[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Escoles Universitaries Gimbernat\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":118},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,72,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100641739","influence-of-manual-and-electrical-vagal-stimulation-on-autonomic-activity-and-other-dysautonomous-symptoms-in-a-healthy-population-100641739",false,"NCT07660744","Influence of Manual and Electrical Vagal Stimulation on Autonomic Activity and Other Dysautonomous Symptoms in a Healthy Population.","Influence of Manual and Electrical Vagal Stimulation on Autonomic Activity (Heart Rate Variability) and Other Dysautonomous Symptoms Such as Fatigue and Sleep Disturbances, in a Healthy Population.","Inclusion Criteria:\n\n* Healthy volunteers between 40 and 70 years of age.\n* No known neurological pathology.\n* Willingness to participate voluntarily in the study.\n\nExclusion criteria:\n\n* Cognitive impairment objectively assessed by a neurologist and considered relevant.\n* Contraindications for the application of transcutaneous auricular stimulation (implanted cardiac pacemaker or deep brain stimulation treatment).\n* Consumption of tea, caffeine, energy drinks, alcohol or tobacco in the two hours prior to the intervention.",true,"ALL","40 Years","70 Years",{"count":21,"type":22},16,"ESTIMATED","INTERVENTIONAL",[25],"NA","The objective of this clinical, longitudinal, prospective, randomised (randomised) unmasked study is to analyse whether electrical and manual vagal stimulation produces changes in heart rate variability in a healthy population and it have a beneficial clinical effect in reducing dysautonomic symptoms.\n\nThe main questions it seeks to answer are:\n\n* Will non-invasive (manual and electrical) stimulation of the vagus nerve produce a significant change in heart rate variability, generating effects on the regulation of the autonomic nervous system, increasing the activation of the parasympathetic nervous system and decreasing the activation of the sympathetic nervous system?\n* Will non-invasive (manual and electrical) stimulation of the vagus nerve have a beneficial clinical effect in reducing dysautonomic symptoms such as fatigue and improving sleep quality?\n* Will noninvasive (manual and electrical) vagus nerve stimulation improve quality of life?\n* Are there differences in the level of satisfaction with the treatment after the intervention program received?\n\nTwo groups of participants will be formed:\n\n* Transcutaneous auricular vagus nerve stimulation consists of applying electrical stimulation to the auricular branch of the vagus nerve using a 2-pole stimulation electrode. Stimulation is performed for 1 hour per day for 10 days (5 days per week).\n* Manual vagus nerve intervention consists of applying a protocol of manual therapy techniques to the vagus nerve and along its path, during 4 sessions lasting 30 minutes, 2 interventions per week.",[28],"Healthy","NOT_YET_RECRUITING","2026-06-16",{"date":32,"type":33},"2026-06-22","ACTUAL",{"date":35,"type":22},"2026-07",{"date":37,"type":22},"2026-10",{"name":39,"class":40},"Escoles Universitaries Gimbernat","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":18,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100598705","manual-therapy-in-vagus-nerve-neuromodulation-for-the-treatment-of-bruxism-100598705","NCT07074964","Manual Therapy in Vagus Nerve Neuromodulation for the Treatment of Bruxism","Efficacy of Manual Therapy in Indirect Non-Invasive Neuromodulation of the Vagus Nerve in the Treatment of Bruxism in Young Adult Population up to 40 Years Old","TMBruxism","Inclusion Criteria:\n\n1. Sleep bruxism diagnosed according to the ICSD-III (International Classification of Sleep Disorders, 3rd edition):\n\n   * Regular or frequent tooth grinding sounds occurring during sleep and the presence of one or more of the following clinical signs and symptoms:\n\n     1. Abnormal tooth wear consistent with reports of clenching\u002Fgrinding the teeth during sleep\n     2. Transient morning pain or fatigue in the jaw muscles; and\u002For temporal headaches; and\u002For jaw locking upon awakening, consistent with reports of clenching\u002Fgrinding the teeth during sleep\n2. Sleep bruxism diagnosed according to the RDC\u002FTMD:\n\n   * Interview: During the interview, subjects are asked about the following symptoms: reports of regular or frequent tooth grinding during sleep, muscle fatigue, temporal headache, transient morning muscle pain in the jaw, and jaw locking upon awakening.\n   * Physical examination: Presence or signs suggesting abnormal dental wear, such as teeth with flattened cusps and\u002For loss of contour with dentin exposure.