[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Erin Rowell\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":114},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,71,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100569269","gonadal-tissue-cryopreservation-for-fertility-preservation-in-children-with-a-disorder-of-sex-development-100569269",false,"NCT06692049","Gonadal Tissue Cryopreservation for Fertility Preservation in Children with a Disorder of Sex Development","DSD","Inclusion Criteria:\n\n* Individual \\\u003C 30 years of age\n* Children diagnosed with a disorder of sex development who have any risk for malignancy in their gonadal tissue or will have their gonads removed for another clinical indication\n\nExclusion Criteria:\n\n* Pregnant children\n* Patients likely to retain inherent fertility and reproductive function\n* Children deemed high risk for perioperative complications\n* Patients 12-18 unable to provide assent (i.e. significant psychiatric problems\u002Fcognitive delay)\n* Patients 18 and older unable to provide consent (i.e. significant psychiatric problems\u002Fcognitive delay)",true,"ALL","30 Years",{"count":20,"type":21},250,"ESTIMATED","10 Years","OBSERVATIONAL","The purpose of this study is to offer gonadal tissue freezing and storage to children who are diagnosed with a disorder of sex development (DSD), who are at increased risk of infertility and certain malignancies (cancer). This study involves the storage of gonadal tissue that is being removed for medical reasons (e.g. prevention of cancer development). It includes the processing and freezing of this gonadal tissue, hopefully for potential future use. The tissue will then be stored long-term until the child wishes to try to use the tissue.",[26,27,28,29,30,31],"DSD, 46,XY","DSD, Ovotesticular","DSD, Sex Chromosome","Disorders of Sex Development","Disorder of Sex Development, 46,XY","Disorder of Sex Development, 46,Xy, Cbx2-Related",[14,33,34,35,36],"GTC","Gonadectomy","Cryopreservation","Fertility Preservation","RECRUITING","2024-11-14",{"date":40,"type":41},"2024-11-18","ACTUAL",{"date":43,"type":41},"2018-04-04",{"date":45,"type":21},"2035-12-31",{"name":47,"class":48},"Erin Rowell","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":57,"minAge":4,"maxAge":58,"enrollmentInfo":59,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":49},"100462288","ovarian-tissue-cryopreservation-in-pre-pubertal-otc-pre-pubertal-100462288","NCT05299710","Ovarian Tissue Cryopreservation in Pre-Pubertal (OTC-Pre Pubertal)","Ovarian Tissue Freezing for Fertility Preservation in Pre-Pubertal Children Facing a Fertility Threatening Medical Diagnosis or Treatment Regimen","Inclusion Criteria:\n\n* Pre- Pubertal Individual\n* Will undergo imminent surgery, chemotherapy or radiation therapy that has implications on future fertility and reproductive hormone potential: any health condition or malignancy that requires removal of all or part of one or both ovaries, whole abdomen or pelvic irradiation ≥10Gy in post-pubertal girls or ≥15Gy in pre-pubertal girls total body irradiation, and alkylating-intensive chemotherapy:\n* cyclophosphamide cumulative dose ≥7.5 g\u002Fm2\n* any treatment regimen containing procarbazine\n* busulfan cumulative dose \\>600 mg\u002Fm2\n* alkylating chemotherapy conditioning prior to stem cell transplantation combination of any alkylating agent with total body irradiation or whole abdomen or pelvic radiation cranial radiation ≥30 Gy summed alkylating agent dose score ≥3 (Green et al., 2009) cyclophosphamide equivalent dose (CED) ≥ 4,000 mg\u002Fm2 (Green et al., 2014)\n\nExclusion Criteria:\n\n* Patients with no anticipated oncologic therapies\n* Post-pubertal individuals\n* Pregnant children\n* Children with one ovary\n* Children deemed high risk for perioperative complications\n* Patients unable to provide consent\u002Fassent (i.e. significant psychiatric problems\u002Fcognitive delay)","FEMALE","11 Years",{"count":20,"type":21},"The purpose of this study is to safely remove ovarian tissue in pre-pubertal pediatric patients, who are at risk for infertility from their medical treatment, for freezing for future restoration of fertility and hormone function.",[62],"Cancers",[64],"OTC, fertility",{"date":40,"type":41},{"date":67,"type":41},"2018-05-29",{"date":69,"type":21},"2035-01",{"name":47,"class":48},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":57,"minAge":4,"maxAge":18,"enrollmentInfo":78,"targetDuration":79,"studyType":23,"phases":4,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":86,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":90,"locationsCount":49},"100463058","ovarian-tissue-cryopreservation-in-post-pubertal-otc-post-pubertal-100463058","NCT05309746","Ovarian