[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Erzincan University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":74},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100611560","supplementary-nerve-blocks-added-to-the-adductor-canal-block-for-postoperative-pain-management-in-primary-total-knee-arthroplasty-a-randomized-controlled-comparison-of-sciatic-bifes-and-ipack-techniques-100611560",false,"NCT07242170","Supplementary Nerve Blocks Added to the Adductor Canal Block for Postoperative Pain Management in Primary Total Knee Arthroplasty: A Randomized Controlled Comparison of Sciatic, BiFeS, and IPACK Techniques","Comparison of the Effectiveness of \"Sciatic Nerve\", \"Biceps Femoris Short Head (BiFeS)\" and \"Interspace Between the Popliteal Artery and the Capsule of the Posterior Knee (IPACK)\" Blocks Added to the Adductor Canal Block for Postoperative Pain Control in Patients Undergoing Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients classified as American Society of Anesthesiologists (ASA) physical status I-III\n* Patients undergoing primary total knee arthroplasty\n* Patients undergoing unilateral total knee arthroplasty\n* Patients between 18 and 75 years of age\n\nExclusion Criteria:\n\n* Patients classified as American Society of Anesthesiologists (ASA) physical status IV or higher\n* Patients undergoing revision total knee arthroplasty\n* Patients undergoing bilateral total knee arthroplasty\n* Patients with neuromuscular disease\n* Patients who decline to participate in the study\n* Patients with cognitive dysfunction\n* Patients with known drug allergies\n* Patients with a history of local anesthetic systemic toxicity\n* Patients with neurological dysfunction\n* Patients with bleeding diathesis\n* Pregnant patients","ALL","18 Years","75 Years",{"count":20,"type":21},102,"ESTIMATED","INTERVENTIONAL",[24],"NA","Postoperative pain following total knee arthroplasty (TKA) is a significant clinical problem that delays early mobilization, reduces patient satisfaction, and increases analgesic requirements. The adductor canal block (ACB), which aims to provide analgesia while preserving motor function, is widely used in postoperative pain management after TKA. However, clinical and anatomical studies have demonstrated that ACB is effective only in the anteromedial sensory innervation of the knee and does not adequately block pain originating from the posterior knee capsule. This limitation reduces analgesic effectiveness, particularly in patients with a prominent posterior pain component.\n\nThe sciatic nerve block has long been considered the gold standard for managing posterior knee pain. However, due to disadvantages such as motor weakness and delayed rehabilitation, current pain management protocols increasingly favor motor-sparing and complementary approaches such as the Biceps Femoris Short Head (BiFeS) block and the Interspace Between the Popliteal Artery and the Capsule of the posterior Knee (IPACK) block for posterior knee analgesia.\n\nIn light of this information, the aim of our study is to guide clinical practice by comparing the postoperative analgesic efficacy, motor function outcomes, and patient satisfaction associated with sciatic nerve, BiFeS, and IPACK block techniques-each administered as a supplement to the adductor canal block-in patients undergoing total knee arthroplasty, with the ultimate goal of determining the optimal block combination for postoperative pain control.",[27,28],"Post Operative Analgesia","Total Knee Arthroplasty",[30,31,32,33,34],"Adductor Canal Block","Sciatic Nerve Block","Biceps Femoris Short Head Block","Interspace Between the Popliteal Artery and the Capsule of the posterior Knee block","post operative pain","RECRUITING","2026-01-12",{"date":38,"type":39},"2026-01-13","ACTUAL",{"date":41,"type":39},"2025-11-01",{"date":43,"type":21},"2026-11-01",{"name":45,"class":46},"Erzincan University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100555324","periodontal-disease-and-salivary-mitofusin-levels-100555324","NCT06510608","Periodontal Disease and Salivary Mitofusin Levels","Evaluation of the Roles of Salivary Mitofusin-1 and Mitofusin-2 Levels in Periodontal Disease","Inclusion Criteria:\n\n* Being between the ages of 18 and 65.\n* Willing to participate in the study and provide a saliva sample.\n* Having a healthy periodontal condition, gingivitis, or periodontitis (Stage 3-4, Grade C).\n* Having fasted from any food or drink (except water) for the past 2 hours prior to providing the saliva sample.\n* Having refrained from brushing teeth or using mouthwash in the past 2 hours prior to providing the saliva sample.\n* Not having any systemic diseases.\n* Not currently taking any medications regularly.\n\nExclusion Criteria:\n\n* Having used antibiotics within the last 6 months.\n* Having received periodontal treatment within the last 6 months.\n* Having fewer than 20 teeth (excluding third molars).\n* Having any systemic diseases.\n* Not smoking or having quit at least 5 years ago.",true,"65 Years",{"count":58,"type":21},81,"OBSERVATIONAL","The aim of this observational study is to find out whether there is a level difference in salivary mitofusin-1 and mitofusin-2 levels due to changes in periodontal status. The main question it aims to answer is:\n\n* Do salivary mitofusin-1 and mitofusin-2 levels of periodontitis patients differ from healthy patients?\n* Could salivary mitofusin-1 and mitofusin-2 levels be biomarkers for periodontal disease?\n\nBiochemical analysis will be performed on saliva samples taken at once from gingivitis or periodontitis patients and healthy individuals who apply to the periodontology clinic, at the initial stage of the treatment. There is no ongoing monitoring or second sampling.",[62,63,64],"Periodontitis","Periodontal Diseases","Gingivitis","NOT_YET_RECRUITING","2024-07-14",{"date":68,"type":39},"2024-07-19",{"date":70,"type":21},"2024-07-25",{"date":72,"type":21},"2024-09-25",{"name":45,"class":46},""]