[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Embry-Riddle Aeronautical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100609605","effects-of-breathing-training-and-nitrate-on-exercise-at-simulated-altitude-100609605",false,"NCT07216755","Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude","Impact of Respiratory Muscle Training and Nitrate Therapy on Exercise Tolerance in Simulated Altitude","Inclusion Criteria:\n\n* Healthy adults between 18 and 40 years old.\n\nRecreationally active (performing ≥3 hours of structured physical activity per week).\n\nNon-smokers for at least the past 6 months.\n\nFree from any known cardiovascular, pulmonary, metabolic, or neuromuscular disease as determined by health screening questionnaire and medical history.\n\nAble to perform cycle ergometer exercise to volitional fatigue.\n\nWilling to abstain from high-nitrate foods and supplements (e.g., beets, spinach, arugula) for 48 hours prior to each testing session.\n\nAble and willing to provide written informed consent and comply with all study procedures.\n\nExclusion Criteria:\n\n* Diagnosis of or history of heart disease, hypertension, diabetes, or chronic respiratory disorders (e.g., asthma, COPD).\n\nCurrent use of medications or supplements known to affect cardiovascular, metabolic, or respiratory function (e.g., beta-blockers, nitrates, stimulants).\n\nSmoking, vaping, or tobacco use within the past 6 months.\n\nKnown allergy or intolerance to beetroot products or nitrates.\n\nParticipation in another interventional research study within the past 30 days.\n\nPregnant or breastfeeding women.\n\nAny orthopedic or musculoskeletal limitation preventing safe exercise testing.\n\nFailure to meet inclusion criteria or inability to complete familiarization and baseline testing.",true,"ALL","18 Years","40 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced oxygen availability at altitude places additional strain on the cardiovascular and respiratory systems, which may limit endurance performance. By combining RMT-designed to strengthen the muscles involved in breathing-with nitrate therapy, which enhances nitric oxide availability and vascular function, this study aims to determine whether these interventions independently or synergistically improve oxygen delivery, reduce physiological strain, and enhance exercise performance. The findings will help identify non-pharmacological strategies to improve physical performance and tolerance to hypoxia in both clinical and operational environments.",[28,29,30,31,32,33,34,35],"Healthy Adults","Mechanical Ventilation Dependence","Hypoxia","Exercise Training","Exercise Intolerance","Dietary Supplement","Nitrate Supplementation","Inspiratory Muscle Training","RECRUITING","2025-10-13",{"date":39,"type":40},"2025-10-15","ACTUAL",{"date":42,"type":40},"2025-09-01",{"date":44,"type":22},"2028-08-31",{"name":46,"class":47},"Embry-Riddle Aeronautical University","OTHER",""]