\n\n     * Hypertrophy of the masticatory muscles\n     * Dental impressions on the tongue\n     * Linea alba on the cheeks along the bite line\n     * Damage to dental tissue\n     * Excessive dental wear\n3. A minimum pain intensity score of 3 on the Visual Analogue Scale at the masseter and temporal algometry points.\n4. EMGs with elevated mean power frequency for the masseter and temporalis muscles (to be defined in the first clinical phase-observational study).\n5. Age between 18 and 40 years.\n\nExclusion Criteria:\n\n1. Having suffered direct trauma, mandibular fractures, or surgeries in the orofacial region.\n2. Loss of more than 2 teeth, except for the third molar.\n3. Use of muscle relaxant medication or medications that may influence motor behavior.\n4. Having received botulinum toxin treatment in the last 6 months.\n5. Periodontal disorders or current orthodontic treatment or prosthesis.\n6. Partial or total dentures.\n7. History of medical disorders (severe psychiatric, physiological, or neurological conditions).","18 Years",{"count":51,"type":22},40,[25],"Introduction:\n\nSleep bruxism is defined as the repetitive activity of the masticatory muscles, characterized by clenching or grinding of the teeth. Studies confirm the association between sleep bruxism and episodes of masticatory muscle activity, with an increase in autonomic sympathetic activity observed during transient periods of sleep. This is associated with nocturnal awakenings, related to increased cardiac, cerebral (cortical arousal), respiratory, and muscular activity.\n\nObjectives: The main objectives are \"To study the mean power frequency (MPF) of the masticatory muscles measured by surface electromyography (sEMG) in the general population (with and without bruxism according to ICSD-3 and DC\u002FTMD criteria)\"; and \"to assess the effectiveness of manual therapy applied to structures adjacent to the vagus nerve based on its impact on orofacial pain and symptomatology in patients with bruxism\".\n\nMaterial and Methods:\n\nA cross-sectional observational study and a randomized controlled experimental study were designed. The first will analyze data collected by sEMG in the masticatory muscles, at rest and during maximum clenching, comparing results between bruxists and non-bruxists. The second will analyze, compared to the control group, data collected on signs (range of motion alteration, presence of sounds), symptomatology (pain, headaches, sensation of blockage, functional limitation) caused by bruxism, sleep quality (Pittsburgh Sleep Quality Index (PSQI)), oral health-related quality of life (OHIP-14), stress and anxiety status (Perceived Stress Scale and GAD-7 (Generalized Anxiety Disorder-7), respectively), and sympathetic-vagal balance (Heart Rate Variability in its frequency and time domains) before and after a manual therapy intervention on structures adjacent to the vagus nerve pathway (head, neck, thorax, diaphragm, abdomen). The collected data will be analyzed using IBM SPSS® version 25.0.0.",[55],"Bruxism, Sleep",[57,58,59,60,61,62],"Sleep Bruxism","Electromyography","Musculoskeletal Manipulations","Vagus Nerve","Autonomic Nervous System","Masticatory Muscles","2025-07-21",{"date":65,"type":33},"2025-07-24",{"date":67,"type":22},"2025-10-01",{"date":69,"type":22},"2028-12-01",{"name":39,"class":40},1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":46,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":16,"sex":17,"minAge":49,"maxAge":18,"enrollmentInfo":79,"targetDuration":81,"studyType":82,"phases":4,"briefSummary":53,"conditions":83,"keywords":84,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":90,"locationsCount":71},"100598396","surface-electromyography-in-the-detection-and-assessment-of-bruxism-100598396","NCT07070947","Surface Electromyography in the Detection and Assessment of Bruxism","EMGBruxism","Inclusion Criteria:\n\nFor patients with bruxism:\n\n1. Sleep bruxism diagnosed according to the ICSD-III (International Classification of Sleep Disorders, 3rd edition):\n\n   * Regular or frequent tooth grinding sounds occurring during sleep and the presence of one or more of the following clinical signs and symptoms:\n\n     1. Abnormal tooth wear consistent with reports of clenching\u002Fgrinding the teeth during sleep\n     2. Transient morning pain or fatigue in the jaw muscles; and\u002For temporal headaches; and\u002For jaw locking upon awakening, consistent with reports of clenching\u002Fgrinding the teeth during sleep\n2. Sleep bruxism diagnosed according to the RDC\u002FTMD:\n\n   * Interview: During the interview, subjects are asked about the following symptoms: reports of regular or frequent tooth grinding during sleep, muscle fatigue, temporal headache, transient morning muscle pain in the jaw, and jaw locking upon awakening.