[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Erzurum City Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":80},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100643437","timing-of-midazolam-n-children-undergoing-adenotonsillectomy-effects-on-stress-cortisol-and-recovery-100643437",false,"NCT07622641","Timing Of Midazolam İn Children Undergoing Adenotonsillectomy: Effects On Stress, Cortisol, And Recovery","Optimization of Midazolam Administration Timing in Pediatric Adenotonsillectomy: Effects on Cortisol Response, Behavioral Stress, and Recovery Quality","Timing-Midazol","Inclusion Criteria:\n\n* Children aged 3-10 years,\n* Scheduled for elective adenoidectomy, tonsillectomy, or adenotonsillectomy,\n* American Society of Anesthesiologists (ASA) physical status I-II,\n* Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* Children younger than 3 years or older than 10 years,\n* American Society of Anesthesiologists (ASA) physical status greater than II,\n* Known allergy to apple or apple-derived products,\n* Known allergy or hypersensitivity to benzodiazepines,\n* Presence of developmental delay,\n* History of neuropsychiatric disorders,\n* Current or recent use of corticosteroids,\n* Expected or actual surgical duration longer than 90 minutes,\n* Refusal of participation by parents or legal guardians","ALL","3 Years","10 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is a prospective, randomized, controlled clinical trial designed to evaluate the optimal timing of midazolam administration in children undergoing adenotonsillectomy. The study will be conducted at the Departments of Otorhinolaryngology and Anesthesiology of Erzurum City Hospital.\n\nMidazolam is commonly used in pediatric patients to reduce anxiety and improve perioperative comfort. However, the optimal timing of its administration (before surgery or during anesthesia induction) remains unclear. This study aims to compare the effects of preoperative oral midazolam and intraoperative intravenous midazolam on stress response, behavioral outcomes, and recovery quality.\n\nParticipants will be randomly assigned to one of two groups. In Group A, children will receive oral midazolam (0.5 mg\u002Fkg) 30 minutes before surgery. In Group B, children will receive intravenous midazolam (0.05-0.1 mg\u002Fkg) during anesthesia induction.\n\nThe primary outcome of the study is the change in serum cortisol levels, which reflects the physiological stress response. Blood samples will be collected twice: once 10 minutes after anesthesia induction and once 15 minutes after surgery in the post-anesthesia care unit.\n\nIn addition to cortisol levels, the study will assess preoperative anxiety using an observational anxiety scale, postoperative pain using a behavioral pain scoring system, and parental satisfaction using a standardized questionnaire. These measures aim to provide a comprehensive evaluation of the child's perioperative experience.\n\nThe findings of this study may help determine the most effective timing of midazolam administration to reduce stress, improve recovery, and enhance overall patient and family satisfaction in pediatric surgical care.",[28,29,30,31],"Adenotonsillectomy","Preoperative Anxiety","Surgical Stress Response","Postoperative Pain",[33,34,28,35,29,36,31,37],"Midazolam","Pediatric Anesthesia","Premedication Timing","Cortisol Response","Recovery Quality","NOT_YET_RECRUITING","2026-06-07",{"date":41,"type":42},"2026-06-10","ACTUAL",{"date":44,"type":22},"2026-08-01",{"date":46,"type":22},"2027-09-01",{"name":48,"class":49},"Erzurum City Hospital","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":63,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":50},"100599679","copd-assessment-test-score-and-perioperative-risk-in-copd-100599679","NCT07087626","COPD Assessment Test Score and Perioperative Risk in COPD","Prediction of Perioperative Complication Risk Using Chronic Obstructive Pulmonary Disease Assessment Test Score in Chronic Obstructive Pulmonary Disease Patients: A Prospective Cohort Study","COPD","Inclusion Criteria:\n\n* Patients aged between 40 and 70 years\n* Diagnosed with stable-stage Chronic Obstructive Pulmonary Disease (COPD) according to GOLD criteria\n* Scheduled for elective surgical intervention\n* Classified as ASA Physical Status II or III according to the American Society of Anesthesiologists (ASA)\n* Planned for postoperative follow-up and eligible for at least 72 hours of observation\n* Undergoing surgery with an expected duration of at least 150 minutes\n* Willing to participate voluntarily in the study\n\nExclusion Criteria:\n\n* Patients younger than 40 years or older than 70 years\n* History of COPD exacerbation within the past 4 weeks\n* Presence of severe cardiac failure (EF \\\u003C30%), end-stage renal disease, or active malignancy\n* Neurological disorders or cognitive impairments\n* Requirement for invasive mechanical ventilation in the preoperative period\n* Altered consciousness or any condition preventing completion of forms before anesthesia\n* Undergoing surgery with an expected duration longer than 150 minutes\n* Unwillingness to participate in the study voluntarily","40 Years","70 Years",{"count":62,"type":22},120,"3 Days","OBSERVATIONAL","The goal of this observational cohort study is to evaluate whether the COPD Assessment Test (CAT) score can predict the risk of perioperative respiratory complications in patients aged 40 to 70 years with diagnosed Chronic Obstructive Pulmonary Disease (COPD), undergoing elective surgical procedures lasting no longer than 150 minutes.\n\nThe main questions it aims to answer are:\n\n* Is there a statistically significant association between preoperative CAT scores and the incidence of intraoperative and early postoperative respiratory complications in COPD patients?\n* Can the CAT score be effectively used as a preoperative risk stratification tool to guide anesthetic and surgical decision-making?\n\nResearchers will compare two patient groups based on CAT scores: those with CAT \\\u003C10 and those with CAT ≥10 to determine whether higher CAT scores are associated with an increased incidence of perioperative respiratory complications.\n\nParticipants will:\n\n* Complete the CAT questionnaire during the preoperative evaluation\n* Undergo elective surgery with an expected duration of ≤150 minutes\n* Be monitored intraoperatively for bronchospasm, oxygen desaturation, and ventilation difficulty\n* Be monitored postoperatively (within the first 72 hours) for hypoxemia, reintubation, bronchospasm episodes, postoperative pneumonia, intensive care unit (ICU) admission, and length of hospital stay\n* Have perioperative clinical data collected and analyzed for comparative outcomes between CAT score subgroups",[57,67],"Preoperative Risk Assessment",[69,57,70,67],"COPD Assessment Test","Postoperative Respiratory Complications","RECRUITING","2026-05-28",{"date":74,"type":42},"2026-06-01",{"date":76,"type":42},"2025-08-15",{"date":78,"type":22},"2027-02-01",{"name":48,"class":49},""]