Attack (TIA) \u002Fstroke less than 6 months old;\n9. Psychiatric illness affecting follow-up;\n10. Left Ventricular Ejection Fraction (LVEF) \\\u003C 40% ;\n11. Uncontrolled ischaemic heart disease (angina, myocardial ischaemia)\n12. Patients under legal protection\n13. Cardiac surgery on left atrium\n14. Inflammatory status in progress (cancer, rheumatoid arthritis, PPRZ, acute or chronic periodontitis, Crohn's disease, RCUH)\n15. Pulmonary embolism or phlebitis less than 6 months old\n16. Prior atrial fibrillation ablation\n17. Active cancer\n\n    Criteria to be validated before randomization, on the day of ablation (these patients cannot be randomized):\n18. Patient in sinus rhythm 4-6 weeks after electric cardioversion: these patients are included in the study registry.\n19. Patient with complete absence of sinus rhythm (less than 10 seconds) after 3 electric cardioversion attempts: these patients will discontinue from the study.",{"count":605,"type":22},450,[25],"This study aims at assessing whether electric cardioversion can act as a discriminant factor between patients requiring Pulmonary Vein Isolation (PVI) procedure alone or PVI procedure combined with substrate modulation.\n\nAll included patients will undergo an electric cardioversion, then:\n\n* Patients with electric cardioversion success will be treated as per Standard of Care and according to ESC recommendations (2020). A prospective registry will be implemented for these patients.\n* Patients with electric cardioversion failure will be randomized in the study between 2 ablative procedures:\n\n  * PVI procedure alone\n  * PVI procedure combined with substrate modulation",[609],"Persistent Atrial Fibrillation",{"date":591,"type":39},{"date":612,"type":39},"2023-02-20",{"date":614,"type":22},"2027-10-01",{"name":45,"class":46},13,{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":622,"acronym":623,"eligibilityCriteria":624,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":625,"targetDuration":4,"studyType":113,"phases":4,"briefSummary":627,"conditions":628,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":630,"lastUpdatePostDateStruct":631,"startDateStruct":633,"completionDateStruct":635,"leadSponsor":637,"locationsCount":73},"100447631","research-of-factors-determining-the-improvement-of-quality-of-life-at-one-year-of-adult-patients-treated-for-spinal-deformity-coftasd-100447631","NCT05108948","Research of Factors Determining the Improvement of Quality of Life at One Year of Adult Patients Treated for Spinal Deformity (COFTASD)","Research of Factors Determining the Improvement of Quality of Life at One Year of Adult Patients Treated for Spinal Deformity : Observational Study (COFTASD)","COFTASD","Inclusion Criteria:\n\n* Age over 18 years-old\n* Diagnosis of Adult Spinal Deformity with any of the deformity characteristics following:\n\n  * Scoliosis with a Cobb angle ≥ 20 °\n  * Vertical sagittal axis (SVA) ≥ 5 cm\n  * Pelvic tilt ≥25 °,\n  * Thoracic kyphosis with a Cobb angle ≥ 60 °\n* Eligible for surgery\n* Having given their participation agreement\n* Affiliate or beneficiary of a social security scheme\n\nExclusion Criteria:\n\n* Age under 18 years-old\n* Patient unlikely to comply with follow-up\n* Patient with long-term complete paraplegia\n* Patient unable to understand and answer questionnaires in due to language difficulties or cognitive impairment\n* Pregnant or breastfeeding woman\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision",{"count":626,"type":22},866,"The objective of this study is to find the predictive factors of improvement of the quality of life of operated patients from spinal deformity.",[629],"Spinal Deformity","2024-02-28",{"date":632,"type":39},"2024-02-29",{"date":634,"type":39},"2021-10-23",{"date":636,"type":22},"2041-10-23",{"name":45,"class":46},""]