Tissue Cryopreservation in Post Pubertal (OTC-Post Pubertal)","Ovarian Tissue Cryopreservation for Fertility Preservation in Post-Pubertal Children Facing a Fertility Threatening Diagnosis or Treatment Regimen","Inclusion Criteria:\n\n* Post-pubertal individuals \\\u003C 30 years of age\n* Will undergo imminent surgery, chemotherapy or radiation therapy that has implications on future fertility and reproductive hormone potential: any health condition or malignancy that requires removal of all or part of one or both ovaries, whole abdomen or pelvic irradiation≥ 10Gy in post-pubertal girls or ≥15 Gy in pre- pubertal girls\n* total body irradiation, and\n* alkylating-intensive chemotherapy\n\n  * cyclophosphamide cumulative dose ≥7.5 g\u002Fm2\n  * any treatment regimen containing procarbazine\n  * busulfan cumulative dose \\>600 mg\u002Fm2\n  * alkylating chemotherapy conditioning prior to stem cell transplantation\n\n    * combination of any alkylating agent with total body irradiation or whole abdomen or pelvic radiation\n    * cranial radiation ≥30 Gy\n    * summed alkylating agent dose score ≥3 (Green et al., 2009)\n    * cyclophosphamide equivalent dose (CED) ≥ 4,000 mg\u002Fm2 (Green et al., 2014)\n* Patients may have newly diagnosed or relapsed disease. Those who were not enrolled at diagnosis are eligible even if they have received therapy that is viewed as likely to result in complete and permanent loss of ovarian function. However, these patients will be required to provide a 4mm punch biopsy of their tissue for research.\n\nExclusion Criteria:\n\n* Patients with no anticipated oncologic therapies\n* Pregnant children\n* Children with one ovary\n* Children deemed high risk for perioperative complications\n* Patients unable to provide consent\u002Fassent (i.e. significant psychiatric problems\u002Fcognitive delay)",{"count":20,"type":21},"20 Years","The purpose of this study is to safely remove ovarian tissue in pediatric patients, who are at risk for infertility from their medical treatment, for freezing for future restoration of fertility and hormone function.",[82],"Pediatric Cancer",[84,85],"OTC","fertility",{"date":40,"type":41},{"date":88,"type":41},"2017-11-01",{"date":69,"type":21},{"name":47,"class":48},{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":16,"sex":57,"minAge":4,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":101,"phases":102,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":108,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":49},"100403750","anti-mullerian-hormone-levels-in-healthy-females-100403750","NCT04537390","Anti-mullerian Hormone Levels in Healthy Females","AMH","Inclusion Criteria:\n\n1. Pre- and post-pubertal females\n2. Ages 0-18 years old\n3. Tanner Stage I- V\n4. Undergoing routine outpatient surgical procedure\n\n   1. Hernia repair (inguinal, umbilical, epigastric)\n   2. Excision of benign mass\n   3. laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n1. Previous diagnosis of an illness associated with premature ovarian failure (Turner's syndrome, Fragile X permutation carrier) or endocrine disorder associated with irregular menstrual cycles (Cushing's disease, poorly-controlled Thyroid disease, hyperprolactinemia, polycystic ovary syndrome, and congenital adrenal hyperplasia) or insulin-dependent diabetes mellitus or autoimmune disorders\n2. Previous diagnosis of any malignancy or any history of systemic\u002Flocal chemotherapy, radiation therapy, or stem-cell transplant.\n3. Previous surgical excision of one ovary or both ovaries\n4. Pregnant females\n5. All inpatient surgical patients\n6. Undergoing non-routine outpatient surgical procedures\n\n   1. Central venous catheter placement\n   2. Supprelin insertion\u002Fremoval\n   3. Breast mass excision\n   4. Gastrostomy tube insertion","18 Years",{"count":100,"type":21},100,"INTERVENTIONAL",[103],"NA","The purpose of this study is to have a better understanding of the normal blood levels of AMH in females from 0-18 years of age and how the blood AMH levels correspond to a female's reproductive development.",[106],"Healthy",[96],{"date":40,"type":41},{"date":110,"type":41},"2016-07-19",{"date":112,"type":21},"2030-12-01",{"name":47,"class":48},""]