\n   * Physical examination: Presence or signs suggesting abnormal dental wear, such as teeth with flattened cusps and\u002For loss of contour with dentin exposure.\n\n     * Hypertrophy of the masticatory muscles\n     * Dental impressions on the tongue\n     * Linea alba on the cheeks along the bite line\n     * Damage to dental tissue\n     * Excessive dental wear\n3. A minimum pain intensity score of 3 on the Visual Analogue Scale at the masseter and temporal algometry points.\n4. EMGs with elevated mean power frequency for the masseter and temporalis muscles (to be defined in the first clinical phase-observational study).\n5. Age between 18 and 40 years.\n\nFor patiens without bruxism:\n\na)Asymptomatic and without signs of bruxism or other craniofacial pathologies.\n\nExclusion Criteria:\n\n1. Having suffered direct trauma, mandibular fractures, or surgeries in the orofacial region.\n2. Loss of more than 2 teeth, except for the third molar.\n3. Use of muscle relaxant medication or medications that may influence motor behavior.\n4. Having received botulinum toxin treatment in the last 6 months.\n5. Periodontal disorders or current orthodontic treatment or prosthesis.\n6. Partial or total dentures.\n7. History of medical disorders (severe psychiatric, physiological, or neurological conditions).",{"count":80,"type":22},54,"1 Day","OBSERVATIONAL",[55],[57,58,62],"2025-07-09",{"date":87,"type":33},"2025-07-17",{"date":67,"type":22},{"date":69,"type":22},{"name":39,"class":40},{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":101,"conditions":102,"keywords":105,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":115,"leadSponsor":117,"locationsCount":71},"100563658","external-body-weight-effects-on-body-weight-in-adults-with-grade-ii-and-iii-obesity-100563658","NCT06619028","External Body Weight Effects on Body Weight in Adults With Grade II and III Obesity","Effectiveness of the Use of External Body Weight in the Regulation of Body Weight, Body Composition and Analytical Parameters in Adults With Grade II and III Obesity","Inclusion Criteria:\n\n* Age\\>18 years\n* BMI (≥35)\n* Compliance at intervention delivery.\n\nExclusion Criteria:\n\n* Chronic pathology that may hinder the performance of the intervention\n* Chronic pain\n* Regular consumption of pharmacology or supplementation that affects body weight\n* Inability to perform any physical activity or high risk of suffering adverse effects from the interventibariatric-metabolic surgery\n* Reduced mobility\n* Changes of 5kg or more in the last 3 months\n* Drastic changes in lifestyle habits in the last 3 months (physical activity, eating habits, nicotine or alcohol consumption)\n* Apparent risk of not being able to complete the study intervention (at the principal investigator\\'s discretion)\n* Pregnancy",{"count":99,"type":22},24,[25],"Obesity is a growing problem in industrialized societies. This condition is associated with an increase in metabolic and cardiovascular diseases. Its cause is multifactorial, influenced by the environment, excessive calorie consumption, insufficient physical activity, sedentary lifestyle and alterations in energy metabolism.\n\nIn this context, the hormone leptin, responsible for regulating appetite and body weight, presents resistance in people with obesity, altering the metabolic balance. Recent research has explored the concept of the \"gravitostat\", a system that responds to the mechanical stimulus of standing upright, as a promising approach in the regulation of body weight. Animal and human studies have shown positive results in weight loss and body recomposition using this system. However, more research is needed to evaluate the clinical applicability and effectiveness of the gravitostat in the management of obesity.\n\nFor this reason, the present study is proposed, with a prospective longitudinal controlled design in the use of external body weight (where the patients are their own control: intrasubject controlled study) during 4 weeks, with a previous control period of 4 weeks and a follow-up of 4 weeks. The proposed objectives are to analyze the effectiveness of the use of external weight in the regulation of body weight, body composition and analytical parameters in people with grade II and III obesity. In this way, to analyze the clinical applicability of the gravitostat in the management of patients with this metabolic pathology.",[103,104],"Obesity Prevention","Obesity",[104,106,107,108,109,110],"Body Weight","Weight loss","Treatment","Leptin","Gravitostat","2024-09-25",{"date":113,"type":33},"2024-10-01",{"date":113,"type":22},{"date":116,"type":22},"2025-07-01",{"name":39,"class":40},""]